ATE79368T1 - Herstellung von 5-acylamino-2,4,6-trijodo- oder tribromo-benzoesaeure-derivate. - Google Patents
Herstellung von 5-acylamino-2,4,6-trijodo- oder tribromo-benzoesaeure-derivate.Info
- Publication number
- ATE79368T1 ATE79368T1 AT88904526T AT88904526T ATE79368T1 AT E79368 T1 ATE79368 T1 AT E79368T1 AT 88904526 T AT88904526 T AT 88904526T AT 88904526 T AT88904526 T AT 88904526T AT E79368 T1 ATE79368 T1 AT E79368T1
- Authority
- AT
- Austria
- Prior art keywords
- tribromo
- pct
- triiodo
- acylamino
- preparation
- Prior art date
Links
- JWHSTVSAXLKNAZ-UHFFFAOYSA-N 2,3,4-tribromobenzoic acid Chemical class OC(=O)C1=CC=C(Br)C(Br)=C1Br JWHSTVSAXLKNAZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000005113 hydroxyalkoxy group Chemical group 0.000 abstract 1
- 125000005191 hydroxyalkylamino group Chemical group 0.000 abstract 1
- 230000008707 rearrangement Effects 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT20647/87A IT1205029B (it) | 1987-05-22 | 1987-05-22 | Processo per la preparazione di derivati dell'acido 5-acilamino-2,4,6-triiodo o tribromo-benzoico e corrispondenti nuovi derivati dell'acido 5-acilamino-2,4,6-triioco o tribromo-benzzoico,ottenuti con tale processo |
| IT8847935A IT1219934B (it) | 1988-05-05 | 1988-05-05 | Processo per la preparazione di derivati dell' acido 5-acilamino-2,4,6-triiodo o tribromo-brenzoico e corrispondenti derivati dell' acido 5-acilamino-2,4,6-triiodo o tribromo-benzoico,ottenuti con tale processo |
| PCT/EP1988/000453 WO1988009328A1 (en) | 1987-05-22 | 1988-05-20 | Preparation of 5-acylamino-2,4,6-triiodo- or tribromo-benzoic acid derivatives |
| EP88904526A EP0365541B1 (de) | 1987-05-22 | 1988-05-20 | Herstellung von 5-acylamino-2,4,6-trijodo- oder tribromo-benzoesäure-derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE79368T1 true ATE79368T1 (de) | 1992-08-15 |
Family
ID=26327605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88904526T ATE79368T1 (de) | 1987-05-22 | 1988-05-20 | Herstellung von 5-acylamino-2,4,6-trijodo- oder tribromo-benzoesaeure-derivate. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5066823A (de) |
| EP (1) | EP0365541B1 (de) |
| JP (1) | JP2585087B2 (de) |
| KR (1) | KR960016747B1 (de) |
| AT (1) | ATE79368T1 (de) |
| AU (1) | AU618535B2 (de) |
| CA (1) | CA1327600C (de) |
| DE (1) | DE3873766T2 (de) |
| ES (1) | ES2006951A6 (de) |
| IE (1) | IE63232B1 (de) |
| IL (1) | IL86450A (de) |
| NZ (1) | NZ224743A (de) |
| WO (1) | WO1988009328A1 (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8717625D0 (en) * | 1987-07-24 | 1987-09-03 | Nycomed As | Chemical compounds |
| EP0410974A4 (en) * | 1988-03-01 | 1991-09-11 | Mallinckrodt, Inc. | Nonionic x-ray contrast agents, compositions and methods |
| DE68922850T2 (de) * | 1988-04-06 | 1995-12-21 | Mallinckrodt Inc | Verfahren zur herstellung von 2,4,6-triiodo-5-amino-n-alkyl-isophthalsäure. |
| FR2643077B1 (fr) * | 1989-01-23 | 1991-10-31 | Guerbet Sa | Nouveaux composes non ioniques iodes et produits de contraste les contenant |
| IL90326A (en) * | 1988-06-02 | 1993-05-13 | Guerbet Sa | Non-ionic triiodobenzene compounds and contrast media containing them |
| US5614638A (en) * | 1989-11-29 | 1997-03-25 | Bracco International B.V. | Nonionic radiographic contrast agents |
| US5191120A (en) * | 1989-12-13 | 1993-03-02 | Mallinckrodt Medical, Inc. | Process for preparing nonionic X-ray contrast agents |
| US5075502A (en) * | 1989-12-13 | 1991-12-24 | Mallinckrodt, Inc. | Nonionic x-ray contrast agents, compositions and methods |
| US5019371A (en) * | 1990-11-21 | 1991-05-28 | Mallinckrodt Medical, Inc. | Novel x-ray contrast agents, compositions and methods |
| US5356613A (en) * | 1991-03-18 | 1994-10-18 | Mallinckrodt Medical, Inc. | X-ray contrast agents, compositions and methods |
| DE4109169A1 (de) * | 1991-03-20 | 1992-09-24 | Koehler Chemie Dr Franz | Wasserloesliche nicht ionische roentgenkontrastmittel sowie mittel und verfahren zu ihrer herstellung |
| IL110391A (en) * | 1993-07-30 | 1998-12-06 | Zambon Spa | Process for the crystallization of iopamidol |
| IT1274027B (it) * | 1994-03-03 | 1997-07-14 | Zambon Spa | Processo per la preparazione e purificazione di mezzi di contrasto iodurati |
| GB9419203D0 (en) * | 1994-09-23 | 1994-11-09 | Nycomed Innovation Ab | Contrast media |
| GB9419206D0 (en) * | 1994-09-23 | 1994-11-09 | Nycomed Innovation Ab | Contrast media |
| IT1271134B (it) * | 1994-12-01 | 1997-05-26 | Bracco Spa | Derivati iodurati del bifenile e loro impiego diagnostico |
| EP0842141A1 (de) * | 1995-07-04 | 1998-05-20 | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY | Verfahren zur herstellung von iopamidol unter mitverwendung von c1-c5 monoalkylether vom c2-c10 alkylenglycol |
| IT1277339B1 (it) * | 1995-07-25 | 1997-11-10 | Bracco Spa | Processo per la produzione di agenti contrastografici iodurati |
| IT1303797B1 (it) * | 1998-11-27 | 2001-02-23 | Bracco Spa | Processo per la preparazione di n,n'-bis(2,3-diidrossipropil)-5-((idrossiacetil)metilammino)-2,4,6-triiodo-1,3-benzendicarbossammide. |
| EP1186305A1 (de) * | 2000-09-07 | 2002-03-13 | Schering Aktiengesellschaft | Neue bromierte Verbindungen als Kontrastmedien für Röntgenmammography |
| AU2001296008A1 (en) * | 2000-10-27 | 2002-05-06 | Takeda Chemical Industries Ltd. | Process for preparing substituted aromatic compounds and intermediates therefor |
| HRP20140649T1 (hr) | 2007-07-12 | 2014-09-26 | Ge Healthcare As, Intellectual Property Dept. | Kontrastna sredstva |
| EP2093206A1 (de) | 2008-02-20 | 2009-08-26 | BRACCO IMAGING S.p.A. | Verfahren zur Iodierung aromatischer Verbindungen |
| EP2243767A1 (de) | 2009-04-21 | 2010-10-27 | Bracco Imaging S.p.A | Verfahren zur Iodierung aromatischer Verbindungen |
| PT2451994E (pt) | 2009-07-07 | 2014-01-07 | Bracco Imaging Spa | Processo para a preparação de um agente de iodação |
| EP2394984A1 (de) | 2010-06-10 | 2011-12-14 | Bracco Imaging S.p.A | Verfahren zur Iodinierung von Phenol-Derivaten |
| CN107253918A (zh) * | 2017-07-27 | 2017-10-17 | 成都丽璟科技有限公司 | 一种制备碘美普尔的新方法 |
| KR102128423B1 (ko) | 2018-09-17 | 2020-07-01 | (주)유케이케미팜 | 조영제 이오메프롤의 제조방법 |
| KR20250006017A (ko) | 2022-04-29 | 2025-01-10 | 브라코 이미징 에스.피.에이. | 2,4,6-트라이요오도페놀 유도체의 제조 방법 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR7020080D0 (pt) * | 1969-06-27 | 1973-03-13 | Nyegaard & Co As | Processo para a preparacao de agentes de contraste para raio x |
| US3660464A (en) * | 1970-06-19 | 1972-05-02 | Squibb & Sons Inc | Tri-iodinated diaminobenzoic acid derivatives |
| BE787669A (fr) * | 1971-08-17 | 1973-02-19 | Schering Ag | Anilides d'acide n-methyl-dicarboxylique triiodes, et leur procede de preparation |
| DD104193A5 (de) * | 1972-12-22 | 1974-03-05 | ||
| CH583562A5 (de) * | 1973-07-17 | 1977-01-14 | Bracco Ind Chimica Spa | |
| US4065553A (en) * | 1974-05-31 | 1977-12-27 | Laboratoires Andre Guerbet | X-Ray contrast media |
| CH608189A5 (de) * | 1974-12-13 | 1978-12-29 | Savac Ag | |
| US4321368A (en) * | 1975-10-20 | 1982-03-23 | Mallinckrodt, Inc. | Glycosyl triidobenzoic acid derivatives |
| DE2629228C2 (de) * | 1976-06-25 | 1984-10-18 | Schering AG, 1000 Berlin und 4709 Bergkamen | Jodierte Isophthalamsäure-Derivate Verfahren zu deren Herstellung sowie deren Verwendung |
| US4191775A (en) * | 1977-12-15 | 1980-03-04 | Imperial Chemical Industries Limited | Amide derivatives |
| DE2852094A1 (de) * | 1978-11-30 | 1980-06-12 | Schering Ag | Neue roentgenkontrastmittel |
| IT1193211B (it) * | 1979-08-09 | 1988-06-15 | Bracco Ind Chimica Spa | Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono |
| IT1207226B (it) * | 1979-08-09 | 1989-05-17 | Bracco Ind Chimica Spa | Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono. |
| DE3150916A1 (de) * | 1981-12-18 | 1983-06-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel" |
| US4396598A (en) * | 1982-01-11 | 1983-08-02 | Mallinckrodt, Inc. | Triiodoisophthalamide X-ray contrast agent |
| FR2541272A1 (fr) * | 1983-02-23 | 1984-08-24 | Guerbet Sa | Composes bromes et produits opacifiants en contenant |
| DE3429949A1 (de) * | 1984-08-10 | 1986-02-20 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue nicht -ionische 2,4,6-trijod-isophthalsaeure-bis-amide, verfahren zu ihrer herstellung und ihre verwendung als roentgenkontrastmittel |
| US4567034A (en) * | 1984-09-07 | 1986-01-28 | E. R. Squibb & Sons, Inc. | Esters of diatrizoic acid as X-ray contrast agents |
-
1988
- 1988-05-20 JP JP63504455A patent/JP2585087B2/ja not_active Expired - Lifetime
- 1988-05-20 NZ NZ224743A patent/NZ224743A/en unknown
- 1988-05-20 EP EP88904526A patent/EP0365541B1/de not_active Expired - Lifetime
- 1988-05-20 KR KR1019890700112A patent/KR960016747B1/ko not_active Expired - Lifetime
- 1988-05-20 ES ES8801607A patent/ES2006951A6/es not_active Expired
- 1988-05-20 DE DE8888904526T patent/DE3873766T2/de not_active Expired - Lifetime
- 1988-05-20 AU AU17978/88A patent/AU618535B2/en not_active Expired
- 1988-05-20 CA CA000567436A patent/CA1327600C/en not_active Expired - Lifetime
- 1988-05-20 WO PCT/EP1988/000453 patent/WO1988009328A1/en not_active Ceased
- 1988-05-20 AT AT88904526T patent/ATE79368T1/de not_active IP Right Cessation
- 1988-05-20 IL IL8645088A patent/IL86450A/en not_active IP Right Cessation
- 1988-05-20 US US07/424,216 patent/US5066823A/en not_active Expired - Lifetime
- 1988-05-20 IE IE151888A patent/IE63232B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL86450A (en) | 1994-05-30 |
| WO1988009328A1 (en) | 1988-12-01 |
| IE63232B1 (en) | 1995-04-05 |
| EP0365541A1 (de) | 1990-05-02 |
| DE3873766D1 (de) | 1992-09-17 |
| JPH02503556A (ja) | 1990-10-25 |
| ES2006951A6 (es) | 1989-05-16 |
| KR890701547A (ko) | 1989-12-20 |
| NZ224743A (en) | 1991-07-26 |
| CA1327600C (en) | 1994-03-08 |
| AU1797888A (en) | 1988-12-21 |
| JP2585087B2 (ja) | 1997-02-26 |
| DE3873766T2 (de) | 1993-02-11 |
| IL86450A0 (en) | 1988-11-15 |
| AU618535B2 (en) | 1992-01-02 |
| US5066823A (en) | 1991-11-19 |
| EP0365541B1 (de) | 1992-08-12 |
| IE881518L (en) | 1988-11-22 |
| KR960016747B1 (ko) | 1996-12-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EEIH | Change in the person of patent owner | ||
| EELA | Cancelled due to lapse of time |