IT1228459B - Inalatore con svuotamento regolare e completo della capsula. - Google Patents

Inalatore con svuotamento regolare e completo della capsula.

Info

Publication number
IT1228459B
IT1228459B IT8919539A IT1953989A IT1228459B IT 1228459 B IT1228459 B IT 1228459B IT 8919539 A IT8919539 A IT 8919539A IT 1953989 A IT1953989 A IT 1953989A IT 1228459 B IT1228459 B IT 1228459B
Authority
IT
Italy
Prior art keywords
capsule
inhaler
regular
complete emptying
chamber
Prior art date
Application number
IT8919539A
Other languages
English (en)
Other versions
IT8919539A0 (it
Inventor
Luigi Valentini
Giancarlo Ceschel
Original Assignee
Phidea S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phidea S R L filed Critical Phidea S R L
Priority to IT8919539A priority Critical patent/IT1228459B/it
Publication of IT8919539A0 publication Critical patent/IT8919539A0/it
Priority to ES199090102555T priority patent/ES2034781T3/es
Priority to AT90102555T priority patent/ATE79284T1/de
Priority to EP90102555A priority patent/EP0388621B1/en
Priority to DE9090102555T priority patent/DE69000249T2/de
Priority to DK90102555.1T priority patent/DK0388621T3/da
Priority to US07/483,744 priority patent/US4995385A/en
Application granted granted Critical
Publication of IT1228459B publication Critical patent/IT1228459B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0041—Details of the piercing or cutting means with movable piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT8919539A 1989-02-23 1989-02-23 Inalatore con svuotamento regolare e completo della capsula. IT1228459B (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
IT8919539A IT1228459B (it) 1989-02-23 1989-02-23 Inalatore con svuotamento regolare e completo della capsula.
ES199090102555T ES2034781T3 (es) 1989-02-23 1990-02-09 Inhalador con vaciado regular y completo de la capsula.
AT90102555T ATE79284T1 (de) 1989-02-23 1990-02-09 Zur vollstaendigen entleerung der kapsel geeigneter inhalator.
EP90102555A EP0388621B1 (en) 1989-02-23 1990-02-09 Inhaler with regular complete emptying of the capsule
DE9090102555T DE69000249T2 (de) 1989-02-23 1990-02-09 Zur vollstaendigen entleerung der kapsel geeigneter inhalator.
DK90102555.1T DK0388621T3 (da) 1989-02-23 1990-02-09 Inhalator
US07/483,744 US4995385A (en) 1989-02-23 1990-02-23 Inhaler with regular complete emptying of the capsule

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8919539A IT1228459B (it) 1989-02-23 1989-02-23 Inalatore con svuotamento regolare e completo della capsula.

Publications (2)

Publication Number Publication Date
IT8919539A0 IT8919539A0 (it) 1989-02-23
IT1228459B true IT1228459B (it) 1991-06-19

Family

ID=11158882

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8919539A IT1228459B (it) 1989-02-23 1989-02-23 Inalatore con svuotamento regolare e completo della capsula.

Country Status (7)

Country Link
US (1) US4995385A (it)
EP (1) EP0388621B1 (it)
AT (1) ATE79284T1 (it)
DE (1) DE69000249T2 (it)
DK (1) DK0388621T3 (it)
ES (1) ES2034781T3 (it)
IT (1) IT1228459B (it)

Families Citing this family (245)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6681767B1 (en) 1991-07-02 2004-01-27 Nektar Therapeutics Method and device for delivering aerosolized medicaments
ES2141108T3 (es) * 1991-07-02 2000-03-16 Inhale Inc Metodo y dispositivo para proporcionar medicamentos en aerosol.
US5337740A (en) * 1991-08-01 1994-08-16 New England Pharmaceuticals, Inc. Inhalation devices
US6673335B1 (en) * 1992-07-08 2004-01-06 Nektar Therapeutics Compositions and methods for the pulmonary delivery of aerosolized medicaments
US6509006B1 (en) 1992-07-08 2003-01-21 Inhale Therapeutic Systems, Inc. Devices compositions and methods for the pulmonary delivery of aerosolized medicaments
US5785049A (en) * 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
US6582728B1 (en) * 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
GB9216038D0 (en) * 1992-07-28 1992-09-09 Bespak Plc Dispensing apparatus for powdered medicaments
US6024090A (en) * 1993-01-29 2000-02-15 Aradigm Corporation Method of treating a diabetic patient by aerosolized administration of insulin lispro
US7448375B2 (en) * 1993-01-29 2008-11-11 Aradigm Corporation Method of treating diabetes mellitus in a patient
PT101450B (pt) * 1994-02-02 1999-11-30 Hovione Produtos Farmaceuticos Novo dispositivo para inalacao
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
DE69535897D1 (de) * 1994-03-07 2009-01-22 Nektar Therapeutics Verfahren und Zusammensetzung für die pulmonale Darreichung von Insulin
JP3372105B2 (ja) * 1994-05-26 2003-01-27 株式会社日立ユニシアオートモティブ 吸入式投薬器
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
JP3388896B2 (ja) * 1994-08-08 2003-03-24 株式会社日立ユニシアオートモティブ 吸入式投薬器
ATE387925T1 (de) * 1994-09-21 2008-03-15 Nektar Therapeutics Vorrichtung und verfahren zum dispergieren von trockenen pulvermedikamenten
US5901703A (en) * 1995-02-06 1999-05-11 Unisia Jecs Corporation Medicine administering device for nasal cavities
US5780014A (en) * 1995-04-14 1998-07-14 Inhale Therapeutic Systems Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin
AUPN976496A0 (en) * 1996-05-10 1996-05-30 Glaxo Wellcome Australia Ltd Unit dose dispensing device
US20030203036A1 (en) * 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
EP0898978B1 (en) * 1997-01-30 2005-03-02 Unisia Jecs Corporation Suction type medicator
US7052678B2 (en) 1997-09-15 2006-05-30 Massachusetts Institute Of Technology Particles for inhalation having sustained release properties
US20020017295A1 (en) * 2000-07-07 2002-02-14 Weers Jeffry G. Phospholipid-based powders for inhalation
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US6257233B1 (en) 1998-06-04 2001-07-10 Inhale Therapeutic Systems Dry powder dispersing apparatus and methods for their use
US6956021B1 (en) * 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
GB9820746D0 (en) † 1998-09-23 1998-11-18 Pharmax Limited Micronised pharmaceutical compositions
US6858199B1 (en) * 2000-06-09 2005-02-22 Advanced Inhalation Research, Inc. High efficient delivery of a large therapeutic mass aerosol
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
EP1649886B1 (en) * 1999-07-23 2008-04-02 MannKind Corporation Unit dose capsules for a dry powder inhaler
AU2005201843B2 (en) * 1999-07-23 2009-01-29 Mannkind Corporation Unit dose capsules and dry powder inhaler
US7305986B1 (en) 1999-07-23 2007-12-11 Mannkind Corporation Unit dose capsules for use in a dry powder inhaler
US7464706B2 (en) 1999-07-23 2008-12-16 Mannkind Corporation Unit dose cartridge and dry powder inhaler
CA2382821A1 (en) * 1999-08-25 2001-03-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
US20010036481A1 (en) * 1999-08-25 2001-11-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
US7252840B1 (en) 1999-08-25 2007-08-07 Advanced Inhalation Research, Inc. Use of simple amino acids to form porous particles
US6586008B1 (en) * 1999-08-25 2003-07-01 Advanced Inhalation Research, Inc. Use of simple amino acids to form porous particles during spray drying
US6810872B1 (en) * 1999-12-10 2004-11-02 Unisia Jecs Corporation Inhalant medicator
US20010029947A1 (en) 1999-12-17 2001-10-18 Steve Paboojian Receptacles to facilitate the extraction of powders
US6948494B1 (en) * 2000-05-10 2005-09-27 Innovative Devices, Llc. Medicament container with same side airflow inlet and outlet and method of use
PT1280520E (pt) * 2000-05-10 2014-12-16 Novartis Ag Pós à base de fosfolípidos para administração de fármacos
US8404217B2 (en) * 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US20030003057A1 (en) * 2000-07-07 2003-01-02 Jeffry Weers Methods for administering leuprolide by inhalation
US7575761B2 (en) * 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
AU2001280934A1 (en) * 2000-07-28 2002-02-13 Alliance Pharmaceutical Corp. Methods and compositions to upregulate, redirect or limit immune responses to bioactive compounds
WO2002013897A2 (en) 2000-08-14 2002-02-21 Advanced Inhalation Research, Inc. Inhalation device and method
US6613308B2 (en) 2000-09-19 2003-09-02 Advanced Inhalation Research, Inc. Pulmonary delivery in treating disorders of the central nervous system
SE517227C2 (sv) * 2000-09-25 2002-05-14 Microdrug Ag Inhalator för torrt pulver med folieskärare
US20020141946A1 (en) * 2000-12-29 2002-10-03 Advanced Inhalation Research, Inc. Particles for inhalation having rapid release properties
EP1238680B1 (en) 2001-03-05 2003-12-10 Ivo Pera Inhaling device for dispersing powdered medicaments contained in a capsule through the respiratory tract
US6766799B2 (en) * 2001-04-16 2004-07-27 Advanced Inhalation Research, Inc. Inhalation device
CA2445516C (en) 2001-04-26 2007-11-20 New England Pharmaceuticals, Inc. Metered dose delivery device for liquid and powder agents
WO2002100370A1 (en) * 2001-06-11 2002-12-19 Warner-Lambert Company Llc Breath protection microcapsules
GB2380410B (en) * 2001-10-05 2003-11-19 Alchemy Healthcare Ltd Apparatus for the nasal or oral delivery of a medicament
WO2003039636A1 (en) 2001-11-02 2003-05-15 Eli Lilly And Company Color-coded therapy unit
US20030094173A1 (en) * 2001-11-14 2003-05-22 Inhale Therapeutic Systems, Inc. Aerosolization device with improved endpiece connection
MXPA04004631A (es) * 2001-11-14 2004-08-12 Nektar Therapeutics Al Corp Aparato en aerosol que comprende cuerpo conectable y pieza de extremo.
CA2465675C (en) * 2001-11-20 2008-06-10 Advanced Inhalation Research, Inc. Improved particulate compositions for pulmonary delivery
US20030129250A1 (en) * 2001-11-20 2003-07-10 Advanced Inhalation Research Inc. Particulate compositions for improving solubility of poorly soluble agents
US20030099601A1 (en) * 2001-11-27 2003-05-29 Gordon Marc S. Inhalation lung surfactant therapy
US20030168057A1 (en) * 2001-12-14 2003-09-11 Inhale Therapeutic Systems, Inc. Electronically controllable aerosol delivery
TWI324518B (en) 2001-12-19 2010-05-11 Nektar Therapeutics Pulmonary delivery of aminoglycosides
JP4739672B2 (ja) 2001-12-21 2011-08-03 ネクター セラピューティクス 湿気のバリアを有するカプセルパッケージ
JP2005514273A (ja) * 2001-12-21 2005-05-19 ネクター セラピューティクス 包装における医薬製剤の密封
ITMI20020078A1 (it) 2002-01-16 2003-07-16 Fabrizio Niccolai Dispositivo utilizzabile nel tratamento di affezzioni delle vie respiratorie
US7008644B2 (en) * 2002-03-20 2006-03-07 Advanced Inhalation Research, Inc. Method and apparatus for producing dry particles
US20050163725A1 (en) * 2002-03-20 2005-07-28 Blizzard Charles D. Method for administration of growth hormone via pulmonary delivery
WO2003079993A2 (en) * 2002-03-20 2003-10-02 Advanced Inhalation Research, Inc. hGH (HUMAN GROWTH HORMONE) FORMULATIONS FOR PULMONARY ADMINISTRATION
CA2478974C (en) 2002-03-20 2014-12-16 Advanced Inhalation Research, Inc. Inhalable sustained therapeutic formulations
JP4681231B2 (ja) 2002-03-20 2011-05-11 マンカインド コーポレイション 吸入装置
SI2630954T1 (sl) 2002-03-20 2017-02-28 Civitas Therapeutics, Inc. Pulmonalno dovajanje za levodopo
GB0216562D0 (en) * 2002-04-25 2002-08-28 Bradford Particle Design Ltd Particulate materials
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
EP1501479A1 (en) * 2002-05-07 2005-02-02 Nektar Therapeutics Capsules for dry powder inhalers and methods of making and using same
US6941980B2 (en) * 2002-06-27 2005-09-13 Nektar Therapeutics Apparatus and method for filling a receptacle with powder
EP1531794B1 (en) 2002-06-28 2017-05-10 Civitas Therapeutics, Inc. Inhalable epinephrine
US20040206350A1 (en) * 2002-12-19 2004-10-21 Nektar Therapeutics Aerosolization apparatus with non-circular aerosolization chamber
US20050236296A1 (en) * 2002-12-30 2005-10-27 Nektar Therapeutics (Formerly Inhale Therapeutic Systems, Inc.) Carry case for aerosolization apparatus
US20050056280A1 (en) * 2002-12-31 2005-03-17 Nektar Therapeutics Receptacle for an aerosolizable pharmaceutical formulation
US7669596B2 (en) * 2002-12-31 2010-03-02 Novartis Pharma Ag Aerosolization apparatus with rotating capsule
CA2511555A1 (en) * 2002-12-31 2004-07-22 Nektar Therapeutics Aerosolizable pharmaceutical formulation for fungal infection therapy
AU2004229446B2 (en) * 2003-04-09 2010-02-25 Bgp Products Operations Gmbh Aerosolization apparatus with air inlet shield
CA2520265C (en) * 2003-04-09 2015-02-17 Bgp Products Operations Gmbh Aerosolization apparatus with capsule puncture alignment guide
US8869794B1 (en) * 2003-04-09 2014-10-28 Novartis Pharma Ag Aerosolization apparatus with capsule puncturing member
WO2005000267A2 (en) * 2003-05-28 2005-01-06 Nektar Therapeutics Spray drying of an alcoholic aqueous solution for the manufacture of a water-insoluble active agentmicroparticle with a partial or complete amino acid and/or phospholipid coat
AU2004249166B2 (en) * 2003-06-13 2008-10-09 Alkermes, Inc. Low dose pharmaceutical powders for inhalation
WO2005044226A2 (en) * 2003-11-04 2005-05-19 Nectar Therapeutics Lipid formulations for spontaneous drug encapsulation
AU2005212315A1 (en) * 2004-02-10 2005-08-25 Advanced Inhalation Research, Inc. Particles for inhalation rapid release properties
EP1755732A4 (en) * 2004-04-23 2008-01-16 Mystic Pharmaceuticals Inc DISPENSING SYSTEM FOR MEDICINAL PRODUCTS IN SEVERAL SINGLE DOSES
JP2007536273A (ja) * 2004-05-07 2007-12-13 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 肺マラリアワクチン
DK1765288T3 (da) 2004-06-18 2013-02-11 Novartis Ag Tobramycinpræparater til behandling af endobronchiale infektioner
MXPA06015220A (es) * 2004-06-21 2007-12-13 Nektar Therapeutics Composiciones comprendiendo anfotericina b, metodos y sistemas.
US8513204B2 (en) * 2004-06-21 2013-08-20 Novartis Ag Compositions comprising amphotericin B, mehods and systems
ATE486064T1 (de) 2004-08-20 2010-11-15 Mannkind Corp Katalyse der diketopiperazinsynthese
HUE025151T2 (en) 2004-08-23 2016-01-28 Mannkind Corp Diceto-piperazine salts for drug delivery
WO2007011396A2 (en) 2004-10-29 2007-01-25 President And Fellows Of Harvard College Particles for treatment of pulmonary infection
KR101348594B1 (ko) 2005-05-18 2014-01-07 노바르티스 아게 기관지 치료를 위한 밸브, 장치 및 방법
US20070031342A1 (en) * 2005-06-22 2007-02-08 Nektar Therapeutics Sustained release microparticles for pulmonary delivery
US20070178141A1 (en) * 2005-09-07 2007-08-02 Bebaas, Inc. Vitamin B12 compositions
US20130131007A1 (en) 2005-09-07 2013-05-23 Bebaas, Inc. Vitamin b12 compositions
MX373000B (es) 2005-09-14 2020-05-21 Mannkind Corp Metodo para formulacion de farmaco basado en el aumento de la afinidad de agentes activos hacia las superficies de microparticulas cristalinas.
AU2006297394B9 (en) * 2005-09-29 2013-09-19 Novartis Ag Receptacles and kits, such as for dry powder packaging
US20070123449A1 (en) * 2005-11-01 2007-05-31 Advanced Inhalation Research, Inc. High load particles for inhalation having rapid release properties
GB0524194D0 (en) * 2005-11-28 2006-01-04 Univ Aston Respirable powders
CN104383546B (zh) 2006-02-22 2021-03-02 曼金德公司 用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法
DE102006016903A1 (de) 2006-04-11 2007-10-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalator
DE102006016904A1 (de) * 2006-04-11 2007-10-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalator
EP1844805A1 (de) 2006-04-13 2007-10-17 Boehringer Ingelheim Pharma GmbH & Co.KG Inhalator
US8201555B2 (en) * 2006-06-27 2012-06-19 Brintech International Limited Inhaler
US20080063722A1 (en) * 2006-09-08 2008-03-13 Advanced Inhalation Research, Inc. Composition of a Spray-Dried Powder for Pulmonary Delivery of a Long Acting Neuraminidase Inhibitor (LANI)
EP2668970B1 (en) * 2006-10-25 2016-07-06 Novartis AG Powder dispersion apparatus
WO2008086413A2 (en) * 2007-01-09 2008-07-17 Mystic Pharmaceuticals, Inc. Intranasal cartridge devices
GB0700839D0 (en) * 2007-01-17 2007-02-21 Braithwaite Philip Device
US8683995B2 (en) 2007-05-16 2014-04-01 Mystic Pharmaceuticals, Inc. Dose dispensing containers
CN105776119B (zh) 2007-05-16 2019-04-23 神秘制药公司 组成物单位剂量分配容器
US9248076B2 (en) 2007-05-16 2016-02-02 Mystic Pharmaceuticals, Inc. Dose dispensing containers
US8496002B2 (en) * 2007-06-12 2013-07-30 Civitas Therapeutics, Inc. Powder inhaler devices
DE102007040366A1 (de) * 2007-08-17 2009-02-19 Aha Kunststofftechnik Gmbh Trockenpulver-Inhalator
CN101380496A (zh) * 2007-09-03 2009-03-11 东鸿远东有限公司 吸入器
CA2699634C (en) * 2007-09-14 2015-06-09 Mystic Pharmaceuticals, Inc. Deep draw container forming method
RU2517140C2 (ru) * 2007-10-25 2014-05-27 Новартис Аг Способ обработки упаковки с однократной дозой лекартвенного препарата
CN101888867B (zh) * 2007-12-05 2013-05-15 诺瓦提斯公司 用于可雾化的药物制剂的容器
CN101980738A (zh) 2008-02-07 2011-02-23 华盛顿大学 圆周气雾设备
DE102008014025A1 (de) * 2008-03-13 2009-09-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalator und Sieb für einen Inhalator
US8834930B2 (en) 2008-05-15 2014-09-16 Novartis Ag Pulmonary delivery of a fluoroquinolone
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
MY155524A (en) 2008-06-13 2015-10-30 Mannkind Corp A dry powder inhaler and system for drug delivery
EP2609954B1 (en) 2008-06-20 2021-12-29 MannKind Corporation An interactive apparatus for real-time profiling of inhalation efforts
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US8538707B2 (en) 2009-03-11 2013-09-17 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
ES3003038T3 (en) 2009-03-18 2025-03-10 Incarda Therapeutics Inc Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration
JP5671001B2 (ja) 2009-03-26 2015-02-18 パルマトリックス，インコーポレイテッド 肺疾患を治療するための乾燥粉末製剤および方法
AU2010259943C1 (en) 2009-06-12 2016-03-03 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
JP5784622B2 (ja) 2009-11-03 2015-09-24 マンカインド コーポレ−ション 吸入活動をシミュレートするための装置及び方法
JP5415341B2 (ja) * 2010-03-31 2014-02-12 株式会社吉野工業所 粉体吸入デバイス
CN102958933B (zh) 2010-06-24 2016-02-03 吉里德科学公司 作为抗病毒药的吡唑并[1,5-a]嘧啶类
PT2595980E (pt) 2010-07-22 2014-11-27 Gilead Sciences Inc Métodos e compostos para tratar infeções pelo vírus da família paramyxoviridae
WO2012030664A1 (en) 2010-08-30 2012-03-08 Pulmatrix, Inc. Dry powder formulations and methods for treating pulmonary diseases
US8758824B2 (en) 2010-08-30 2014-06-24 Pulmatrix, Inc. Respirably dry powder comprising calcium lactate, sodium chloride and leucine
TW201305185A (zh) 2010-09-13 2013-02-01 吉李德科學股份有限公司 用於抗病毒治療之２’－氟取代之碳－核苷類似物
EP4008326A1 (en) 2010-09-29 2022-06-08 Pulmatrix Operating Company, Inc. Monovalent metal cation dry powders for inhalation
PT2621488T (pt) 2010-09-29 2019-02-12 Pulmatrix Operating Co Inc Pós secos catiónicos
AT510585B1 (de) 2010-11-18 2012-05-15 Apeptico Forschung & Entwicklung Gmbh Zusammensetzung umfassend ein peptid und ein hemmstoff der viralen neuraminidase
EP2680913B1 (en) 2011-03-03 2020-05-06 Impel NeuroPharma Inc. Nasal drug delivery device
MX353285B (es) 2011-04-01 2018-01-05 Mannkind Corp Paquete de blister para cartuchos farmaceuticos.
CN107376071B (zh) 2011-05-09 2021-07-09 英倍尔药业股份有限公司 用于将化合物递送到使用者的上部嗅觉区的喷嘴
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
HK1201475A1 (en) 2011-10-24 2015-09-04 Mannkind Corporation Methods and compositions for treating pain
US8327610B1 (en) * 2011-12-16 2012-12-11 JCDS Holdings, LLC Capsule opener and emptier
US10682476B2 (en) 2012-02-21 2020-06-16 Respira Therapeutics, Inc. Powder inhaler, system and methods
US10463815B2 (en) 2012-02-21 2019-11-05 Respira Therapeutics, Inc. Inhaler to deliver substances for prophylaxis or prevention of disease or injury caused by the inhalation of biological or chemical agents
US20150136130A1 (en) 2012-02-29 2015-05-21 Pulmatrix, Inc. Inhalable dry powders
NZ629996A (en) 2012-03-13 2016-10-28 Gilead Sciences Inc 2’- substituted carba-nucleoside analogs for antiviral treatment
EA027855B1 (ru) 2012-04-17 2017-09-29 Гайлид Сайэнсиз, Инк. Соединения и способы для противовирусной терапии
EP2679239A1 (de) 2012-06-28 2014-01-01 Apeptico Forschung und Entwicklung GmbH Pharmazeutische Zusammensetzung zur Behandlung der durch Sauerstoffarmut und verringerten Luftdruck vermittelten pulmonalen Form der Höhenkrankheit
AU2013289957B2 (en) 2012-07-12 2017-02-23 Mannkind Corporation Dry powder drug delivery systems and methods
EP2708219A1 (en) * 2012-09-12 2014-03-19 PARI Pharma GmbH Opening element for opening an ampoule in an aerosol generation device and aerosol generation device comprising the opening element
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
US9757395B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9757529B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
BR112015023168B1 (pt) 2013-03-15 2021-08-10 Mannkind Corporation Composição de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina cristalina, método de produção de partículas de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina e uso de uma composição de dicetopiperazina cristalina
KR20150135328A (ko) 2013-04-01 2015-12-02 풀매트릭스 인코퍼레이티드 티오트로피움 건조 분말
HK1222358A1 (zh) 2013-04-28 2017-06-30 Impel Neuropharma Inc. 医用单位剂量容器
CN105473133A (zh) 2013-04-30 2016-04-06 欧缇托匹克公司 干粉制剂及使用方法
BR122019026637B1 (pt) 2013-07-18 2023-09-26 Mannkind Corporation Formulações farmacêuticas de pó seco e método para a fabricação de uma formulação de pó seco
CA2920488C (en) 2013-08-05 2022-04-26 Mannkind Corporation Insufflation apparatus and methods
UA119050C2 (uk) 2013-11-11 2019-04-25 Ґілеад Саєнсиз, Інк. ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ
US9272123B2 (en) * 2013-12-16 2016-03-01 Esther Gallant Device and method for inserting lubricating capsule
EP3107548B8 (en) 2014-02-20 2022-07-20 Otitopic Inc. Dry powder formulations for inhalation
USD752204S1 (en) 2014-03-10 2016-03-22 Civitas Therapeutics, Inc. Indicator for an inhaler
USD752734S1 (en) 2014-03-10 2016-03-29 Civitas Therapeutics, Inc. Inhaler grip
USD755367S1 (en) 2014-03-10 2016-05-03 Civitas Therapeutics, Inc. Indicator for an inhaler
CA2940351A1 (en) 2014-03-18 2015-09-24 Apeptico Forschung Und Entwicklung Gmbh Dry-powder peptide medicament
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
TWI678369B (zh) 2014-07-28 2019-12-01 美商基利科學股份有限公司 用於治療呼吸道合胞病毒感染之噻吩並［３,２-ｄ］嘧啶、呋喃並［３,２-ｄ］嘧啶及吡咯並［３,２-ｄ］嘧啶化合物類
DE102014215064A1 (de) 2014-07-31 2016-02-04 Pari GmbH Spezialisten für effektive Inhalation Vernebler
CA2991760C (en) 2014-07-31 2025-05-06 Aspeya US Inc. DRY INHALATION POWDER FORMULATIONS
TWI673283B (zh) 2014-08-21 2019-10-01 美商基利科學股份有限公司 ２’－氯胺基嘧啶酮及嘧啶二酮核苷類
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
CA2972826C (en) 2015-01-14 2023-09-12 Respira Therapeutics, Inc. Powder dispersion methods and devices
DE102015108931B3 (de) * 2015-06-05 2016-06-09 Gerresheimer Regensburg Gmbh Gitterelement für einen Inhalator
EP3341059B1 (en) 2015-09-10 2022-03-02 Impel NeuroPharma Inc. In-line nasal delivery device
EP3393560B1 (en) * 2015-12-24 2020-03-25 Philip Morris Products S.a.s. Nicotine powder delivery system
US10960152B2 (en) 2015-12-24 2021-03-30 Philip Morris Products S.A. Nicotine particle capsule
WO2017136421A1 (en) 2016-02-01 2017-08-10 Incarda Therapeutics, Inc. Combining electronic monitoring with inhaled pharmacological therapy to manage cardiac arrhythmias including atrial fibrillation
AU2017281931B2 (en) 2016-06-24 2023-02-02 Merz Pharmaceuticals, Llc Surfactant formulations for inhalation
US11116722B2 (en) 2016-10-14 2021-09-14 Pulmatrix Operating Company, Inc. Antifungal dry powders
JP7061123B2 (ja) * 2016-11-30 2022-04-27 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム サイズ設定された空洞を備えた吸入器
CA3038252A1 (en) * 2016-11-30 2018-06-07 Philip Morris Products S.A. Inhaler with swirl end plug
WO2018195086A1 (en) * 2017-04-17 2018-10-25 Respira Therapeutics, Inc. Powder dispersion devices and methods
CA3060702A1 (en) 2017-05-10 2018-11-15 Incarda Therapeutics, Inc. Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration
GB2577420B (en) 2017-05-22 2022-07-06 Insmed Inc Glycopeptide derivative compounds and uses thereof
US10786456B2 (en) 2017-09-22 2020-09-29 Otitopic Inc. Inhaled aspirin and magnesium to treat inflammation
CA3076353A1 (en) 2017-09-22 2019-03-28 Otitopic Inc. Dry powder compositions with magnesium stearate
EP3950029A1 (en) 2017-10-25 2022-02-09 Philip Morris Products S.A. Piercing accessory for inhaler article and system
WO2019082056A1 (en) 2017-10-25 2019-05-02 Philip Morris Products S.A. INHALER WITH DELIMITATION ELEMENT
US11571532B2 (en) 2017-11-21 2023-02-07 Impel Pharmaceuticals Inc. Intranasal device with dip tube
US11395887B2 (en) 2017-11-21 2022-07-26 Impel Pharmaceuticals Inc. Intranasal device with inlet interface
CN111465423B (zh) * 2017-12-28 2022-08-16 菲利普莫里斯生产公司 具有涡旋通道的吸入器
BR112020013744A8 (pt) 2018-01-05 2022-10-18 Impel Neuropharma Inc Dispensação intranasal de di-hidroergotamina por dispositivo olfativo de precisão
EP3735223A4 (en) 2018-01-05 2021-10-13 Impel Neuropharma Inc. INTRANASAL ADMINISTRATION OF OLANZAPINE BY A PRECISION OLFACTORY DEVICE
EP3517117A1 (en) 2018-01-30 2019-07-31 Medizinische Universität Wien Medicament for prevention or treatment of rhinovirus infection
US10744087B2 (en) 2018-03-22 2020-08-18 Incarda Therapeutics, Inc. Method to slow ventricular rate
KR102840146B1 (ko) * 2018-03-26 2025-08-01 필립모리스 프로덕츠 에스.에이. 천공형 다공성 지지 요소를 갖는 흡입기
WO2019204583A1 (en) 2018-04-18 2019-10-24 Pulmatrix Operating Company, Inc. Antifungal formulations for pulmonary administration comprising itraconazole
KR20210014629A (ko) 2018-04-18 2021-02-09 시플라 테크놀로지스 엘엘씨 진균 감염의 치료방법
JP2021532098A (ja) 2018-07-19 2021-11-25 インペル ニューロファーマ インコーポレイテッド パーキンソン病の治療のためのレボドパおよびドーパデカルボキシラーゼ阻害剤の呼吸管路送達
US20220023282A1 (en) 2018-12-13 2022-01-27 Mannkind Corporation Compositions of Bedaquiline, Combinations Comprising Them, Processes for Their Preparation, Uses and Methods of Treatment Comprising Them
CN113473967B (zh) 2019-01-03 2022-09-09 英倍尔制药公司 经鼻药物递送装置
MA55082A (fr) 2019-03-01 2022-01-05 Flagship Pioneering Innovations Vi Llc Compositions, procédés, et kits pour l'administration de polyribonucléotides
AU2020277313A1 (en) 2019-05-17 2022-01-20 Impel Pharmaceuticals Inc. Single-use nasal delivery device
WO2020239696A1 (en) 2019-05-24 2020-12-03 Stichting Katholieke Universiteit Improved administration of glycylcyclines by inhalation
EP3760203A1 (en) 2019-07-03 2021-01-06 Medizinische Universität Graz Medicament for prevention or treatment of a metabolic disorder
KR20250171439A (ko) 2019-08-01 2025-12-08 인카다 테라퓨틱스, 인크. 항부정맥 제제
US11007185B2 (en) 2019-08-01 2021-05-18 Incarda Therapeutics, Inc. Antiarrhythmic formulation
US12496414B2 (en) * 2019-10-25 2025-12-16 Philip Morris Products S.A. Holder for inhaler article
JP7733645B2 (ja) * 2019-10-25 2025-09-03 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム 接線方向気流端要素を有する吸入器物品
US12370330B2 (en) 2019-11-08 2025-07-29 Philip Morris Products S.A. Double activation prevention
CN115362003B (zh) 2019-12-24 2024-03-22 卡尔那生物科学株式会社 二酰基甘油激酶调节化合物
TWI794742B (zh) 2020-02-18 2023-03-01 美商基利科學股份有限公司 抗病毒化合物
KR20250133471A (ko) 2020-02-18 2025-09-05 길리애드 사이언시즈, 인코포레이티드 항바이러스 화합물
TWI791193B (zh) 2020-02-18 2023-02-01 美商基利科學股份有限公司 抗病毒化合物
TWI775313B (zh) 2020-02-18 2022-08-21 美商基利科學股份有限公司 抗病毒化合物
JP7564888B2 (ja) 2020-05-01 2024-10-09 ギリアード サイエンシーズ， インコーポレイテッド Ｃｄ７３阻害性２，４－ジオキソピリミジン化合物
IL294894A (en) 2020-05-08 2022-09-01 Apeptico Forschung & Entwicklung Gmbh A peptide for the prevention or treatment of covid-19
TW202228792A (zh) 2020-10-09 2022-08-01 殷漢生技股份有限公司 吸入用奈米載體製劑
EP4259248B1 (en) * 2020-12-11 2024-08-28 Philip Morris Products S.A. Inhaler system with offset piercing
WO2022133317A1 (en) 2020-12-17 2022-06-23 Incarda Therapeutics, Inc. Kits and methods for induction of cardioversion in subjects with atrial arrhythmias
WO2022187222A1 (en) 2021-03-03 2022-09-09 Pulmatrix Operating Company, Inc. Dihydroergotamine dry power formulations and methods of use
WO2022189662A1 (en) 2021-03-12 2022-09-15 Alvarius Pharmaceuticals Ltd. Compositions and methods for treating addictions comprising 5-meo-dmt
JP7651018B2 (ja) 2021-06-23 2025-03-25 ギリアード サイエンシーズ， インコーポレイテッド ジアシルグリセロールキナーゼ調節化合物
MX2023014762A (es) 2021-06-23 2024-01-15 Gilead Sciences Inc Compuestos moduladores de diacilglicerol quinasa.
CN117355531A (zh) 2021-06-23 2024-01-05 吉利德科学公司 二酰基甘油激酶调节化合物
EP4359413A1 (en) 2021-06-23 2024-05-01 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
PE20241186A1 (es) 2021-10-29 2024-06-03 Gilead Sciences Inc Compuestos de cd73
US20250049717A1 (en) 2021-12-20 2025-02-13 Pulmatrix Operating Company, Inc. Dry powder formulations of narrow spectrum kinase inhibitors
EP4511000A1 (en) 2022-04-22 2025-02-26 Quench Medical Inc. Dry powder inhalation delivery of pharmaceuticals
WO2024040175A1 (en) 2022-08-18 2024-02-22 Pulmatrix Operating Company, Inc. Methods for treating cancer using inhaled angiogenesis inhibitor
EP4582080A1 (en) 2024-01-02 2025-07-09 G.ST Antivirals GmbH Dispenser for mucosal administration comprising 2-deoxy-glucose or analogues thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4069819A (en) * 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device

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IT8919539A0 (it) 1989-02-23
EP0388621A1 (en) 1990-09-26
DE69000249D1 (de) 1992-09-17
DE69000249T2 (de) 1993-03-11
ATE79284T1 (de) 1992-08-15
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US4995385A (en) 1991-02-26
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