ATE79278T1 - Markierung von traegermolekuelen mit metallionen. - Google Patents
Markierung von traegermolekuelen mit metallionen.Info
- Publication number
- ATE79278T1 ATE79278T1 AT87301869T AT87301869T ATE79278T1 AT E79278 T1 ATE79278 T1 AT E79278T1 AT 87301869 T AT87301869 T AT 87301869T AT 87301869 T AT87301869 T AT 87301869T AT E79278 T1 ATE79278 T1 AT E79278T1
- Authority
- AT
- Austria
- Prior art keywords
- labeling
- metal ions
- carrier molecules
- metal ion
- dihydroxyl
- Prior art date
Links
- 229910021645 metal ion Inorganic materials 0.000 title abstract 4
- 238000002372 labelling Methods 0.000 title 1
- XXAXVMUWHZHZMJ-UHFFFAOYSA-N Chymopapain Chemical compound OC1=CC(S(O)(=O)=O)=CC(S(O)(=O)=O)=C1O XXAXVMUWHZHZMJ-UHFFFAOYSA-N 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 239000013522 chelant Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/534—Production of labelled immunochemicals with radioactive label
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
- A61K51/1048—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell determinant being a carcino embryonic antigen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Food Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/836,535 US4732974A (en) | 1986-03-05 | 1986-03-05 | Metal ion labeling of carrier molecules |
| EP87301869A EP0248506B1 (de) | 1986-03-05 | 1987-03-04 | Markierung von Trägermolekülen mit Metallionen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE79278T1 true ATE79278T1 (de) | 1992-08-15 |
Family
ID=25272173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87301869T ATE79278T1 (de) | 1986-03-05 | 1987-03-04 | Markierung von traegermolekuelen mit metallionen. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4732974A (de) |
| EP (1) | EP0248506B1 (de) |
| JP (1) | JPH0791317B2 (de) |
| AT (1) | ATE79278T1 (de) |
| AU (1) | AU596828B2 (de) |
| CA (1) | CA1288197C (de) |
| DE (1) | DE3781031T2 (de) |
| ES (1) | ES2035041T3 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4830847A (en) * | 1985-06-28 | 1989-05-16 | The Procter & Gamble Company | Diphosphonate-derivatized macromolecules |
| US5082930A (en) * | 1986-05-29 | 1992-01-21 | Mallinckrodt Medical, Inc. | Coupling agents for joining radionuclide metal ions with biologically useful proteins |
| US5177192A (en) * | 1987-04-02 | 1993-01-05 | Centocor, Incorporated | Method for labeling antibodies with a metal ion |
| US4952393A (en) * | 1987-04-02 | 1990-08-28 | The General Hospital Corporation | Organ infarct imaging with technetium labelled glucarate |
| JP2520262B2 (ja) * | 1987-08-21 | 1996-07-31 | 春幸 川原 | パツチテスト材料 |
| US5648471A (en) * | 1987-12-03 | 1997-07-15 | Centocor, Inc. | One vial method for labeling antibodies with Technetium-99m |
| US5059541A (en) * | 1988-04-29 | 1991-10-22 | Neorx Corporation | Minimal derivatization of proteins |
| US5218128A (en) * | 1988-06-15 | 1993-06-08 | Centocor, Inc. | Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom |
| US4946668A (en) * | 1988-10-07 | 1990-08-07 | Centocor, Inc. | Tumor imaging with technetium labelled glucarate |
| MY106120A (en) * | 1988-12-05 | 1995-03-31 | Novartis Ag | Peptide derivatives. |
| GR1002475B (el) * | 1988-12-05 | 1996-11-26 | Novartis Ag (Novartis Sa) (Novartis Inc.) | Μεθοδος παρασκευης πεπτιδικων παραγωγων. |
| JPH05504763A (ja) * | 1989-11-30 | 1993-07-22 | マリンクロッド・メディカル・インコーポレイテッド | 金属放射性核種でラベル付けされたタンパク質の調製方法 |
| US5130129A (en) * | 1990-03-06 | 1992-07-14 | The Regents Of The University Of California | Method for enhancing antibody transport through capillary barriers |
| DE69126124T2 (de) * | 1990-09-28 | 1997-08-28 | Neorx Corp | Polymere träger zur freisetzung kovalent gebundener wirkstoffe |
| WO1992011039A1 (en) * | 1990-12-17 | 1992-07-09 | The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce | Derivatized tris-catechol chelating agents |
| US5645815A (en) | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
| KR100238558B1 (ko) * | 1991-02-27 | 2000-02-01 | 에프.쥐.엠.헤르만스 | 단백질의 테크네튬-99m 표지화 |
| AU2307092A (en) * | 1991-07-01 | 1993-02-11 | Mallinckrodt Medical, Inc. | Tissue specific imaging agents using internal image anti-idiotypic antibodies |
| US5326856A (en) * | 1992-04-09 | 1994-07-05 | Cytogen Corporation | Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding |
| US5413778A (en) * | 1992-10-05 | 1995-05-09 | The Regents Of The University Of Michigan | Labelled monocyte chemoattractant protein material and medical uses thereof |
| US5605671A (en) * | 1992-10-05 | 1997-02-25 | The Regents Of The University Of Michigan | Radiolabeled neutrophil activating peptides for imaging |
| US5346686A (en) * | 1992-10-05 | 1994-09-13 | Mallinckrodt Medical, Inc. | Labelled interleukin-8 and medical uses thereof |
| WO1994009128A1 (en) * | 1992-10-22 | 1994-04-28 | Mallinckrodt Medical, Inc. | Therapeutic treatment for inhibiting vascular restenosis |
| CA2154667A1 (en) * | 1993-02-02 | 1994-08-18 | Linda M. Gustavson | Directed biodistribution of small molecules |
| US6203775B1 (en) * | 1993-03-19 | 2001-03-20 | The General Hospital Corporation | Chelating polymers for labeling of proteins |
| CA2141739A1 (en) * | 1993-05-03 | 1994-11-10 | Alfons M. Verbruggen | Method for preparing a metal-radionuclide-labelled protein |
| CA2190727C (en) * | 1994-05-19 | 2006-07-18 | Sudhakar Kasina | Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging |
| US6005083A (en) | 1997-03-28 | 1999-12-21 | Neorx Corporation | Bridged aromatic substituted amine ligands with donor atoms |
| US20030031627A1 (en) * | 2001-07-31 | 2003-02-13 | Mallinckrodt Inc. | Internal image antibodies for optical imaging and therapy |
| TW593919B (en) * | 2002-05-31 | 2004-06-21 | Matsushita Refrigeration | Vacuum heat insulating material and method for producing the same, and refrigerator using the vacuum heat insulating material |
| CN119456224B (zh) * | 2024-10-31 | 2025-11-28 | 郑州大学 | 一种矿物的预处理方法协同浮选药剂的分离工艺 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2334107A1 (fr) * | 1975-12-05 | 1977-07-01 | Pasteur Institut | Procede de couplage de substances biologiques par des liaisons covalentes |
| SE428332B (sv) * | 1979-03-08 | 1983-06-20 | Wallac Oy | Forfarande for fluorescensspektroskopisk bestemning av biologiskt aktivt emne, sasom hapten, antikropp eller antigen |
| US4331647A (en) * | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
| US4421735A (en) * | 1980-04-17 | 1983-12-20 | The Massachusetts General Hospital | Radiolabeled diagnostic compositions and method for making the same |
| SE8006102L (sv) * | 1980-09-02 | 1982-03-03 | Gambro Ab | Sett att utvinna en peptidinnehallande forening samt medel for genomforande av settet |
| NO169947C (no) * | 1981-10-27 | 1992-08-26 | Hybritech Inc | Fremgangsmaate for fremstilling av et monoklonalt antistoff til et tumorassosiert antigen |
| CA1222691A (en) * | 1981-12-29 | 1987-06-09 | Wilhelmus T. Goedemans | Method of preparing radionuclide-labelled proteins, in particular antibodies or antibody fragments |
| US4472509A (en) * | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
| US4707352A (en) * | 1984-01-30 | 1987-11-17 | Enzo Biochem, Inc. | Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group |
| US4837003A (en) * | 1984-09-13 | 1989-06-06 | Mallinckrodt, Inc. | Radiolabeled antibody fragments |
| US4659839A (en) * | 1984-10-10 | 1987-04-21 | Mallinckrodt, Inc. | Coupling agents for radiolabeled antibody fragments |
| US5238808A (en) * | 1984-10-31 | 1993-08-24 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| US4569794A (en) * | 1984-12-05 | 1986-02-11 | Eli Lilly And Company | Process for purifying proteins and compounds useful in such process |
-
1986
- 1986-03-05 US US06/836,535 patent/US4732974A/en not_active Expired - Fee Related
-
1987
- 1987-03-04 ES ES198787301869T patent/ES2035041T3/es not_active Expired - Lifetime
- 1987-03-04 EP EP87301869A patent/EP0248506B1/de not_active Expired - Lifetime
- 1987-03-04 AU AU69701/87A patent/AU596828B2/en not_active Ceased
- 1987-03-04 AT AT87301869T patent/ATE79278T1/de active
- 1987-03-04 JP JP62047871A patent/JPH0791317B2/ja not_active Expired - Lifetime
- 1987-03-04 DE DE8787301869T patent/DE3781031T2/de not_active Expired - Lifetime
- 1987-03-05 CA CA000531302A patent/CA1288197C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0791317B2 (ja) | 1995-10-04 |
| ES2035041T3 (es) | 1993-04-16 |
| US4732974A (en) | 1988-03-22 |
| AU596828B2 (en) | 1990-05-17 |
| DE3781031T2 (de) | 1992-12-17 |
| CA1288197C (en) | 1991-08-27 |
| JPS62270600A (ja) | 1987-11-24 |
| DE3781031D1 (de) | 1992-09-17 |
| EP0248506A1 (de) | 1987-12-09 |
| EP0248506B1 (de) | 1992-08-12 |
| AU6970187A (en) | 1987-09-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE79278T1 (de) | Markierung von traegermolekuelen mit metallionen. | |
| EP0336678A3 (en) | Method for radiolabeling proteins | |
| ES2088995T3 (es) | Utilizacion de complejos de cobre de alfa amino acidos que contienen grupos amino terminales como suplemento nutritivo. | |
| EP0452858A3 (en) | Metal complexes of acid adducts to dioxime ligands useful in labelling proteins and other amine-containing compounds | |
| DE3588226D1 (de) | Kontrollierte Oxidation von mikrobiell herstellten, Cystein-enthaltenden Proteinen | |
| EP0383234A3 (de) | Pasteurisiertes, gereinigtes von Willebrand-Faktor-Konzentrat und Verfahren zu seiner Herstellung | |
| ATE57694T1 (de) | Verfahren zur herstellung von 2,5dicetopiperazinen. | |
| EP0155786A3 (en) | New peptide, and production and use thereof | |
| DK543087A (da) | Fremgangsmaade til fremstilling af 2,6-di-tert.butyl-4-mercaptophenol samt fremgangsmaade til fremstilling af derved anvendeligt mellemprodukt | |
| PT86233A (fr) | Procede de preparation d:une variant de l:hirudine | |
| AU4629885A (en) | 4,5-dihydro-4-oxo-2-((2-trans-phenylcyclopropyl) amino)-3- furancarboxylic acid derivatives | |
| GB1492252A (en) | Determination of antipyrine | |
| PL238572A1 (en) | Pesticide and method of manufacture of novel substituted diamides of hydroxymalonic acids | |
| ATE130009T1 (de) | Antitumor-aminosäuren und peptid-derivate von 1,4-bis((aminoalkyl und hydroxyaminoalkyl)amino>5,8- dihydroxyanthraquinonen. | |
| ATE120747T1 (de) | Pro-drugs von 6-mercaptopurin und 6-thioguanin. | |
| EP0429644A4 (en) | Chelating agents for attaching metal ions to proteins | |
| GR3006748T3 (de) | ||
| ATE34747T1 (de) | Verfahren zur herstellung von thiotetronsaeure. | |
| PL151373B2 (de) | ||
| JPS5522691A (en) | Manufacture of r*ss55pphydroxyphenyll2*44 imidazolidione or r*ss55pphydroxyphenylhydantoin | |
| DE3669263D1 (de) | Stabilisierung von interferonen. | |
| ATE16279T1 (de) | Verfahren zur gewinnung von d,l-homocystin. | |
| DE3361077D1 (en) | Bis-(benzoylthio)-carboxylic acids, their preparation and use in the production of active ingredients | |
| IN156668B (de) | ||
| KR860003012A (ko) | (-)시스-1,2-에폭시프로필포스폰산과 아미노산과의 염을 함유하는 수용성 제약 조성물 |