ATE80949T1 - Ziel- und hintergrundfangmethoden sowie vorrichtung fuer affinitaetsuntersuchungen. - Google Patents

Ziel- und hintergrundfangmethoden sowie vorrichtung fuer affinitaetsuntersuchungen.

Info

Publication number
ATE80949T1
ATE80949T1 AT87309308T AT87309308T ATE80949T1 AT E80949 T1 ATE80949 T1 AT E80949T1 AT 87309308 T AT87309308 T AT 87309308T AT 87309308 T AT87309308 T AT 87309308T AT E80949 T1 ATE80949 T1 AT E80949T1
Authority
AT
Austria
Prior art keywords
target
sample
capture methods
affinity studies
background capture
Prior art date
Application number
AT87309308T
Other languages
English (en)
Inventor
Mark Leo Collins
Original Assignee
Amoco Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amoco Corp filed Critical Amoco Corp
Application granted granted Critical
Publication of ATE80949T1 publication Critical patent/ATE80949T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/005—Pretreatment specially adapted for magnetic separation
    • B03C1/01—Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/025—High gradient magnetic separators
    • B03C1/031—Component parts; Auxiliary operations
    • B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/0335—Component parts; Auxiliary operations characterised by the magnetic circuit using coils
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/28—Magnetic plugs and dipsticks
    • B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/30—Combinations with other devices, not otherwise provided for
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Silicon Compounds (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Sampling And Sample Adjustment (AREA)
AT87309308T 1986-10-23 1987-10-21 Ziel- und hintergrundfangmethoden sowie vorrichtung fuer affinitaetsuntersuchungen. ATE80949T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92215586A 1986-10-23 1986-10-23
EP87309308A EP0265244B1 (de) 1986-10-23 1987-10-21 Ziel- und Hintergrundfangmethoden sowie Vorrichtung für Affinitätsuntersuchungen

Publications (1)

Publication Number Publication Date
ATE80949T1 true ATE80949T1 (de) 1992-10-15

Family

ID=25446589

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87309308T ATE80949T1 (de) 1986-10-23 1987-10-21 Ziel- und hintergrundfangmethoden sowie vorrichtung fuer affinitaetsuntersuchungen.

Country Status (9)

Country Link
US (1) US5780224A (de)
EP (1) EP0265244B1 (de)
JP (1) JP2975603B2 (de)
CN (1) CN1016645B (de)
AT (1) ATE80949T1 (de)
AU (1) AU621812B2 (de)
CA (1) CA1309329C (de)
DE (1) DE3781860T2 (de)
ZA (1) ZA877772B (de)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4882269A (en) * 1985-12-13 1989-11-21 Princeton University Amplified hybridization assay
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
EP0365595A4 (de) * 1987-06-26 1990-06-05 Du Pont Abtrennung kontaminierter sequenzen von rekombinanter geklonter dns unter verwendung von affinitätspartikeln.
AU2735988A (en) * 1987-12-21 1989-07-13 Amoco Corporation Target and background capture methods with amplification for affinity assays
NO165894C (no) * 1988-05-24 1991-04-24 Gunnar Paulsen Analysemetode for gener.
US5817797A (en) * 1988-06-01 1998-10-06 The United States Of America As Represented By The Department Of Health And Human Services Sequencing DNA; a modification of the polymerase chain reaction
US5512439A (en) * 1988-11-21 1996-04-30 Dynal As Oligonucleotide-linked magnetic particles and uses thereof
ATE122721T1 (de) * 1988-11-21 1995-06-15 Dynal As Verfahren zur herstellung von cdns.
EP0446260B1 (de) * 1988-11-21 1994-03-02 Dynal A.S. Sonden aus nukleinsäuren
US5759820A (en) * 1988-11-21 1998-06-02 Dynal As Process for producing cDNA
GB8827167D0 (en) * 1988-11-21 1988-12-29 Apothekernes Lab In vitro mutagenesis
GB8827160D0 (en) * 1988-11-21 1988-12-29 Apothekernes Lab Detection & quantitative determination of rna & dna
DE3840462A1 (de) * 1988-12-01 1990-06-07 Berthold Lab Prof R Verfahren und vorrichtung zur messung der chemilumineszenz
WO1990008840A1 (en) * 1989-02-03 1990-08-09 Eastman Kodak Company Nucleic acid test article and its use to detect a predetermined nucleic acid
US5856092A (en) * 1989-02-13 1999-01-05 Geneco Pty Ltd Detection of a nucleic acid sequence or a change therein
WO1990010717A1 (en) * 1989-03-10 1990-09-20 Gene-Trak Systems Preventing interference with affinity capture schemes
ATE118824T1 (de) 1989-03-10 1995-03-15 Amoco Corp Immobilisierte oligonukleotidsonden und ihre verwendungen.
CA2011818A1 (en) * 1989-03-17 1990-09-17 Fred T. Oakes Methods for purification, amplification and detection of a nucleic acid
US5580970A (en) * 1989-12-01 1996-12-03 Amoco Corporation Detection of HPV transcripts
ATE152777T1 (de) * 1989-12-04 1997-05-15 Microprobe Corp Verstärkter einfang von ziel-nukleinsäuren mittels verwendung von oligonukleotiden, die kovalent an polymere gebunden sind
EP0529070A1 (de) * 1991-02-27 1993-03-03 Amoco Corporation Verfahren zur verbesserung der empfindlichkeit von hybridisierungsassays
US5556748A (en) * 1991-07-30 1996-09-17 Xenopore Corporation Methods of sandwich hybridization for the quantitative analysis of oligonucleotides
US5437976A (en) * 1991-08-08 1995-08-01 Arizona Board Of Regents, The University Of Arizona Multi-domain DNA ligands bound to a solid matrix for protein and nucleic acid affinity chromatography and processing of solid-phase DNA
JPH0560761A (ja) * 1991-08-30 1993-03-12 Imuno Baion:Kk 重合体の分析方法
US5468852A (en) * 1992-02-18 1995-11-21 Shimadzu Corporation Oligonucleotides for detecting bacteria
US5750335A (en) * 1992-04-24 1998-05-12 Massachusetts Institute Of Technology Screening for genetic variation
US5312730A (en) * 1992-05-27 1994-05-17 Ciba Corning Diagnostics Corp. Immune complex transfer with lypophilic bridge
DE69432897T2 (de) * 1993-05-10 2004-05-27 Nissui Pharmaceutical Co., Ltd. Verfahren zur bestimmung von mehr als einem immunologischen liganden und bestimmungsreagenz sowie satz dafuer
EP0649910A1 (de) * 1993-10-22 1995-04-26 Sumitomo Electric Industries, Limited DNA-Probe zur Detektion allergischer Krankheiten, Detektionsprozess für allergische Krankheiten hervorrüfendes Gen mittels einer solchen Probe
DE4421058A1 (de) 1994-06-16 1995-12-21 Boehringer Mannheim Gmbh Verfahren zur magnetischen Abtrennung von Flüssigkeitskomponenten
US5837144A (en) * 1994-06-16 1998-11-17 Boehringer Mannheim Gmbh Method of magnetically separating liquid components
DE4434093A1 (de) * 1994-09-23 1996-03-28 Boehringer Mannheim Gmbh Verfahren zum qualitativen oder/und quantitativen Nachweis einer zu bestimmenden Substanz
US5604097A (en) * 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
DE19512368A1 (de) * 1995-04-01 1996-10-02 Boehringer Mannheim Gmbh System zur Freisetzung und Isolierung von Nukleinsäuren
US6919175B1 (en) 1995-04-01 2005-07-19 Roche Diagnostics Gmbh System for releasing and isolating nucleic acids
US5683875A (en) * 1995-05-04 1997-11-04 Hewlett-Packard Company Method for detecting a target nucleic acid analyte in a sample
US5853974A (en) 1995-06-07 1998-12-29 Chiron Corporation Enhancement of alkaline phosphatase with SDS in chemiluminescent substrates
EP0975807B1 (de) * 1997-05-02 2006-09-27 Gen-Probe Incorporated Zwei-schritt hybridisierung und einfang von einem polynukleotid
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
WO1999037819A2 (en) 1998-01-27 1999-07-29 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
US6686150B1 (en) 1998-01-27 2004-02-03 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
US20040203078A1 (en) * 1998-07-22 2004-10-14 National Institute Of Advanced Industrial Science And Technology Labeled complex, process for producing same and process for utilizing same
US5973138A (en) 1998-10-30 1999-10-26 Becton Dickinson And Company Method for purification and manipulation of nucleic acids using paramagnetic particles
US20030032029A1 (en) * 1998-12-21 2003-02-13 Nanogen, Inc. Three dimensional apparatus and method for integrating sample preparation and multiplex assays
US6852493B2 (en) 1999-05-14 2005-02-08 Iris Biotechnologies, Inc. Magnetic field enhanced hybridization of target molecules to immobilized probes
WO2000073506A1 (en) * 1999-05-27 2000-12-07 Iris Biotechnologies, Inc. Method for increasing the hybridization rate of nucleic acids
AU779220B2 (en) 1999-07-26 2005-01-13 Clinical Micro Sensors, Inc. Sequence determination of nucleic acids using electronic detection
AU2001241939A1 (en) * 2000-02-28 2001-09-12 Maxygen, Inc. Single-stranded nucleic acid template-mediated recombination and nucleic acid fragment isolation
DE10211321A1 (de) * 2002-03-14 2003-09-25 Gnothis Holding Sa Ecublens Verwendung von Abfangsonden beim Nachweis von Nukleinsäuren
EP1498486A4 (de) * 2002-03-29 2005-08-03 Prec System Science Co Ltd Nukleinsäurebibliothek und proteinbibliothek
EP1506413B1 (de) 2002-05-17 2016-07-06 Becton Dickinson and Company Automatisches system zum isolieren, amplifizieren und nachweisen einer zielnukleinsäuresequenz
US7601491B2 (en) 2003-02-06 2009-10-13 Becton, Dickinson And Company Pretreatment method for extraction of nucleic acid from biological samples and kits therefor
WO2005113827A2 (en) * 2004-05-19 2005-12-01 THE UNITED STATES OF AMERICA AS REPRESENTED BY THESECRETARY OF THE ARMY, Walter REED ARMY INSTITUTE OF RESEARCH Construction of live attenuated shigella vaccine strains that express cfa/i antigens (cfab and cfae) and the b subunit of heat-labile enterotoxin (ltb) from enterotoxigenic e. coli
CA2572472C (en) 2004-07-01 2013-08-13 Gen-Probe Incorporated Methods and compositions to detect nucleic acids in a biological sample
JP2008507296A (ja) * 2004-07-26 2008-03-13 ナノスフェアー　インコーポレイテッド 混合培養物中でメチシリン耐性黄色ブドウ球菌とメチシリン感受性黄色ブドウ球菌とを区別する方法
US7964413B2 (en) 2005-03-10 2011-06-21 Gen-Probe Incorporated Method for continuous mode processing of multiple reaction receptacles in a real-time amplification assay
EP1930730B1 (de) 2005-03-10 2019-08-14 Gen-Probe Incorporated Systeme und Verfahren zur Durchführung von Tests zum Nachweis oder zur Quantifizierung von Analyten
US9051601B2 (en) * 2006-08-01 2015-06-09 Gen-Probe Incorporated Methods of nonspecific target capture of nucleic acids
WO2008045158A1 (en) * 2006-10-10 2008-04-17 Illumina, Inc. Compositions and methods for representational selection of nucleic acids fro complex mixtures using hybridization
DE102006058374A1 (de) * 2006-12-08 2008-07-03 Biosensor Gmbh Analyseverfahren und portables Analysegerät
GB0701253D0 (en) 2007-01-23 2007-02-28 Diagnostics For The Real World Nucleic acid amplification and testing
US10316352B2 (en) * 2008-05-13 2019-06-11 Gen-Probe Incorporated Methods of capturing a target nucleic acid for amplification and detection using an inactivatable target capture oligomer
CN102292457B (zh) * 2008-11-25 2014-04-09 简·探针公司 检测小rna的组合物和方法及其用途
US9011771B2 (en) * 2009-05-15 2015-04-21 Gen-Probe Incorporated Method and apparatus for effecting automated movement of a magnet in an instrument for performing a magnetic separation procedure
JP2010183910A (ja) * 2010-05-17 2010-08-26 Sekisui Medical Co Ltd 核酸固定用磁性粒子
CN104450680A (zh) 2011-05-12 2015-03-25 精密科学公司 核酸的分离
US8993341B2 (en) 2011-05-12 2015-03-31 Exact Sciences Corporation Removal of PCR inhibitors
US8808990B2 (en) 2011-05-12 2014-08-19 Exact Sciences Corporation Serial isolation of multiple DNA targets from stool
US9909181B2 (en) 2013-12-13 2018-03-06 Northwestern University Biomarkers for post-traumatic stress states
KR102323205B1 (ko) * 2014-08-22 2021-11-08 삼성전자주식회사 표적물질 분리장치 및 표적물질 분리방법
US10753938B2 (en) 2015-03-04 2020-08-25 The University Of Chicago Beta-catenin inhibitors in cancer immunotherapy
WO2018053174A1 (en) 2016-09-15 2018-03-22 Abbott Laboratories Devices and methods for sample analysis
WO2018186924A1 (en) 2017-01-17 2018-10-11 The University Of Chicago Dysfunctional antigen-specific cd8+ t cells in the tumor microenvironment
JP7232438B2 (ja) * 2018-04-27 2023-03-03 国立大学法人 東京大学 メチル含有基修飾核酸を精製、分離または濃縮する方法
CN112946253B (zh) * 2019-12-11 2022-11-08 广东菲鹏生物有限公司 用于免疫诊断试剂中固相载体的封闭阶段处理剂及应用和产品

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3970518A (en) * 1975-07-01 1976-07-20 General Electric Company Magnetic separation of biological particles
US4351824A (en) * 1981-02-05 1982-09-28 Icl Scientific Polystyrene latex reagents, methods of preparation, and use in immunological procedures
US4554088A (en) * 1983-05-12 1985-11-19 Advanced Magnetics Inc. Magnetic particles for use in separations
US4672040A (en) * 1983-05-12 1987-06-09 Advanced Magnetics, Inc. Magnetic particles for use in separations
NO843838L (no) * 1983-09-26 1985-03-27 Ortho Diagnostic Systems Inc Fremgangsmaate for detektering av nukleinsyre
CA1260372A (en) * 1984-04-27 1989-09-26 Elazar Rabbani Hybridization method for the detection of genetic materials
GB8507706D0 (en) * 1985-03-25 1985-05-01 Genetics Int Inc Magnetic nucleic acid sequences
US4824776A (en) * 1985-07-25 1989-04-25 Molecular Biosystems, Inc. Method for increasing the sensitivity of nucleic acid hybridization assays
US4752566A (en) * 1985-12-17 1988-06-21 Genetics Institute, Inc. Displacement polynucleotide method and reagent complex employing labeled probe polynucleotide
CA1304006C (en) * 1985-12-20 1992-06-23 Edwin F. Ullman Particle separation method
ATE88761T1 (de) * 1986-01-10 1993-05-15 Amoco Corp Kompetitiver homogener test.

Also Published As

Publication number Publication date
DE3781860T2 (de) 1993-05-06
AU621812B2 (en) 1992-03-26
CN87107800A (zh) 1988-07-13
EP0265244A3 (en) 1989-05-10
EP0265244A2 (de) 1988-04-27
JPS63188399A (ja) 1988-08-03
CA1309329C (en) 1992-10-27
CN1016645B (zh) 1992-05-13
JP2975603B2 (ja) 1999-11-10
EP0265244B1 (de) 1992-09-23
DE3781860D1 (de) 1992-10-29
US5780224A (en) 1998-07-14
AU8009787A (en) 1988-04-28
ZA877772B (en) 1988-04-20

Similar Documents

Publication Publication Date Title
ATE80949T1 (de) Ziel- und hintergrundfangmethoden sowie vorrichtung fuer affinitaetsuntersuchungen.
AU3090889A (en) Method for determination of a polyvalent substance using an immunoaggregate
ATE177206T1 (de) Vorrichtung zur chromatographischen bestimmung, die einander entgegenstellbare teile enthalten
NO891929D0 (no) Nye komposisjoner med loeselige signalmolekyler for in vitro overvaaking av diabetes mellitus.
AU3156489A (en) Solid-phase analytical device and method for using same
DE3851967D1 (de) Verfahren zur Bestimmung von Antikörpern.
ES2075196T3 (es) Metodo para el uso y la sintesis de peptidos.
CA2254108A1 (en) Improvements in or relating to specific binding assays
CA2033168A1 (en) Method of Optical Analysis
FI915150A7 (fi) Menetelmät, reagenssit ja testikäyttöpakkaukset biologisten yksiköiden alapopulaatioiden määrittämiseksi
DE69528375D1 (de) Chemilumineszente dialkylsubstituierte 1,2-dioxetanverbindungen, synthesemethode und anwendung
DE69530315D1 (de) Rückgewinnung und verwendungen von spezifischen bindungsreagenzen
SE8406219L (sv) Sett och anordning for utforande av biokemiska analyser
DK314987D0 (da) Fremgangsmaade til specifik bestemmelse af serumfructosaminindhold samt hertil egnet reagensblanding
AU2856484A (en) Wipe-off test device
DE69108554D1 (de) Analyse der varianten von analyten.
NO874937L (no) Stabil immobilisert haptenreagens for anvendelse i hetrogene, immunometriske analyser.
DE3785567D1 (de) Immunologischer testkit.
KR890006828A (ko) 효소 분석법
ATE80948T1 (de) Diagnostisches immuntest-verfahren mittels festphasenabscheidung.
PT81050B (pt) Anticorpo monoclonal anti-urocinase e processo para a preparacao de composicoes de materia de teste biologicos que o utilizam
DK272288D0 (da) Fremgangsmaade til oprensning af proteiner
Altria Analytical Division Diary

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties