ATE84025T1 - N-acylpyrrolidin-derivate, verfahren zur herstellung, heilmittel, die sie enthalten und ihre anwendung. - Google Patents

N-acylpyrrolidin-derivate, verfahren zur herstellung, heilmittel, die sie enthalten und ihre anwendung.

Info

Publication number: ATE84025T1
Authority: AT; Austria
Prior art keywords: medications; manufacture; contain; compound; acylpyrrolidine derivatives
Prior art date: 1985-04-16

Application number

AT86105232T

Other languages

English (en)

Inventor

Takaharu Tanaka

Masayuki Saitoh

Masaki Hashimoto

Naoki Higuchi

Original Assignee

Suntory Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-04-16

Filing date

1986-04-16

Publication date

1993-01-15

1986-04-16 Application filed by Suntory Ltd filed Critical Suntory Ltd

1993-01-15 Application granted granted Critical

1993-01-15 Publication of ATE84025T1 publication Critical patent/ATE84025T1/de

Links

238000000034 method Methods 0.000 title abstract 2
229940079593 drug Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
102000056251 Prolyl Oligopeptidases Human genes 0.000 abstract 1
101710178372 Prolyl endopeptidase Proteins 0.000 abstract 1
229940122210 Prolyl endopeptidase inhibitor Drugs 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
230000003496 anti-amnesic effect Effects 0.000 abstract 1
ORZXYSPOAVJYRU-UHFFFAOYSA-N benzyl 2-(2-formylpyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate Chemical compound O=CC1CCCN1C(=O)C1N(C(=O)OCC=2C=CC=CC=2)CCC1 ORZXYSPOAVJYRU-UHFFFAOYSA-N 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
239000002475 cognitive enhancer Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000003649 prolyl endopeptidase inhibitor Substances 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

AT86105232T 1985-04-16 1986-04-16 N-acylpyrrolidin-derivate, verfahren zur herstellung, heilmittel, die sie enthalten und ihre anwendung. ATE84025T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP60080870A JPH0623190B2 (ja)	1985-04-16	1985-04-16	インヒビタ−活性を有するｎ−アシルピロリジン誘導体及びその製法並びに用途
EP86105232A EP0201742B1 (de)	1985-04-16	1986-04-16	N-Acylpyrrolidin-Derivate, Verfahren zur Herstellung, Heilmittel, die sie enthalten und ihre Anwendung

Publications (1)

Publication Number	Publication Date
ATE84025T1 true ATE84025T1 (de)	1993-01-15

Family

ID=13730376

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86105232T ATE84025T1 (de)	1985-04-16	1986-04-16	N-acylpyrrolidin-derivate, verfahren zur herstellung, heilmittel, die sie enthalten und ihre anwendung.

Country Status (6)

Country	Link
US (1)	US4701465A (de)
EP (1)	EP0201742B1 (de)
JP (1)	JPH0623190B2 (de)
AT (1)	ATE84025T1 (de)
CA (1)	CA1267149A (de)
DE (1)	DE3687365T2 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0651677B2 (ja) *	1985-12-23	1994-07-06	サントリー株式会社	ジペプチド誘導体及びその製法並びに用途
US5198458A (en) *	1986-02-04	1993-03-30	Suntory Limited	Pyrrolidineamide derivatives of acylamino acid and pharmaceutical composition containing the same
CA1320734C (en) *	1986-02-04	1993-07-27	Suntory Limited	Pyrrolidineamide derivative of acylamino acid and pharmaceutical composition containing the same
US4880827A (en) *	1986-03-18	1989-11-14	Sumitomo Pharmaceuticals Company, Ltd.	Pyrrolidine derivatives having inhibitory action for proline specific endopepidase
JPH08806B2 (ja) *	1986-11-18	1996-01-10	サントリー株式会社	プロリルエンドペプチダ−ゼ阻害作用を有する新規ピロリジンアミド誘導体
DE3786229T2 (de) *	1986-11-20	1993-10-07	Ono Pharmaceutical Co	Prolinalderivate.
US5254550A (en) *	1986-11-20	1993-10-19	Ono Pharmaceutical Co., Ltd.	Prolinal derivatives and pharmaceutical compositions thereof
DE3783754T2 (de) *	1986-12-29	1993-08-05	Ono Pharmaceutical Co	Prolin-derivate.
US5262431A (en) *	1986-12-29	1993-11-16	Ono Pharmaceutical Co., Ltd.	Prolinal derivatives and pharmaceutical compositions thereof
JPH089591B2 (ja) *	1986-12-29	1996-01-31	小野薬品工業株式会社	新規なプロリナール誘導体
EP0277588B1 (de) *	1987-02-04	1993-03-24	Ono Pharmaceutical Co., Ltd.	Prolinalderivate
DE3875361T2 (de) *	1987-02-23	1993-03-25	Ono Pharmaceutical Co	Thiazolidin-derivate.
DE3712365A1 (de) *	1987-04-11	1988-10-27	Hoechst Ag	Neue 2-acylpyrrolidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung
DE3712364A1 (de) *	1987-04-11	1988-10-27	Hoechst Ag	Neue pyrrolidin-2-(1,3-dicarbonyl)-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung
US5043348A (en) *	1987-04-24	1991-08-27	Cassella Aktiengesellschaft	Pyrrolealdehydes, their preparation and their use
JPH0774194B2 (ja) *	1987-06-11	1995-08-09	財団法人微生物化学研究会	生理活性を有する新規なアクチノニン誘導体
US5142065A (en) *	1988-08-20	1992-08-25	Bayer Aktiengesellschaft	3-aryl-pyrrolidine-2,4-diones
JP2691442B2 (ja) *	1989-02-20	1997-12-17	株式会社ヤクルト本社	新規なプロリン誘導体
EP0419683A4 (en) *	1989-04-13	1992-03-11	Japan Tobacco Inc.	New amino acid derivatives having prolylendopeptidase inhibitor activity
US4999349A (en) *	1990-03-22	1991-03-12	Bristol-Myers Squibb Co.	BU-4164E - A and B, prolyl endopeptidase inhibitors
US5073549A (en) *	1990-03-22	1991-12-17	Bristol-Myers Squibb Company	BU-4164E - A and B, prolyl endopeptidase inhibitors and their methods of use
DE4029054A1 (de) *	1990-09-13	1992-03-19	Bayer Ag	N-acylpyrrolidin-derivate
US5254696A (en) *	1990-09-13	1993-10-19	Bayer Aktiengesellschaft	N-acylpyrrolidine derivatives
FR2669029B1 (fr) *	1990-11-14	1994-09-02	Adir	Nouveaux derives de la n-benzoyl proline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2672598A1 (fr) *	1991-02-11	1992-08-14	Adir	Nouveaux inhibiteurs de n-myristoyltransferase, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
DE4301112A1 (de) *	1993-01-18	1994-07-21	Bayer Ag	N-substituierte alpha-Fluoralkyl-Lactame
WO2004098591A2 (en)	2003-05-05	2004-11-18	Probiodrug Ag	Inhibitors of glutaminyl cyclase and their use in the treatment of neurological diseases
AU2004290499C1 (en)	2003-11-03	2011-02-24	Probiodrug Ag	Combinations useful for the treatment of neuronal disorders
CA2554809C (en)	2004-02-05	2014-04-29	Probiodrug Ag	Novel n-alkyl thiourea- and thioamide-substituted imidazolyl inhibitors of glutaminyl cyclase
SG133452A1 (en) *	2005-12-30	2007-07-30	Novartis Ag	Peptide deformylase inhibitors for treatment of mycobacterial and other parasitic diseases
US8278345B2 (en)	2006-11-09	2012-10-02	Probiodrug Ag	Inhibitors of glutaminyl cyclase
ATE554085T1 (de)	2006-11-30	2012-05-15	Probiodrug Ag	Neue inhibitoren von glutaminylcyclase
JP5930573B2 (ja)	2007-03-01	2016-06-15	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤の新規使用
EP2142514B1 (de)	2007-04-18	2014-12-24	Probiodrug AG	Thioharnstoffderivate als glutaminylcyclaseinhibitoren
JP5934645B2 (ja)	2009-09-11	2016-06-15	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
JP6026284B2 (ja)	2010-03-03	2016-11-16	プロビオドルグエージー	グルタミニルシクラーゼの阻害剤
NZ602312A (en)	2010-03-10	2014-02-28	Probiodrug Ag	Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
WO2011131748A2 (en)	2010-04-21	2011-10-27	Probiodrug Ag	Novel inhibitors
EP2686313B1 (de)	2011-03-16	2016-02-03	Probiodrug AG	Benzimidazolderivate als glutaminylcyclase-hemmer
ES2812698T3 (es)	2017-09-29	2021-03-18	Probiodrug Ag	Inhibidores de glutaminil ciclasa

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4052511A (en) *	1976-02-13	1977-10-04	E. R. Squibb & Sons, Inc.	Carboxyacylproline derivatives
US4154937A (en) *	1977-02-11	1979-05-15	E. R. Squibb & Sons, Inc.	Hydroxycarbamoylalkylacylpipecolic acid compounds
US4226775A (en) *	1979-06-01	1980-10-07	American Cyanamid Company	Substituted thio-substituted benzyl-propionyl-L-prolines
NZ190995A (en) *	1978-09-05	1982-03-09	American Cyanamid Co	Substituted omega propionyl or butyryl l-prolines and pharmaceutical compositions
ZA802552B (en) *	1979-05-21	1981-04-29	Ici Ltd	1-phenyl-2-aminoethanol derivatives
US4374847A (en) *	1980-10-27	1983-02-22	Ciba-Geigy Corporation	1-Carboxyalkanoylindoline-2-carboxylic acids
US4479963A (en) *	1981-02-17	1984-10-30	Ciba-Geigy Corporation	1-Carboxyalkanoylindoline-2-carboxylic acids
US4439611A (en) *	1982-06-28	1984-03-27	American Cyanamid Company	Isolation of [S-(R, S]-1-(3-acetylthio-3-benzoyl-2-methylpropionyl)-L-proline from a diastereomeric mixture
JPS6137764A (ja) *	1984-07-31	1986-02-22	Suntory Ltd	抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物
JP3063122B2 (ja) *	1990-07-23	2000-07-12	セイコーエプソン株式会社	半導体装置およびその製造方法

1985
- 1985-04-16 JP JP60080870A patent/JPH0623190B2/ja not_active Expired - Lifetime
1986
- 1986-04-16 CA CA000506768A patent/CA1267149A/en not_active Expired - Lifetime
- 1986-04-16 DE DE8686105232T patent/DE3687365T2/de not_active Expired - Fee Related
- 1986-04-16 EP EP86105232A patent/EP0201742B1/de not_active Expired - Lifetime
- 1986-04-16 US US06/852,711 patent/US4701465A/en not_active Expired - Fee Related
- 1986-04-16 AT AT86105232T patent/ATE84025T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
JPS61238776A (ja)	1986-10-24
EP0201742A2 (de)	1986-11-20
JPH0623190B2 (ja)	1994-03-30
EP0201742B1 (de)	1992-12-30
US4701465A (en)	1987-10-20
CA1267149A (en)	1990-03-27
EP0201742A3 (en)	1988-12-14
DE3687365D1 (de)	1993-02-11
DE3687365T2 (de)	1993-05-19

Legal Events

Date	Code	Title	Description
1999-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE84025T1 (de)	1993-01-15	N-acylpyrrolidin-derivate, verfahren zur herstellung, heilmittel, die sie enthalten und ihre anwendung.
AU575668B2 (en)	1988-08-04	N - acylpyrrolidine compound
BR8600428A (pt)	1986-10-21	Compostos heterociclicos,processo para sua preparacao,composicoes inseticidas,processo para combate a insetos daninhos,utilizacao e processo para a preparacao de composicoes
DE69723869D1 (de)	2003-09-04	Heterozyklische verbindungen, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen die diese enthalten und ihre anwendung in der behandlung von diabetis und verwandten krankheiten
ES2168737T3 (es)	2002-06-16	Inhibidores de la oxido nitrico sintasa.
ATE151764T1 (de)	1997-05-15	Neue benzopyran-derivate, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltenden zubereitungen
ES2053609T3 (es)	1994-08-01	Derivados de urea inhibidores de lipoxigenasa.
EA199700186A1 (ru)	1998-02-26	Новые дипептидные амидины, используемые в качестве ингибиторов тромбина
EP0680328A1 (de)	1995-11-08	Topisches ketoconazoles arzneimittel.
CO4290432A1 (es)	1996-04-17	Nuevos derivados de pirazinacarboxamida, su preparacion y su utilizacion en medicamentos.
PT83961B (pt)	1989-05-12	Processo para a preparacao de derivados da pirazolina e de composicoes insecticidas e acaricidas que os contem
DE69007337D1 (de)	1994-04-21	Gaserzeugende Zusammensetzungen, die Salze der 5-Nitro-Barbitursäure oder Salze der Nitro-Orotsäure oder 5-Nitro-Uracil enthalten.
ATE218142T1 (de)	2002-06-15	Nitratester von corticoid verbindungen und die therapeutische verwendungen davon
DE3767839D1 (de)	1991-03-07	Pyrrolidinamid-derivate mit antipropylendopeptidase-wirkung, zusammenstellungen, die sie enthalten, verfahren zu ihrer herstellung und heilmittel, die sie enthalten.
AU6319480A (en)	1981-04-30	2-hydroxyalkyl-3,4,5-trihydroxypiperidines
ATE38836T1 (de)	1988-12-15	Substituierte benzopyrane, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln.
MX9700807A (es)	1997-05-31	Derivados de 3-azabiciclo (3.2.0)heptano n-sustituidos utiles como neurolepticos.
DE3784526D1 (de)	1993-04-08	Cembran-diterpene-verbindungen zur herstellung von zusammensetzungen, die inhibitoren der histamin-freisetzung enthalten.
ES548330A0 (es)	1986-11-16	Un metodo de preparacion de un compuesto de tiadiazina
ZA806786B (en)	1981-10-28	4-substituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase
ES2128313T3 (es)	1999-05-16	Naftalimidas n-substituidas, su obtencion y empleo.
PT1001942E (pt)	2003-11-28	Poli-hidroxibutilpirazinas sua preparacao e medicamentos que as contem
DE69620013D1 (de)	2002-04-25	Zusammensetzungen, die modifizierte polyalkadiene enthalten
IL77009A0 (en)	1986-04-29	Biphenylyloxy and biphenylylalkoxy aryl acyl urea derivatives,processes for the preparation thereof and pesticidal compositions containing the same
ATE26577T1 (de)	1987-05-15	1-0-alkyl-3-amino-propan-1.2-diol-2-0phospholipide, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die sie enthalten.