NO20022976L - 2-(1H-indol-3yl)-2-okso-acetamider med antitumoraktivitet - Google Patents

2-(1H-indol-3yl)-2-okso-acetamider med antitumoraktivitet

Info

Publication number: NO20022976L
Authority: NO; Norway
Prior art keywords: indol; antitumor activity; oxoacetamides; acetamides; colon
Prior art date: 1999-12-23

Application number

NO20022976A

Other languages

English (en)

Other versions

NO20022976D0 (no

NO323312B1 (no

Inventor

Ernesto Menta

Nicoletta Pescalli

Original Assignee

Novuspharma Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-23

Filing date

2002-06-20

Publication date

2002-06-20

2002-06-20 Application filed by Novuspharma Spa filed Critical Novuspharma Spa

2002-06-20 Publication of NO20022976D0 publication Critical patent/NO20022976D0/no

2002-06-20 Publication of NO20022976L publication Critical patent/NO20022976L/no

2007-03-12 Publication of NO323312B1 publication Critical patent/NO323312B1/no

Links

AWMLDBKLOPNOAR-UHFFFAOYSA-N 2-(1h-indol-3-yl)-2-oxoacetamide Chemical class C1=CC=C2C(C(=O)C(=O)N)=CNC2=C1 AWMLDBKLOPNOAR-UHFFFAOYSA-N 0.000 title abstract 2
230000000259 anti-tumor effect Effects 0.000 title abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
210000001072 colon Anatomy 0.000 abstract 1
208000029742 colonic neoplasm Diseases 0.000 abstract 1
208000037841 lung tumor Diseases 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

NO20022976A 1999-12-23 2002-06-20 2-(1H-indol-3yl)-2-okso-acetamider, sammensetninger inneholdende disse og deres anvendelse NO323312B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT1999MI002693A IT1315267B1 (it)	1999-12-23	1999-12-23	Derivati di 2-(1h-indol-3-il)-2-oxo-acetammidi ad attivita'antitumorale
PCT/EP2000/013068 WO2001047916A1 (en)	1999-12-23	2000-12-21	2-(1h-indol-3-yl)-2-oxo-acetamides with antitumor activity

Publications (3)

Publication Number	Publication Date
NO20022976D0 NO20022976D0 (no)	2002-06-20
NO20022976L true NO20022976L (no)	2002-06-20
NO323312B1 NO323312B1 (no)	2007-03-12

Family

ID=11384182

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20022976A NO323312B1 (no)	1999-12-23	2002-06-20	2-(1H-indol-3yl)-2-okso-acetamider, sammensetninger inneholdende disse og deres anvendelse

Country Status (24)

Country	Link
US (1)	US6753342B2 (no)
EP (1)	EP1244652B1 (no)
JP (1)	JP2003519140A (no)
KR (1)	KR100795533B1 (no)
CN (1)	CN1250542C (no)
AT (1)	ATE302772T1 (no)
AU (1)	AU776332B2 (no)
BR (1)	BR0016553A (no)
CA (1)	CA2395205A1 (no)
CZ (1)	CZ20022170A3 (no)
DE (1)	DE60022227T2 (no)
EA (1)	EA004925B1 (no)
ES (1)	ES2246918T3 (no)
HU (1)	HUP0203524A3 (no)
IL (2)	IL150329A0 (no)
IT (1)	IT1315267B1 (no)
MX (1)	MXPA02006217A (no)
NO (1)	NO323312B1 (no)
NZ (1)	NZ519689A (no)
PL (1)	PL356541A1 (no)
SK (1)	SK285682B6 (no)
TR (1)	TR200201613T2 (no)
WO (1)	WO2001047916A1 (no)
ZA (1)	ZA200204964B (no)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK1076657T3 (da)	1998-04-28	2004-11-08	Elbion Ag	Hidtil ukendte hydroxyindoler, deres anvendelse som inhibitorer for phosphodiesterase 4 og fremgangsmåde til deres fremstilling
IT1318641B1 (it)	2000-07-25	2003-08-27	Novuspharma Spa	Ammidi di acidi 2-(1h-indol-3-il)-2-oxo-acetici ad attivita'antitumorale.
DE10037310A1 (de)	2000-07-28	2002-02-07	Asta Medica Ag	Neue Indolderivate und deren Verwendung als Arzneimittel
US7649012B2 (en) *	2002-07-09	2010-01-19	Fasgen, Inc.	Compounds, pharmaceutical compositions containing same, and methods of use for same
SG146624A1 (en)	2003-09-11	2008-10-30	Kemia Inc	Cytokine inhibitors
RU2376286C2 (ru) *	2004-03-11	2009-12-20	Актелион Фармасьютиклз Лтд	Производные индол-1-илуксусной кислоты
US7645789B2 (en)	2006-04-07	2010-01-12	Vertex Pharmaceuticals Incorporated	Indole derivatives as CFTR modulators
JP5420395B2 (ja)	2006-04-07	2014-02-19	バーテックスファーマシューティカルズインコーポレイテッド	Ａｔｐ結合カセット輸送体の調節剤
USRE50453E1 (en)	2006-04-07	2025-06-10	Vertex Pharmaceuticals Incorporated	Indole derivatives as CFTR modulators
US10022352B2 (en)	2006-04-07	2018-07-17	Vertex Pharmaceuticals Incorporated	Modulators of ATP-binding cassette transporters
WO2008019357A2 (en) *	2006-08-07	2008-02-14	Ironwood Pharmaceuticals, Inc.	Indole compounds
US8563573B2 (en)	2007-11-02	2013-10-22	Vertex Pharmaceuticals Incorporated	Azaindole derivatives as CFTR modulators
US8802868B2 (en)	2010-03-25	2014-08-12	Vertex Pharmaceuticals Incorporated	Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
RU2569678C2 (ru)	2010-04-22	2015-11-27	Вертекс Фармасьютикалз Инкорпорейтед	Способ получения циклоалкилкарбоксамидо-индольных соединений
AR084433A1 (es)	2010-12-22	2013-05-15	Ironwood Pharmaceuticals Inc	Inhibidores de la faah y composiciones farmaceuticas que los contienen
WO2012135027A2 (en) *	2011-03-25	2012-10-04	The Research Foundation Of State University Of New York	Thiolactone antibiotics
AU2013290444B2 (en)	2012-07-16	2018-04-26	Vertex Pharmaceuticals Incorporated	Pharmaceutical compositions of (R)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof
PL3925607T5 (pl)	2014-04-15	2026-06-01	Vertex Pharmaceuticals Incorporated	Kompozycje farmaceutyczne do leczenia chorób, w których pośredniczy mukowiscydozowy przezbłonowy regulator przewodnictwa
CN115785079B (zh) *	2022-11-28	2024-02-13	沈阳药科大学	4-(1h-吲哚-5-基)氨基呋喃-2(5h)-酮类化合物及其制备和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0841924T3 (da) *	1995-08-02	2003-02-10	Univ Newcastle Ventures Ltd	Benzimidazolforbindelser
CO4970714A1 (es) *	1997-09-05	2000-11-07	Boehringer Mannheim Gmbh	Derivados ureido y tioureido de 4-amino-2(5h)-furanonas y 4-amino-2(5h) tiofenonas como agentes antitumorales
DE19814838C2 (de) *	1998-04-02	2001-01-18	Asta Medica Ag	Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
DK1076657T3 (da) *	1998-04-28	2004-11-08	Elbion Ag	Hidtil ukendte hydroxyindoler, deres anvendelse som inhibitorer for phosphodiesterase 4 og fremgangsmåde til deres fremstilling

1999
- 1999-12-23 IT IT1999MI002693A patent/IT1315267B1/it active
2000
- 2000-12-21 WO PCT/EP2000/013068 patent/WO2001047916A1/en not_active Ceased
- 2000-12-21 TR TR2002/01613T patent/TR200201613T2/xx unknown
- 2000-12-21 CN CNB00817492XA patent/CN1250542C/zh not_active Expired - Fee Related
- 2000-12-21 AU AU21704/01A patent/AU776332B2/en not_active Ceased
- 2000-12-21 MX MXPA02006217A patent/MXPA02006217A/es active IP Right Grant
- 2000-12-21 KR KR1020027007960A patent/KR100795533B1/ko not_active Expired - Fee Related
- 2000-12-21 DE DE60022227T patent/DE60022227T2/de not_active Expired - Fee Related
- 2000-12-21 AT AT00985225T patent/ATE302772T1/de not_active IP Right Cessation
- 2000-12-21 SK SK896-2002A patent/SK285682B6/sk not_active IP Right Cessation
- 2000-12-21 BR BR0016553-0A patent/BR0016553A/pt not_active Application Discontinuation
- 2000-12-21 CZ CZ20022170A patent/CZ20022170A3/cs unknown
- 2000-12-21 HU HU0203524A patent/HUP0203524A3/hu unknown
- 2000-12-21 IL IL15032900A patent/IL150329A0/xx active IP Right Grant
- 2000-12-21 US US10/149,406 patent/US6753342B2/en not_active Expired - Fee Related
- 2000-12-21 JP JP2001549386A patent/JP2003519140A/ja active Pending
- 2000-12-21 PL PL00356541A patent/PL356541A1/xx not_active IP Right Cessation
- 2000-12-21 NZ NZ519689A patent/NZ519689A/en unknown
- 2000-12-21 ES ES00985225T patent/ES2246918T3/es not_active Expired - Lifetime
- 2000-12-21 CA CA002395205A patent/CA2395205A1/en not_active Abandoned
- 2000-12-21 EP EP00985225A patent/EP1244652B1/en not_active Expired - Lifetime
- 2000-12-21 EA EA200200558A patent/EA004925B1/ru not_active IP Right Cessation
2002
- 2002-06-19 IL IL150329A patent/IL150329A/en not_active IP Right Cessation
- 2002-06-20 ZA ZA200204964A patent/ZA200204964B/en unknown
- 2002-06-20 NO NO20022976A patent/NO323312B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
TR200201613T2 (tr)	2002-10-21
MXPA02006217A (es)	2004-02-26
IL150329A0 (en)	2002-12-01
EP1244652B1 (en)	2005-08-24
NO20022976D0 (no)	2002-06-20
IL150329A (en)	2006-07-05
WO2001047916A1 (en)	2001-07-05
CZ20022170A3 (cs)	2002-09-11
US20030158153A1 (en)	2003-08-21
CA2395205A1 (en)	2001-07-05
ES2246918T3 (es)	2006-03-01
CN1413205A (zh)	2003-04-23
ATE302772T1 (de)	2005-09-15
IT1315267B1 (it)	2003-02-03
DE60022227D1 (de)	2005-09-29
HUP0203524A3 (en)	2008-01-28
DE60022227T2 (de)	2006-06-22
SK285682B6 (sk)	2007-06-07
EA200200558A1 (ru)	2002-12-26
KR100795533B1 (ko)	2008-01-16
EA004925B1 (ru)	2004-10-28
EP1244652A1 (en)	2002-10-02
ZA200204964B (en)	2004-01-29
BR0016553A (pt)	2002-09-17
HUP0203524A2 (hu)	2003-03-28
JP2003519140A (ja)	2003-06-17
ITMI992693A0 (it)	1999-12-23
PL356541A1 (en)	2004-06-28
ITMI992693A1 (it)	2001-06-23
SK8962002A3 (en)	2002-11-06
CN1250542C (zh)	2006-04-12
AU2170401A (en)	2001-07-09
NO323312B1 (no)	2007-03-12
US6753342B2 (en)	2004-06-22
AU776332B2 (en)	2004-09-02
KR20020063247A (ko)	2002-08-01
NZ519689A (en)	2004-02-27

Legal Events

Date	Code	Title	Description
2010-07-19	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO20022976D0 (no)	2002-06-20	2-(1H-indol-3yl)-2-okso-acetamider med antitumoraktivitet
DE60015927D1 (en)	2004-12-23	Phenylharnstoff und phenylthioharnstoffderivate
DE69918422D1 (de)	2004-08-05	Phthalazinone pde iii/iv hemmer
TR199901653T2 (xx)	1999-10-21	Fitalazinonlar.
ES2184077T3 (es)	2003-04-01	Nuevas fenantridinas sustituidas en la posicion 6.
EE200000033A (et)	2000-10-16	Uudsed tetrasoolderivaadid
DE69821530D1 (de)	2004-03-11	Dihydrobenzifurane
ATE245642T1 (de)	2003-08-15	Benzamide mit tetrahydrofuranyloxy-substituenten als inhibitoren der phosphodiesterase 4
DE60005689D1 (de)	2003-11-06	Neue aminobenzophenone
SE9903290D0 (sv)	1999-09-15	Novel compounds
ATE330958T1 (de)	2006-07-15	Pyrazino 1'2':1,6öpyrido 3,4-böindolderivate
DK1377574T3 (da)	2005-04-25	6-phenylbenzonaphtyridiner
BG106937A (en)	2003-04-30	Novel indole derivatives
DE60017374D1 (de)	2005-02-17	Antibakterielle mittel
MA24197A1 (fr)	1997-12-31	Nouvelles fungarrestines
ATE462707T1 (de)	2010-04-15	Alkylsubstituierte indolochinoxaline
ATE213236T1 (de)	2002-02-15	Substituierte benzyloxyimino-verbindungen
DE59901563D1 (de)	2002-07-04	N-substituierte azabicycloheptan-derivate, ihre herstellung und verwendung
ATE243698T1 (de)	2003-07-15	1,2-dihydro-1-oxo-pyrazino(1,2-)indolederivate
ES2166710A1 (es)	2003-12-01	Nuevos compuestos heterociclicos con actividad antiinflamatoria.
CY1110529T1 (el)	2015-04-29	Παρασκευη ν-υποκατεστημενων 2,7-διαλκυλο-4-υδροξυ-5-αμινο-8-αρυλοοκτανοϋλαμιδιων