ATE76756T1 - Influenzaimpfstoff. - Google Patents

Influenzaimpfstoff.

Info

Publication number: ATE76756T1
Authority: AT; Austria
Prior art keywords: vaccine; complex; mdp derivative; particle; influenza
Prior art date: 1985-06-06

Application number

AT86107631T

Other languages

English (en)

Inventor

Kuniaki Nerome

Akira Oya

Kunio Ohkuma

Atsuo Inoue

Original Assignee

Nat Inst Health

Daiichi Seiyaku Co

Chemo Sero Therapeut Res Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-06-06

Filing date

1986-06-05

Publication date

1992-06-15

1986-06-05 Application filed by Nat Inst Health, Daiichi Seiyaku Co, Chemo Sero Therapeut Res Inst filed Critical Nat Inst Health

1992-06-15 Application granted granted Critical

1992-06-15 Publication of ATE76756T1 publication Critical patent/ATE76756T1/de

Links

229960003971 influenza vaccine Drugs 0.000 title abstract 3
239000002245 particle Substances 0.000 abstract 6
WVCHIGAIXREVNS-UHFFFAOYSA-N 2-hydroxy-1,4-naphthoquinone Chemical compound C1=CC=C2C(O)=CC(=O)C(=O)C2=C1 WVCHIGAIXREVNS-UHFFFAOYSA-N 0.000 abstract 5
239000000427 antigen Substances 0.000 abstract 4
102000036639 antigens Human genes 0.000 abstract 4
108091007433 antigens Proteins 0.000 abstract 4
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
238000000502 dialysis Methods 0.000 abstract 2
239000012528 membrane Substances 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
239000004094 surface-active agent Substances 0.000 abstract 2
241000712461 unidentified influenza virus Species 0.000 abstract 2
229960005486 vaccine Drugs 0.000 abstract 2
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 1
229940107161 cholesterol Drugs 0.000 abstract 1
235000012000 cholesterol Nutrition 0.000 abstract 1
229940028617 conventional vaccine Drugs 0.000 abstract 1
RNPXCFINMKSQPQ-UHFFFAOYSA-N dicetyl hydrogen phosphate Chemical compound CCCCCCCCCCCCCCCCOP(O)(=O)OCCCCCCCCCCCCCCCC RNPXCFINMKSQPQ-UHFFFAOYSA-N 0.000 abstract 1
229940093541 dicetylphosphate Drugs 0.000 abstract 1
206010022000 influenza Diseases 0.000 abstract 1
229940067606 lecithin Drugs 0.000 abstract 1
235000010445 lecithin Nutrition 0.000 abstract 1
239000000787 lecithin Substances 0.000 abstract 1
150000002632 lipids Chemical class 0.000 abstract 1
230000007928 solubilization Effects 0.000 abstract 1
238000005063 solubilization Methods 0.000 abstract 1
230000003381 solubilizing effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
- A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/5555—Muramyl dipeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/829—Liposomes, e.g. encapsulation
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Virology (AREA)
Epidemiology (AREA)
Dispersion Chemistry (AREA)
Molecular Biology (AREA)
Mycology (AREA)
Microbiology (AREA)
Immunology (AREA)
Pulmonology (AREA)
Biophysics (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Communicable Diseases (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Cell Biology (AREA)
Botany (AREA)
Zoology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AT86107631T 1985-06-06 1986-06-05 Influenzaimpfstoff. ATE76756T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP60123341A JPH0688911B2 (ja)	1985-06-06	1985-06-06	インフルエンザワクチン及びその製造方法
EP86107631A EP0205098B1 (de)	1985-06-06	1986-06-05	Influenzaimpfstoff

Publications (1)

Publication Number	Publication Date
ATE76756T1 true ATE76756T1 (de)	1992-06-15

Family

ID=14858166

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86107631T ATE76756T1 (de)	1985-06-06	1986-06-05	Influenzaimpfstoff.

Country Status (12)

Country	Link
US (1)	US4826687A (de)
EP (1)	EP0205098B1 (de)
JP (1)	JPH0688911B2 (de)
KR (1)	KR940001373B1 (de)
CN (1)	CN1020407C (de)
AT (1)	ATE76756T1 (de)
AU (1)	AU585353B2 (de)
CA (1)	CA1262091A (de)
CS (1)	CS269981B2 (de)
DE (1)	DE3685519T2 (de)
ES (1)	ES8707113A1 (de)
SU (1)	SU1651782A3 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
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US5897873A (en) *	1984-04-12	1999-04-27	The Liposome Company, Inc.	Affinity associated vaccine
US6090406A (en) *	1984-04-12	2000-07-18	The Liposome Company, Inc.	Potentiation of immune responses with liposomal adjuvants
US5916588A (en) *	1984-04-12	1999-06-29	The Liposome Company, Inc.	Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use
US5026557A (en) *	1987-09-09	1991-06-25	The Liposome Company, Inc.	Adjuvant composition
AU631377B2 (en) *	1988-08-25	1992-11-26	Liposome Company, Inc., The	Affinity associated vaccine
WO1990001947A1 (en) *	1988-08-25	1990-03-08	The Liposome Company, Inc.	Affinity associated vaccine
US5100662A (en) *	1989-08-23	1992-03-31	The Liposome Company, Inc.	Steroidal liposomes exhibiting enhanced stability
AU7239191A (en) *	1990-01-25	1991-08-21	University Of Colorado Foundation, Inc., The	Method for preventing immune suppression in trauma patients
JP2777258B2 (ja) *	1990-03-13	1998-07-16	第一製薬株式会社	ムラミルジペプチド含有脂質膜構造体
US5246707A (en) *	1990-04-26	1993-09-21	Haynes Duncan H	Sustained release delivery of water-soluble bio-molecules and drugs using phospholipid-coated microcrystals, microdroplets and high-concentration liposomes
US5091188A (en) *	1990-04-26	1992-02-25	Haynes Duncan H	Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
GB9018690D0 (en) *	1990-08-24	1990-10-10	Wellcome Found	Vaccines
NZ240369A (en) *	1990-10-30	1993-09-27	Daiichi Seiyaku Co	Muramyl dipeptide derivatives and vaccine compositions
DE69533693T2 (de) *	1994-02-24	2005-12-22	Novavax Inc.(n.d.Ges.d.Staates Delaware)	Impfstoffe, die paucilamelläre Lipidvesikel als Adjuvans enthalten
ATE386506T1 (de)	1995-10-17	2008-03-15	Jagotec Ag	Verabreichung unlöslicher arzneistoffe
US7255877B2 (en) *	1996-08-22	2007-08-14	Jagotec Ag	Fenofibrate microparticles
US6465016B2 (en)	1996-08-22	2002-10-15	Research Triangle Pharmaceuticals	Cyclosporiine particles
DE69908304T2 (de) *	1998-02-11	2004-02-19	Rtp Pharma Corp.	Ungesättigte fettsäure und steroide enthaltende kombinationspräparate zur behandlung von entzündungen
US6979456B1 (en)	1998-04-01	2005-12-27	Jagotec Ag	Anticancer compositions
KR100635456B1 (ko)	1998-05-29	2006-10-18	스키에파마 캐나다 인코포레이티드	열보호화 마이크로입자 조성물 및 그의 말단의 스팀멸균방법
DE69912441T2 (de)	1998-08-19	2004-08-19	Skyepharma Canada Inc., Verdun	Injizierbare wässerige propofoldispersionen
IL143197A0 (en) *	1998-11-20	2002-04-21	Rtp Pharma Inc	Dispersible phospholipid stabilized microparticles
AU7984200A (en) *	1999-09-21	2001-04-24	Skyepharma Canada Inc.	Surface modified particulate compositions of biologically active substances
EP1276465B1 (de)	2000-04-20	2014-03-12	Jagotec AG	Verbessertes verfahren zur herstellung wasserunlöslicher arzneistoffpartikel
JP4969761B2 (ja)	2000-08-31	2012-07-04	オバン・エナジー・リミテッド	所望粒度を持つ固体基材の小粒子および第一材料の小粒状物を含む相乗作用性混合物を製造する方法
EP1320362B1 (de) *	2000-09-20	2011-08-31	Jagotec AG	Stabilisierte fibrat-mikropartikel
US8586094B2 (en) *	2000-09-20	2013-11-19	Jagotec Ag	Coated tablets
NZ527408A (en) *	2001-02-22	2005-04-29	Skyepharma Canada Inc	Hydroxymethylglutarylcoenzyme A (HMG CoA) reductase inhibitor (or a statin) and a fibrate in a single effective oral dosage form to treat dyslipidaemia and dyslipoproteinaemia
EP2281573A3 (de) *	2001-02-23	2011-12-07	GlaxoSmithKline Biologicals s.a.	Influenza Vakzinzusammensetzungen zur intradermaler Verabreichung
GB2386072A (en) *	2001-04-27	2003-09-10	Becton Dickinson Co	Novel vaccine
CN1253220C (zh) *	2001-06-29	2006-04-26	贝克顿迪肯森公司	通过微管在真皮内输入疫苗和基因治疗剂
CA2515779A1 (en)	2003-02-14	2004-09-02	The Curators Of The University Of Missouri	Contraceptive method and compositions related to proteasomal interference
US7588774B2 (en) *	2003-05-12	2009-09-15	Becton, Dickinson And Company	Molecules enhancing dermal delivery of influenza vaccines
US20050123550A1 (en) *	2003-05-12	2005-06-09	Laurent Philippe E.	Molecules enhancing dermal delivery of influenza vaccines
AR056245A1 (es)	2003-06-19	2007-10-03	Bestewil Holding Bv	Membranas virales reconstituidas funcionales que contienen un coadyuvante
JP2007516968A (ja) *	2003-12-05	2007-06-28	ベクトン・ディキンソン・アンド・カンパニー	皮内コンパートメントにおける免疫応答を増強する方法、およびそれらの方法で有用な化合物
US20060121055A1 (en) *	2004-12-06	2006-06-08	Becton, Dickinson And Company, Inc.	Compositions with enhanced immunogenicity
US7468187B2 (en)	2005-10-18	2008-12-23	Iowa State University Research Foundation, Inc.	Canine influenza virus and related compositions and methods of use
US20090060889A1 (en) *	2007-03-12	2009-03-05	Von Hofe Eric	Ii-RNAi involved Ii suppression in cancer immunotherapy
EP2278997B1 (de)	2008-04-21	2016-08-10	Nanobio Corporation	Nanoemulsions-grippeimpfstoff
EP2729169A1 (de)	2011-07-06	2014-05-14	Nanobio Corporation	Impfstoff gegen humanes respiratorisches synzytialvirus
JP6205360B2 (ja)	2011-08-22	2017-09-27	ナノバイオコーポレーション	単純ヘルペスウイルスのナノエマルジョンワクチン

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Publication number	Priority date	Publication date	Assignee	Title
US4009258A (en) *	1972-09-25	1977-02-22	The Mount Sinai School Of Medicine Of The City University Of New York	Influenza vaccine containing a recombinant, antigenically hybridized virus and method of using the same
CH589453A5 (de) *	1974-01-14	1977-07-15	Sandoz Ag
US4117113A (en) *	1974-06-25	1978-09-26	National Research Development Corporation	Immunological preparations
US4196191A (en) *	1975-09-29	1980-04-01	Burroughs Wellcome Co.	Biological preparations
US4261975A (en) *	1979-09-19	1981-04-14	Merck & Co., Inc.	Viral liposome particle
DE3068743D1 (en) *	1980-01-16	1984-08-30	Weder Hans G	Process and dialysis-installation for the preparation of bilayer-vesicles and their use
DE3173713D1 (en) *	1980-09-05	1986-03-20	Frappier Armand Inst	Formation of an immunosome exclusively made of viral antigens reconstituted on an artificial membrane
US4327182A (en) *	1981-01-22	1982-04-27	Connaught Laboratories Incorporated	Purification of influenza sub-unit vaccine
US4565696A (en) *	1983-08-03	1986-01-21	The Regents Of The University Of California	Production of immunogens by antigen conjugation to liposomes
FR2551758B1 (fr) *	1983-08-16	1986-01-31	Anvar	Derives de muramyl-peptides et de steroides ayant des proprietes d'activation des macrophages
IL69720A (en) *	1983-09-14	1987-08-31	Univ Ramot	Anti-tumor pharmaceutical compositions comprising liposome-bound porphyrins
US4663161A (en) *	1985-04-22	1987-05-05	Mannino Raphael J	Liposome methods and compositions

1985
- 1985-06-06 JP JP60123341A patent/JPH0688911B2/ja not_active Expired - Lifetime
1986
- 1986-05-28 US US06/867,539 patent/US4826687A/en not_active Expired - Fee Related
- 1986-06-04 CA CA000510861A patent/CA1262091A/en not_active Expired
- 1986-06-05 DE DE8686107631T patent/DE3685519T2/de not_active Expired - Fee Related
- 1986-06-05 EP EP86107631A patent/EP0205098B1/de not_active Expired - Lifetime
- 1986-06-05 SU SU864027675A patent/SU1651782A3/ru active
- 1986-06-05 AU AU58365/86A patent/AU585353B2/en not_active Ceased
- 1986-06-05 ES ES555748A patent/ES8707113A1/es not_active Expired
- 1986-06-05 AT AT86107631T patent/ATE76756T1/de not_active IP Right Cessation
- 1986-06-05 KR KR1019860004500A patent/KR940001373B1/ko not_active Expired - Fee Related
- 1986-06-06 CN CN86103717A patent/CN1020407C/zh not_active Expired - Fee Related
- 1986-06-06 CS CS864197A patent/CS269981B2/cs unknown

Also Published As

Publication number	Publication date
AU5836586A (en)	1986-12-18
JPH0688911B2 (ja)	1994-11-09
US4826687A (en)	1989-05-02
ES555748A0 (es)	1987-07-01
DE3685519T2 (de)	1993-01-21
AU585353B2 (en)	1989-06-15
EP0205098A2 (de)	1986-12-17
EP0205098A3 (en)	1989-03-22
CS269981B2 (en)	1990-05-14
CA1262091A (en)	1989-10-03
EP0205098B1 (de)	1992-06-03
CN86103717A (zh)	1987-02-11
CN1020407C (zh)	1993-05-05
KR870000075A (ko)	1987-02-16
DE3685519D1 (de)	1992-07-09
KR940001373B1 (ko)	1994-02-21
SU1651782A3 (ru)	1991-05-23
JPS61282321A (ja)	1986-12-12
CS419786A2 (en)	1989-04-14
ES8707113A1 (es)	1987-07-01

Legal Events

Date	Code	Title
1993-05-15	EEFA	Change of the company name
1993-06-15	UEP	Publication of translation of european patent specification
2000-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE76756T1 (de)	1992-06-15	Influenzaimpfstoff.
AU722647B2 (en)	2000-08-10	Protein-lipid vesicles and autogenous vaccine comprising the same
NO172727C (no)	1993-09-01	Fremgangsmaate for fremstilling av legemiddelholdige klorfluorcarbonaerosoldrivmiddelformuleringer
DK55891D0 (da)	1991-03-27	Matrix med immunomodulerende virkning
SE8201351L (sv)	1982-03-04	Sett att framstella liposomberedningar
EP0335133A3 (de)	1990-05-16	Arzneistoffabgabe mit Hilfe eines Lungentensids zur Absorptionsförderung
EP0047480B1 (de)	1986-02-05	Bildung eines Immunosoms, das ausschliesslich aus Virusantigenen, die auf einer künstlichen Membran rekonstruiert sind, hergestellt wird
Ribi et al.	1979	Peptides as requirement for immunotherapy of the guinea-pig line-10 tumor with endotoxins
WO1990004412A1 (en)	1990-05-03	Liposome immunoadjuvants containing il-2
ATE99949T1 (de)	1994-01-15	Natuerliches oberflaechenwirksames lungenpraeparat, verfahren zu seiner herstellung und pharmazeutische zusammensetzungen.
US5573779A (en)	1996-11-12	Liposome composition
ATE133423T1 (de)	1996-02-15	Rekonstituierte hdl-teilchen und ihre verwendung
ATE544470T1 (de)	2012-02-15	Immuntherapeutische methoden und zusammensetzungen
ATE130198T1 (de)	1995-12-15	Herstellung eines virus und reinigung von virenüberzugsproteinen zur impfstoffverwendung.
ATE87467T1 (de)	1993-04-15	Pharmazeutische zubereitung.
Kersten et al.	1988	Immunogenicity of liposomes and iscoms containing the major outer membrane protein of Neisseria gonorrhoeae: influence of protein content and liposomal bilayer composition
AU6078399A (en)	2000-04-17	Ligand presenting assembly (lpa), method of preparation and uses thereof
UA26313A (uk)	1999-08-30	Засіб для замісhої терапії захворюваhь дихальhих шляхів, переважhо при сиhдромі задухи
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