ATE85051T1 - Histamin-derivat, verfahren zu dessen herstellung und therapeutischen anwendung. - Google Patents

Histamin-derivat, verfahren zu dessen herstellung und therapeutischen anwendung.

Info

Publication number: ATE85051T1
Authority: AT; Austria
Prior art keywords: production; therapeutic application; histamine derivative; alkyl; histamine
Prior art date: 1988-04-22

Application number

AT89401143T

Other languages

English (en)

Inventor

Jean-Michel Res Du Chat Arrang

Leclerc General

Monique Garbarg

Walter Schunack

Jean-Charles Schwartz

Ralph Ortwin Lipp

Original Assignee

Inst Nat Sante Rech Med

Bioprojet Soc Civ

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-04-22

Filing date

1989-04-21

Publication date

1993-02-15

1989-04-21 Application filed by Inst Nat Sante Rech Med, Bioprojet Soc Civ filed Critical Inst Nat Sante Rech Med

1993-02-15 Application granted granted Critical

1993-02-15 Publication of ATE85051T1 publication Critical patent/ATE85051T1/de

Links

NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical class NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
-1 alkyl 2-amino-3-(1H-imidazol-4-yl)butyrate Chemical compound 0.000 abstract 2
QQTWSOMOTYJIQP-UHFFFAOYSA-N 3-(1h-imidazol-5-yl)butan-2-amine Chemical compound CC(N)C(C)C1=CN=CN1 QQTWSOMOTYJIQP-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)

AT89401143T 1988-04-22 1989-04-21 Histamin-derivat, verfahren zu dessen herstellung und therapeutischen anwendung. ATE85051T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8805399A FR2630328B1 (fr)	1988-04-22	1988-04-22	Derive de l'histamine, sa preparation et son application en therapeutique
EP89401143A EP0338939B1 (de)	1988-04-22	1989-04-21	Histamin-Derivat, Verfahren zu dessen Herstellung und therapeutischen Anwendung

Publications (1)

Publication Number	Publication Date
ATE85051T1 true ATE85051T1 (de)	1993-02-15

Family

ID=9365603

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89401143T ATE85051T1 (de)	1988-04-22	1989-04-21	Histamin-derivat, verfahren zu dessen herstellung und therapeutischen anwendung.

Country Status (7)

Country	Link
US (1)	US5034539A (de)
EP (1)	EP0338939B1 (de)
JP (1)	JPH0655728B2 (de)
AT (1)	ATE85051T1 (de)
DE (1)	DE68904586T2 (de)
ES (1)	ES2046500T3 (de)
FR (1)	FR2630328B1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2661909B1 (fr) *	1990-05-09	1997-08-14	Inst Nat Sante Rech Med	Nouveaux composes agonistes du recepteur h3 de l'histamine a usage therapeutique, compositions pharmaceutiques agissant comme agonistes dudit recepteur et procede de preparation.
NZ238688A (en) *	1990-06-28	1992-05-26	Smithkline Beecham Corp	Substituted histidines: pharmaceutical compositions, preparation and uses thereof
US5162541A (en) *	1990-09-10	1992-11-10	Schering Corporation	Transfer hydrogenolysis of alkylheteroaryl halo-containing compounds
US5932596A (en) *	1991-12-18	1999-08-03	Schering Corporation	Imidazoylalkyl substituted with a six membered nitrogen containing nitrogen containing heterocyclic ring
ATE128708T1 (de) *	1991-12-18	1995-10-15	Schering Corp	Imidazolylalkyl- piperazin und -diazepin derivate als histamin h3 agonisten/antagonisten.
US5807872A (en) *	1992-12-16	1998-09-15	Schering Corporation	Imidazoylalkyl substituted with a six membered nitrogen containing heterocyclic ring
NZ246441A (en) *	1991-12-18	1996-02-27	Schering Corp	Imidazol or imidazolalkyl substituted with a 4 or 5 membered nitrogen containing heterocycle, preparation and pharmaceutical compositions thereof
FR2686084B1 (fr) *	1992-01-10	1995-12-22	Bioprojet Soc Civ	Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques.
USRE37303E1 (en) *	1992-01-10	2001-07-31	Institut National Del La Sante Et De La Recherche Medicale	Imidazole compounds and their therapeutic applications
US5639775A (en) *	1992-04-01	1997-06-17	The University Of Toledo	4-[4'-piperodinyl or 3'-pirrolidinyl] substituted imidazoles as H3 -receptor antagonists and therapeutic uses thereof
US5486526A (en) *	1992-04-01	1996-01-23	The University Of Toledo	Histamine H3 -receptor antagonists and therapeutic uses thereof
SK118794A3 (en) *	1992-04-01	1995-06-07	Univ Toledo	4(4'-piperidinyl or 3'- pyrrolidinyl) substitutes imidazoles as h3-receptor
US5648355A (en) *	1994-02-09	1997-07-15	Kos Pharmaceutical, Inc.	Method of treatment of endogenous, painful gastrointestinal conditions of non-inflammatory, non-ulcerative origin
US5905152A (en) *	1996-08-08	1999-05-18	Schering Corporation	Preparation of aminomethyl-phenylimidazoles
JP2002534511A (ja)	1999-01-18	2002-10-15	ノボノルディスクアクティーゼルスカブ	置換型イミダゾール、それらの調製及び使用
US6908926B1 (en)	1999-04-16	2005-06-21	Novo Nordisk A/S	Substituted imidazoles, their preparation and use
US6610721B2 (en)	2000-03-17	2003-08-26	Novo Nordisk A/S	Imidazo heterocyclic compounds
US6437147B1 (en)	2000-03-17	2002-08-20	Novo Nordisk	Imidazole compounds
RU2287524C1 (ru) *	2005-03-31	2006-11-20	ООО "Фарминтерпрайсез"	Аспартильные производные гистамина, способ их получения, фармацевтическая композиция и их применение в качестве модуляторов активности ферментов антиоксидантной защиты
JP3892894B2 (ja) *	2005-04-28	2007-03-14	大塚製薬株式会社	カルボスチリル化合物の製造法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2586562B1 (fr) *	1985-09-02	1989-03-10	Inst Nat Sante Rech Med	Composition pharmaceutique contenant de l'a-methylhistamine

1988
- 1988-04-22 FR FR8805399A patent/FR2630328B1/fr not_active Expired - Lifetime
1989
- 1989-04-21 EP EP89401143A patent/EP0338939B1/de not_active Expired - Lifetime
- 1989-04-21 ES ES198989401143T patent/ES2046500T3/es not_active Expired - Lifetime
- 1989-04-21 JP JP1100383A patent/JPH0655728B2/ja not_active Expired - Lifetime
- 1989-04-21 DE DE8989401143T patent/DE68904586T2/de not_active Expired - Lifetime
- 1989-04-21 AT AT89401143T patent/ATE85051T1/de not_active IP Right Cessation
- 1989-09-29 US US07/414,923 patent/US5034539A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0338939B1 (de)	1993-01-27
EP0338939A1 (de)	1989-10-25
US5034539A (en)	1991-07-23
ES2046500T3 (es)	1994-02-01
JPH0655728B2 (ja)	1994-07-27
DE68904586T2 (de)	1993-08-19
JPH037264A (ja)	1991-01-14
FR2630328A1 (fr)	1989-10-27
DE68904586D1 (de)	1993-03-11
FR2630328B1 (fr)	1990-08-24

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Legal Events

Date	Code	Title	Description
1993-09-15	UEP	Publication of translation of european patent specification
2009-07-15	EELA	Cancelled due to lapse of time