ATE67244T1 - Herstellung und reinigung von lymphokinen. - Google Patents

Herstellung und reinigung von lymphokinen.

Info

Publication number: ATE67244T1
Authority: AT; Austria
Prior art keywords: csf; cdna; preparing; protein; rna
Prior art date: 1984-07-06

Application number

AT85903275T

Other languages

English (en)

Inventor

Steven C Clark

Randal J Kaufman

Gordon G Wong

Elizabeth A Wang

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-07-06

Filing date

1985-07-04

Publication date

1991-09-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27417446&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE67244(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1985-07-04 Application filed by Sandoz Ag filed Critical Sandoz Ag

1991-09-15 Application granted granted Critical

1991-09-15 Publication of ATE67244T1 publication Critical patent/ATE67244T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
102000008072 Lymphokines Human genes 0.000 title 1
108010074338 Lymphokines Proteins 0.000 title 1
238000000746 purification Methods 0.000 title 1
239000002299 complementary DNA Substances 0.000 abstract 9
102000004169 proteins and genes Human genes 0.000 abstract 5
108090000623 proteins and genes Proteins 0.000 abstract 5
239000013598 vector Substances 0.000 abstract 4
230000000694 effects Effects 0.000 abstract 3
238000000034 method Methods 0.000 abstract 3
108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 2
238000012258 culturing Methods 0.000 abstract 2
108020004999 messenger RNA Proteins 0.000 abstract 2
244000005700 microbiome Species 0.000 abstract 2
239000013612 plasmid Substances 0.000 abstract 2
230000009466 transformation Effects 0.000 abstract 2
241000894006 Bacteria Species 0.000 abstract 1
238000012216 screening Methods 0.000 abstract 1
239000006228 supernatant Substances 0.000 abstract 1
230000001131 transforming effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

Landscapes

Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Mycology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Medicinal Chemistry (AREA)
Immunology (AREA)
Toxicology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Steroid Compounds (AREA)
Investigating Or Analysing Biological Materials (AREA)
Detergent Compositions (AREA)
Fats And Perfumes (AREA)
Compounds Of Unknown Constitution (AREA)
Debugging And Monitoring (AREA)

AT85903275T 1984-07-06 1985-07-04 Herstellung und reinigung von lymphokinen. ATE67244T1 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US62834284A	1984-07-06	1984-07-06
US65274284A	1984-09-19	1984-09-19
US65244784A	1984-09-19	1984-09-19
EP85903275A EP0188479B1 (de)	1984-07-06	1985-07-04	Herstellung und reinigung von lymphokinen
PCT/EP1985/000326 WO1986000639A1 (en)	1984-07-06	1985-07-04	Lymphokine production and purification

Publications (1)

Publication Number	Publication Date
ATE67244T1 true ATE67244T1 (de)	1991-09-15

Family

ID=27417446

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT85903275T ATE67244T1 (de)	1984-07-06	1985-07-04	Herstellung und reinigung von lymphokinen.
AT89106339T ATE172494T1 (de)	1984-07-06	1985-07-04	Lymphokin-herstellung und -reinigung

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT89106339T ATE172494T1 (de)	1984-07-06	1985-07-04	Lymphokin-herstellung und -reinigung

Country Status (28)

Country	Link
EP (2)	EP0188479B1 (de)
JP (4)	JP2540509B2 (de)
KR (1)	KR910001809B1 (de)
AT (2)	ATE67244T1 (de)
AU (3)	AU599572B2 (de)
CA (2)	CA1341618C (de)
CY (1)	CY1629A (de)
DE (3)	DE3588199T2 (de)
DK (2)	DK168709B1 (de)
ES (1)	ES8701226A1 (de)
FI (1)	FI108796B (de)
GR (1)	GR851643B (de)
HK (1)	HK111594A (de)
HU (1)	HU208711B (de)
IE (2)	IE60819B1 (de)
IL (2)	IL75725A (de)
LU (1)	LU88337I2 (de)
MY (1)	MY102902A (de)
NL (1)	NL930089I2 (de)
NO (4)	NO179455C (de)
NZ (2)	NZ228031A (de)
PL (1)	PL153139B1 (de)
PT (1)	PT80776B (de)
SA (1)	SA94150015A (de)
SG (1)	SG108991G (de)
SK (1)	SK280265B6 (de)
UA (1)	UA39161C2 (de)
WO (1)	WO1986000639A1 (de)

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ES8705470A1 (es) *	1984-11-20	1987-05-01	Schering Biotech Corp	Un procedimiento para producir un polipeptido
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DE3681551D1 (de) *	1985-09-30	1991-10-24	Chugai Pharmaceutical Co Ltd	Menschlicher granulozyten-colony stimulierender faktor.
WO1987002060A1 (en) *	1985-10-03	1987-04-09	Biogen N.V.	Human granulocyte-macrophage colony stimulating factor-like polypeptides and processes for producing them in high yields in microbial cells
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DE3545568A1 (de) *	1985-12-21	1987-07-16	Hoechst Ag	Gm-csf-protein, seine derivate, herstellung solcher proteine und ihre verwendung
US5298603A (en) *	1985-12-21	1994-03-29	Hoechst Aktiengesellschaft	GM-CSF protein, its derivatives, the preparation of proteins of this type, and their use
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EP0276846A3 (de) *	1987-01-29	1989-07-26	Zymogenetics, Inc.	Derivate des koloniestimulierenden Faktors
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WO1988010310A1 (en) *	1987-06-25	1988-12-29	Immunex Corporation	Bovine granulocyte-macrophage colony stimulating factor
US5391706A (en) *	1987-07-16	1995-02-21	Schering Plough Corporation	Purification of GM-CSF
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IE63514B1 (en) *	1987-07-17	1995-05-03	Schering Biotech Corp	Expression vectors for the production of human granulocyte-macrophage colony stimulation factor in a mammalian cell host
AU626530B2 (en) *	1987-07-17	1992-08-06	Schering Biotech Corporation	Human granulocyte-macrophage colony stimulating factor and muteins thereof
CA1317244C (en) *	1987-07-24	1993-05-04	Ernest Seigo Kawasaki	Production of biologically active forms of csf using a baculovirus (acnpv)-insect cell expression system
EP0347057A1 (de) *	1988-05-31	1989-12-20	Schering Biotech Corporation	Behandlung von Myeloid Leukämien
AU618283B2 (en) *	1988-10-10	1991-12-19	Instituto Nazionale Per Lo Studio E La Cura Dei Tumori	The use of GM-CSF in the treatment of a patient requiring high-dose chemo- or radiotherapy for cancer
US5811523A (en)	1988-11-10	1998-09-22	Trinchieri; Giorgio	Antibodies to natural killer stimulatory factor
JPH0322973A (ja) *	1989-01-19	1991-01-31	Wan Shen-Yuan	ヒトヘパトーム細胞系によるコロニー形成促進因子（ＣＳＦｓ）の構成性産生
JPH04503815A (ja) *	1989-07-14	1992-07-09	シェリング・コーポレーション	カルボキシル末端から誘導されたｇｍ―ｃｓｆのアンタゴニスト
AU3657893A (en)	1992-02-28	1993-09-13	Board Of Regents, The University Of Texas System	Compositions and methods for the treatment of thermal injury
US6004807A (en) *	1992-03-30	1999-12-21	Schering Corporation	In vitro generation of human dendritic cells
US6057133A (en) *	1992-11-24	2000-05-02	G. D. Searle	Multivariant human IL-3 fusion proteins and their recombinant production
US7091319B1 (en)	1992-11-24	2006-08-15	Bauer S Christopher	IL-3 variant hematopoiesis fusion protein
US6361976B1 (en)	1992-11-24	2002-03-26	S. Christopher Bauer	Co-administration of interleukin-3 mutant polypeptides with CSF'S for multi-lineage hematopoietic cell production
US6361977B1 (en)	1992-11-24	2002-03-26	S. Christopher Bauer	Methods of using multivariant IL-3 hematopoiesis fusion protein
US6403076B1 (en)	1992-11-24	2002-06-11	S. Christopher Bauer	Compositions for increasing hematopoiesis with interleukin-3 mutants
US6413509B1 (en)	1992-11-24	2002-07-02	S. Christopher Bauer	Methods of ex-vivo expansion of hematopoietic cells using interleukin-3 mutant polypeptides with other hematopoietic growth factors
US5738849A (en) *	1992-11-24	1998-04-14	G. D. Searle & Co.	Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
US5772992A (en) *	1992-11-24	1998-06-30	G.D. Searle & Co.	Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors
US6153183A (en) *	1992-11-24	2000-11-28	G. D. Searle & Company	Co-administration of interleukin-3 mutant polypeptides with CSF's or cytokines for multi-lineage hematopoietic cell production
KR100227406B1 (ko)	1993-05-12	1999-12-01	브루스 엠. 에이센	Bmp-11 조성물
EP0646643B1 (de) *	1993-06-30	2001-12-05	Lucky Ltd.	Modifizierte-Granulocyte-Makrophage-Kolonie-stimulierender-Faktor-Gen und seine Expression in Hefe
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US6027919A (en)	1993-12-07	2000-02-22	Genetics Institute, Inc.	BMP-12 and BMP-13 proteins and DNA encoding them
US5578301A (en) *	1993-12-14	1996-11-26	Sandoz Ltd.	Method for using GM-CSF to reduce the acute phase response in a patient being administered IL-6 therapy
US5599536A (en) *	1993-12-13	1997-02-04	Sandoz Ltd.	Method for suppressing the acute phase response in a patient receiving IL-6 therapy
US6165748A (en)	1997-07-11	2000-12-26	Genetics Institute, Inc.	Frazzled nucleotide sequences and expression products
US6676937B1 (en)	1998-03-09	2004-01-13	Caritas St. Elizabeth's Medical Center Of Boston Inc.	Compositions and methods for modulating vascularization
US6727224B1 (en)	1999-02-01	2004-04-27	Genetics Institute, Llc.	Methods and compositions for healing and repair of articular cartilage
DE19905501B4 (de)	1999-02-10	2005-05-19	MediGene AG, Gesellschaft für molekularbiologische Kardiologie und Onkologie	Verfahren zur Herstellung eines rekombinanten Adeno-assoziierten Virus, geeignete Mittel hierzu sowie Verwendung zur Herstellung eines Arzneimittels
WO2000047195A1 (en) *	1999-02-12	2000-08-17	Washington University	Stimulating neutrophil function to treat inflammatory bowel disease
EP2286847A1 (de)	1999-10-15	2011-02-23	Genetics Institute, LLC	Hyaluronsäure enthaltende Zusammensetzungen zur Abgabe osteogener Proteine
US6869762B1 (en)	1999-12-10	2005-03-22	Whitehead Institute For Biomedical Research	Crohn's disease-related polymorphisms
EP1276899A2 (de) *	1999-12-10	2003-01-22	Whitehead Institute For Biomedical Research	Ibd-verwandte polymorphismen
US6689599B1 (en)	2000-10-20	2004-02-10	Genetics Institute, Llc	Aggrecanase molecules
TWI329129B (en)	2001-02-08	2010-08-21	Wyeth Corp	Modified and stabilized gdf propeptides and uses thereof
US7226587B2 (en)	2001-06-01	2007-06-05	Wyeth	Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins
TWI267378B (en)	2001-06-08	2006-12-01	Wyeth Corp	Calcium phosphate delivery vehicles for osteoinductive proteins
AU2002319703A1 (en)	2001-07-27	2003-02-17	Wyeth	Aggrecanase molecules
EP1476545A4 (de)	2002-01-31	2006-11-29	Wyeth Corp	Aggrecanasemoleküle
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JPS6030654B2 (ja) *	1980-12-31	1985-07-17	株式会社林原生物化学研究所	ヒトコロニ−刺激因子の製造方法
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1985
- 1985-07-04 DE DE3588199T patent/DE3588199T2/de not_active Expired - Lifetime
- 1985-07-04 JP JP60503011A patent/JP2540509B2/ja not_active Expired - Lifetime
- 1985-07-04 AT AT85903275T patent/ATE67244T1/de active
- 1985-07-04 NZ NZ228031A patent/NZ228031A/en unknown
- 1985-07-04 ES ES544868A patent/ES8701226A1/es not_active Expired
- 1985-07-04 AT AT89106339T patent/ATE172494T1/de not_active IP Right Cessation
- 1985-07-04 AU AU45456/85A patent/AU599572B2/en not_active Expired
- 1985-07-04 KR KR1019860700138A patent/KR910001809B1/ko not_active Expired
- 1985-07-04 WO PCT/EP1985/000326 patent/WO1986000639A1/en not_active Ceased
- 1985-07-04 EP EP85903275A patent/EP0188479B1/de not_active Expired - Lifetime
- 1985-07-04 NZ NZ212645A patent/NZ212645A/xx unknown
- 1985-07-04 HU HU853131A patent/HU208711B/hu unknown
- 1985-07-04 DE DE8585903275T patent/DE3584089D1/de not_active Expired - Lifetime
- 1985-07-04 DE DE198585903275T patent/DE188479T1/de active Pending
- 1985-07-04 GR GR851643A patent/GR851643B/el unknown
- 1985-07-04 UA UA4027096A patent/UA39161C2/uk unknown
- 1985-07-04 IL IL75725A patent/IL75725A/xx not_active IP Right Cessation
- 1985-07-04 EP EP89106339A patent/EP0337359B1/de not_active Expired - Lifetime
- 1985-07-04 IE IE169585A patent/IE60819B1/en not_active IP Right Cessation
- 1985-07-04 IE IE930961A patent/IE930961L/xx not_active IP Right Cessation
- 1985-07-05 CA CA486372A patent/CA1341618C/en active Active
- 1985-07-05 PT PT80776A patent/PT80776B/pt unknown
- 1985-07-05 PL PL1985254400A patent/PL153139B1/pl unknown
- 1985-07-05 SK SK5059-85A patent/SK280265B6/sk unknown
1986
- 1986-01-22 FI FI860308A patent/FI108796B/fi not_active IP Right Cessation
- 1986-03-03 NO NO860775A patent/NO179455C/no not_active IP Right Cessation
- 1986-03-06 DK DK102886A patent/DK168709B1/da not_active IP Right Cessation
1987
- 1987-09-22 MY MYPI87001870A patent/MY102902A/en unknown
1989
- 1989-08-21 AU AU40090/89A patent/AU628069B2/en not_active Expired
1990
- 1990-05-14 AU AU54976/90A patent/AU644359B2/en not_active Expired
- 1990-06-17 IL IL94754A patent/IL94754A0/xx not_active IP Right Cessation
1991
- 1991-12-24 SG SG1089/91A patent/SG108991G/en unknown
1992
- 1992-07-10 CY CY1629A patent/CY1629A/xx unknown
1993
- 1993-05-21 DK DK199300594A patent/DK172679B1/da not_active IP Right Cessation
- 1993-06-22 JP JP5176039A patent/JP2594744B2/ja not_active Expired - Lifetime
- 1993-06-22 JP JP5175978A patent/JP2594743B2/ja not_active Expired - Lifetime
- 1993-06-24 NL NL930089C patent/NL930089I2/nl unknown
- 1993-06-25 LU LU88337C patent/LU88337I2/fr unknown
1994
- 1994-06-20 SA SA94150015A patent/SA94150015A/ar unknown
- 1994-09-07 NO NO19943300A patent/NO314941B1/no not_active IP Right Cessation
- 1994-10-12 HK HK111594A patent/HK111594A/en not_active IP Right Cessation
- 1994-10-19 JP JP6253317A patent/JP2594768B2/ja not_active Expired - Lifetime
1996
- 1996-01-05 CA CA000617042A patent/CA1340852C/en not_active Expired - Lifetime
- 1996-04-12 NO NO961452A patent/NO307348B1/no not_active IP Right Cessation
- 1996-12-18 NO NO1996016C patent/NO1996016I1/no unknown

Also Published As

Publication number	Publication date
IL94754A0 (en)	1991-04-15
JP2540509B2 (ja)	1996-10-02
NO943300D0 (no)	1994-09-07
DK102886A (da)	1986-03-06
JP2594744B2 (ja)	1997-03-26
AU628069B2 (en)	1992-09-10
UA39161C2 (uk)	2001-06-15
HUT38675A (en)	1986-06-30
NZ212645A (en)	1990-02-26
CA1341618C (en)	2011-07-19
ES544868A0 (es)	1986-11-16
FI860308A0 (fi)	1986-01-22
DE3584089D1 (de)	1991-10-17
WO1986000639A1 (en)	1986-01-30
KR860700264A (ko)	1986-08-01
HK111594A (en)	1994-10-21
AU4009089A (en)	1989-12-07
KR910001809B1 (ko)	1991-03-26
AU599572B2 (en)	1990-07-26
JPS61502682A (ja)	1986-11-20
DE3588199D1 (de)	1998-11-26
NO314941B1 (no)	2003-06-16
NO961452D0 (no)	1996-04-12
JPH06319557A (ja)	1994-11-22
AU644359B2 (en)	1993-12-09
SA94150015A (ar)	2005-12-03
HK1011709A1 (en)	1999-07-16
LU88337I2 (fr)	1994-05-04
IE930961L (en)	1986-01-06
NO943300L (no)	1986-03-13
PT80776A (en)	1985-08-01
ATE172494T1 (de)	1998-11-15
NO1996016I1 (no)	1996-12-18
NO307348B1 (no)	2000-03-20
CA1340852C (en)	1999-12-14
JPH06199897A (ja)	1994-07-19
PT80776B (pt)	1987-09-30
PL254400A1 (en)	1986-06-17
DK59493A (da)	1993-05-21
IE60819B1 (en)	1994-08-10
DK102886D0 (da)	1986-03-06
SK505985A3 (en)	1999-10-08
AU5497690A (en)	1990-09-13
NZ228031A (en)	1991-12-23
NO961452L (no)	1996-04-12
IL75725A (en)	1993-02-21
AU4545685A (en)	1986-02-10
JP2594743B2 (ja)	1997-03-26
EP0188479B1 (de)	1991-09-11
SA94150015B1 (ar)	2004-09-04
ES8701226A1 (es)	1986-11-16
SK280265B6 (sk)	1999-10-08
GR851643B (de)	1985-11-26
EP0337359B1 (de)	1998-10-21
FI108796B (fi)	2002-03-28
JP2594768B2 (ja)	1997-03-26
NL930089I2 (nl)	1994-07-01
EP0337359A2 (de)	1989-10-18
DK172679B1 (da)	1999-05-17
CY1629A (en)	1992-07-10
PL153139B1 (en)	1991-03-29
HU208711B (en)	1993-12-28
DE188479T1 (de)	1987-05-21
DK168709B1 (da)	1994-05-24
EP0337359A3 (de)	1990-02-07
FI860308A7 (fi)	1986-01-22
NO179455B (no)	1996-07-01
EP0188479A1 (de)	1986-07-30
DK59493D0 (da)	1993-05-21
SG108991G (en)	1992-03-20
NO860775L (no)	1986-03-13
JPH07163351A (ja)	1995-06-27
IL75725A0 (en)	1985-11-29
NL930089I1 (nl)	1993-10-01
MY102902A (en)	1993-03-31
DE3588199T2 (de)	1999-04-08
IE851695L (en)	1986-01-06
NO179455C (no)	1996-10-09

Publication	Publication Date	Title
ATE67244T1 (de)	1991-09-15	Herstellung und reinigung von lymphokinen.
ATE77104T1 (de)	1992-06-15	Menge und verfahren zur herstellung rekombinierter erzeugnisse in grosser ausbeute.
ATE185604T1 (de)	1999-10-15	Gentechnische herstellung von faktor xiiia
ATE107959T1 (de)	1994-07-15	Klonierung des isoamylaseenzym kodierenden gens und seine verwendung zur herstellung dieses enzyms.
ATE122097T1 (de)	1995-05-15	Expressionsvektor und verfahren zur regulierbaren herstellung von proteinen in eukaryonten.