ES2019267A4 - Proceso para la produccion de alfa-6-desoxitetraciclinas - Google Patents

Proceso para la produccion de alfa-6-desoxitetraciclinas

Info

Publication number: ES2019267A4
Authority: ES; Spain
Prior art keywords: alpha; rhodium; production; deoxytetracycline; tetracycline
Prior art date: 1989-04-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES89400911T

Other languages

English (en)

Other versions

ES2019267T3 (es

Inventor

Jagmohan Khanna

Kiran Bala

Inder Pal Singh Grover

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ranbaxy Laboratories Ltd

Original Assignee

Ranbaxy Laboratories Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-03

Filing date

1989-04-03

Publication date

1991-06-16

1989-04-03 Application filed by Ranbaxy Laboratories Ltd filed Critical Ranbaxy Laboratories Ltd

1991-06-16 Publication of ES2019267A4 publication Critical patent/ES2019267A4/es

1993-09-16 Application granted granted Critical

1993-09-16 Publication of ES2019267T3 publication Critical patent/ES2019267T3/es

2009-04-03 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

238000000034 method Methods 0.000 title abstract 3
238000005984 hydrogenation reaction Methods 0.000 abstract 3
239000004098 Tetracycline Substances 0.000 abstract 2
239000003054 catalyst Substances 0.000 abstract 2
229910052703 rhodium Inorganic materials 0.000 abstract 2
239000010948 rhodium Substances 0.000 abstract 2
MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 abstract 2
229960002180 tetracycline Drugs 0.000 abstract 2
229910052723 transition metal Inorganic materials 0.000 abstract 2
150000003624 transition metals Chemical class 0.000 abstract 2
RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 abstract 2
SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 abstract 1
229910018957 MClx Inorganic materials 0.000 abstract 1
101100030361 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) pph-3 gene Proteins 0.000 abstract 1
230000003115 biocidal effect Effects 0.000 abstract 1
229910052802 copper Inorganic materials 0.000 abstract 1
229960003722 doxycycline Drugs 0.000 abstract 1
229910052751 metal Inorganic materials 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
229910052759 nickel Inorganic materials 0.000 abstract 1
150000003283 rhodium Chemical class 0.000 abstract 1
229930101283 tetracycline Natural products 0.000 abstract 1
235000019364 tetracycline Nutrition 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Catalysts (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Epoxy Compounds (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)

ES198989400911T 1989-04-03 1989-04-03 Un procedimiento para la preparacion de alfa-6-desoxitetraciclinas. Expired - Lifetime ES2019267T3 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP89400911A EP0391005B1 (en)	1989-04-03	1989-04-03	Process for the production of alpha-6-deoxytetracyclines

Publications (2)

Publication Number	Publication Date
ES2019267A4 true ES2019267A4 (es)	1991-06-16
ES2019267T3 ES2019267T3 (es)	1993-09-16

Family

ID=8202944

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES198989400911T Expired - Lifetime ES2019267T3 (es)	1989-04-03	1989-04-03	Un procedimiento para la preparacion de alfa-6-desoxitetraciclinas.

Country Status (7)

Country	Link
US (1)	US4997959A (es)
EP (1)	EP0391005B1 (es)
AT (1)	ATE68476T1 (es)
AU (1)	AU619323B2 (es)
DE (2)	DE68900339D1 (es)
ES (1)	ES2019267T3 (es)
GR (1)	GR3003554T3 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
YU45590A (sh) *	1990-03-07	1992-07-20	PLIVA FARMACEVTSKA, KEMIJSKA, PREHRAMBENA I KOZMETIČKA INDUSTRIJA s.p.o.	Novi kompleksi odnosno helati antibiotika s dvovalentnim i/ili trovalentnim metalima i postupci za njihovo dobijanje

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1121642A (en) *	1965-02-18	1968-07-31	Ici Ltd	New organic rhodium complexes and uses thereof
US2984986A (en) *	1957-12-06	1961-05-23	Raymond A Hill	Automatically controlled hydraulic gate and gate control
FR1430859A (es) *	1960-05-23	1966-05-25
US3489786A (en) *	1964-12-10	1970-01-13	Shell Oil Co	Hydrogenation process
US3639439A (en) *	1964-12-10	1972-02-01	Shell Oil Co	Rhodium (i) halide complexes
GB1138601A (en) *	1964-12-15	1969-01-01	Geoffrey Wilkinson	Improvements in catalytic reactions
GB1121643A (en) *	1966-02-07	1968-07-31	Ici Ltd	Hydrogenation process
GB1219763A (en) *	1967-02-02	1971-01-20	Johnson Matthey & Company	Improvements in catalytic hydrogenation or hydroformylation
US3444198A (en) *	1967-02-13	1969-05-13	Pfizer & Co C	Process for producing alpha-6-deoxytetracyclines
US3703561A (en) *	1968-03-28	1972-11-21	Phillips Petroleum Co	Olefin conversion using complexes of cu,ag and au with organoaluminums
US3549780A (en) *	1969-01-15	1970-12-22	Simplex Wire & Cable Co	Contraction joint
NL7109740A (es) *	1971-02-24	1972-08-28
US4207258A (en) *	1972-02-24	1980-06-10	Ankerfarm S.P.A.	Process for the preparatin of α-6-deoxytetracyclines
SE435619C (sv) *	1973-02-01	1985-11-18	Pfizer	Forfarande for framstellning av en 6alfa-deoxitetracyklin
US3954862A (en) *	1973-04-20	1976-05-04	Pfizer Inc.	Process for producing α-6-deoxytetracyclines
HU167250B (es) *	1973-06-08	1975-09-27
US3907890A (en) *	1974-05-28	1975-09-23	Pfizer	Preparation of alpha-6-deoxy-5-hydroxytetracycline
US4001321A (en) *	1975-06-26	1977-01-04	Pfizer Inc.	Preparation of α-6-deoxytetracyclines
US3962131A (en) *	1975-01-28	1976-06-08	Pfizer Inc.	Rhodium containing catalyst and use thereof in preparation of 6-deoxy-5-oxytetracycline
GB2025403A (en) *	1978-03-09	1980-01-23	Albright & Wilson	Improvements in and Relating to the Ullmann Reaction
US4550096A (en) *	1982-01-19	1985-10-29	Plurichemie Anstalt	Homogeneous catalytic system comprising rhodium, hydrazine and phosphine and a process for the preparation of same
US4743699A (en) *	1982-01-19	1988-05-10	Plurichemie Anstalt	Homogeneous catalytic system and a process for the preparation of same
DK386784A (da) *	1983-08-17	1985-02-18	Hovione Int Ltd	Fremgangsmaade til fremstilling af alfa-6-desoxy-tetracykliner
ATE63312T1 (de) *	1987-03-25	1991-05-15	Plurichemie Anstalt	Rhodium enthaltende hydrierungskatalysatoren.
DE3771705D1 (de) *	1987-03-25	1991-08-29	Plurichemie Anstalt	Rhodiumhydrierungskatalysatoren.

1989
- 1989-04-03 DE DE8989400911T patent/DE68900339D1/de not_active Expired - Fee Related
- 1989-04-03 DE DE198989400911T patent/DE391005T1/de active Pending
- 1989-04-03 AT AT89400911T patent/ATE68476T1/de active
- 1989-04-03 ES ES198989400911T patent/ES2019267T3/es not_active Expired - Lifetime
- 1989-04-03 EP EP89400911A patent/EP0391005B1/en not_active Expired - Lifetime
- 1989-04-13 US US07/337,288 patent/US4997959A/en not_active Expired - Fee Related
- 1989-07-20 AU AU38833/89A patent/AU619323B2/en not_active Ceased
1992
- 1992-01-09 GR GR920400012T patent/GR3003554T3/el unknown

Also Published As

Publication number	Publication date
US4997959A (en)	1991-03-05
EP0391005A1 (en)	1990-10-10
ES2019267T3 (es)	1993-09-16
GR3003554T3 (es)	1993-03-16
ATE68476T1 (de)	1991-11-15
DE68900339D1 (de)	1991-11-21
EP0391005B1 (en)	1991-10-16
DE391005T1 (de)	1991-04-11
AU619323B2 (en)	1992-01-23
AU3883389A (en)	1990-10-04

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Legal Events

Date

Code

Title

Description

1993-09-16

FG2A

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