ES8801305A1 - Procedimiento para preparar peptidos difluorcetonicos - Google Patents

Procedimiento para preparar peptidos difluorcetonicos

Info

Publication number
ES8801305A1
ES8801305A1 ES555826A ES555826A ES8801305A1 ES 8801305 A1 ES8801305 A1 ES 8801305A1 ES 555826 A ES555826 A ES 555826A ES 555826 A ES555826 A ES 555826A ES 8801305 A1 ES8801305 A1 ES 8801305A1
Authority
ES
Spain
Prior art keywords
difluorketonic
peptides
formulas
mixture
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES555826A
Other languages
English (en)
Other versions
ES555826A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zeneca Inc
Original Assignee
ICI Americas Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858514436A external-priority patent/GB8514436D0/en
Priority claimed from GB858514440A external-priority patent/GB8514440D0/en
Priority claimed from GB858514438A external-priority patent/GB8514438D0/en
Application filed by ICI Americas Inc filed Critical ICI Americas Inc
Publication of ES555826A0 publication Critical patent/ES555826A0/es
Publication of ES8801305A1 publication Critical patent/ES8801305A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Detergent Compositions (AREA)
  • Cosmetics (AREA)

Abstract

METODO DE PREPARAR PEPTIDOS DIFLUORCETONICOS. CONSISTE EN OXIDAR UN ALCOHOL DE FORMULAS (IV), (V) O (VI) POR REACCION CON UN AGENTE DE OXIDACION TAL COMO UNA MEZCLA DE CLORURO DE OXALILO, DIMETIL SULFOXIDO Y UNA AMINA TERCIARIA; UNA MEZCLA DE ANHIDRIDO ACETICO Y DIMETIL SULF''OIDO; COMPLEJO DE TRIOXIDO DE CROMO PIRIDINA; O 1,1,1-TRIACETOXI-2,1-BENZOXIDO-3(3H)-ONA; Y A TEMPERATURA ENTRE 0 Y 35JC, PARA OBTENER PEPTIDOS DIFLUORCETONICOS DE FORMULAS (I), (II) O (III), DONDE R1 ES UN GRUPO ALQUILO DE C 1 A 5; R2 ES UN GRUPO ALQUILO DE C 1 A 6, ALQUILO DE C 1 A 10 Y OTROS; R3 ES UN GRUPO ALQUILO DE C 1 A 12 Y OTROS; R4 ES H Y METILO; Y RA ES CH3 Y OTROS. TIENEN APLICACIONES FARMACEUTICAS PARA TRATAR ARTRITIS REUMATOIDE, OSTEOARTRITIS Y OTRAS ENFERMEDADES.
ES555826A 1985-06-07 1986-06-06 Procedimiento para preparar peptidos difluorcetonicos Expired ES8801305A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB858514436A GB8514436D0 (en) 1985-06-07 1985-06-07 Selected difluoro derivatives
GB858514440A GB8514440D0 (en) 1985-06-07 1985-06-07 Difluoro ketone tripeptide derivatives
GB858514438A GB8514438D0 (en) 1985-06-07 1985-06-07 Selected difluoro ketone dipeptide derivatives

Publications (2)

Publication Number Publication Date
ES555826A0 ES555826A0 (es) 1987-12-16
ES8801305A1 true ES8801305A1 (es) 1987-12-16

Family

ID=27262698

Family Applications (4)

Application Number Title Priority Date Filing Date
ES555826A Expired ES8801305A1 (es) 1985-06-07 1986-06-06 Procedimiento para preparar peptidos difluorcetonicos
ES557733A Expired ES8802619A1 (es) 1985-06-07 1987-09-16 Procedimiento para preparar peptidos difluorcetonicos
ES557735A Expired ES8802321A1 (es) 1985-06-07 1987-09-16 Procedimiento para preparar peptidos difluorcetonicos
ES557734A Expired ES8900051A1 (es) 1985-06-07 1987-09-16 Procedimiento para preparar peptidos difluorcetonicos

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES557733A Expired ES8802619A1 (es) 1985-06-07 1987-09-16 Procedimiento para preparar peptidos difluorcetonicos
ES557735A Expired ES8802321A1 (es) 1985-06-07 1987-09-16 Procedimiento para preparar peptidos difluorcetonicos
ES557734A Expired ES8900051A1 (es) 1985-06-07 1987-09-16 Procedimiento para preparar peptidos difluorcetonicos

Country Status (16)

Country Link
US (1) US4880780A (es)
EP (1) EP0204571B1 (es)
JP (1) JPH07116159B2 (es)
AT (1) ATE71934T1 (es)
AU (1) AU594683B2 (es)
DE (1) DE3683541D1 (es)
DK (1) DK267686A (es)
ES (4) ES8801305A1 (es)
FI (1) FI86859C (es)
GR (1) GR861488B (es)
HU (1) HU208438B (es)
IE (1) IE59146B1 (es)
IL (1) IL79049A0 (es)
NO (1) NO170585C (es)
NZ (1) NZ216437A (es)
PT (1) PT82724B (es)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
US5496927A (en) * 1985-02-04 1996-03-05 Merrell Pharmaceuticals Inc. Peptidase inhibitors
GB8613703D0 (en) * 1986-06-05 1986-07-09 Ici America Inc Difluoro peptide compounds
GB8711748D0 (en) * 1986-06-05 1987-06-24 Ici America Inc Difluoro keto compounds
GB8809316D0 (en) * 1987-05-11 1988-05-25 Ici America Inc Heterocyclic ketones
EP0371179A1 (en) * 1988-10-28 1990-06-06 Merrell Dow Pharmaceuticals Inc. Novel analogs of peptidase substrates
EP0369391A3 (en) * 1988-11-15 1991-09-25 Boehringer Ingelheim Pharmaceuticals Inc. N-substituted amides
GB8910547D0 (en) * 1989-05-08 1989-06-21 Ici America Inc Substituted ketones
US5221665A (en) * 1989-10-27 1993-06-22 Boehringer Ingelheim Pharmaceuticals, Inc. N-substituted amides
US5391705A (en) * 1991-03-15 1995-02-21 Merrell Dow Pharmaceuticals Inc. Polyfluorinated tripeptide thrombin inhibitors
ATE181925T1 (de) * 1991-05-23 1999-07-15 Merrell Pharma Inc Hemmstoffe für kathepsin-g und elastase zur verhütung von bindegewebsabbau
US5478811A (en) * 1991-08-22 1995-12-26 Merrell Dow Pharmaceuticals Inc. Orally-active elastase inhibitors
US5714470A (en) 1991-08-22 1998-02-03 Merrell Pharmaceuticals, Inc. Orally-active elastase inhibitors
US5486529A (en) * 1992-04-16 1996-01-23 Zeneca Limited Certain pyridyl ketones for treating diseases involving leukocyte elastase
IL108031A0 (en) * 1992-12-22 1994-04-12 Procter & Gamble Difluoro pentapeptide derivatives and pharmaceutical compositions containing them
HU221197B1 (en) * 1994-06-02 2002-08-28 Aventis Pharma Inc Elastase inhibitor tripeptides and pharmaceutical compositions comprising thereof
ES2161293T3 (es) * 1994-06-02 2001-12-01 Merrell Pharma Inc Derivados de enol acilados como profarmacos de inhibidores de la elastasa.
DK0763055T3 (da) * 1994-06-02 2000-05-08 Merrell Pharma Inc Perflouralkylketon-inhibitorer af elastase og fremgangsmåde til fremstilling deraf
US6069232A (en) * 1995-10-02 2000-05-30 Hoechst Marion Roussel, Inc. Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
US6673784B1 (en) 1996-03-19 2004-01-06 G. D. Searle & Co. Electrophilic ketones for the treatment of herpesvirus infections
US5739354A (en) * 1996-03-26 1998-04-14 Hoechst Marion Roussel, Inc. Process for the preparation of N-methyl-D-phenylalanyl-N- 1- 3- (aminoiminomethyl)amino!propyl!-3,3-difluoro-2-oxohexyl!-L-prolinamide
CZ298749B6 (cs) 1996-10-18 2008-01-16 Vertex Pharmaceuticals Incorporated Inhibitory serinových proteáz a farmaceutické prostředky s jejich obsahem
SV2003000617A (es) * 2000-08-31 2003-01-13 Lilly Co Eli Inhibidores de la proteasa peptidomimetica ref. x-14912m
PE20050374A1 (es) 2003-09-05 2005-05-30 Vertex Pharma Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc
US7964624B1 (en) 2005-08-26 2011-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
AR055395A1 (es) 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
CA2643688A1 (en) 2006-02-27 2007-08-30 Vertex Pharmaceuticals Incorporated Co-crystals and pharmaceutical compositions comprising the same
WO2007109080A2 (en) * 2006-03-16 2007-09-27 Vertex Pharmaceuticals Incorporated Deuterated hepatitis c protease inhibitors
CN101534824A (zh) * 2006-11-17 2009-09-16 艾博特公司 作为化学活素受体拮抗剂的氨基吡咯烷
WO2008106058A2 (en) 2007-02-27 2008-09-04 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
GEP20125645B (en) 2007-02-27 2012-09-25 Vertex Pharma Co-crystals and pharmaceutical compositions comprising the same
WO2009032198A1 (en) 2007-08-30 2009-03-12 Vertex Pharmaceuticals Incorporated Co-crystals and pharmaceutical compositions comprising the same
US8623358B2 (en) 2009-08-29 2014-01-07 Abbvie Inc. Therapeutic DLL4 binding proteins
EP2542582A4 (en) 2010-03-02 2013-12-04 Abbvie Inc THERAPEUTIC PROTEINS LINKING TO DLL4
US8735546B2 (en) 2010-08-03 2014-05-27 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
AU2013337775B2 (en) 2012-11-01 2017-03-30 Abbvie Inc. Anti-VEGF/DLL4 dual variable domain immunoglobulins and uses thereof
US10093733B2 (en) 2014-12-11 2018-10-09 Abbvie Inc. LRP-8 binding dual variable domain immunoglobulin proteins
CN107531653B (zh) * 2015-05-11 2021-10-19 豪夫迈·罗氏有限公司 新的二氟酮酰胺衍生物
TW201710286A (zh) 2015-06-15 2017-03-16 艾伯維有限公司 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白
EP3994148A1 (en) 2019-07-01 2022-05-11 Basf Se Peptide acetals for stabilising enzymes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787249A (fr) 1971-08-05 1973-02-05 Squibb & Sons Inc Derives amino d'acides pyrazolopyridine carboxyliques, leurs esters et les sels de ces composes, ainsi que leurs procedes de preparation
US3935280A (en) 1975-01-10 1976-01-27 Aldrich-Boranes, Inc. Reduction of amino acids in the presence of boron trifluoride
US4277395A (en) * 1980-06-16 1981-07-07 Richardson-Merrell Inc. Novel enzyme inhibitors
EP0124317B1 (en) 1983-04-27 1990-04-11 Ici Americas Inc. Proline derivatives
US4518528A (en) * 1983-05-19 1985-05-21 Rasnick David W α Amino fluoro ketones
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives

Also Published As

Publication number Publication date
JPH07116159B2 (ja) 1995-12-13
ES8900051A1 (es) 1988-11-16
NZ216437A (en) 1990-06-26
ES555826A0 (es) 1987-12-16
IE59146B1 (en) 1994-01-12
ES557734A0 (es) 1988-11-16
NO862269D0 (no) 1986-06-06
AU5845486A (en) 1986-12-18
DK267686A (da) 1986-12-08
ES8802321A1 (es) 1988-05-01
JPS6253951A (ja) 1987-03-09
FI86859B (fi) 1992-07-15
EP0204571A2 (en) 1986-12-10
DK267686D0 (da) 1986-06-06
AU594683B2 (en) 1990-03-15
GR861488B (en) 1986-09-05
US4880780A (en) 1989-11-14
NO862269L (no) 1986-12-08
EP0204571A3 (en) 1988-09-21
IE861513L (en) 1986-12-07
PT82724A (en) 1986-07-01
ES557733A0 (es) 1988-09-01
FI862434A7 (fi) 1986-12-08
ATE71934T1 (de) 1992-02-15
FI86859C (fi) 1992-10-26
NO170585B (no) 1992-07-27
ES557735A0 (es) 1988-05-01
HU208438B (en) 1993-10-28
FI862434A0 (fi) 1986-06-06
PT82724B (pt) 1988-12-15
IL79049A0 (en) 1986-09-30
DE3683541D1 (de) 1992-03-05
ES8802619A1 (es) 1988-09-01
NO170585C (no) 1992-11-04
EP0204571B1 (en) 1992-01-22
HUT40811A (en) 1987-02-27

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001102