ATE70530T1 - Entzuendungshemmende arylderivate. - Google Patents

Entzuendungshemmende arylderivate.

Info

Publication number: ATE70530T1
Authority: AT; Austria
Prior art keywords: alkyl; hydrogen; aryl derivatives; chem; formula
Prior art date: 1987-07-15

Application number

AT88306446T

Other languages

English (en)

Inventor

John Anthony Salmon

William Paul Jackson

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-07-15

Filing date

1988-07-14

Publication date

1992-01-15

1987-07-15 Priority claimed from GB878716640A external-priority patent/GB8716640D0/en

1988-02-03 Priority claimed from GB888802378A external-priority patent/GB8802378D0/en

1988-03-16 Priority claimed from GB888806278A external-priority patent/GB8806278D0/en

1988-07-14 Application filed by Wellcome Found filed Critical Wellcome Found

1992-01-15 Application granted granted Critical

1992-01-15 Publication of ATE70530T1 publication Critical patent/ATE70530T1/de

Links

230000003110 anti-inflammatory effect Effects 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
- A01N37/28—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof containing the group; Thio analogues thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Agronomy & Crop Science (AREA)
Environmental Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Dentistry (AREA)
Plant Pathology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Pest Control & Pesticides (AREA)
Epidemiology (AREA)
Ophthalmology & Optometry (AREA)
Cardiology (AREA)
Neurology (AREA)
Oncology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Neurosurgery (AREA)
Communicable Diseases (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT88306446T 1987-07-15 1988-07-14 Entzuendungshemmende arylderivate. ATE70530T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB878716640A GB8716640D0 (en)	1987-07-15	1987-07-15	Aryl derivatives
GB888802378A GB8802378D0 (en)	1988-02-03	1988-02-03	New aryl derivatives
GB888806278A GB8806278D0 (en)	1988-03-16	1988-03-16	New aryl derivatives

Publications (1)

Publication Number	Publication Date
ATE70530T1 true ATE70530T1 (de)	1992-01-15

Family

ID=27263507

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88306446T ATE70530T1 (de)	1987-07-15	1988-07-14	Entzuendungshemmende arylderivate.

Country Status (18)

Country	Link
US (1)	US4988733A (de)
EP (1)	EP0299761B1 (de)
JP (1)	JPS6445344A (de)
KR (1)	KR890001966A (de)
AT (1)	ATE70530T1 (de)
AU (1)	AU603468B2 (de)
DE (1)	DE3866981D1 (de)
DK (1)	DK392788A (de)
ES (1)	ES2051854T3 (de)
FI (1)	FI883355A7 (de)
GR (1)	GR3003393T3 (de)
HU (1)	HU203076B (de)
IL (1)	IL87105A0 (de)
MC (1)	MC1959A1 (de)
NO (1)	NO883146L (de)
NZ (1)	NZ225408A (de)
PL (1)	PL154186B1 (de)
PT (1)	PT87987B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0288553A (ja) *	1988-07-14	1990-03-28	Wellcome Found Ltd:The	抗炎症性アリール誘導体
AU624896B2 (en) *	1989-02-03	1992-06-25	Wellcome Foundation Limited, The	Anti-inflammatory aryl derivatives
US5476873A (en) *	1990-07-25	1995-12-19	Abbott Laboratories	Acetylene derivatives having lipoxygenase inhibitory activity
ES2095325T3 (es) *	1990-07-25	1997-02-16	Abbott Lab	Derivados de acetileno con una actividad de inhibicion de la lipoxigenasa.
US5234933A (en) *	1991-10-31	1993-08-10	Board Of Governors Of Wayne State University And Vanderbilt University	Cyclic hydroxamic acids
US5169854A (en) *	1992-02-26	1992-12-08	Abbott Laboratories	N-substituted-furylalkenyl hydroxamic acid and N-hydroxyurea compounds having lipoxygenase inhibitory activity
US5187192A (en) *	1992-03-13	1993-02-16	Abbott Laboratories	Cyclobutyl derivatives having lipoxygenase inhibitory activity
ES2141162T3 (es) *	1992-06-30	2000-03-16	Us Health	Metodo para producir materiales de barrera con proteccion contra virus.
GB9215921D0 (en) *	1992-07-27	1992-09-09	Wellcome Found	Anti-inflammatory compounds
AU5016793A (en) *	1992-08-20	1994-03-15	Cytomed, Inc	Dual functional anti-inflammatory and immunosuppressive agents
GB9308652D0 (en) *	1993-04-27	1993-06-09	Wellcome Found	Anti-inflammatory compounds
ES2247604T3 (es) *	1995-06-12	2006-03-01	G.D. SEARLE & CO.	Composiciones que comprenden un inhibidor de ciclooxigenasa-2 y un inhibidor de 5-lipoxigenasa.
AR029916A1 (es) *	2000-05-05	2003-07-23	Smithkline Beecham Corp	N-formil-n-hidroxi-ariloxi alquilaminas y metodos para tratar infecciones bacterianas
AR028075A1 (es) *	2000-05-05	2003-04-23	Smithkline Beecham Corp	Inhibidores de la peptido-desformilasa
US20040034024A1 (en) *	2001-05-04	2004-02-19	Aubart Kelly M	Peptide deformylase inhibitors
AU2002322720B2 (en)	2001-07-25	2008-11-13	Raptor Pharmaceutical Inc.	Compositions and methods for modulating blood-brain barrier transport
CA2789262C (en)	2005-04-28	2016-10-04	Proteus Digital Health, Inc.	Pharma-informatics system
EP2063905B1 (de)	2006-09-18	2014-07-30	Raptor Pharmaceutical Inc	Behandlungen von lebererkrankungen durch verabreichung von konjugaten aus rezeptor-assoziierten proteinen
GB0624187D0 (en) *	2006-12-04	2007-01-10	Jackson William P	HDAC inhibitors
TR201908314T4 (tr)	2009-02-20	2019-06-21	2 Bbb Medicines B V	Glutatyon bazlı ilaç dağıtım sistemi.
KR101909711B1 (ko)	2009-05-06	2018-12-19	라보라토리 스킨 케어, 인크.	활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en)	2010-09-29	2012-03-29	Andrea Bourdelais	Ladder-Frame Polyether Conjugates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3686733T2 (de) *	1985-03-16	1993-02-11	Wellcome Found	Aryl-derivate.
IE59397B1 (en) *	1985-03-16	1994-02-23	Wellcome Found	New aryl derivatives
US4608390A (en) *	1985-04-26	1986-08-26	Abbott Laboratories	Lipoxygenase inhibiting compounds
GB8718212D0 (en) *	1987-07-31	1987-09-09	Angus Fire Armour Ltd	Lining tubular objects

1988
- 1988-07-12 PL PL1988273728A patent/PL154186B1/pl unknown
- 1988-07-14 JP JP63176198A patent/JPS6445344A/ja active Pending
- 1988-07-14 FI FI883355A patent/FI883355A7/fi not_active Application Discontinuation
- 1988-07-14 EP EP88306446A patent/EP0299761B1/de not_active Expired - Lifetime
- 1988-07-14 DE DE8888306446T patent/DE3866981D1/de not_active Expired - Fee Related
- 1988-07-14 PT PT87987A patent/PT87987B/pt not_active IP Right Cessation
- 1988-07-14 US US07/219,096 patent/US4988733A/en not_active Expired - Fee Related
- 1988-07-14 NZ NZ225408A patent/NZ225408A/xx unknown
- 1988-07-14 DK DK392788A patent/DK392788A/da not_active Application Discontinuation
- 1988-07-14 KR KR1019880008745A patent/KR890001966A/ko not_active Withdrawn
- 1988-07-14 NO NO88883146A patent/NO883146L/no unknown
- 1988-07-14 HU HU883683A patent/HU203076B/hu unknown
- 1988-07-14 AT AT88306446T patent/ATE70530T1/de not_active IP Right Cessation
- 1988-07-14 ES ES88306446T patent/ES2051854T3/es not_active Expired - Lifetime
- 1988-07-14 AU AU19068/88A patent/AU603468B2/en not_active Ceased
- 1988-07-14 IL IL87105A patent/IL87105A0/xx unknown
- 1988-07-14 MC MC881991A patent/MC1959A1/fr unknown
1991
- 1991-12-19 GR GR91401878T patent/GR3003393T3/el unknown

Also Published As

Publication number	Publication date
IL87105A0 (en)	1988-12-30
EP0299761B1 (de)	1991-12-18
AU1906888A (en)	1989-01-19
EP0299761A1 (de)	1989-01-18
GR3003393T3 (en)	1993-02-17
DK392788D0 (da)	1988-07-14
PL273728A1 (en)	1989-04-03
PT87987A (pt)	1989-06-30
FI883355A0 (fi)	1988-07-14
PL154186B1 (en)	1991-07-31
MC1959A1 (fr)	1989-06-30
AU603468B2 (en)	1990-11-15
HUT48572A (en)	1989-06-28
JPS6445344A (en)	1989-02-17
NO883146D0 (no)	1988-07-14
ES2051854T3 (es)	1994-07-01
PT87987B (pt)	1995-03-01
DK392788A (da)	1989-01-16
HU203076B (en)	1991-05-28
DE3866981D1 (de)	1992-01-30
FI883355A7 (fi)	1989-01-16
NO883146L (no)	1989-01-16
US4988733A (en)	1991-01-29
KR890001966A (ko)	1989-04-07
NZ225408A (en)	1991-09-25

Legal Events

Date	Code	Title	Description
1992-08-15	UEP	Publication of translation of european patent specification
1998-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE3866981D1 (de)	1992-01-30	Entzuendungshemmende arylderivate.
DE10199003I2 (de)	2003-09-18
NO173139C (no)	1993-11-03	Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-aminopyrimidinonderivater
AU7987187A (en)	1988-04-21	Heterocyclic derivatives
ZA898678B (en)	1990-09-26	Compositions and compounds
NO891176D0 (no)	1989-03-17	Fremstilling av antivirale tetrahydroimidazo(1,4)benzodiazepin-2-oner.
NO171906C (no)	1993-05-19	Analogifremgangsmaate for fremstilling av anti-inflammatorisk aktive arylforbindelser
FI881816A0 (fi)	1988-04-19	Nya bicykliska foereningar, foerfarane foer deras framstaellning och dessa innehaollande farmaceutiska blandningar.
SE8800171L (sv)	1988-07-28	Nya 5-oxi-derivat av tetrahydrofuran
IL103417A0 (en)	1993-03-15	Bis(phenyl)ethane derivatives,their preparation and pharmaceutical compositions containing them
FI894125A0 (fi)	1989-09-01	Analogiamenetelmä terapeuttisesti käyttökelpoisen 3-piperidinyyli-indatsolin valmistamiseksi
TH6256A (th)	1989-07-03	อนุพันธ์ แอริล สารต่อต้านการอักเสบ