ATE83926T1 - Antivirale anwendung von alpha-oligonucleotiden. - Google Patents

Antivirale anwendung von alpha-oligonucleotiden.

Info

Publication number: ATE83926T1
Authority: AT; Austria
Prior art keywords: inhibit; activity; compounds; antiviral use; reverse transcriptase
Prior art date: 1987-10-14

Application number

AT88909539T

Other languages

English (en)

Inventor

Jean-Louis Imbach

Bernard Rayner

Clerq Erik De

Original Assignee

Centre Nat Rech Scient

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-14

Filing date

1988-10-13

Publication date

1993-01-15

1988-10-13 Application filed by Centre Nat Rech Scient filed Critical Centre Nat Rech Scient

1993-01-15 Application granted granted Critical

1993-01-15 Publication of ATE83926T1 publication Critical patent/ATE83926T1/de

Links

108091034117 Oligonucleotide Proteins 0.000 title 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
230000000840 anti-viral effect Effects 0.000 title 1
102100034343 Integrase Human genes 0.000 abstract 2
108010092799 RNA-directed DNA polymerase Proteins 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
208000030507 AIDS Diseases 0.000 abstract 1
241000713772 Human immunodeficiency virus 1 Species 0.000 abstract 1
238000011161 development Methods 0.000 abstract 1
230000018109 developmental process Effects 0.000 abstract 1
241001493065 dsRNA viruses Species 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Virology (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Organic Chemistry (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)

AT88909539T 1987-10-14 1988-10-13 Antivirale anwendung von alpha-oligonucleotiden. ATE83926T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR8714200A FR2621816B1 (fr)	1987-10-14	1987-10-14	Application antivirale des ologonucleotides
PCT/FR1988/000506 WO1989003217A1 (fr)	1987-10-14	1988-10-13	APPLICATION ANTIVIRALE DES OLIGONUCLEOTIDES alpha
EP88909539A EP0395672B1 (de)	1987-10-14	1988-10-13	Antivirale anwendung von alpha-oligonucleotiden

Publications (1)

Publication Number	Publication Date
ATE83926T1 true ATE83926T1 (de)	1993-01-15

Family

ID=9355825

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88909539T ATE83926T1 (de)	1987-10-14	1988-10-13	Antivirale anwendung von alpha-oligonucleotiden.

Country Status (6)

Country	Link
EP (1)	EP0395672B1 (de)
JP (1)	JPH03504004A (de)
AT (1)	ATE83926T1 (de)
DE (1)	DE3877212T2 (de)
FR (1)	FR2621816B1 (de)
WO (1)	WO1989003217A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2648045B1 (fr) *	1989-06-13	1991-09-27	Centre Nat Rech Scient	Composes oligonucleotidiques anomeres alpha inhibant la replication des retrovirus

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3125291A1 (de) *	1980-03-18	1983-01-27	Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen	Verwendung von 5-alkyl-pyrimidinnucleosiden als virostatika und arzneimittel mit virostatischer wirkung
FR2607507B1 (fr) *	1986-12-02	1990-04-13	Centre Nat Rech Scient	Nouveaux derives a-d-oligonucleotides, leur preparation et leur emploi

1987
- 1987-10-14 FR FR8714200A patent/FR2621816B1/fr not_active Expired - Lifetime
1988
- 1988-10-13 EP EP88909539A patent/EP0395672B1/de not_active Expired - Lifetime
- 1988-10-13 JP JP63508818A patent/JPH03504004A/ja active Pending
- 1988-10-13 WO PCT/FR1988/000506 patent/WO1989003217A1/fr not_active Ceased
- 1988-10-13 DE DE8888909539T patent/DE3877212T2/de not_active Expired - Fee Related
- 1988-10-13 AT AT88909539T patent/ATE83926T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
FR2621816B1 (fr)	1990-12-28
FR2621816A1 (fr)	1989-04-21
EP0395672B1 (de)	1992-12-30
WO1989003217A1 (fr)	1989-04-20
DE3877212T2 (de)	1993-05-19
DE3877212D1 (de)	1993-02-11
JPH03504004A (ja)	1991-09-05
EP0395672A1 (de)	1990-11-07

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Legal Events

Date	Code	Title	Description
1995-01-15	REN	Ceased due to non-payment of the annual fee