ATE68476T1 - Verfahren zur herstellung von alpha-6deoxytetracyclinen. - Google Patents
Verfahren zur herstellung von alpha-6deoxytetracyclinen.Info
- Publication number
- ATE68476T1 ATE68476T1 AT89400911T AT89400911T ATE68476T1 AT E68476 T1 ATE68476 T1 AT E68476T1 AT 89400911 T AT89400911 T AT 89400911T AT 89400911 T AT89400911 T AT 89400911T AT E68476 T1 ATE68476 T1 AT E68476T1
- Authority
- AT
- Austria
- Prior art keywords
- alpha
- rhodium
- production
- deoxytetracycline
- tetracycline
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000005984 hydrogenation reaction Methods 0.000 abstract 3
- 239000004098 Tetracycline Substances 0.000 abstract 2
- 239000003054 catalyst Substances 0.000 abstract 2
- 229910052703 rhodium Inorganic materials 0.000 abstract 2
- 239000010948 rhodium Substances 0.000 abstract 2
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 abstract 2
- 229960002180 tetracycline Drugs 0.000 abstract 2
- 229910052723 transition metal Inorganic materials 0.000 abstract 2
- 150000003624 transition metals Chemical class 0.000 abstract 2
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 abstract 2
- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 abstract 1
- 229910018957 MClx Inorganic materials 0.000 abstract 1
- 101100030361 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) pph-3 gene Proteins 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 229960003722 doxycycline Drugs 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 229910052759 nickel Inorganic materials 0.000 abstract 1
- 150000003283 rhodium Chemical class 0.000 abstract 1
- 229930101283 tetracycline Natural products 0.000 abstract 1
- 235000019364 tetracycline Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Epoxy Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP89400911A EP0391005B1 (de) | 1989-04-03 | 1989-04-03 | Verfahren zur Herstellung von alpha-6-Deoxytetracyclinen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE68476T1 true ATE68476T1 (de) | 1991-11-15 |
Family
ID=8202944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89400911T ATE68476T1 (de) | 1989-04-03 | 1989-04-03 | Verfahren zur herstellung von alpha-6deoxytetracyclinen. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4997959A (de) |
| EP (1) | EP0391005B1 (de) |
| AT (1) | ATE68476T1 (de) |
| AU (1) | AU619323B2 (de) |
| DE (2) | DE68900339D1 (de) |
| ES (1) | ES2019267T3 (de) |
| GR (1) | GR3003554T3 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU45590A (sh) * | 1990-03-07 | 1992-07-20 | PLIVA FARMACEVTSKA, KEMIJSKA, PREHRAMBENA I KOZMETIČKA INDUSTRIJA s.p.o. | Novi kompleksi odnosno helati antibiotika s dvovalentnim i/ili trovalentnim metalima i postupci za njihovo dobijanje |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1121642A (en) * | 1965-02-18 | 1968-07-31 | Ici Ltd | New organic rhodium complexes and uses thereof |
| US2984986A (en) * | 1957-12-06 | 1961-05-23 | Raymond A Hill | Automatically controlled hydraulic gate and gate control |
| FR1430859A (de) * | 1960-05-23 | 1966-05-25 | ||
| US3489786A (en) * | 1964-12-10 | 1970-01-13 | Shell Oil Co | Hydrogenation process |
| US3639439A (en) * | 1964-12-10 | 1972-02-01 | Shell Oil Co | Rhodium (i) halide complexes |
| GB1138601A (en) * | 1964-12-15 | 1969-01-01 | Geoffrey Wilkinson | Improvements in catalytic reactions |
| GB1121643A (en) * | 1966-02-07 | 1968-07-31 | Ici Ltd | Hydrogenation process |
| GB1219763A (en) * | 1967-02-02 | 1971-01-20 | Johnson Matthey & Company | Improvements in catalytic hydrogenation or hydroformylation |
| US3444198A (en) * | 1967-02-13 | 1969-05-13 | Pfizer & Co C | Process for producing alpha-6-deoxytetracyclines |
| US3703561A (en) * | 1968-03-28 | 1972-11-21 | Phillips Petroleum Co | Olefin conversion using complexes of cu,ag and au with organoaluminums |
| US3549780A (en) * | 1969-01-15 | 1970-12-22 | Simplex Wire & Cable Co | Contraction joint |
| NL7109740A (de) * | 1971-02-24 | 1972-08-28 | ||
| US4207258A (en) * | 1972-02-24 | 1980-06-10 | Ankerfarm S.P.A. | Process for the preparatin of α-6-deoxytetracyclines |
| SE435619C (sv) * | 1973-02-01 | 1985-11-18 | Pfizer | Forfarande for framstellning av en 6alfa-deoxitetracyklin |
| US3954862A (en) * | 1973-04-20 | 1976-05-04 | Pfizer Inc. | Process for producing α-6-deoxytetracyclines |
| HU167250B (de) * | 1973-06-08 | 1975-09-27 | ||
| US3907890A (en) * | 1974-05-28 | 1975-09-23 | Pfizer | Preparation of alpha-6-deoxy-5-hydroxytetracycline |
| US4001321A (en) * | 1975-06-26 | 1977-01-04 | Pfizer Inc. | Preparation of α-6-deoxytetracyclines |
| US3962131A (en) * | 1975-01-28 | 1976-06-08 | Pfizer Inc. | Rhodium containing catalyst and use thereof in preparation of 6-deoxy-5-oxytetracycline |
| GB2025403A (en) * | 1978-03-09 | 1980-01-23 | Albright & Wilson | Improvements in and Relating to the Ullmann Reaction |
| US4550096A (en) * | 1982-01-19 | 1985-10-29 | Plurichemie Anstalt | Homogeneous catalytic system comprising rhodium, hydrazine and phosphine and a process for the preparation of same |
| US4743699A (en) * | 1982-01-19 | 1988-05-10 | Plurichemie Anstalt | Homogeneous catalytic system and a process for the preparation of same |
| DK386784A (da) * | 1983-08-17 | 1985-02-18 | Hovione Int Ltd | Fremgangsmaade til fremstilling af alfa-6-desoxy-tetracykliner |
| ATE63312T1 (de) * | 1987-03-25 | 1991-05-15 | Plurichemie Anstalt | Rhodium enthaltende hydrierungskatalysatoren. |
| DE3771705D1 (de) * | 1987-03-25 | 1991-08-29 | Plurichemie Anstalt | Rhodiumhydrierungskatalysatoren. |
-
1989
- 1989-04-03 DE DE8989400911T patent/DE68900339D1/de not_active Expired - Fee Related
- 1989-04-03 DE DE198989400911T patent/DE391005T1/de active Pending
- 1989-04-03 AT AT89400911T patent/ATE68476T1/de active
- 1989-04-03 ES ES198989400911T patent/ES2019267T3/es not_active Expired - Lifetime
- 1989-04-03 EP EP89400911A patent/EP0391005B1/de not_active Expired - Lifetime
- 1989-04-13 US US07/337,288 patent/US4997959A/en not_active Expired - Fee Related
- 1989-07-20 AU AU38833/89A patent/AU619323B2/en not_active Ceased
-
1992
- 1992-01-09 GR GR920400012T patent/GR3003554T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US4997959A (en) | 1991-03-05 |
| EP0391005A1 (de) | 1990-10-10 |
| ES2019267T3 (es) | 1993-09-16 |
| GR3003554T3 (de) | 1993-03-16 |
| DE68900339D1 (de) | 1991-11-21 |
| EP0391005B1 (de) | 1991-10-16 |
| DE391005T1 (de) | 1991-04-11 |
| AU619323B2 (en) | 1992-01-23 |
| AU3883389A (en) | 1990-10-04 |
| ES2019267A4 (es) | 1991-06-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE222514T1 (de) | Verfahren zur herstellung von kobaltkatalysatoren | |
| ATE192453T1 (de) | Verfahren zur herstellung von kobaltkatalysatoren | |
| DE69023289D1 (de) | Verfahren zur Vorbereitung eines Substrats für die Herstellung von Halbleiterbauelementen. | |
| ATE41609T1 (de) | Pd/re-hydrogenierungskatalysator und verfahren zur herstellung von tetrahydrofuran und 1.4butandiol. | |
| DE69423231D1 (de) | Verfahren mit hoher produktivität zur herstellung von niederen olefinen durch katalytische umwandlung | |
| ATE156480T1 (de) | Verfahren zur herstellung von zwischenprodukten für die synthese von chinolin-antibiotika | |
| ATE85601T1 (de) | Verfahren zur herstellung von 4demethoxydaunomycinon. | |
| ATE148110T1 (de) | Verfahren zur herstellung von metallkomplexen der n-beta-hydroxy-alkyl-tri-n-carboxyalkyl-1,4,7,1 - tetraazacyclododecan- und n-beta-hydroxyalkyl-tri-n-carboxyalkyl-1,4,8,11 tetraazacyclotetradecan- derivate | |
| DE69016735D1 (de) | Verfahren zur Herstellung eines Trägers für eine Druckplatte. | |
| ATE68476T1 (de) | Verfahren zur herstellung von alpha-6deoxytetracyclinen. | |
| DE69312806D1 (de) | Metall auf Trägerkatalysator für die Hydrierung von organischen Verbindungen und Verfahren zur dessen Herstellung | |
| DE69801991D1 (de) | Verfahren zur herstellung von hexamminkobaltnitrat | |
| EP0366565A3 (de) | Verfahren zur Herstellung von alpha-6-Deoxytetracyclinen und Hydrierkatalysator dafür | |
| ATE175967T1 (de) | Verfahren zur herstellung von 2-amino-6- halogenopurin und synthese einer zwischenverbindung | |
| DE3856098D1 (de) | Verfahren zur selektiven Reduktion von 2-Chinoxalinol-4-Oxiden zu 2-Chinoxalinolen | |
| ATE73360T1 (de) | Verfahren zur herstellung von kobaltkatalysatoren. | |
| ATE79854T1 (de) | Verfahren zur selektiven hydrogenolyse von perhalogenethanderivaten. | |
| ES2054755T3 (es) | Un proceso para la produccion de 2,4,5-trifluoroisoftalonitrilo. | |
| ATE76409T1 (de) | Verfahren zur herstellung von anhydrosorbit und anhydromannit aus sorbit und mannit. | |
| ATE203245T1 (de) | Verfahren zur herstellung von aldosen oder von aldosederivaten | |
| DE69003411D1 (de) | Verfahren zum Regenerieren eines Katalysators für die Herstellung von Aziridinverbindungen. | |
| ATE111458T1 (de) | Verfahren zur darstellung von hochreinem tetrahydrofuran. | |
| EP0226942A3 (de) | Verfahren zur Herstellung von ungesättigten aliphatischen Carbonsäureanhydriden | |
| EP0212287A3 (de) | Verfahren zur Herstellung von aliphatischen Diamindimeren | |
| CA2059449A1 (en) | Process for the synthesis of citroconimides |