ATE81467T1 - Immunosuppression bei der auf immunotoxin basierten behandlung von menschen. - Google Patents

Immunosuppression bei der auf immunotoxin basierten behandlung von menschen.

Info

Publication number: ATE81467T1
Authority: AT; Austria
Prior art keywords: immunotoxin; immunosuppression; humans; based treatment; cyclophosphamide
Prior art date: 1987-02-24

Application number

AT88902708T

Other languages

English (en)

Inventor

Ronald P Mischak

Patrick J Scannon

Lynn E Spitler

W Scott Harkonen

Langdon Miller

Original Assignee

Xoma Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-02-24

Filing date

1988-02-23

Publication date

1992-10-15

1988-02-23 Application filed by Xoma Corp filed Critical Xoma Corp

1992-10-15 Application granted granted Critical

1992-10-15 Publication of ATE81467T1 publication Critical patent/ATE81467T1/de

Links

230000001506 immunosuppresive effect Effects 0.000 title abstract 2
206010062016 Immunosuppression Diseases 0.000 title 1
230000002637 immunotoxin Effects 0.000 abstract 3
229940051026 immunotoxin Drugs 0.000 abstract 3
239000002596 immunotoxin Substances 0.000 abstract 3
231100000608 immunotoxin Toxicity 0.000 abstract 3
CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 abstract 2
229960004397 cyclophosphamide Drugs 0.000 abstract 2
GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 abstract 2
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 1
108010036949 Cyclosporine Proteins 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 abstract 1
229960002170 azathioprine Drugs 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
229960001265 ciclosporin Drugs 0.000 abstract 1
229930182912 cyclosporin Natural products 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000028993 immune response Effects 0.000 abstract 1
230000007774 longterm Effects 0.000 abstract 1
229960001428 mercaptopurine Drugs 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Microbiology (AREA)
Mycology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines Containing Plant Substances (AREA)
Pyrane Compounds (AREA)

AT88902708T 1987-02-24 1988-02-23 Immunosuppression bei der auf immunotoxin basierten behandlung von menschen. ATE81467T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US1832487A	1987-02-24	1987-02-24
EP88902708A EP0303681B1 (de)	1987-02-24	1988-02-23	Immunosuppression bei der auf immunotoxin basierten behandlung von menschen
PCT/US1988/000576 WO1988006451A1 (en)	1987-02-24	1988-02-23	Immunosuppression in immunotoxin based human therapy

Publications (1)

Publication Number	Publication Date
ATE81467T1 true ATE81467T1 (de)	1992-10-15

Family

ID=21787358

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88902708T ATE81467T1 (de)	1987-02-24	1988-02-23	Immunosuppression bei der auf immunotoxin basierten behandlung von menschen.

Country Status (7)

Country	Link
EP (1)	EP0303681B1 (de)
JP (1)	JPH01502909A (de)
KR (1)	KR890700353A (de)
AT (1)	ATE81467T1 (de)
AU (1)	AU619740B2 (de)
DE (1)	DE3875306T2 (de)
WO (1)	WO1988006451A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9200417D0 (en)	1992-01-09	1992-02-26	Bagshawe Kenneth D	Cytotoxic drug therapy
US6077680A (en) *	1996-11-27	2000-06-20	The University Of Florida	ShK toxin compositions and methods of use
US6593362B2 (en)	2001-05-21	2003-07-15	Guilford Pharmaceuticals Inc.	Non-peptidic cyclophilin binding compounds and their use
US7833979B2 (en)	2005-04-22	2010-11-16	Amgen Inc.	Toxin peptide therapeutic agents
GB0605395D0 (en) *	2006-03-16	2006-04-26	Norwegian Radium Hospital Res	Anti-cancer therapy
PE20081140A1 (es)	2006-10-25	2008-09-22	Amgen Inc	Agentes terapeuticos a base de peptidos derivados de toxinas
WO2008125903A2 (en) *	2006-12-12	2008-10-23	Chaim Sheba Medical Center	Method of inhibiting an undesired immune response
MX2009012609A (es)	2007-05-22	2009-12-07	Amgen Inc	Composiciones y metodos para producir proteinas de fusion bioactivas.
CN107320734A (zh)	2011-04-29	2017-11-07	西莱克塔生物科技公司	从合成纳米载体中控制释放免疫抑制剂
CN105307641A (zh)	2013-05-03	2016-02-03	西莱克塔生物科技公司	用于降低不期望体液免疫应答的给药组合
EA201790551A1 (ru)	2014-09-07	2017-07-31	Селекта Байосайенсиз, Инк.	Способы и композиции для ослабления иммунных ответов к пропускающему экзон вирусному трансферному вектору
EP4599848A3 (de)	2017-03-11	2025-12-03	Cartesian Therapeutics, Inc.	Verfahren und zusammensetzungen in zusammenhang mit einer kombinierten behandlung mit entzündungshemmenden mitteln und synthetischen nanoträgern mit einem immunsuppressivum
US12553041B2 (en)	2019-06-04	2026-02-17	Cartesian Therapeutics Inc.	Formulations and doses of pegylated uricase

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2573656B1 (fr) *	1984-11-29	1987-02-27	Sanofi Sa	Medicament comportant en tant qu'association au moins une immunotoxine et au moins un polymere contenant du mannose
FR2577135B1 (fr) *	1985-02-13	1989-12-15	Sanofi Sa	Immunotoxines a longue duree d'action comportant un constituant glycopeptidique inactivant les ribosomes modifie sur ses motifs polysaccharidiques
FR2584294B1 (fr) *	1985-07-08	1992-02-21	Berdal Pascal	Compositions pharmaceutiques a visee cytotrophique
ATE87318T1 (de) *	1985-11-29	1993-04-15	Consolidated Pharmaceuticals L	Ricin-antikoerper-konjugate.

1988
- 1988-02-23 WO PCT/US1988/000576 patent/WO1988006451A1/en not_active Ceased
- 1988-02-23 AT AT88902708T patent/ATE81467T1/de not_active IP Right Cessation
- 1988-02-23 EP EP88902708A patent/EP0303681B1/de not_active Expired - Lifetime
- 1988-02-23 AU AU14214/88A patent/AU619740B2/en not_active Ceased
- 1988-02-23 JP JP63502503A patent/JPH01502909A/ja active Pending
- 1988-02-23 DE DE8888902708T patent/DE3875306T2/de not_active Expired - Fee Related
- 1988-10-13 KR KR1019880701280A patent/KR890700353A/ko not_active Withdrawn

Also Published As

Publication number	Publication date
JPH01502909A (ja)	1989-10-05
EP0303681B1 (de)	1992-10-14
KR890700353A (ko)	1989-04-24
EP0303681A1 (de)	1989-02-22
AU619740B2 (en)	1992-02-06
DE3875306D1 (de)	1992-11-19
WO1988006451A1 (en)	1988-09-07
EP0303681A4 (de)	1989-12-28
DE3875306T2 (de)	1993-04-01
AU1421488A (en)	1988-09-26

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Legal Events

Date	Code	Title	Description
1993-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties