ATE76897T1 - Vorrichtung und verfahren zum massentransfer von biologisch-pharmazeutischen medien. - Google Patents

Vorrichtung und verfahren zum massentransfer von biologisch-pharmazeutischen medien.

Info

Publication number
ATE76897T1
ATE76897T1 AT87310442T AT87310442T ATE76897T1 AT E76897 T1 ATE76897 T1 AT E76897T1 AT 87310442 T AT87310442 T AT 87310442T AT 87310442 T AT87310442 T AT 87310442T AT E76897 T1 ATE76897 T1 AT E76897T1
Authority
AT
Austria
Prior art keywords
mass transfer
bioreactor
biological
pharmaceutical media
cell growth
Prior art date
Application number
AT87310442T
Other languages
English (en)
Inventor
Henry B Kopf
Original Assignee
Henry B Kopf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25468714&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE76897(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Henry B Kopf filed Critical Henry B Kopf
Application granted granted Critical
Publication of ATE76897T1 publication Critical patent/ATE76897T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
    • B01D65/08—Prevention of membrane fouling or of concentration polarisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/24—Dialysis ; Membrane extraction
    • B01D61/32—Controlling or regulating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/08—Flat membrane modules
    • B01D63/082—Flat membrane modules comprising a stack of flat membranes
    • B01D63/084—Flat membrane modules comprising a stack of flat membranes at least one flow duct intersecting the membranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/10—Hollow fibers or tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/12—Pulsatile flow
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/16—Hollow fibers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/16—Use of chemical agents
    • B01D2321/168—Use of other chemical agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/20—By influencing the flow
    • B01D2321/2066—Pulsated flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/20—By influencing the flow
    • B01D2321/2083—By reversing the flow

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Water Supply & Treatment (AREA)
  • Immunology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • External Artificial Organs (AREA)
AT87310442T 1986-11-26 1987-11-26 Vorrichtung und verfahren zum massentransfer von biologisch-pharmazeutischen medien. ATE76897T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/936,486 US4885087A (en) 1986-11-26 1986-11-26 Apparatus for mass transfer involving biological/pharmaceutical media

Publications (1)

Publication Number Publication Date
ATE76897T1 true ATE76897T1 (de) 1992-06-15

Family

ID=25468714

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87310442T ATE76897T1 (de) 1986-11-26 1987-11-26 Vorrichtung und verfahren zum massentransfer von biologisch-pharmazeutischen medien.

Country Status (5)

Country Link
US (2) US4885087A (de)
EP (1) EP0269444B1 (de)
JP (1) JPS63151306A (de)
AT (1) ATE76897T1 (de)
DE (1) DE3779578T2 (de)

Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885087A (en) * 1986-11-26 1989-12-05 Kopf Henry B Apparatus for mass transfer involving biological/pharmaceutical media
US5593580A (en) * 1986-11-26 1997-01-14 Kopf; Henry B. Filtration cassette article, and filter comprising same
US5868930A (en) * 1986-11-26 1999-02-09 Kopf; Henry B. Filtration cassette article and filter comprising same
US6022742A (en) * 1986-11-26 2000-02-08 Kopf; Henry B. Culture device and method
US4973558A (en) * 1988-04-28 1990-11-27 Endotronics, Inc. Method of culturing cells using highly gas saturated media
DE3818776C2 (de) * 1988-06-02 1994-06-30 Maerkl Herbert Verfahren zur Kultivierung von Zellen in einem Fermenter und zur Durchführung des Verfahrens bestimmter Fermenter
US5683916A (en) * 1988-10-31 1997-11-04 Hemasure Inc. Membrane affinity apparatus and purification methods related thereto
US6378657B2 (en) * 1991-10-23 2002-04-30 James P. Viken Fluid exchange system
US7657297B2 (en) * 2004-05-03 2010-02-02 Dexcom, Inc. Implantable analyte sensor
US6097025A (en) * 1997-10-31 2000-08-01 Ljl Biosystems, Inc. Light detection device having an optical-path switching mechanism
US6469311B1 (en) 1997-07-16 2002-10-22 Molecular Devices Corporation Detection device for light transmitted from a sensed volume
US6071748A (en) * 1997-07-16 2000-06-06 Ljl Biosystems, Inc. Light detection device
US6982431B2 (en) 1998-08-31 2006-01-03 Molecular Devices Corporation Sample analysis systems
US6576476B1 (en) 1998-09-02 2003-06-10 Ljl Biosystems, Inc. Chemiluminescence detection method and device
US6326605B1 (en) 1998-02-20 2001-12-04 Ljl Biosystems, Inc. Broad range light detection system
US6825921B1 (en) 1999-11-10 2004-11-30 Molecular Devices Corporation Multi-mode light detection system
US6992761B2 (en) 1997-09-20 2006-01-31 Molecular Devices Corporation Broad range light detection system
US6297018B1 (en) 1998-04-17 2001-10-02 Ljl Biosystems, Inc. Methods and apparatus for detecting nucleic acid polymorphisms
US6315900B1 (en) 1998-06-03 2001-11-13 Accurate Polymers Static separation method using non-porous cellulose beads
US6177049B1 (en) * 1998-06-10 2001-01-23 Dsu Medical Corporation Reversing flow blood processing system
US5894011A (en) * 1998-06-24 1999-04-13 Prosl; Frank R. Flow reversing device for hemodialysis
AU5667599A (en) 1998-07-27 2000-02-21 Ljl Biosystems, Inc. Apparatus and methods for time-resolved spectroscopic measurements
AU5223899A (en) 1998-07-27 2000-02-21 Ljl Biosystems, Inc. Apparatus and methods for spectroscopic measurements
US8026096B1 (en) * 1998-10-08 2011-09-27 Protein Sciences Corporation In vivo active erythropoietin produced in insect cells
US6726647B1 (en) 1998-10-23 2004-04-27 Gambro Ab Method and device for measuring access flow
US7316780B1 (en) 1999-01-29 2008-01-08 Pall Corporation Range separation devices and processes
AU3005400A (en) 1999-02-23 2000-09-14 Ljl Biosystems, Inc. Frequency-domain light detection device
US6319465B1 (en) * 1999-06-03 2001-11-20 Dsu Medical Corporation Reversing flow blood processing system having reduced clotting potential
SE9904782D0 (sv) * 1999-12-22 1999-12-22 Gambro Lundia Ab Remote control for extracorporeal blood processing machines
US6308737B1 (en) 2000-03-10 2001-10-30 Transonic Systems, Inc. Method and apparatus for selectively reversing flow between a dialyzer and a patient access
US6368067B1 (en) * 2000-08-22 2002-04-09 Chemand Corporation Dual chamber liquid pump
US7273981B2 (en) * 2001-02-09 2007-09-25 Bsst, Llc. Thermoelectric power generation systems
US7942010B2 (en) 2001-02-09 2011-05-17 Bsst, Llc Thermoelectric power generating systems utilizing segmented thermoelectric elements
US20020139741A1 (en) * 2001-03-27 2002-10-03 Henry Kopf Integral gasketed filtration cassette article and method of making the same
US6572576B2 (en) * 2001-07-07 2003-06-03 Nxstage Medical, Inc. Method and apparatus for leak detection in a fluid line
US6743193B2 (en) 2001-07-17 2004-06-01 Nx Stage Medical, Inc. Hermetic flow selector valve
US20040248125A1 (en) * 2001-08-13 2004-12-09 Stremler Mark A Distribution of solutions across a surface
US7040142B2 (en) * 2002-01-04 2006-05-09 Nxstage Medical, Inc. Method and apparatus for leak detection in blood circuits combining external fluid detection and air infiltration detection
US6695807B2 (en) 2002-01-18 2004-02-24 Dsu Medical, Inc. Blood flow reversing system
DE10208311B4 (de) * 2002-02-27 2005-01-13 Tuhh-Technologie-Gmbh Vorrichtung und Verfahren zur Kultivierung von Gewebezellen
FR2836831B1 (fr) * 2002-03-07 2004-06-25 Centre Nat Rech Scient Combinaison chimiotherapie et antisens de la dna demethylase
US7160719B2 (en) * 2002-06-07 2007-01-09 Mayo Foundation For Medical Education And Research Bioartificial liver system
EP2095835B1 (de) * 2003-01-28 2013-04-03 Gambro Lundia AB Gerät zum Überwachen eines Gefässzugangs zu einem Patienten
WO2005042059A2 (en) * 2003-10-31 2005-05-12 Gambro Lundia Ab A circuit for extracorporeal blood treatment and flow-inverting device utilized therein
JP4416797B2 (ja) * 2003-11-07 2010-02-17 ネクステージ メディカル インコーポレイテッド 血液処理システムにおける漏れ検出のための改善方法及び装置
EP1691862A1 (de) * 2003-11-20 2006-08-23 Gambro Lundia AB Verfahren, gerät und softwareprogramme zur messung eines parameters in verbindung mit einem herz-lungen-system eines säugetieres
ES2471953T3 (es) * 2003-12-11 2014-06-27 Gambro Lundia Ab Dispositivo de conmutación y aparato para controlar el flujo de un fluido
WO2005074657A2 (en) * 2004-02-02 2005-08-18 The General Hospital Corporation Modified organ support devices
WO2006042016A2 (en) * 2004-10-07 2006-04-20 Fresenius Medical Care Holdings, Inc. Blood flow reversal valves and related systems and methods
US20060161094A1 (en) * 2005-01-14 2006-07-20 Utterberg David S 3D clampable valve flow reversing system
DE602005023356D1 (de) * 2005-05-18 2010-10-14 Gambro Lundia Ab Vorrichtung zur steuerung des blutflusses in einem extrakorporalen kreislauf
US9006556B2 (en) 2005-06-28 2015-04-14 Genthem Incorporated Thermoelectric power generator for variable thermal power source
EP1754505A1 (de) * 2005-08-19 2007-02-21 The Automation Partnership (Cambridge) Limited Spritzenpumpe
DE102006008687A1 (de) * 2006-02-24 2007-08-30 Bayer Technology Services Gmbh Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten
ATE532575T1 (de) * 2006-12-11 2011-11-15 Pall Corp Filteranordnungen und verfahren zur installation von filterungseinheiten in filteranordnungen
WO2008109674A2 (en) * 2007-03-05 2008-09-12 Caridianbct, Inc. Cell expansion system and methods of use
JP2010519936A (ja) * 2007-03-05 2010-06-10 カリディアンビーシーティー、インコーポレーテッド 中空繊維バイオリアクター内における細胞の動きを制御する方法
EP2152851B1 (de) * 2007-04-06 2018-04-25 Terumo BCT, Inc. Verbesserte bioreaktoroberflächen
WO2008128165A2 (en) * 2007-04-13 2008-10-23 Caridianbct, Inc. Cell expansion system and methods of use
GB0800311D0 (en) * 2008-01-09 2008-02-20 Cytosystems Ltd Apparatus and method for filtering biological material
US8043512B2 (en) * 2008-04-11 2011-10-25 Pall Corporation Fluid treatment arrangements and methods
US20100063947A1 (en) * 2008-05-16 2010-03-11 Burnside Elizabeth S System and Method for Dynamically Adaptable Learning Medical Diagnosis System
US8048315B2 (en) * 2008-07-28 2011-11-01 Pall Corporation Fluid treatment arrangements and methods
WO2010090864A2 (en) 2009-01-21 2010-08-12 Smartflow Technologies, Inc. Optimization of separation for viscous suspensions
EP2405957B1 (de) 2009-03-13 2020-12-23 Mayo Foundation For Medical Education And Research Bioartifizielle leber
CN102549789B (zh) * 2009-07-24 2015-03-18 Bsst有限责任公司 基于热电的发电系统和方法
US9101883B2 (en) 2009-11-28 2015-08-11 Smartflow Technologies, Inc. Portable filtration unit
US9057045B2 (en) * 2009-12-29 2015-06-16 Terumo Bct, Inc. Method of loading and distributing cells in a bioreactor of a cell expansion system
EP2566951B1 (de) 2010-05-05 2020-03-04 Terumo BCT, Inc. Verfahren zur neuaussaat von in einem hohlfaser-bioreaktorsystem gezüchteten adhärenten zellen
WO2012048275A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
DE102010048422B4 (de) * 2010-10-15 2016-01-07 Thomas Melin Verfahren zur Produktisolierung und Substratzufuhr in einem Bioreaktor
US10005697B1 (en) 2011-02-21 2018-06-26 Smartflow Technologies, Inc. Method and systems for isolation and/or separation of target products from animal produced waste streams
US9163265B2 (en) 2011-02-21 2015-10-20 Smartflow Technologies, Inc. Method and systems for isolation and/or separation of products from production processes
EP2710118B1 (de) 2011-05-17 2018-02-07 Terumo BCT, Inc. Systeme und verfahren zur ausdehnung hochdichter, nichthaftender zellen
US9006557B2 (en) 2011-06-06 2015-04-14 Gentherm Incorporated Systems and methods for reducing current and increasing voltage in thermoelectric systems
KR101654587B1 (ko) 2011-06-06 2016-09-06 젠썸 인코포레이티드 카트리지 기반 열전 시스템
US9802161B2 (en) * 2011-11-10 2017-10-31 Pall Corporation Fluid treatment assemblies
US9783750B2 (en) 2012-02-16 2017-10-10 Smartflow Technologies, Inc. Biodiesel fuel production, separation methods and systems
EP2880270A2 (de) 2012-08-01 2015-06-10 Gentherm Incorporated Hocheffiziente wärmeenergieerzeugung
CN104540933A (zh) 2012-08-20 2015-04-22 泰尔茂比司特公司 在细胞扩增系统的生物反应器中加载和分配细胞的方法
US10786784B2 (en) 2012-09-06 2020-09-29 Smartflow Technologies, Inc. Permeate channel alterations for counter current filtration for use in cross-flow filtration modules useful in osmotic systems
US9415151B2 (en) 2012-09-25 2016-08-16 Fresenius Medical Care Holdings, Inc. Blood flow reversal valves and related systems and methods
KR102749545B1 (ko) * 2013-09-16 2025-01-07 젠자임 코포레이션 세포 배양물을 가공하는 방법 및 시스템
CN103463989B (zh) * 2013-09-18 2015-08-19 中国科学院过程工程研究所 一种提高膜分离过程效率的方法
CN105793411B (zh) 2013-11-16 2018-04-17 泰尔茂比司特公司 生物反应器中的细胞扩增
JP6783143B2 (ja) 2014-03-25 2020-11-11 テルモ ビーシーティー、インコーポレーテッド 培地の受動的補充
WO2015164808A1 (en) 2014-04-24 2015-10-29 Terumo Bct, Inc. Measuring flow rate
US20160090569A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled Feed
CN105709599B (zh) * 2014-12-01 2018-10-19 佛山市顺德区美的饮水机制造有限公司 滤芯、具有其的净水设备和滤芯的废水排出方法
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11426504B2 (en) 2017-03-29 2022-08-30 Nxstage Medical, Inc. Flow reversing device
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US11629332B2 (en) 2017-03-31 2023-04-18 Terumo Bct, Inc. Cell expansion
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
CA3251145A1 (en) 2018-04-17 2025-07-08 Smartflow Technologies, Inc. Filter cassette article, and filter comprising same
EP4314244B1 (de) 2021-03-23 2025-07-23 Terumo BCT, Inc. Zellerfassung und -erweiterung
CN115253708A (zh) * 2021-04-29 2022-11-01 天津膜天膜科技股份有限公司 集成反洗功能的一体化中空纤维膜组件
US12152699B2 (en) 2022-02-28 2024-11-26 Terumo Bct, Inc. Multiple-tube pinch valve assembly
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device
GB2640885A (en) * 2024-05-08 2025-11-12 Sterling Bio Machines Ltd Reactor apparatus

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3697418A (en) * 1971-01-25 1972-10-10 Cci Aerospace Corp Method and apparatus for regenerating the dialyzing fluid for an artificial kidney
JPS4851905A (de) * 1971-10-30 1973-07-21
US3821087A (en) * 1972-05-18 1974-06-28 Dedrick R Cell culture on semi-permeable tubular membranes
US3883393A (en) * 1972-05-18 1975-05-13 Us Health Education & Welfare Cell culture on semi-permeable tubular membranes
US4420398A (en) * 1981-08-13 1983-12-13 American National Red Cross Filteration method for cell produced antiviral substances
CH663422A5 (de) * 1982-05-27 1987-12-15 Chemap Ag Verfahren und fermenter zur zuechtung von gewebezellen.
WO1984001959A1 (en) * 1982-11-16 1984-05-24 Univ California Rapid production of biological products by fermentation in a densely-packed microbial membrane reactor
JPS60804A (ja) * 1983-06-20 1985-01-05 Poritetsukusu:Kk ウルトラフイルタ装置
JPS6188872A (ja) * 1984-10-09 1986-05-07 Snow Brand Milk Prod Co Ltd 高濃度連続培養方法及び装置
WO1986002379A1 (en) * 1984-10-09 1986-04-24 Endotronics, Inc. Hollow fiber culture device for improved nutrient perfusion and product concentration and method of operation
US4600694A (en) * 1985-05-24 1986-07-15 Clyde Robert A Apparatus for harvesting cells
US4720462A (en) * 1985-11-05 1988-01-19 Robert Rosenson Culture system for the culture of solid tissue masses and method of using the same
US4889812A (en) * 1986-05-12 1989-12-26 C. D. Medical, Inc. Bioreactor apparatus
US4966707A (en) * 1986-05-13 1990-10-30 Celanese Corporation Liquid/liquid extractions with microporous membranes
US4885087A (en) * 1986-11-26 1989-12-05 Kopf Henry B Apparatus for mass transfer involving biological/pharmaceutical media
US4724548A (en) * 1987-03-13 1988-02-16 Jeff London Hugging novelty device

Also Published As

Publication number Publication date
EP0269444A3 (en) 1989-07-19
US4885087A (en) 1989-12-05
DE3779578D1 (de) 1992-07-09
DE3779578T2 (de) 1992-12-24
EP0269444A2 (de) 1988-06-01
EP0269444B1 (de) 1992-06-03
JPS63151306A (ja) 1988-06-23
US6048727A (en) 2000-04-11

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