ATE176668T1 - Neue 9-n-bicyclische nucleosidverbindungen nützlich als selektive inhibitoren von proinflammatorische cytokinen - Google Patents

Neue 9-n-bicyclische nucleosidverbindungen nützlich als selektive inhibitoren von proinflammatorische cytokinen

Info

Publication number: ATE176668T1
Authority: AT; Austria
Prior art keywords: new; selective inhibitors; proinflammatory cytokines; bicyclic nucleoside; compounds useful
Prior art date: 1993-07-23

Application number

AT94923241T

Other languages

English (en)

Inventor

David R Borcherding

Carl K Edwards Iii

H Randall Munson Jr

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-23

Filing date

1994-06-24

Publication date

1999-02-15

1994-06-24 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

1999-02-15 Application granted granted Critical

1999-02-15 Publication of ATE176668T1 publication Critical patent/ATE176668T1/de

Links

102000004127 Cytokines Human genes 0.000 title abstract 2
108090000695 Cytokines Proteins 0.000 title abstract 2
229940124639 Selective inhibitor Drugs 0.000 title abstract 2
239000002777 nucleoside Substances 0.000 title abstract 2
230000000770 proinflammatory effect Effects 0.000 title abstract 2
-1 NUCLEOSIDE COMPOUNDS Chemical class 0.000 title 1
239000003795 chemical substances by application Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Diabetes (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Hematology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Toxicology (AREA)
Virology (AREA)
Endocrinology (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Obesity (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Neurology (AREA)
Vascular Medicine (AREA)
Transplantation (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Nutrition Science (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Neurosurgery (AREA)

AT94923241T 1993-07-23 1994-06-24 Neue 9-n-bicyclische nucleosidverbindungen nützlich als selektive inhibitoren von proinflammatorische cytokinen ATE176668T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US9734093A	1993-07-23	1993-07-23

Publications (1)

Publication Number	Publication Date
ATE176668T1 true ATE176668T1 (de)	1999-02-15

Family

ID=22262875

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94923241T ATE176668T1 (de)	1993-07-23	1994-06-24	Neue 9-n-bicyclische nucleosidverbindungen nützlich als selektive inhibitoren von proinflammatorische cytokinen

Country Status (15)

Country	Link
US (1)	US6420373B1 (de)
EP (1)	EP0710239B1 (de)
JP (2)	JP3696882B2 (de)
KR (1)	KR100340374B1 (de)
AT (1)	ATE176668T1 (de)
AU (1)	AU683287B2 (de)
CA (1)	CA2166692C (de)
DE (1)	DE69416518T2 (de)
DK (1)	DK0710239T3 (de)
ES (1)	ES2132419T3 (de)
GR (1)	GR3029454T3 (de)
IL (1)	IL110392A (de)
TW (1)	TW397833B (de)
WO (1)	WO1995003304A1 (de)
ZA (1)	ZA945246B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1997033591A1 (en) *	1996-03-13	1997-09-18	Novo Nordisk A/S	A method of treating disorders related to cytokines in mammals
WO1997033590A1 (en) *	1996-03-13	1997-09-18	Novo Nordisk A/S	A method of treating disorders related to cytokines in mammals
GB9813554D0 (en) *	1998-06-23	1998-08-19	Glaxo Group Ltd	Chemical compounds
AU4589800A (en) *	1999-05-05	2000-11-21	Darwin Discovery Limited	9-(1,2,3,4-tetrahydronaphthalen-1-yl)-1,9-dihydropurin-6-one derivatives as pde7inhibitors
EP1252160B1 (de)	2000-01-14	2006-08-16	The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services	Methonocarbacycloalkylanaloga von nucleosiden
US20070042978A1 (en) *	2002-12-19	2007-02-22	Jean-Philippe Girard	Nf-hev compositions and methods of use
EP1896072A4 (de)	2005-06-24	2013-01-09	Univ Duke	System zur direkten heilmittelverabreichung auf der basis wärmegesteuerter biopolymere
TWI429404B (zh) *	2008-03-03	2014-03-11	Senomyx Inc	異山梨醇衍生物及彼等作為風味改良劑、促味劑及促味增強劑之用途
EP2507241A1 (de)	2009-12-02	2012-10-10	The U.S.A. As Represented By The Secretary, Department Of Health And Human Services	Methanocarba adenosin-derivate und dendrimerkonjugate daraus
US8822460B2 (en) *	2012-04-06	2014-09-02	Janssen Pharmaceutica Nv	Fused cyclopentyl antagonists of CCR2
JP2015526468A (ja) *	2012-08-22	2015-09-10	メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋＳｈａｒｐ＆ＤｏｈｍｅＣｏｒｐ．	新規なアザベンズイミダゾールヘキサヒドロフロ［３，２−ｂ］フラン誘導体
JP2016510740A (ja) *	2013-03-05	2016-04-11	アーチャー−ダニエルズ−ミッドランドカンパニー	イソヘキシドモノトリフレートおよびそれを合成するプロセス
CN105916859A (zh)	2014-02-03	2016-08-31	卡迪拉保健有限公司	杂环化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3028288A1 (de)	1980-07-25	1982-02-25	Fa. Dr. Willmar Schwabe, 7500 Karlsruhe	Gegebenenfalls n-substituierte aminodesoxy-1.4;3.6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und deren verwendung
DE3028273A1 (de) *	1980-07-25	1982-02-25	Fa. Dr. Willmar Schwabe, 7500 Karlsruhe	Durch purinbasen substituierte 1.4;3.6-dianhydro-hexit-nitrate
US5091431A (en)	1988-02-08	1992-02-25	Schering Corporation	Phosphodiesterase inhibitors
AU3192289A (en) *	1988-02-08	1989-08-25	Schering Corporation	Nucleosidetype compounds which are phosphodiesterase inhibitors

1994
- 1994-06-24 JP JP50515695A patent/JP3696882B2/ja not_active Expired - Fee Related
- 1994-06-24 KR KR1019960700346A patent/KR100340374B1/ko not_active Expired - Fee Related
- 1994-06-24 ES ES94923241T patent/ES2132419T3/es not_active Expired - Lifetime
- 1994-06-24 EP EP94923241A patent/EP0710239B1/de not_active Expired - Lifetime
- 1994-06-24 CA CA002166692A patent/CA2166692C/en not_active Expired - Fee Related
- 1994-06-24 DE DE69416518T patent/DE69416518T2/de not_active Expired - Lifetime
- 1994-06-24 AU AU73167/94A patent/AU683287B2/en not_active Ceased
- 1994-06-24 DK DK94923241T patent/DK0710239T3/da active
- 1994-06-24 WO PCT/US1994/007147 patent/WO1995003304A1/en not_active Ceased
- 1994-06-24 AT AT94923241T patent/ATE176668T1/de not_active IP Right Cessation
- 1994-07-18 ZA ZA945246A patent/ZA945246B/xx unknown
- 1994-07-19 TW TW083106593A patent/TW397833B/zh not_active IP Right Cessation
- 1994-07-21 IL IL11039294A patent/IL110392A/en not_active IP Right Cessation
1995
- 1995-01-13 US US08/372,712 patent/US6420373B1/en not_active Expired - Fee Related
1999
- 1999-02-19 GR GR990400539T patent/GR3029454T3/el unknown
2004
- 2004-06-09 JP JP2004171934A patent/JP2004315538A/ja active Pending

Also Published As

Publication number	Publication date
DK0710239T3 (da)	1999-09-20
ZA945246B (en)	1995-03-20
IL110392A0 (en)	1994-10-21
ES2132419T3 (es)	1999-08-16
EP0710239B1 (de)	1999-02-10
WO1995003304A1 (en)	1995-02-02
CA2166692A1 (en)	1995-02-02
AU7316794A (en)	1995-02-20
KR100340374B1 (ko)	2002-11-13
DE69416518D1 (de)	1999-03-25
JP3696882B2 (ja)	2005-09-21
US6420373B1 (en)	2002-07-16
EP0710239A1 (de)	1996-05-08
JPH09500643A (ja)	1997-01-21
JP2004315538A (ja)	2004-11-11
IL110392A (en)	2001-01-28
DE69416518T2 (de)	1999-07-01
TW397833B (en)	2000-07-11
GR3029454T3 (en)	1999-05-28
AU683287B2 (en)	1997-11-06
CA2166692C (en)	1999-01-26

Legal Events

Date	Code	Title	Description
1999-11-15	UEP	Publication of translation of european patent specification
2006-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DK0693073T3 (da)	1998-10-12	Bicykliske ansamyciner og deres anvendelse som antitumormidler
ES2106965T3 (es)	1997-11-16	Nuevas 4-aza-5alfa-androstan-3-onas 7beta-sustituidas como inhibidores de 5alfa-reductasa.
ATE193839T1 (de)	2000-06-15	Reinigung von proteinen
ATE148130T1 (de)	1997-02-15	Typ-iv-dipeptidyl-aminopeptidase-inhibitoren
BG99177A (bg)	1995-07-28	Нови 7 бета-заместени-4-аза-5 алфа-холестанони като инхибитори на 5 алфа-редуктаза
DE69316223D1 (de)	1998-02-12	Sulfonylalkanoylaminohydroxyethylaminosulfonamide verwendbar als retrovirale protease-inhibitoren
EP0677048A1 (de)	1995-10-18	Cyclische sulfone als inhibitoren retroviralen proteasen.
FI20012317L (fi)	2001-11-27	Retrovirusproteaasi-inhibiittoreina käyttökelpoisia hydroksietyyliaminosulfoniamideja
KR950700323A (ko)	1995-01-16	엔케팔리나제 및 안지오텐신 전환 효소의 억제제로서 유용한 아미노아세틸머캅토아세틸아미드 유도체(Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE)
DE69901840D1 (de)	2002-07-18	Neue salzform von pantoprazol
DE69416518D1 (de)	1999-03-25	Neue 9-n-bicyclische nucleosidverbindungen nützlich als selektive inhibitoren von proinflammatorische cytokinen
ATE167670T1 (de)	1998-07-15	N-alkylthiopolyaminderivate als radioprotektive mittel
DE69400036D1 (de)	1996-01-18	Reinigung von Pentafluorethan.
DE69326474D1 (de)	1999-10-21	Neue 2-substituierte tricyclische derivate von indan-2-mercaptoacetylamid verwendbar als enkephalinase inhibitoren
MX9801190A (es)	1998-04-30	Inhibidores de prolil endopeptidasa.
EP0705263A1 (de)	1996-04-10	Carbocyclische nucleozide mittel nützlich als selektive inhibitoren von proinflammatorischen cytokinen
SE9604582D0 (sv)	1996-12-13	Novel compounds
ATE267209T1 (de)	2004-06-15	Reinigung von carboxaldehyd
FI930265A0 (fi)	1993-01-22	Antikoagulantpeptider
ATE68486T1 (de)	1991-11-15	1-((2-fluorophenyl)(4-fluorophenyl)phenylmethyl - 1h-imidazol.
ATE136884T1 (de)	1996-05-15	Neue 2-mercaptomethylen-tetrahydronaphthalin- und -indan-2-carboxamide als enkephalinaseinhibitoren
DE69418050D1 (de)	1999-05-27	Antivirale analoge von difluorostaton
DK0642574T3 (da)	1999-08-16	Detergentsammensætninger
ES2173634T3 (es)	2002-10-16	Compuestos heterociclicos que presentan actividad inhibidora de mmp y tnf.
ATE92755T1 (de)	1993-08-15	Phenol-thioether als inhibitoren von 5lipoxygenase.