ATE64391T1 - Azacyclische verbindungen, verfahren zu ihrer herstellung und ihre verwendung als pharmazeutisches mittel. - Google Patents
Azacyclische verbindungen, verfahren zu ihrer herstellung und ihre verwendung als pharmazeutisches mittel.Info
- Publication number
- ATE64391T1 ATE64391T1 AT89301256T AT89301256T ATE64391T1 AT E64391 T1 ATE64391 T1 AT E64391T1 AT 89301256 T AT89301256 T AT 89301256T AT 89301256 T AT89301256 T AT 89301256T AT E64391 T1 ATE64391 T1 AT E64391T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- hydrogen
- group
- production
- pharmaceutical agent
- Prior art date
Links
- 150000004030 azacyclic compounds Chemical class 0.000 title 1
- 239000008177 pharmaceutical agent Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000006590 (C2-C6) alkenylene group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 229910003813 NRa Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- -1 polymethylene Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Photoreceptors In Electrophotography (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888803259A GB8803259D0 (en) | 1988-02-12 | 1988-02-12 | Compounds |
| EP89301256A EP0333315B1 (de) | 1988-02-12 | 1989-02-09 | Azacyclische Verbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung als pharmazeutisches Mittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE64391T1 true ATE64391T1 (de) | 1991-06-15 |
Family
ID=10631593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89301256T ATE64391T1 (de) | 1988-02-12 | 1989-02-09 | Azacyclische verbindungen, verfahren zu ihrer herstellung und ihre verwendung als pharmazeutisches mittel. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4994450A (de) |
| EP (1) | EP0333315B1 (de) |
| JP (1) | JPH01246258A (de) |
| KR (1) | KR890012963A (de) |
| AT (1) | ATE64391T1 (de) |
| AU (1) | AU615984B2 (de) |
| DE (1) | DE68900113D1 (de) |
| DK (1) | DK65489A (de) |
| ES (1) | ES2039845T3 (de) |
| GB (1) | GB8803259D0 (de) |
| GR (1) | GR3002230T3 (de) |
| NZ (1) | NZ227930A (de) |
| PT (1) | PT89677A (de) |
| ZA (1) | ZA891052B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0232612B1 (de) * | 1985-12-23 | 1990-04-04 | Dr. Lo. Zambeletti S.p.A. | Azacyclische Verbindungen, Verfahren zur ihrer Herstellung und ihre Verwendung als Pharmazeutika |
| US5512567A (en) * | 1988-08-24 | 1996-04-30 | Sankyo Company, Limited | Analgesic compounds, their preparation, and pharmaceutical compositions containing them |
| EP0361791B1 (de) * | 1988-09-26 | 1995-11-08 | Smithkline Beecham Farmaceutici S.p.A. | Azacyclische Verbindungen, verwendbar als Arzneimittel |
| GB8926560D0 (en) * | 1989-11-24 | 1990-01-17 | Zambeletti Spa L | Pharmaceuticals |
| EP0447704A1 (de) * | 1990-03-21 | 1991-09-25 | Smithkline Beecham Farmaceutici S.p.A. | N-Acylierte azyklische Verbindungen, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel |
| US5428042A (en) * | 1990-04-28 | 1995-06-27 | Dr Lo Zambeletti S.P.A. | 1-(2H-1-oxo-3,4-dihydronaphtyl-6-yl)-acetyl-piperidines as kappa agonists |
| GB9011656D0 (en) * | 1990-05-24 | 1990-07-11 | Zambeletti Spa L | Novel compounds |
| AU2002322720B2 (en) | 2001-07-25 | 2008-11-13 | Raptor Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
| CA2789262C (en) | 2005-04-28 | 2016-10-04 | Proteus Digital Health, Inc. | Pharma-informatics system |
| EP2063905B1 (de) | 2006-09-18 | 2014-07-30 | Raptor Pharmaceutical Inc | Behandlungen von lebererkrankungen durch verabreichung von konjugaten aus rezeptor-assoziierten proteinen |
| TR201908314T4 (tr) | 2009-02-20 | 2019-06-21 | 2 Bbb Medicines B V | Glutatyon bazlı ilaç dağıtım sistemi. |
| KR101909711B1 (ko) | 2009-05-06 | 2018-12-19 | 라보라토리 스킨 케어, 인크. | 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| CN105299030B (zh) * | 2015-11-23 | 2018-03-23 | 荣腾实业（苏州）有限公司 | 一种驱动轴导向机构 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0052311A1 (de) * | 1980-11-19 | 1982-05-26 | Sterling Drug Inc. | 1-(Benzoylphenyl-niederalkyl)-piperidine und entsprechende Carbinole und ihre Herstellung |
| US4656182A (en) * | 1983-12-06 | 1987-04-07 | Warner-Lambert Company | Substituted trans-1,2-diaminocyclohexyl amide compounds |
| DE3409237A1 (de) * | 1984-03-14 | 1985-09-19 | Dr. Karl Thomae Gmbh, 7950 Biberach | Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| EP0232612B1 (de) * | 1985-12-23 | 1990-04-04 | Dr. Lo. Zambeletti S.p.A. | Azacyclische Verbindungen, Verfahren zur ihrer Herstellung und ihre Verwendung als Pharmazeutika |
| ES2052560T3 (es) * | 1986-06-05 | 1994-07-16 | Ici America Inc | Compuestos difluorcetonicos. |
| EP0260041B1 (de) * | 1986-09-02 | 1991-01-30 | Dr. Lo. Zambeletti S.p.A. | 1-Acylsubstituierte Piperidinderivate |
| PT86427B (pt) * | 1986-12-22 | 1990-11-20 | Zambeletti Spa L | Processo para a preparacao de derivados de piperidina |
-
1988
- 1988-02-12 GB GB888803259A patent/GB8803259D0/en active Pending
-
1989
- 1989-02-09 EP EP89301256A patent/EP0333315B1/de not_active Expired - Lifetime
- 1989-02-09 ES ES198989301256T patent/ES2039845T3/es not_active Expired - Lifetime
- 1989-02-09 AT AT89301256T patent/ATE64391T1/de active
- 1989-02-09 DE DE8989301256T patent/DE68900113D1/de not_active Expired - Fee Related
- 1989-02-10 NZ NZ227930A patent/NZ227930A/en unknown
- 1989-02-10 AU AU29834/89A patent/AU615984B2/en not_active Ceased
- 1989-02-10 PT PT89677A patent/PT89677A/pt not_active Application Discontinuation
- 1989-02-10 US US07/309,687 patent/US4994450A/en not_active Expired - Fee Related
- 1989-02-10 DK DK065489A patent/DK65489A/da not_active Application Discontinuation
- 1989-02-10 ZA ZA891052A patent/ZA891052B/xx unknown
- 1989-02-11 KR KR1019890001604A patent/KR890012963A/ko not_active Withdrawn
- 1989-02-13 JP JP1031285A patent/JPH01246258A/ja active Pending
-
1991
- 1991-07-02 GR GR91400933T patent/GR3002230T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US4994450A (en) | 1991-02-19 |
| EP0333315A1 (de) | 1989-09-20 |
| GB8803259D0 (en) | 1988-03-09 |
| NZ227930A (en) | 1992-05-26 |
| ZA891052B (en) | 1991-03-27 |
| AU2983489A (en) | 1989-08-17 |
| AU615984B2 (en) | 1991-10-17 |
| DK65489A (da) | 1989-08-13 |
| GR3002230T3 (en) | 1992-12-30 |
| PT89677A (pt) | 1989-10-04 |
| JPH01246258A (ja) | 1989-10-02 |
| EP0333315B1 (de) | 1991-06-12 |
| ES2039845T3 (es) | 1993-10-01 |
| KR890012963A (ko) | 1989-09-20 |
| DE68900113D1 (de) | 1991-07-18 |
| DK65489D0 (da) | 1989-02-10 |
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