ATE86247T1 - 3-indolpyruvsaeure-derivate und deren verwendung als arznemittel. - Google Patents

3-indolpyruvsaeure-derivate und deren verwendung als arznemittel.

Info

Publication number: ATE86247T1
Authority: AT; Austria
Prior art keywords: pct; acid derivatives; pharmaceuticals; sec; date
Prior art date: 1987-06-03

Application number

AT88904984T

Other languages

English (en)

Inventor

Luca Giovanna De

Stazio Giovanni Di

Andrea Margonelli

Mario Materazzi

Vincenzo Politi

Original Assignee

Polifarma Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-06-03

Filing date

1988-06-01

Publication date

1993-03-15

1988-06-01 Application filed by Polifarma Spa filed Critical Polifarma Spa

1993-03-15 Application granted granted Critical

1993-03-15 Publication of ATE86247T1 publication Critical patent/ATE86247T1/de

Links

RSTKLPZEZYGQPY-UHFFFAOYSA-N 3-(indol-3-yl)pyruvic acid Chemical class C1=CC=C2C(CC(=O)C(=O)O)=CNC2=C1 RSTKLPZEZYGQPY-UHFFFAOYSA-N 0.000 title abstract 2
239000003814 drug Substances 0.000 title 1
210000003169 central nervous system Anatomy 0.000 abstract 1
239000003257 excitatory amino acid Substances 0.000 abstract 1
230000002461 excitatory amino acid Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT88904984T 1987-06-03 1988-06-01 3-indolpyruvsaeure-derivate und deren verwendung als arznemittel. ATE86247T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IT8748014A IT1206078B (it)	1987-06-03	1987-06-03	Procedimento per la produzione di acido 3-indolpiruvico e suoi derivati loro uso farmaceutico
EP88904984A EP0321516B1 (de)	1987-06-03	1988-06-01	3-indolpyruvsäure-derivate und deren verwendung als arznemittel
PCT/IT1988/000041 WO1988009789A2 (en)	1987-06-03	1988-06-01	3-indolepyruvic acid derivatives and pharmaceutical use thereof

Publications (1)

Publication Number	Publication Date
ATE86247T1 true ATE86247T1 (de)	1993-03-15

Family

ID=11263959

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88904984T ATE86247T1 (de)	1987-06-03	1988-06-01	3-indolpyruvsaeure-derivate und deren verwendung als arznemittel.

Country Status (13)

Country	Link
US (1)	US5002963A (de)
EP (1)	EP0321516B1 (de)
JP (1)	JPH02500369A (de)
KR (1)	KR960016522B1 (de)
AT (1)	ATE86247T1 (de)
AU (1)	AU609500B2 (de)
CA (1)	CA1328658C (de)
DE (1)	DE3878866T2 (de)
DK (1)	DK170438B1 (de)
FI (1)	FI92055C (de)
IT (1)	IT1206078B (de)
NO (1)	NO890408L (de)
WO (1)	WO1988009789A2 (de)

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IT1224546B (it) *	1988-09-29	1990-10-04	Polifarma Spa	Utilizzatore farmaceutica di acido 3 -indolpiruvico come agente inibitore di patologie degenerative
US4960786A (en) *	1989-04-24	1990-10-02	Merrell Dow Pharmaceuticals Inc.	Excitatory amino acid antagonists
PT93943A (pt) *	1989-05-05	1991-02-08	Searle & Co	Processo para a preparacao de composicoes contendo compostos indole-2-carboxilato para tratamento de perturbacoes do snc
DE3917880A1 (de) *	1989-06-01	1990-12-06	Kali Chemie Ag	Neue acylaminosaeurederivate enthaltende arzneimittel und diaetetika
IT218019Z2 (it) *	1989-09-08	1992-03-05	Enea	Dispositivo protettivo individuale, portatile ad isolamento totale conatmosfera controllata
IT1237472B (it) *	1989-10-04	1993-06-07	Polifarma Spa	Derivati di acido 3-indolpiruvico, loro procedimento di produzione ed impiego terapeutico.
US5037846A (en) *	1990-01-02	1991-08-06	Pfizer Inc.	Indolyl-3 polyamines and their use as antagonists of excitatory amino acid neurotransmitters
US5360814A (en) *	1991-02-28	1994-11-01	Merrell Dow Pharmaceuticals Inc.	NMDA antagonists
AU643365B2 (en) *	1991-02-28	1993-11-11	Aventisub Ii Inc.	NMDA antagonists
US5484814A (en) *	1991-02-28	1996-01-16	Merrell Dow Pharmaceuticals Inc.	NMDA antagonists
IT1261165B (it) *	1993-01-25	1996-05-09	Polifarma Spa	Agente attivo per ridurre il livello ematico di glucocorticoidi e prevenire disturbi cerebrali da stress e senilita'.
FR2701948B1 (fr) *	1993-02-22	1996-07-26	Exsymol Sa	Produit de couplage de l'histamine ou l'histamine méthyl-substituée et d'un acide aminé, procédé de préparation et applications thérapeutiques, cosmétologiques et agroalimentaires.
US5859031A (en)	1995-06-07	1999-01-12	Gpi Nil Holdings, Inc.	Small molecule inhibitors of rotamase enzyme activity
US7056935B2 (en) *	1995-06-07	2006-06-06	Gpi Nil Holdings, Inc.	Rotamase enzyme activity inhibitors
US5801197A (en) *	1995-10-31	1998-09-01	Gpi Nil Holdings, Inc.	Rotamase enzyme activity inhibitors
US5786378A (en) *	1996-09-25	1998-07-28	Gpi Nil Holdings, Inc.	Heterocyclic thioesters
US6218424B1 (en)	1996-09-25	2001-04-17	Gpi Nil Holdings, Inc.	Heterocyclic ketone and thioester compounds and uses
US5801187A (en)	1996-09-25	1998-09-01	Gpi-Nil Holdings, Inc.	Heterocyclic esters and amides
US6242468B1 (en)	1997-02-27	2001-06-05	Jia-He Li	Carbamate and urea compositions and neurotrophic uses
US5846979A (en)	1997-02-28	1998-12-08	Gpi Nil Holdings, Inc.	N-oxides of heterocyclic esters, amides, thioesters, and ketones
US6274602B1 (en)	1998-06-03	2001-08-14	Gpi Nil Holdings, Inc.	Heterocyclic thioester and ketone hair growth compositions and uses
US6187784B1 (en)	1998-06-03	2001-02-13	Gpi Nil Holdings, Inc.	Pipecolic acid derivative hair growth compositions and uses
US6271244B1 (en)	1998-06-03	2001-08-07	Gpi Nil Holdings, Inc.	N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses
US6187796B1 (en)	1998-06-03	2001-02-13	Gpi Nil Holdings, Inc.	Sulfone hair growth compositions and uses
US20010049381A1 (en)	1997-06-04	2001-12-06	Gpl Nil Holdings, Inc.,	Pyrrolidine derivative hair growth compositions and uses
US5945441A (en)	1997-06-04	1999-08-31	Gpi Nil Holdings, Inc.	Pyrrolidine carboxylate hair revitalizing agents
US6075150A (en)	1998-01-26	2000-06-13	Cv Therapeutics, Inc.	α-ketoamide inhibitors of 20S proteasome
US6172087B1 (en)	1998-06-03	2001-01-09	Gpi Nil Holding, Inc.	N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US6429215B1 (en)	1998-06-03	2002-08-06	Gpi Nil Holdings, Inc.	N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US6331537B1 (en)	1998-06-03	2001-12-18	Gpi Nil Holdings, Inc.	Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
WO1999062880A1 (en)	1998-06-03	1999-12-09	Gpi Nil Holdings, Inc.	N-linked sulfonamides of n-heterocyclic carboxylic acids or carboxylic acid isosteres
EP1085853A1 (de)	1998-06-03	2001-03-28	GPI NIL Holdings, Inc.	Haarwuchszusammensetzungen basiernd auf heterozyklischem ester und amid und anwendungen
US6376517B1 (en)	1998-08-14	2002-04-23	Gpi Nil Holdings, Inc.	Pipecolic acid derivatives for vision and memory disorders
US6333340B1 (en)	1998-08-14	2001-12-25	Gpi Nil Holdings, Inc.	Small molecule sulfonamides for vision and memory disorders
US6339101B1 (en)	1998-08-14	2002-01-15	Gpi Nil Holdings, Inc.	N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
US6506788B1 (en)	1998-08-14	2003-01-14	Gpi Nil Holdings, Inc.	N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders
US6395758B1 (en)	1998-08-14	2002-05-28	Gpi Nil Holdings, Inc.	Small molecule carbamates or ureas for vision and memory disorders
US6335348B1 (en)	1998-08-14	2002-01-01	Gpi Nil Holdings, Inc.	Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders
US6399648B1 (en)	1998-08-14	2002-06-04	Gpi Nil Holdings, Inc.	N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
US7338976B1 (en)	1998-08-14	2008-03-04	Gpi Nil Holdings, Inc.	Heterocyclic esters or amides for vision and memory disorders
US6337340B1 (en)	1998-08-14	2002-01-08	Gpi Nil Holdings, Inc.	Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders
US6384056B1 (en)	1998-08-14	2002-05-07	Gpi Nil Holdings, Inc.	Heterocyclic thioesters or ketones for vision and memory disorders
US6218423B1 (en)	1998-08-14	2001-04-17	Gpi Nil Holdings, Inc.	Pyrrolidine derivatives for vision and memory disorders
US6462072B1 (en)	1998-09-21	2002-10-08	Gpi Nil Holdings, Inc.	Cyclic ester or amide derivatives
US7253169B2 (en)	1999-11-12	2007-08-07	Gliamed, Inc.	Aza compounds, pharmaceutical compositions and methods of use
US6417189B1 (en)	1999-11-12	2002-07-09	Gpi Nil Holdings, Inc.	AZA compounds, pharmaceutical compositions and methods of use
EP1244670B1 (de)	1999-12-21	2006-03-08	MGI GP, Inc.	Hydantoin derivate, pharmazeutische zusammensetzungen und verfahren zu ihrer verwendung
US6608196B2 (en)	2001-05-03	2003-08-19	Galileo Pharmaceuticals, Inc.	Process for solid supported synthesis of pyruvate-derived compounds
US20030013656A1 (en) *	2001-05-03	2003-01-16	Bing Wang	Pyruvate derivatives
WO2003056026A1 (en)	2001-12-27	2003-07-10	Ajinomoto Co., Inc.	Process for production of glutamic acid derivatives
WO2009028338A1 (ja) *	2007-08-24	2009-03-05	Ajinomoto Co., Inc.	新規オキシダーゼ遺伝子、および該遺伝子を利用する３－インドールピルビン酸の製造方法
EP2479272A4 (de)	2010-10-14	2013-11-20	Ajinomoto Kk	Verfahren zur herstellung von monatin
WO2020012373A1 (en) *	2018-07-10	2020-01-16	Polindols S.R.L.S.	New drugs chronic invalidating pathologies and to slow aging, based on a new metabolic tryptophan route and production process thereof

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CA1096881A (en) *	1976-10-07	1981-03-03	Roger R. Gaudette	Preparation of aliphatic and heterocyclic alpha-keto carboxylic acids
GR74635B (de) *	1980-08-18	1984-06-29	Merck & Co Inc
DE3177130D1 (de) *	1980-08-30	1990-01-11	Hoechst Ag	Aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung.
EP0048159A3 (de) *	1980-09-17	1982-05-12	University Of Miami	Carboxyalkyl-Peptide und Thioäther und Äther von Peptiden als antihypertensive Mittel
IT1148618B (it) *	1982-10-11	1986-12-03	Polifarma Spa	Procedimento enzimatico per la produzione di acido 3-indolpiruvico e utilizzazione farmaceutica di questo
IT1184282B (it) *	1985-06-28	1987-10-22	Polifarma Spa	Procedimento per la produzione di alfa-chetoacidi indolici a partire da un rispettivo alfa-ammino-acido,particolarmente per produrre acido indolpiruvico

1987
- 1987-06-03 IT IT8748014A patent/IT1206078B/it active
1988
- 1988-05-25 CA CA000567675A patent/CA1328658C/en not_active Expired - Fee Related
- 1988-06-01 WO PCT/IT1988/000041 patent/WO1988009789A2/en not_active Ceased
- 1988-06-01 KR KR1019890700193A patent/KR960016522B1/ko not_active Expired - Fee Related
- 1988-06-01 AU AU19433/88A patent/AU609500B2/en not_active Expired
- 1988-06-01 DE DE8888904984T patent/DE3878866T2/de not_active Expired - Lifetime
- 1988-06-01 EP EP88904984A patent/EP0321516B1/de not_active Expired - Lifetime
- 1988-06-01 JP JP63504630A patent/JPH02500369A/ja active Pending
- 1988-06-01 US US07/327,804 patent/US5002963A/en not_active Expired - Lifetime
- 1988-06-01 AT AT88904984T patent/ATE86247T1/de not_active IP Right Cessation
1989
- 1989-02-01 NO NO89890408A patent/NO890408L/no unknown
- 1989-02-02 DK DK046789A patent/DK170438B1/da not_active IP Right Cessation
- 1989-02-02 FI FI890508A patent/FI92055C/fi active IP Right Grant

Also Published As

Publication number	Publication date
DK46789A (da)	1989-03-31
DE3878866T2 (de)	1993-09-02
KR890701559A (ko)	1989-12-20
DK46789D0 (da)	1989-02-02
NO890408D0 (no)	1989-02-01
WO1988009789A3 (en)	1989-02-09
IT1206078B (it)	1989-04-14
US5002963A (en)	1991-03-26
FI92055C (fi)	1994-09-26
JPH02500369A (ja)	1990-02-08
WO1988009789A2 (en)	1988-12-15
AU609500B2 (en)	1991-05-02
EP0321516B1 (de)	1993-03-03
NO890408L (no)	1989-03-30
DK170438B1 (da)	1995-09-04
FI92055B (fi)	1994-06-15
CA1328658C (en)	1994-04-19
FI890508A0 (fi)	1989-02-02
AU1943388A (en)	1989-01-04
KR960016522B1 (ko)	1996-12-14
IT8748014A0 (it)	1987-06-03
FI890508L (fi)	1989-02-02
DE3878866D1 (de)	1993-04-08
EP0321516A1 (de)	1989-06-28

Legal Events

Date	Code	Title	Description
1993-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE3878866D1 (de)	1993-04-08	3-indolpyruvsaeure-derivate und deren verwendung als arznemittel.
DE69021530D1 (de)	1995-09-14	Neue Derivate von A-nor-3-Carboxysteroiden.
MX9203053A (es)	1992-12-01	Derivados de aza nor bornano.
ATE166650T1 (de)	1998-06-15	Spiroazacyclischderivate als substanz p antagonisten
DE3684190D1 (de)	1992-04-16	Verwendung von tetrahydrobiopterinen zur herstellung eines medikaments zur behandlung von kinderautismus.
ATE192045T1 (de)	2000-05-15	Verwendung von substituierten adeninderivaten zur behandlung von multiplesklerose
ATE119522T1 (de)	1995-03-15	Substituierte cyclohexanole mit zentraler nervensystemwirkung.
KR950700296A (ko)	1995-01-16	비닐렌-아자인돌 유도체 및 이의 제조방법(Vinylene-Azaindole derivatives and process for their preparation)
PT100901A (pt)	1994-02-28	Compostos heterociclicos triciclicos condensados, que contem azoto
DE3684409D1 (de)	1992-04-23	Verwendung von gamma-linolensaeure und verwandten verbindungen zur herstellung eubnes arzneimittels zur behandlung von endometriose.
ATE320804T1 (de)	2006-04-15	Behandlung negativer und kognitiver symptome der schizophrenie mit antagonisten der glycinaufnahme
MY132875A (en)	2007-10-31	Pyridazino quinoline compounds
IL81887A0 (en)	1987-10-20	Dihydroisoxazole derivatives,their preparation and pharmaceutical compositions containing them
FI974447A0 (fi)	1997-12-05	Semikarbatsonit, joilla on keskushermostoaktiivisuutta, ja niitä sisältävät farmaseuttiset valmisteet
ATE27457T1 (de)	1987-06-15	1,2,4-triazine und pyrazin-derivate.
MY115211A (en)	2003-04-30	Novel amino acid derivatives, their preparation and use
ES2135769T3 (es)	1999-11-01	Derivados de isotiourea como inhibidores de no-sintasa.
ATE95064T1 (de)	1993-10-15	Verwendung von angiotensin-converting-enzyminhibitoren zur behandlung von atherosklerose, thrombose und der peripheren gefaesskrankheit.
DE3852935D1 (de)	1995-03-16	Substituierte Alpha-Aminosäuren mit pharmazeutischer Aktivität.
DE59403966D1 (de)	1997-10-09	Hydroxymethylfurazancarbonsäurederivate und ihre verwendung in der behandlung von kardiovaskulären erkrankungen
ATE71620T1 (de)	1992-02-15	N-substituierte 3,4-dihydropyrimidinverbindungen als mittel zur behandlung von erkrankungen des kardiovaskularen systems.
FR2658190B1 (fr)	1992-06-05	Esters d'aminoacides de l'hydroquinone, leur procede de preparation et compositions pharmaceutiques ou cosmetiques les contenant.
ATE165344T1 (de)	1998-05-15	Herstellung von symmetrischen und unsymmetrischen disubstituierten n-cyandithioiminocarbonaten
DE3684825D1 (de)	1992-05-21	Verwendung von n-(1-allyl-2-pyrrolidinylmethyl)-2-methoxy-4-amino-5-methylsulfamoylbenzamid zur behandlung der parkinson-krankheit.