ATE79284T1 - Zur vollstaendigen entleerung der kapsel geeigneter inhalator. - Google Patents

Zur vollstaendigen entleerung der kapsel geeigneter inhalator.

Info

Publication number
ATE79284T1
ATE79284T1 AT90102555T AT90102555T ATE79284T1 AT E79284 T1 ATE79284 T1 AT E79284T1 AT 90102555 T AT90102555 T AT 90102555T AT 90102555 T AT90102555 T AT 90102555T AT E79284 T1 ATE79284 T1 AT E79284T1
Authority
AT
Austria
Prior art keywords
capsule
complete emptying
chamber
discharge holes
inhaler suitable
Prior art date
Application number
AT90102555T
Other languages
English (en)
Inventor
Luigi Valentini
Giancarlo Ceschel
Original Assignee
Phidea Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phidea Spa filed Critical Phidea Spa
Application granted granted Critical
Publication of ATE79284T1 publication Critical patent/ATE79284T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033Details of the piercing or cutting means
    • A61M15/0041Details of the piercing or cutting means with movable piercing or cutting means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/06Solids
    • A61M2202/064Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT90102555T 1989-02-23 1990-02-09 Zur vollstaendigen entleerung der kapsel geeigneter inhalator. ATE79284T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8919539A IT1228459B (it) 1989-02-23 1989-02-23 Inalatore con svuotamento regolare e completo della capsula.

Publications (1)

Publication Number Publication Date
ATE79284T1 true ATE79284T1 (de) 1992-08-15

Family

ID=11158882

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90102555T ATE79284T1 (de) 1989-02-23 1990-02-09 Zur vollstaendigen entleerung der kapsel geeigneter inhalator.

Country Status (7)

Country Link
US (1) US4995385A (de)
EP (1) EP0388621B1 (de)
AT (1) ATE79284T1 (de)
DE (1) DE69000249T2 (de)
DK (1) DK0388621T3 (de)
ES (1) ES2034781T3 (de)
IT (1) IT1228459B (de)

Families Citing this family (242)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6681767B1 (en) 1991-07-02 2004-01-27 Nektar Therapeutics Method and device for delivering aerosolized medicaments
DE69230613T2 (de) * 1991-07-02 2000-12-28 Inhale Inc Verfahren und vorrichtung zum abgeben von medikamenten in aerosolform
US5337740A (en) * 1991-08-01 1994-08-16 New England Pharmaceuticals, Inc. Inhalation devices
US5785049A (en) * 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
US6673335B1 (en) * 1992-07-08 2004-01-06 Nektar Therapeutics Compositions and methods for the pulmonary delivery of aerosolized medicaments
US6509006B1 (en) 1992-07-08 2003-01-21 Inhale Therapeutic Systems, Inc. Devices compositions and methods for the pulmonary delivery of aerosolized medicaments
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
GB9216038D0 (en) * 1992-07-28 1992-09-09 Bespak Plc Dispensing apparatus for powdered medicaments
US7448375B2 (en) * 1993-01-29 2008-11-11 Aradigm Corporation Method of treating diabetes mellitus in a patient
US6024090A (en) * 1993-01-29 2000-02-15 Aradigm Corporation Method of treating a diabetic patient by aerosolized administration of insulin lispro
PT101450B (pt) * 1994-02-02 1999-11-30 Hovione Produtos Farmaceuticos Novo dispositivo para inalacao
EP0748213B1 (de) 1994-03-07 2004-04-14 Nektar Therapeutics Verfahren und mittel zur verabreichung von insulin über die lunge
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
JP3372105B2 (ja) * 1994-05-26 2003-01-27 株式会社日立ユニシアオートモティブ 吸入式投薬器
US6290991B1 (en) * 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
JP3388896B2 (ja) * 1994-08-08 2003-03-24 株式会社日立ユニシアオートモティブ 吸入式投薬器
JP3706136B2 (ja) 1994-09-21 2005-10-12 ネクター セラピューティクス 乾燥粉末薬剤の分散装置及び方法
US5901703A (en) * 1995-02-06 1999-05-11 Unisia Jecs Corporation Medicine administering device for nasal cavities
US5780014A (en) * 1995-04-14 1998-07-14 Inhale Therapeutic Systems Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin
AUPN976496A0 (en) * 1996-05-10 1996-05-30 Glaxo Wellcome Australia Ltd Unit dose dispensing device
US20030203036A1 (en) * 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
DE69829139T2 (de) * 1997-01-30 2006-04-06 Hitachi, Ltd. Medikator vom ansaugtyp
US7052678B2 (en) 1997-09-15 2006-05-30 Massachusetts Institute Of Technology Particles for inhalation having sustained release properties
US20060165606A1 (en) * 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US20020017295A1 (en) * 2000-07-07 2002-02-14 Weers Jeffry G. Phospholipid-based powders for inhalation
US6257233B1 (en) 1998-06-04 2001-07-10 Inhale Therapeutic Systems Dry powder dispersing apparatus and methods for their use
US6956021B1 (en) * 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
GB9820746D0 (en) 1998-09-23 1998-11-18 Pharmax Limited Micronised pharmaceutical compositions
US6858199B1 (en) 2000-06-09 2005-02-22 Advanced Inhalation Research, Inc. High efficient delivery of a large therapeutic mass aerosol
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
AU2005201843B2 (en) * 1999-07-23 2009-01-29 Mannkind Corporation Unit dose capsules and dry powder inhaler
US7464706B2 (en) 1999-07-23 2008-12-16 Mannkind Corporation Unit dose cartridge and dry powder inhaler
EP1649886B1 (de) * 1999-07-23 2008-04-02 MannKind Corporation Einzelportionskapseln für einen Trockenpulverinhalator
US7305986B1 (en) 1999-07-23 2007-12-11 Mannkind Corporation Unit dose capsules for use in a dry powder inhaler
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
US6586008B1 (en) * 1999-08-25 2003-07-01 Advanced Inhalation Research, Inc. Use of simple amino acids to form porous particles during spray drying
CA2382821A1 (en) * 1999-08-25 2001-03-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
US7252840B1 (en) 1999-08-25 2007-08-07 Advanced Inhalation Research, Inc. Use of simple amino acids to form porous particles
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
US20010036481A1 (en) * 1999-08-25 2001-11-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
US6810872B1 (en) * 1999-12-10 2004-11-02 Unisia Jecs Corporation Inhalant medicator
US6679256B2 (en) 1999-12-17 2004-01-20 Nektar Therapeutics Systems and methods for extracting powders from receptacles
WO2001085136A2 (en) * 2000-05-10 2001-11-15 Alliance Pharmaceutical Corporation Phospholipid-based powders for drug delivery
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US8404217B2 (en) * 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US20030003057A1 (en) * 2000-07-07 2003-01-02 Jeffry Weers Methods for administering leuprolide by inhalation
US6948494B1 (en) * 2000-05-10 2005-09-27 Innovative Devices, Llc. Medicament container with same side airflow inlet and outlet and method of use
US7575761B2 (en) * 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
WO2002009674A2 (en) * 2000-07-28 2002-02-07 Inhale Therapeutic Systems, Inc. Methods and compositions to upregulate, redirect or limit immune responses to bioactive compounds
WO2002013897A2 (en) 2000-08-14 2002-02-21 Advanced Inhalation Research, Inc. Inhalation device and method
US6613308B2 (en) 2000-09-19 2003-09-02 Advanced Inhalation Research, Inc. Pulmonary delivery in treating disorders of the central nervous system
SE517227C2 (sv) * 2000-09-25 2002-05-14 Microdrug Ag Inhalator för torrt pulver med folieskärare
US20020141946A1 (en) * 2000-12-29 2002-10-03 Advanced Inhalation Research, Inc. Particles for inhalation having rapid release properties
ATE255929T1 (de) 2001-03-05 2003-12-15 Ivo Pera Inhalationsvorrichtung zum dispergieren von in kapseln enthaltenen pulverförmigen medikamente durch den respirationstrakt
US6766799B2 (en) * 2001-04-16 2004-07-27 Advanced Inhalation Research, Inc. Inhalation device
WO2002092154A1 (en) 2001-04-26 2002-11-21 New England Pharmaceuticals, Inc. Metered dose delivery device for liquid and powder agents
WO2002100370A1 (en) * 2001-06-11 2002-12-19 Warner-Lambert Company Llc Breath protection microcapsules
GB2380410B (en) * 2001-10-05 2003-11-19 Alchemy Healthcare Ltd Apparatus for the nasal or oral delivery of a medicament
JP2005508234A (ja) 2001-11-02 2005-03-31 イーライ・リリー・アンド・カンパニー 色分けされた治療ユニット
WO2003041777A1 (en) * 2001-11-14 2003-05-22 Nektar Therapeutics Aerosolization device with improved endpiece connection
JP4437040B2 (ja) * 2001-11-14 2010-03-24 ネクター セラピューティクス 接続可能な本体およびエンドピースを備えるエーロゾル化装置
AU2002346472A1 (en) * 2001-11-20 2003-06-10 Advanced Inhalation Research, Inc. Particulate compositions for improving solubility of poorly soluble agents
WO2003043585A2 (en) * 2001-11-20 2003-05-30 Advanced Inhalation Research, Inc. Improved particulate compositions for pulmonary delivery
US20030099601A1 (en) * 2001-11-27 2003-05-29 Gordon Marc S. Inhalation lung surfactant therapy
US20030168057A1 (en) * 2001-12-14 2003-09-11 Inhale Therapeutic Systems, Inc. Electronically controllable aerosol delivery
JP2005514393A (ja) 2001-12-19 2005-05-19 ネクター セラピューティクス アミノグリコシドの肺への供給
AU2002360491A1 (en) * 2001-12-21 2003-07-24 Nektar Therapeutics Apparatus and method for sealing cavities
JP4739672B2 (ja) 2001-12-21 2011-08-03 ネクター セラピューティクス 湿気のバリアを有するカプセルパッケージ
ITMI20020078A1 (it) * 2002-01-16 2003-07-16 Fabrizio Niccolai Dispositivo utilizzabile nel tratamento di affezzioni delle vie respiratorie
ES2389156T3 (es) 2002-03-20 2012-10-23 Civitas Therapeutics, Inc. Administración pulmonar de levodopa
WO2003080149A2 (en) 2002-03-20 2003-10-02 Mannkind Corporation Inhalation apparatus
US7008644B2 (en) 2002-03-20 2006-03-07 Advanced Inhalation Research, Inc. Method and apparatus for producing dry particles
US20050163725A1 (en) * 2002-03-20 2005-07-28 Blizzard Charles D. Method for administration of growth hormone via pulmonary delivery
AU2003218306B2 (en) * 2002-03-20 2006-09-14 Advanced Inhalation Research, Inc. Method for administration of growth hormone via pulmonary delivery
AU2003230689B2 (en) 2002-03-20 2006-06-29 Alkermes, Inc. Inhalable sustained therapeutic formulations
GB0216562D0 (en) * 2002-04-25 2002-08-28 Bradford Particle Design Ltd Particulate materials
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
JP2005530765A (ja) * 2002-05-07 2005-10-13 ネクター セラピューティクス 乾燥粉末吸入器のためのカプセル及びそれを製造及び使用する方法
US6941980B2 (en) * 2002-06-27 2005-09-13 Nektar Therapeutics Apparatus and method for filling a receptacle with powder
EP1531794B1 (de) 2002-06-28 2017-05-10 Civitas Therapeutics, Inc. Epinephrin zur inhalation
US20040206350A1 (en) * 2002-12-19 2004-10-21 Nektar Therapeutics Aerosolization apparatus with non-circular aerosolization chamber
US20050236296A1 (en) * 2002-12-30 2005-10-27 Nektar Therapeutics (Formerly Inhale Therapeutic Systems, Inc.) Carry case for aerosolization apparatus
US20050056280A1 (en) * 2002-12-31 2005-03-17 Nektar Therapeutics Receptacle for an aerosolizable pharmaceutical formulation
MXPA05007156A (es) * 2002-12-31 2005-09-21 Nektar Therapeutics Formulacion farmaceuticas aerosolizable para terapia para infecciones fungicas.
US7669596B2 (en) * 2002-12-31 2010-03-02 Novartis Pharma Ag Aerosolization apparatus with rotating capsule
DK1610850T3 (da) * 2003-04-09 2012-06-25 Novartis Ag Aerosolapparat med luftindløbsskærm
EP1615689B1 (de) 2003-04-09 2016-02-03 Novartis AG Medikamentenspender mit ausrichtungsführung zum durchstechen einer kapsel
US8869794B1 (en) * 2003-04-09 2014-10-28 Novartis Pharma Ag Aerosolization apparatus with capsule puncturing member
CA2523475C (en) * 2003-05-28 2013-02-05 Nektar Therapeutics Pharmaceutical formulation comprising a water-insoluble active agent
WO2004112702A2 (en) 2003-06-13 2004-12-29 Advanced Inhalation Research, Inc. Low dose pharmaceutical powders for inhalation
US20050214224A1 (en) * 2003-11-04 2005-09-29 Nektar Therapeutics Lipid formulations for spontaneous drug encapsulation
CA2554973A1 (en) * 2004-02-10 2005-08-25 Advanced Inhalation Research, Inc. Particles for inhalation rapid release properties
JP2007534384A (ja) * 2004-04-23 2007-11-29 ミスティック ファーマシューティカルズ, インコーポレイテッド 複数の単位用量の薬物送達システム
WO2005110379A2 (en) * 2004-05-07 2005-11-24 President And Fellows Of Harvard College Pulmonary malarial vaccine
WO2006002178A1 (en) 2004-06-18 2006-01-05 Novartis Vaccines And Diagnostics Inc. Methods of treatment of endobronchial infections
US8513204B2 (en) * 2004-06-21 2013-08-20 Novartis Ag Compositions comprising amphotericin B, mehods and systems
EP1773301A2 (de) * 2004-06-21 2007-04-18 Nektar Therapeutics Zusammensetzungen mit amphotericinb, verfahren und systeme
ATE486064T1 (de) 2004-08-20 2010-11-15 Mannkind Corp Katalyse der diketopiperazinsynthese
HUE025151T2 (en) 2004-08-23 2016-01-28 Mannkind Corp Diceto-piperazine salts for drug delivery
BRPI0517374A (pt) 2004-10-29 2008-10-07 Harvard College formulação para tratamento ou prevenção de infecção respiratória, método para tratamento
BRPI0610062A2 (pt) * 2005-05-18 2010-05-25 Nektar Therapeutics válvulas, dispositivos e métodos para terapia endobronquial
US20070031342A1 (en) * 2005-06-22 2007-02-08 Nektar Therapeutics Sustained release microparticles for pulmonary delivery
US20130131007A1 (en) 2005-09-07 2013-05-23 Bebaas, Inc. Vitamin b12 compositions
US20070178141A1 (en) * 2005-09-07 2007-08-02 Bebaas, Inc. Vitamin B12 compositions
KR101486397B1 (ko) 2005-09-14 2015-01-28 맨카인드 코포레이션 활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법
US20090032427A1 (en) * 2005-09-29 2009-02-05 Nektar Therapeutics Receptacles and Kits, Such as for Dry Powder Packaging
US20070123449A1 (en) * 2005-11-01 2007-05-31 Advanced Inhalation Research, Inc. High load particles for inhalation having rapid release properties
GB0524194D0 (en) * 2005-11-28 2006-01-04 Univ Aston Respirable powders
KR20080096809A (ko) 2006-02-22 2008-11-03 맨카인드 코포레이션 디케토피페라진 및 활성제를 포함하는 마이크로입자의 약학특성의 개선 방법
DE102006016904A1 (de) * 2006-04-11 2007-10-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalator
DE102006016903A1 (de) * 2006-04-11 2007-10-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalator
EP1844805A1 (de) 2006-04-13 2007-10-17 Boehringer Ingelheim Pharma GmbH & Co.KG Inhalator
US8201555B2 (en) * 2006-06-27 2012-06-19 Brintech International Limited Inhaler
US20080063722A1 (en) * 2006-09-08 2008-03-13 Advanced Inhalation Research, Inc. Composition of a Spray-Dried Powder for Pulmonary Delivery of a Long Acting Neuraminidase Inhibitor (LANI)
RU2463085C2 (ru) * 2006-10-25 2012-10-10 Новартис Аг Аппарат для распыления порошка, способ его изготовления и применения и его компоненты
JP2010515541A (ja) * 2007-01-09 2010-05-13 ミスティック ファーマシューティカルズ, インコーポレイテッド 経鼻カートリッジデバイス
GB0700839D0 (en) * 2007-01-17 2007-02-21 Braithwaite Philip Device
US8683995B2 (en) 2007-05-16 2014-04-01 Mystic Pharmaceuticals, Inc. Dose dispensing containers
CA2887187C (en) 2007-05-16 2017-10-24 Mystic Pharmaceuticals, Inc. COMBINED DISPENSING CONTAINERS - UNIT DOSE
US9248076B2 (en) 2007-05-16 2016-02-02 Mystic Pharmaceuticals, Inc. Dose dispensing containers
US8496002B2 (en) * 2007-06-12 2013-07-30 Civitas Therapeutics, Inc. Powder inhaler devices
DE102007040366A1 (de) * 2007-08-17 2009-02-19 Aha Kunststofftechnik Gmbh Trockenpulver-Inhalator
CN101380496A (zh) * 2007-09-03 2009-03-11 东鸿远东有限公司 吸入器
CA2886525A1 (en) * 2007-09-14 2009-03-19 Mystic Pharmaceuticals, Inc. Deep draw container forming method
US20100287884A1 (en) * 2007-10-25 2010-11-18 Sangita Seshadri Powder conditioning of unit dose drug packages
CN101888867B (zh) * 2007-12-05 2013-05-15 诺瓦提斯公司 用于可雾化的药物制剂的容器
ES2648196T3 (es) 2008-02-07 2017-12-29 The University Of Washington Dispositivo aerosol circunferencial
DE102008014025A1 (de) * 2008-03-13 2009-09-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalator und Sieb für einen Inhalator
JP5727927B2 (ja) * 2008-05-15 2015-06-03 ノバルティス アーゲー フルオロキノロンの肺送達
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
ES2929343T3 (es) 2008-06-13 2022-11-28 Mannkind Corp Inhalador de polvo seco accionado por aspiración para la administración de fármacos
MX2010014240A (es) 2008-06-20 2011-03-25 Mankind Corp Un metodo y aparato interactivo para perfilar en tiempo real esfuerzos de inhalacion.
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
WO2010105094A1 (en) 2009-03-11 2010-09-16 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
DK2413902T3 (da) 2009-03-18 2019-10-07 Incarda Therapeutics Inc Enhedsdoser, aerosoler, kits og fremgangsmåder til behandling af hjertetilstande ved pulmonal indgivelse
ES2625260T5 (es) 2009-03-26 2020-07-29 Pulmatrix Operating Co Inc Formulaciones de polvo seco y métodos para el tratamiento de enfermedades pulmonares
MY157166A (en) 2009-06-12 2016-05-13 Mankind Corp Diketopiperazine microparticles with defined specific surface areas
WO2011056889A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
JP5415341B2 (ja) * 2010-03-31 2014-02-12 株式会社吉野工業所 粉体吸入デバイス
RS54761B1 (sr) 2010-06-24 2016-10-31 Gilead Sciences Pirazolo[1,5-a]pirimidini i-triazini kao antiviralni agensi
PH12013500035A1 (en) 2010-07-22 2013-03-11 Gilead Sciences Inc Methods and compounds for treating paramyxoviridae virus infections
EP2611438B1 (de) 2010-08-30 2020-04-01 Pulmatrix Operating Company, Inc. Trockenpulverformulierungen und verfahren zur behandlung von lungenerkrankugen
WO2012030647A1 (en) 2010-08-30 2012-03-08 Pulmatrix, Inc. Treatment of cystic fibrosis using calcium lactate, leucine and sodium chloride in a respiraple dry powder
TW201305185A (zh) 2010-09-13 2013-02-01 Gilead Sciences Inc 用於抗病毒治療之2’-氟取代之碳-核苷類似物
JP5877204B2 (ja) 2010-09-29 2016-03-02 パルマトリックス,インコーポレイテッド 吸入用の一価金属カチオン乾燥粉末
DK2621488T3 (en) 2010-09-29 2019-03-04 Pulmatrix Operating Co Inc CATIONIC DRY POWDER
AT510585B1 (de) 2010-11-18 2012-05-15 Apeptico Forschung & Entwicklung Gmbh Zusammensetzung umfassend ein peptid und ein hemmstoff der viralen neuraminidase
EP4088769A1 (de) 2011-03-03 2022-11-16 Impel Pharmaceuticals Inc. Vorrichtung für nasale arzneimittelabgabe
AU2012236150B2 (en) 2011-04-01 2016-03-31 Mannkind Corporation Blister package for pharmaceutical cartridges
JP6645735B2 (ja) 2011-05-09 2020-02-14 インペル ニューロファーマ インコーポレイテッド 鼻薬送達用ノズル
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
BR112014009686A2 (pt) 2011-10-24 2018-08-07 Mannkind Corp composição analgésica inalável, pó seco e método para tratar dor
US8327610B1 (en) * 2011-12-16 2012-12-11 JCDS Holdings, LLC Capsule opener and emptier
US10463815B2 (en) 2012-02-21 2019-11-05 Respira Therapeutics, Inc. Inhaler to deliver substances for prophylaxis or prevention of disease or injury caused by the inhalation of biological or chemical agents
CN107596518B (zh) 2012-02-29 2021-04-23 普马特里克斯营业公司 可吸入干粉剂
AU2013232378B2 (en) 2012-03-13 2017-09-28 Gilead Sciences, Inc. 2'- substituted carba-nucleoside analogs for antiviral treatment
CN106986869A (zh) 2012-04-17 2017-07-28 吉利德科学公司 用于抗病毒治疗的化合物和方法
EP2679239A1 (de) 2012-06-28 2014-01-01 Apeptico Forschung und Entwicklung GmbH Pharmazeutische Zusammensetzung zur Behandlung der durch Sauerstoffarmut und verringerten Luftdruck vermittelten pulmonalen Form der Höhenkrankheit
AU2013289957B2 (en) 2012-07-12 2017-02-23 Mannkind Corporation Dry powder drug delivery systems and methods
EP2708219A1 (de) * 2012-09-12 2014-03-19 PARI Pharma GmbH Öffnungselement zum Öffnen einer Ampulle in einer Aerosolerzeugungsvorrichtung und Aerosolerzeugungsvorrichtung mit dem Öffnungselement
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
US9757395B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9757529B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
KR102246914B1 (ko) 2013-03-15 2021-04-30 맨카인드 코포레이션 미세결정성 디케토피페라진 조성물 및 방법
WO2014165303A1 (en) 2013-04-01 2014-10-09 Pulmatrix, Inc. Tiotropium dry powders
CA2909954C (en) 2013-04-28 2021-03-23 Impel Neuropharma, Inc. Medical unit dose container
CA2910766C (en) 2013-04-30 2020-12-15 Otitopic Inc. Dry powder formulations and methods of use
CN114848614A (zh) 2013-07-18 2022-08-05 曼金德公司 热稳定性干粉药物组合物和方法
EP3030294B1 (de) 2013-08-05 2020-10-07 MannKind Corporation Insufflationsvorrichtung
UA119050C2 (uk) 2013-11-11 2019-04-25 Ґілеад Саєнсиз, Інк. ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ
US9272123B2 (en) * 2013-12-16 2016-03-01 Esther Gallant Device and method for inserting lubricating capsule
CN112656780A (zh) 2014-02-20 2021-04-16 奥迪托皮克股份有限公司 用于吸入的干粉制剂
CN106794325B (zh) * 2014-02-21 2020-06-30 瑞必治公司 粉末吸入器、系统和方法
USD752204S1 (en) 2014-03-10 2016-03-22 Civitas Therapeutics, Inc. Indicator for an inhaler
USD755367S1 (en) 2014-03-10 2016-05-03 Civitas Therapeutics, Inc. Indicator for an inhaler
USD752734S1 (en) 2014-03-10 2016-03-29 Civitas Therapeutics, Inc. Inhaler grip
EP3062772B1 (de) 2014-03-18 2018-01-24 APEPTICO Forschung und Entwicklung GmbH Peptidmedikament in der form eines trockenpulvers
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
TWI678369B (zh) 2014-07-28 2019-12-01 美商基利科學股份有限公司 用於治療呼吸道合胞病毒感染之噻吩並[3,2-d]嘧啶、呋喃並[3,2-d]嘧啶及吡咯並[3,2-d]嘧啶化合物類
DE102014215064A1 (de) 2014-07-31 2016-02-04 Pari GmbH Spezialisten für effektive Inhalation Vernebler
PL3179986T3 (pl) 2014-07-31 2023-06-26 Vectura Inc. Suche formulacje w proszku do inhalacji
TWI673283B (zh) 2014-08-21 2019-10-01 美商基利科學股份有限公司 2’-氯胺基嘧啶酮及嘧啶二酮核苷類
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
WO2016115379A1 (en) * 2015-01-14 2016-07-21 Respira Therapeutics, Inc. Powder dispersion methods and devices
DE102015108931B3 (de) * 2015-06-05 2016-06-09 Gerresheimer Regensburg Gmbh Gitterelement für einen Inhalator
MA42708A (fr) 2015-09-10 2018-07-04 Impel Neuropharma Inc Dispositif d'administration nasale en ligne
WO2017109678A1 (en) 2015-12-24 2017-06-29 Philip Morris Products S.A. Nicotine particle capsule
CA3008211A1 (en) 2015-12-24 2017-06-29 Philip Morris Products S.A. Nicotine powder delivery system
SG10202012584UA (en) 2016-02-01 2021-01-28 Incarda Therapeutics Inc Combining electronic monitoring with inhaled pharmacological therapy to manage cardiac arrhythmias including atrial fibrillation
EP3474832B1 (de) 2016-06-24 2026-03-18 Merz Pharmaceuticals, LLC Tensidformulierungen zur inhalation
RU2766086C2 (ru) 2016-10-14 2022-02-07 Пулматрикс Оперэйтинг Компани, Инк. Противогрибковые сухие порошки
BR112019008497A2 (pt) * 2016-11-30 2019-07-09 Philip Morris Products Sa inalador com cavidade dimensionada
CN109922852B (zh) * 2016-11-30 2023-11-07 菲利普莫里斯生产公司 具有涡旋端塞的吸入器
EP3612259B1 (de) * 2017-04-17 2022-11-09 Respira Therapeutics, Inc. Einheitsdosiertrockenpulverinhalator
CA3060702A1 (en) 2017-05-10 2018-11-15 Incarda Therapeutics, Inc. Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration
IL270685B (en) 2017-05-22 2022-09-01 Insmed Inc Cleavable derivatives of lipoglycopeptide and their uses
US10786456B2 (en) 2017-09-22 2020-09-29 Otitopic Inc. Inhaled aspirin and magnesium to treat inflammation
CA3076353A1 (en) 2017-09-22 2019-03-28 Otitopic Inc. Dry powder compositions with magnesium stearate
CN114642275A (zh) 2017-10-25 2022-06-21 菲利普莫里斯生产公司 用于吸入器制品和系统的刺穿附件
US12576222B2 (en) 2017-10-25 2026-03-17 Philip Morris Products S.A. Inhaler with boundary element
CA3081680A1 (en) 2017-11-21 2019-05-31 Impel Neuropharma, Inc. Intranasal device with inlet interface
EP3713628A4 (de) 2017-11-21 2021-08-18 Impel Neuropharma Inc. Intranasale vorrichtung mit tauchrohr
EP3731909B2 (de) * 2017-12-28 2024-08-14 Philip Morris Products S.A. Inhalator mit wirbelertunnel
KR20200118032A (ko) 2018-01-05 2020-10-14 임펠 뉴로파마 인코포레이티드 정밀 후각기관 장치에 의한 디하이드로에르고타민의 비강내 전달
AU2019205329B2 (en) 2018-01-05 2023-04-20 Impel Pharmaceuticals Inc. Intranasal delivery of olanzapine by precision olfactory device
EP3517117A1 (de) 2018-01-30 2019-07-31 Medizinische Universität Wien Arzneimittel zur vorbeugung oder behandlung von rhinovirusinfektionen
EP3768378B1 (de) 2018-03-22 2025-08-06 InCarda Therapeutics, Inc. Neuartiges verfahren zur verlangsamung der ventrikulären rate
EP3772252B1 (de) * 2018-03-26 2022-05-04 Philip Morris Products S.A. Inhalator mit einem durchlöcherten porösen trägerelement
EP3781125A1 (de) 2018-04-18 2021-02-24 Pulmatrix Operating Company, Inc. Antimykotische formulierungen zur pulmonalen verabreichung mit itraconazol
AU2019256453B2 (en) 2018-04-18 2024-10-17 Cipla Usa Inc. Methods of treating fungal infections
WO2020018959A1 (en) 2018-07-19 2020-01-23 Impel Neuropharma, Inc. Respiratory tract delivery of levodopa and dopa decarboxylase inhibitor for treatment of parkinson's disease
US20220023282A1 (en) 2018-12-13 2022-01-27 Mannkind Corporation Compositions of Bedaquiline, Combinations Comprising Them, Processes for Their Preparation, Uses and Methods of Treatment Comprising Them
CN113473967B (zh) 2019-01-03 2022-09-09 英倍尔制药公司 经鼻药物递送装置
KR20210134716A (ko) 2019-03-01 2021-11-10 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 폴리리보뉴클레오티드의 전달을 위한 조성물, 방법, 및 키트
KR20220010011A (ko) 2019-05-17 2022-01-25 임펠 뉴로파마 인코포레이티드 일회용 비강 전달 장치
EP4523754A3 (de) 2019-05-24 2025-05-07 Stichting Radboud universitair medisch centrum Verbesserte verabreichung von glycylcyclinen
EP3760203A1 (de) 2019-07-03 2021-01-06 Medizinische Universität Graz Medikament zur vorbeugung oder behandlung einer stoffwechselstörung
US11020384B2 (en) 2019-08-01 2021-06-01 Incarda Therapeutics, Inc. Antiarrhythmic formulation
IL290088B2 (en) 2019-08-01 2023-10-01 Incarda Therapeutics Inc A pharmaceutical preparation containing flacainide, cyclodextrin and acid, a dosage unit of the preparation and a kit containing the preparation
ES2956467T3 (es) * 2019-10-25 2023-12-21 Philip Morris Products Sa Contenedor para artículo inhalador
US12370330B2 (en) 2019-11-08 2025-07-29 Philip Morris Products S.A. Double activation prevention
JP7711068B2 (ja) 2019-12-24 2025-07-22 カルナバイオサイエンス株式会社 ジアシルグリセロールキナーゼ調節化合物
TWI794742B (zh) 2020-02-18 2023-03-01 美商基利科學股份有限公司 抗病毒化合物
EP4106876B1 (de) 2020-02-18 2025-09-17 Gilead Sciences, Inc. Antivirale verbindungen
TWI884403B (zh) 2020-02-18 2025-05-21 美商基利科學股份有限公司 抗病毒化合物
TWI874791B (zh) 2020-02-18 2025-03-01 美商基利科學股份有限公司 抗病毒化合物
CR20220547A (es) 2020-05-01 2022-12-15 Gilead Sciences Inc Compuestos de 2,4-dioxopirimidina inhibidores de cd73
US20250241978A1 (en) 2020-05-08 2025-07-31 Apeptico Forschung Und Entwicklung Gmbh Peptide for prevention or treatment of covid-19
TW202228792A (zh) 2020-10-09 2022-08-01 殷漢生技股份有限公司 吸入用奈米載體製劑
MX2023010120A (es) 2021-03-03 2023-10-30 Pulmatrix Operating Co Inc Formulaciones de polvo seco de dihidroergotamina y metodos de uso.
EP4304582A1 (de) 2021-03-12 2024-01-17 Alvarius Pharmaceuticals Ltd. Zusammensetzungen und verfahren zur behandlung von sucht mit 5-meo-dmt
KR20240005901A (ko) 2021-06-23 2024-01-12 길리애드 사이언시즈, 인코포레이티드 디아실글리세롤 키나제 조절 화합물
AU2022298639C1 (en) 2021-06-23 2025-07-17 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
AU2022299051B2 (en) 2021-06-23 2025-03-13 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
KR20240025616A (ko) 2021-06-23 2024-02-27 길리애드 사이언시즈, 인코포레이티드 다이아실글리세롤 키나제 조절 화합물
CA3235986A1 (en) 2021-10-29 2023-05-04 Gilead Science, Inc. Cd73 compounds
US20250049717A1 (en) 2021-12-20 2025-02-13 Pulmatrix Operating Company, Inc. Dry powder formulations of narrow spectrum kinase inhibitors
EP4511000A1 (de) 2022-04-22 2025-02-26 Quench Medical Inc. Inhalationsverabreichung von arzneimitteln in trockenpulverform
WO2024040175A1 (en) 2022-08-18 2024-02-22 Pulmatrix Operating Company, Inc. Methods for treating cancer using inhaled angiogenesis inhibitor
EP4582080A1 (de) 2024-01-02 2025-07-09 G.ST Antivirals GmbH 2-desoxy-glucose oder analoga davon enthaltender spender zur mukosalen verabreichung

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4069819A (en) * 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device

Also Published As

Publication number Publication date
EP0388621B1 (de) 1992-08-12
US4995385A (en) 1991-02-26
IT1228459B (it) 1991-06-19
DK0388621T3 (da) 1992-11-02
IT8919539A0 (it) 1989-02-23
DE69000249D1 (de) 1992-09-17
DE69000249T2 (de) 1993-03-11
EP0388621A1 (de) 1990-09-26
ES2034781T3 (es) 1993-04-01

Similar Documents

Publication Publication Date Title
DE69000249D1 (de) Zur vollstaendigen entleerung der kapsel geeigneter inhalator.
SU656472A3 (ru) Аэрозольный ингал тор
ATE99967T1 (de) Inhalator zur einmaligen verwendung mit vorperforierter kapsel.
SE8504541D0 (sv) Dosing device
AU569743B2 (en) Medicinal inhaler
HK67589A (en) Devices for administering medicaments to patients
ATE185977T1 (de) Inhalator
IT1230313B (it) Inalatore per medicamenti in capsule.
ATE139130T1 (de) Inhalator zur verabreichung von pulverförmigen substanzen
DE69203541D1 (de) Einblasgerät für Mehrfachdosierungen von pulverförmigen Medikamenten.
ATE97822T1 (de) Verteiler fuer eine pulverfoermige medikation.
ATE93151T1 (de) Wegwerfvorrichtung zur inhalation von arzneimitteln.
IT1225348B (it) Apparecchiatura per la somministrazione di farmaci pressurizzati in bombolette