ATE84797T1 - Nona- und dekapeptidanaloga von lhrh, welche als lhrh-antagonisten dienen. - Google Patents

Nona- und dekapeptidanaloga von lhrh, welche als lhrh-antagonisten dienen.

Info

Publication number
ATE84797T1
ATE84797T1 AT85114386T AT85114386T ATE84797T1 AT E84797 T1 ATE84797 T1 AT E84797T1 AT 85114386 T AT85114386 T AT 85114386T AT 85114386 T AT85114386 T AT 85114386T AT E84797 T1 ATE84797 T1 AT E84797T1
Authority
AT
Austria
Prior art keywords
lhrh
nona
serve
antagonists
decapeptide analogs
Prior art date
Application number
AT85114386T
Other languages
English (en)
Inventor
John Joseph Nestor
Brian Henry Vickery
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Application granted granted Critical
Publication of ATE84797T1 publication Critical patent/ATE84797T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/13—Luteinizing hormone-releasing hormone; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Semiconductor Memories (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
AT85114386T 1984-11-13 1985-11-12 Nona- und dekapeptidanaloga von lhrh, welche als lhrh-antagonisten dienen. ATE84797T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/671,153 US4690916A (en) 1984-11-13 1984-11-13 Nona and decapeptide analogs of LHRH useful as LHRH antagonists
EP85114386A EP0182262B1 (de) 1984-11-13 1985-11-12 Nona- und Dekapeptidanaloga von LHRH, welche als LHRH-Antagonisten dienen

Publications (1)

Publication Number Publication Date
ATE84797T1 true ATE84797T1 (de) 1993-02-15

Family

ID=24693330

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85114386T ATE84797T1 (de) 1984-11-13 1985-11-12 Nona- und dekapeptidanaloga von lhrh, welche als lhrh-antagonisten dienen.

Country Status (11)

Country Link
US (1) US4690916A (de)
EP (1) EP0182262B1 (de)
JP (1) JP2542362B2 (de)
AT (1) ATE84797T1 (de)
AU (1) AU594652B2 (de)
CA (1) CA1303627C (de)
DE (1) DE3587016T2 (de)
DK (1) DK521285A (de)
IE (1) IE59709B1 (de)
NZ (1) NZ214154A (de)
ZA (1) ZA858675B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0268066A3 (de) * 1986-10-17 1990-07-11 Syntex (U.S.A.) Inc. Fertilitäts-Kontrolle und Uterin-Therapie bei Hunden mit LHRH-Antagonisten
US4801577A (en) * 1987-02-05 1989-01-31 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
US5688519A (en) * 1987-04-06 1997-11-18 Leonard; Robert J. Flash-flow fused medicinal implants
US4800191A (en) * 1987-07-17 1989-01-24 Schally Andrew Victor LHRH antagonists
NZ226557A (en) * 1987-10-15 1990-07-26 Syntex Inc Pharmaceutical compositions for the intranasal administration of a biologically active polypeptide in powder form and process for their preparation
US5110904A (en) * 1989-08-07 1992-05-05 Abbott Laboratories Lhrh analogs
US5140009A (en) * 1988-02-10 1992-08-18 Tap Pharmaceuticals, Inc. Octapeptide LHRH antagonists
DE68915784T2 (de) * 1989-03-09 1994-09-29 Endocom, Inc., Boston, Mass. Teilweise geschmolzenes peptidpellet.
US5068221A (en) * 1989-05-09 1991-11-26 Mathias John R Treatment of motility disorders with a gnrh analog
US5108760A (en) * 1989-07-21 1992-04-28 Terumo Corporation Enhances lak cell activation by treatment of human peripheral blood mononuclear cells with amino acid amides
US5064939A (en) * 1990-02-06 1991-11-12 The Salk Institute For Biological Studies Cyclic gnrh antagonists
US5783562A (en) * 1990-11-10 1998-07-21 Asta Medica Aktiengesellschaft Luteinizing hormone releasing hormone analogs
US5434136A (en) * 1990-12-14 1995-07-18 Mathias; John R. Treatment of motility disorders with a GNRH analog
TW333456B (en) * 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
UA61046C2 (en) * 1992-12-07 2003-11-17 Takeda Chemical Industries Ltd Sustained-release preparation and method for its manufacture
US5413990A (en) * 1993-08-06 1995-05-09 Tap Pharmaceuticals Inc. N-terminus modified analogs of LHRH
EP0738154A1 (de) * 1993-08-06 1996-10-23 Abbott Laboratories N-terminus modifizierte lhrh analoge
US5502035A (en) * 1993-08-06 1996-03-26 Tap Holdings Inc. N-terminus modified analogs of LHRH
US5730990A (en) * 1994-06-24 1998-03-24 Enzon, Inc. Non-antigenic amine derived polymers and polymer conjugates
US5843901A (en) * 1995-06-07 1998-12-01 Advanced Research & Technology Institute LHRH antagonist peptides
US6407205B1 (en) * 1997-06-04 2002-06-18 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College FSH-releasing peptides
CN102464702B (zh) * 2010-12-23 2014-02-19 上海丽珠制药有限公司 制备醋酸亮丙瑞林的方法、产品及用途
MX2020002010A (es) 2017-08-21 2020-07-13 Celgene Corp Procesos para la preparacion de 4,5-diamino-5-oxopentanoato de (s)-terc-butilo.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2465486A1 (fr) * 1979-09-21 1981-03-27 Roussel Uclaf Nouvelle application utilisant la lh-rh ou des agonistes
EP0033976B1 (de) * 1980-02-12 1984-05-30 Takeda Chemical Industries, Ltd. Verfahren zum Schutz der Guanidingruppe und deren Wiederherstellung
FI832053A7 (fi) * 1982-06-10 1983-12-11 Syntex Inc LHRH-antagonistina käyttökelpoinen LHRH:n nonapeptidi- ja dekapeptidianalogit sekä niiden valmistusmenetevalmistusmenetelmä.
US4581169A (en) * 1982-12-21 1986-04-08 Syntex (U.S.A.) Inc. Nona-peptide and deca-peptide analogs of LHRH, useful as LHRH antagonists
US4481190A (en) * 1982-12-21 1984-11-06 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
IL70888A0 (en) * 1983-03-10 1984-05-31 Salk Inst For Biological Studi Gn rh antagonist peptides and pharmaceutical compositions containing them
DE3467173D1 (en) * 1983-08-16 1987-12-10 Akzo Nv Lh- rh antagonists
US4530920A (en) * 1983-11-07 1985-07-23 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH agonist

Also Published As

Publication number Publication date
ZA858675B (en) 1987-06-24
AU4982085A (en) 1986-05-22
AU594652B2 (en) 1990-03-15
DE3587016D1 (de) 1993-03-04
EP0182262B1 (de) 1993-01-20
IE852815L (en) 1986-05-13
EP0182262A3 (en) 1988-10-26
DK521285A (da) 1986-05-14
CA1303627C (en) 1992-06-16
EP0182262A2 (de) 1986-05-28
JP2542362B2 (ja) 1996-10-09
DE3587016T2 (de) 1993-06-03
DK521285D0 (da) 1985-11-12
JPS61122297A (ja) 1986-06-10
IE59709B1 (en) 1994-03-23
US4690916A (en) 1987-09-01
NZ214154A (en) 1990-07-26

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