ATE81119T1 - 2-(acylthio)methyl-dihydropyridine, ein verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. - Google Patents

2-(acylthio)methyl-dihydropyridine, ein verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.

Info

Publication number: ATE81119T1
Authority: AT; Austria
Prior art keywords: dihydropyridine; acylthio; methyl; preparation; pharmaceutical compositions
Prior art date: 1986-07-29

Application number

AT87110821T

Other languages

English (en)

Inventor

Marco Frigerio

Carlo Riva

Andrea Zaliani

Carmelo A Gandolfi

Odoardo Tofanetti

Sergio Tognella

Original Assignee

Boehringer Mannheim Italia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-07-29

Filing date

1987-07-25

Publication date

1992-10-15

1987-07-25 Application filed by Boehringer Mannheim Italia filed Critical Boehringer Mannheim Italia

1992-10-15 Application granted granted Critical

1992-10-15 Publication of ATE81119T1 publication Critical patent/ATE81119T1/de

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
239000001301 oxygen Substances 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
AJGKBIRMMVYXPG-UHFFFAOYSA-N 1,4-dihydropyridin-2-ylmethanethiol Chemical compound SCC1=CCC=CN1 AJGKBIRMMVYXPG-UHFFFAOYSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
150000002829 nitrogen Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)

AT87110821T 1986-07-29 1987-07-25 2-(acylthio)methyl-dihydropyridine, ein verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. ATE81119T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT21290/86A IT1197012B (it)	1986-07-29	1986-07-29	2-(aciltio) metil diidropiridine, un processo per la loro preparazione e composizioni farmaceutiche che le contengono
EP87110821A EP0255075B1 (de)	1986-07-29	1987-07-25	2-(Acylthio)methyl-dihydropyridine, ein Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen

Publications (1)

Publication Number	Publication Date
ATE81119T1 true ATE81119T1 (de)	1992-10-15

Family

ID=11179618

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87110821T ATE81119T1 (de)	1986-07-29	1987-07-25	2-(acylthio)methyl-dihydropyridine, ein verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.

Country Status (6)

Country	Link
US (1)	US4935433A (de)
EP (1)	EP0255075B1 (de)
JP (1)	JPS6366169A (de)
AT (1)	ATE81119T1 (de)
DE (1)	DE3781973D1 (de)
IT (1)	IT1197012B (de)

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4284634A (en) *	1975-07-02	1981-08-18	Fujisawa Pharmaceutical Co., Ltd.	1,4-Dihydropyridine derivatives, and pharmaceutical method of the same
DE2658183A1 (de) *	1976-12-22	1978-07-06	Bayer Ag	In 2-position substituierte 1,4- dihydropyridin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
JPS57175166A (en) *	1981-04-23	1982-10-28	Banyu Pharmaceut Co Ltd	Carbamoyloxyalkyl-1,4-dihydropyridine derivative and its preparation
NZ201395A (en) *	1981-07-30	1987-02-20	Bayer Ag	Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
DE3207982A1 (de) *	1982-03-05	1983-09-08	Bayer Ag, 5090 Leverkusen	Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln
IL68604A0 (en) *	1982-05-21	1983-09-30	Haessle Ab	Processes for preparing therapeutically active dihydropyridines and intermediates for the processes
HU197881B (en) *	1982-08-06	1989-06-28	Banyu Pharma Co Ltd	Process for producing new carbamoyl-oxy-alkyl-carboxy-lic acid derivatives
EP0107293A3 (de) *	1982-09-04	1984-06-06	Pfizer Limited	Dihydropyridine
PH19166A (en) *	1982-09-04	1986-01-16	Pfizer	Dihydropyridined,pharmaceutical compositions and method of use
JPS59152373A (ja) *	1983-02-16	1984-08-31	Banyu Pharmaceut Co Ltd	１，４―ジヒドロピリジン誘導体
GB8306666D0 (en) *	1983-03-10	1983-04-13	Pfizer Ltd	Therapeutic agents
US4568677A (en) *	1983-07-23	1986-02-04	Pfizer Inc.	2-(4-Pyrimidone alkoxyalkyl) dihydropyridine anti-ischaemic and antihypertensive agents
GB8401288D0 (en) *	1984-01-18	1984-02-22	Pfizer Ltd	Therapeutic agents
DE3412947A1 (de) *	1984-04-06	1985-10-17	Bayer Ag, 5090 Leverkusen	Tetrahydothienopyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
CA1267416A (en) *	1985-06-17	1990-04-03	Ila Sircar	1,4-dihydropyridine derivatives useful for the treatment of cardiovascular disorders
WO1987000836A1 (en) *	1985-08-06	1987-02-12	Boehringer Biochemia Robin S.P.A.	Pharmaceutically active 2-thiomethyl-substituted-1,4-dihydropyridines

1986
- 1986-07-29 IT IT21290/86A patent/IT1197012B/it active
1987
- 1987-07-25 DE DE8787110821T patent/DE3781973D1/de not_active Expired - Lifetime
- 1987-07-25 EP EP87110821A patent/EP0255075B1/de not_active Expired - Lifetime
- 1987-07-25 AT AT87110821T patent/ATE81119T1/de not_active IP Right Cessation
- 1987-07-28 US US07/080,397 patent/US4935433A/en not_active Expired - Fee Related
- 1987-07-28 JP JP62189967A patent/JPS6366169A/ja active Pending

Also Published As

Publication number	Publication date
EP0255075A1 (de)	1988-02-03
IT1197012B (it)	1988-11-25
DE3781973D1 (de)	1992-11-05
JPS6366169A (ja)	1988-03-24
US4935433A (en)	1990-06-19
EP0255075B1 (de)	1992-09-30
IT8621290A1 (it)	1988-01-29

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Legal Events

Date	Code	Title	Description
1993-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties