NO167577C - Fremgangsmaate for fremstilling av lmv-heparin ved enzymatisk depolymerisering. - Google Patents

Fremgangsmaate for fremstilling av lmv-heparin ved enzymatisk depolymerisering.

Info

Publication number: NO167577C
Authority: NO; Norway
Prior art keywords: heparin; lmw; molecular weight; depolymerization; polydispersity
Prior art date: 1986-04-30

Application number

NO871784A

Other languages

English (en)

Norwegian (no)

Other versions

NO167577B (no

NO871784L (no

NO871784D0 (no

Inventor

Joergen Ilum Nielsen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-04-30

Filing date

1987-04-29

Publication date

1991-11-20

1987-04-29 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1987-04-29 Publication of NO871784D0 publication Critical patent/NO871784D0/no

1987-11-02 Publication of NO871784L publication Critical patent/NO871784L/no

1991-08-12 Publication of NO167577B publication Critical patent/NO167577B/no

1991-11-20 Publication of NO167577C publication Critical patent/NO167577C/no

Links

HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title abstract 3
229960002897 heparin Drugs 0.000 title abstract 3
229920000669 heparin Polymers 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 3
230000002255 enzymatic effect Effects 0.000 title abstract 2
239000003055 low molecular weight heparin Substances 0.000 abstract 6
229940127215 low-molecular weight heparin Drugs 0.000 abstract 6
238000004519 manufacturing process Methods 0.000 abstract 2
108010022901 Heparin Lyase Proteins 0.000 abstract 1
238000012691 depolymerization reaction Methods 0.000 abstract 1
239000000706 filtrate Substances 0.000 abstract 1
239000000047 product Substances 0.000 abstract 1
239000012465 retentate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Materials Engineering (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Polymers & Plastics (AREA)
Organic Chemistry (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

NO871784A 1986-04-30 1987-04-29 Fremgangsmaate for fremstilling av lmv-heparin ved enzymatisk depolymerisering. NO167577C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK196886A DK196886D0 (da)	1986-04-30	1986-04-30	Fremstilling af polysaccharider

Publications (4)

Publication Number	Publication Date
NO871784D0 NO871784D0 (no)	1987-04-29
NO871784L NO871784L (no)	1987-11-02
NO167577B NO167577B (no)	1991-08-12
NO167577C true NO167577C (no)	1991-11-20

Family

ID=8109192

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO871784A NO167577C (no)	1986-04-30	1987-04-29	Fremgangsmaate for fremstilling av lmv-heparin ved enzymatisk depolymerisering.

Country Status (12)

Country	Link
EP (1)	EP0244235B1 (de)
JP (1)	JPS62283102A (de)
AT (1)	ATE84801T1 (de)
AU (1)	AU585709B2 (de)
CA (1)	CA1334080C (de)
DE (1)	DE3783644T2 (de)
DK (1)	DK196886D0 (de)
ES (1)	ES2052559T3 (de)
FI (1)	FI89943C (de)
GR (1)	GR3006929T3 (de)
IE (1)	IE60409B1 (de)
NO (1)	NO167577C (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK196986D0 (da) *	1986-04-30	1986-04-30	Novo Industri As	Fremstilling af polysaccharider
FR2663639B1 (fr) *	1990-06-26	1994-03-18	Rhone Poulenc Sante	Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation.
USRE38743E1 (en)	1990-06-26	2005-06-14	Aventis Pharma S.A.	Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
US5707973A (en) *	1991-04-23	1998-01-13	Rhone-Poulenc Rorer S.A.	Sulfated polysaccharids for treatment or prevention of thromboses
FR2675806B1 (fr) *	1991-04-23	1994-06-10	Rhone Poulenc Rorer Sa	Polysaccharides sulfates, procede de preparation, composition pharmaceutique et utilisation.
US6001820A (en) *	1995-03-31	1999-12-14	Hamilton Civic Hospitals Research Development Inc.	Compositions and methods for inhibiting thrombogenesis
US5763427A (en) *	1995-03-31	1998-06-09	Hamilton Civic Hospitals Research Development Inc.	Compositions and methods for inhibiting thrombogenesis
US5744457A (en) *	1995-03-31	1998-04-28	Hamilton Civic Hospitals Research Development Inc.	Compositions and methods for inhibiting thrombogenesis
US5767269A (en) *	1996-10-01	1998-06-16	Hamilton Civic Hospitals Research Development Inc.	Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
SI0946185T2 (sl) *	1996-11-27	2010-08-31	Aventis Pharma Inc	Farmacevtski sestavek, ki obsega spojino z anti-Xa-aktivnostjo in antagonistično spojino za agregacijo ploščic
US6075013A (en) *	1997-06-06	2000-06-13	Hamilton Civic Hospitals Research Development Inc.	Modified low molecular weight heparin that inhibits clot associated coagulation factors
HK1045532A1 (zh) *	1999-06-30	2002-11-29	Hamilton Civic Hospitals Research Development, Inc.	抑制与凝结有关凝结因子的肝素成份
US7575886B2 (en)	2002-03-11	2009-08-18	Momenta Pharmaceuticals, Inc.	Analysis of sulfated polysaccharides
EP1582531A1 (de) *	2004-03-24	2005-10-05	Aventis Pharma S.A.	Verfahren zur Oxydierung nicht-fraktionierten Heparins und die Detektion der Anwesenheit oder Abwesenheit von Glykoserin in Heparin und in von Heparin abgeleiteten Produkten
RU2295538C2 (ru) *	2005-03-01	2007-03-20	Гематологический научный центр РАМН	Способ получения гепаринов с низкой молекулярной массой
EP1792621B1 (de)	2005-11-30	2012-04-04	Istituto di Ricerche Chimiche e Biochimiche "G. Ronzoni"	Oral verabreichbare Heparinderivate
US9139876B1 (en)	2007-05-03	2015-09-22	Momenta Pharmacueticals, Inc.	Method of analyzing a preparation of a low molecular weight heparin
RU2377993C2 (ru) *	2007-11-08	2010-01-10	Государственное учреждение гематологический научный центр Российской академии медицинских наук (ГУ ГНЦ РАМН)	Способ получения низкомолекулярного гепарина
CN102791742B (zh)	2010-01-19	2014-12-24	动量制药公司	评价肝素制剂
WO2012115952A1 (en)	2011-02-21	2012-08-30	Momenta Pharmaceuticals, Inc.	Evaluating heparin preparations
CN102690862B (zh) *	2012-06-08	2015-01-28	上海太阳生物技术有限公司	抗凝血酶ⅲ(at-ⅲ)测定试剂盒(发色底物法)
WO2022015794A1 (en)	2020-07-14	2022-01-20	Optimvia, Llc	Methods for synthesizing non-anticoagulant heparan sulfate
AU2020310172A1 (en)	2019-07-09	2022-03-03	Optimvia Llc	Methods for synthesizing anticoagulant polysaccharides
CN111763702A (zh) *	2020-07-13	2020-10-13	福州大学	一种制备硫酸乙酰肝素寡糖的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4351938A (en) *	1980-05-19	1982-09-28	Riker Laboratories, Inc.	Anticoagulant substance
US4396762A (en) *	1981-08-24	1983-08-02	Massachusetts Institute Of Technology	Heparinase derived anticoagulants
DE3244214A1 (de) *	1982-11-30	1984-05-30	B. Braun Melsungen Ag, 3508 Melsungen	Verfahren zur reinigung und fraktionierung von heparin
DK196986D0 (da) *	1986-04-30	1986-04-30	Novo Industri As	Fremstilling af polysaccharider

1986
- 1986-04-30 DK DK196886A patent/DK196886D0/da not_active Application Discontinuation
1987
- 1987-04-29 FI FI871909A patent/FI89943C/fi not_active IP Right Cessation
- 1987-04-29 AT AT87303835T patent/ATE84801T1/de not_active IP Right Cessation
- 1987-04-29 DE DE8787303835T patent/DE3783644T2/de not_active Expired - Fee Related
- 1987-04-29 EP EP87303835A patent/EP0244235B1/de not_active Expired - Lifetime
- 1987-04-29 NO NO871784A patent/NO167577C/no not_active IP Right Cessation
- 1987-04-29 ES ES87303835T patent/ES2052559T3/es not_active Expired - Lifetime
- 1987-04-30 JP JP62104845A patent/JPS62283102A/ja active Granted
- 1987-04-30 CA CA000536095A patent/CA1334080C/en not_active Expired - Fee Related
- 1987-04-30 AU AU72253/87A patent/AU585709B2/en not_active Ceased
- 1987-05-11 IE IE115287A patent/IE60409B1/en not_active IP Right Cessation
1993
- 1993-01-28 GR GR930400176T patent/GR3006929T3/el unknown

Also Published As

Publication number	Publication date
IE871152L (en)	1987-10-30
EP0244235B1 (de)	1993-01-20
FI871909L (fi)	1987-10-31
EP0244235A2 (de)	1987-11-04
NO167577B (no)	1991-08-12
DE3783644T2 (de)	1993-05-13
ATE84801T1 (de)	1993-02-15
JPH0542918B2 (de)	1993-06-30
NO871784L (no)	1987-11-02
AU7225387A (en)	1987-11-05
FI89943C (fi)	1993-12-10
EP0244235A3 (en)	1988-09-28
NO871784D0 (no)	1987-04-29
DK196886D0 (da)	1986-04-30
GR3006929T3 (de)	1993-06-30
DE3783644D1 (de)	1993-03-04
CA1334080C (en)	1995-01-24
ES2052559T3 (es)	1994-07-16
AU585709B2 (en)	1989-06-22
FI871909A0 (fi)	1987-04-29
IE60409B1 (en)	1994-07-13
JPS62283102A (ja)	1987-12-09
FI89943B (fi)	1993-08-31

Legal Events

Date	Code	Title	Description
2004-12-27	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
AU585709B2 (en)	1989-06-22	Process for the preparation of LMW-heparin
BR9000791A (pt)	1991-01-22	Processo para producao de material polimero de propileno,composicoes de polimero de propileno,metodos de processamentos de fusao para producao de artigos uteis e os ditos artigos uteis
ES446182A1 (es)	1977-06-01	Procedimiento para la obtencion de materiales sinteticos inorganicos-organicos duros.
DE3768431D1 (de)	1991-04-11	Waessrige schreibfluessigkeiten sowie ein verfahren zu deren herstellung.
FR2429848A1 (fr)	1980-01-25	Procede pour preparer du brai pour la production de fibres de carbone
CS315887A2 (en)	1990-04-11	Method of perflupropolyether production
EP0339503A3 (de)	1991-03-27	Verfahren zur Herstellung von Polycarbonat
US2563771A (en)	1951-08-07	Carbonates of unsaturated diols
ATE524496T1 (de)	2011-09-15	Von k5-polysaccharid abgeleitete glycosaminoglycane mit hoher anthithrombinwirkung und verfahren zu ihrer herstellung
FI873901A0 (fi)	1987-09-09	Foerfarande foer tillverkning av sjaelvbaerande keramiska artiklar foersedda med zonvis avtrappade egenskaper.
DE3772847D1 (de)	1991-10-17	Verfahren zur herstellung von 2-methyl-1,4-naphthochinon.
DE3167913D1 (en)	1985-02-07	Production of 2-keto-d-gluconic acid and hydrogen peroxide
ATE74933T1 (de)	1992-05-15	Verfahren zum herstellen von propylen-ethylenpolymerisaten.
DE3579896D1 (de)	1990-10-31	Verfahren zur herstellung von 2,2,4-trimethyl-1,3-pentandiolmonoisobutyrat.
NO913475D0 (no)	1991-09-04	Fremgangsmaate for kontinuerlig omsetning av cefalosporin i glutaryl-7-aminocefalosporansyre.
DK217087A (da)	1987-10-31	Fremstilling af lmw-heparin
ATE233751T1 (de)	2003-03-15	Verfahren zur herstellung und zwischenprodukt der 2-(10,11-dihydro-10-oxodibenzo(b,f)thiepin-2-yl - propionsäure
CA1059533A (en)	1979-07-31	Hydrolyzing di-and tricarboxy celluloses with sulfurous acid
DE3874846D1 (de)	1992-10-29	Verfahren zur herstellung von harnstoff.
ATE38821T1 (de)	1988-12-15	Verfahren zur herstellung eines aerosolstromes.
ATE76662T1 (de)	1992-06-15	Enzymatisches verfahren zur herstellung von 3substituierten cephalosporinen.
IE781396L (en)	1979-01-12	Purification of mercaptobenzothiazole
ATE153373T1 (de)	1997-06-15	Mikroorganismen und verfahren zur herstellung von biotin unter verwendung derselben
DE3061516D1 (en)	1983-02-03	Method of reducing the friction in the wet steps of leather manufacture
ES2055023T3 (es)	1994-08-16	Procedimiento para la preparacion de derivados de carbaciclina por introduccion estereoselectiva del doble enlace 5,6.