ATE169016T1 - Kristalline formen von endo-2,3-dihydro-n-(8- methyl-8-azabicyclo(3.2.1)oct-3-yl)-2-oxo-1h- benzimidazol-1-carboxamid hydrochlorid monohydrat und von endo-3-ethyl-2,3-dihydro-n-(8-methyl-8- azabicyclo(3.2.1)oct-3-yl)-2-oxo-1h-benzimidazo - 1-carboxamid hydrochlorid monohydrat als 5-ht antagonisten - Google Patents

Kristalline formen von endo-2,3-dihydro-n-(8- methyl-8-azabicyclo(3.2.1)oct-3-yl)-2-oxo-1h- benzimidazol-1-carboxamid hydrochlorid monohydrat und von endo-3-ethyl-2,3-dihydro-n-(8-methyl-8- azabicyclo(3.2.1)oct-3-yl)-2-oxo-1h-benzimidazo - 1-carboxamid hydrochlorid monohydrat als 5-ht antagonisten

Info

Publication number: ATE169016T1
Authority: AT; Austria
Prior art keywords: azabicyclo; endo; dihydro; oct; methyl
Prior art date: 1992-03-26

Application number

AT93104564T

Other languages

English (en)

Inventor

Enzo Cereda

Enrica Dubini

Antoine Ezhaya

Grazia Maffione

Marco Turconi

Original Assignee

Boehringer Ingelheim Italia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-03-26

Filing date

1993-03-19

Publication date

1998-08-15

1992-03-26 Priority claimed from ITMI920720A external-priority patent/IT1254562B/it

1992-03-26 Priority claimed from ITMI920723A external-priority patent/IT1254565B/it

1993-03-19 Application filed by Boehringer Ingelheim Italia filed Critical Boehringer Ingelheim Italia

1998-08-15 Application granted granted Critical

1998-08-15 Publication of ATE169016T1 publication Critical patent/ATE169016T1/de

Links

239000003420 antiserotonin agent Substances 0.000 title 1
DKAGJZJALZXOOV-UHFFFAOYSA-N hydrate;hydrochloride Chemical compound O.Cl DKAGJZJALZXOOV-UHFFFAOYSA-N 0.000 title 1
YLEIFZAVNWDOBM-ZTNXSLBXSA-N ac1l9hc7 Chemical compound C([C@H]12)C[C@@H](C([C@@H](O)CC3)(C)C)[C@@]43C[C@@]14CC[C@@]1(C)[C@@]2(C)C[C@@H]2O[C@]3(O)[C@H](O)C(C)(C)O[C@@H]3[C@@H](C)[C@H]12 YLEIFZAVNWDOBM-ZTNXSLBXSA-N 0.000 abstract 1
SRVFFFJZQVENJC-IHRRRGAJSA-N aloxistatin Chemical compound CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C SRVFFFJZQVENJC-IHRRRGAJSA-N 0.000 abstract 1
150000004682 monohydrates Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

AT93104564T 1992-03-26 1993-03-19 Kristalline formen von endo-2,3-dihydro-n-(8- methyl-8-azabicyclo(3.2.1)oct-3-yl)-2-oxo-1h- benzimidazol-1-carboxamid hydrochlorid monohydrat und von endo-3-ethyl-2,3-dihydro-n-(8-methyl-8- azabicyclo(3.2.1)oct-3-yl)-2-oxo-1h-benzimidazo - 1-carboxamid hydrochlorid monohydrat als 5-ht antagonisten ATE169016T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ITMI920720A IT1254562B (it)	1992-03-26	1992-03-26	Forma cristallina dell'endo-3-etil-2,3-diidro-n-(8-metil-8-azabiciclo (3.2.1) ott-3-il)- 2-oxo-1h-benzimidazolo-1-carbossamide cloridrato
ITMI920723A IT1254565B (it)	1992-03-26	1992-03-26	Forma cristallina dell'endo-2,3-diidro-n-(8 metil-8-azabiciclo-(3.2.1) ott-3-il)-2-oxo-1h-benzimidazolo-1-carbossamide cloridrato

Publications (1)

Publication Number	Publication Date
ATE169016T1 true ATE169016T1 (de)	1998-08-15

Family

ID=26330860

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93104564T ATE169016T1 (de)	1992-03-26	1993-03-19	Kristalline formen von endo-2,3-dihydro-n-(8- methyl-8-azabicyclo(3.2.1)oct-3-yl)-2-oxo-1h- benzimidazol-1-carboxamid hydrochlorid monohydrat und von endo-3-ethyl-2,3-dihydro-n-(8-methyl-8- azabicyclo(3.2.1)oct-3-yl)-2-oxo-1h-benzimidazo - 1-carboxamid hydrochlorid monohydrat als 5-ht antagonisten

Country Status (27)

Country	Link
US (1)	US5468758A (de)
EP (1)	EP0567767B1 (de)
JP (1)	JP3279707B2 (de)
AT (1)	ATE169016T1 (de)
AU (1)	AU654082B2 (de)
BR (1)	BR1100564A (de)
CA (1)	CA2092510C (de)
CZ (1)	CZ286590B6 (de)
DE (1)	DE69319955T2 (de)
DK (1)	DK0567767T3 (de)
ES (1)	ES2118846T3 (de)
FI (1)	FI113472B (de)
HR (1)	HRP930479B1 (de)
HU (2)	HU211075B (de)
IL (1)	IL105143A (de)
MX (1)	MX9301668A (de)
NO (1)	NO300975B1 (de)
NZ (1)	NZ247234A (de)
PH (1)	PH30413A (de)
PL (1)	PL172890B1 (de)
RU (1)	RU2125054C1 (de)
SG (1)	SG43225A1 (de)
SI (1)	SI9300150B (de)
SK (1)	SK280555B6 (de)
TW (1)	TW385310B (de)
UA (1)	UA37179C2 (de)
UY (2)	UY25939A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69726323T2 (de)	1996-01-17	2004-05-27	Ricoh Co., Ltd.	Fixiergerät für ein Bilderzeugungsgerät
JPH1039679A (ja) *	1996-05-24	1998-02-13	Ricoh Co Ltd	定着装置
PE20001420A1 (es)	1998-12-23	2000-12-18	Pfizer	Moduladores de ccr5
US8697722B2 (en) *	2007-11-02	2014-04-15	Sri International	Nicotinic acetylcholine receptor modulators
WO2011085389A1 (en) *	2010-01-11	2011-07-14	Astraea Therapeutics, Llc	Nicotinic acetylcholine receptor modulators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4136189A (en) *	1975-09-16	1979-01-23	Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T.	2-(5-nitro-furfurylidene)-amino-benzimidoles and fungicidal compositions containing the same
IT1231413B (it) *	1987-09-23	1991-12-04	Angeli Inst Spa	Derivati dell'acido benzimidazolin-2-osso-1-carbossilico utili come antagonisti dei recettori 5-ht
US5223511A (en) *	1987-09-23	1993-06-29	Boehringer Ingelheim Italia S.P.A.	Benzimidazoline-2-oxo-1-carboxylic acid compounds useful as 5-HT receptor antagonists
GB9121835D0 (en) *	1991-10-15	1991-11-27	Smithkline Beecham Plc	Pharmaceuticals
PH31171A (en) *	1992-02-04	1998-03-20	Esai Co Ltd	Aminobenzonic acid derivatives useful for treatinggastrointestinal conditions.

1993
- 1993-03-11 PH PH45858A patent/PH30413A/en unknown
- 1993-03-19 DE DE69319955T patent/DE69319955T2/de not_active Expired - Lifetime
- 1993-03-19 ES ES93104564T patent/ES2118846T3/es not_active Expired - Lifetime
- 1993-03-19 EP EP93104564A patent/EP0567767B1/de not_active Expired - Lifetime
- 1993-03-19 CZ CZ1993443A patent/CZ286590B6/cs not_active IP Right Cessation
- 1993-03-19 AT AT93104564T patent/ATE169016T1/de active
- 1993-03-19 DK DK93104564T patent/DK0567767T3/da active
- 1993-03-19 SG SG1996005867A patent/SG43225A1/en unknown
- 1993-03-22 SK SK226-93A patent/SK280555B6/sk not_active IP Right Cessation
- 1993-03-23 HR HRMI92A000723A patent/HRP930479B1/xx not_active IP Right Cessation
- 1993-03-24 TW TW082102205A patent/TW385310B/zh not_active IP Right Cessation
- 1993-03-24 IL IL10514393A patent/IL105143A/en not_active IP Right Cessation
- 1993-03-24 NZ NZ247234A patent/NZ247234A/en not_active IP Right Cessation
- 1993-03-24 AU AU35413/93A patent/AU654082B2/en not_active Ceased
- 1993-03-25 CA CA002092510A patent/CA2092510C/en not_active Expired - Lifetime
- 1993-03-25 PL PL93298263A patent/PL172890B1/pl not_active IP Right Cessation
- 1993-03-25 MX MX9301668A patent/MX9301668A/es not_active IP Right Cessation
- 1993-03-25 HU HU9300868A patent/HU211075B/hu not_active IP Right Cessation
- 1993-03-25 FI FI931329A patent/FI113472B/fi not_active IP Right Cessation
- 1993-03-25 RU RU93004710A patent/RU2125054C1/ru not_active IP Right Cessation
- 1993-03-25 NO NO931112A patent/NO300975B1/no not_active IP Right Cessation
- 1993-03-25 JP JP06649293A patent/JP3279707B2/ja not_active Expired - Lifetime
- 1993-03-26 SI SI9300150A patent/SI9300150B/sl not_active IP Right Cessation
- 1993-06-08 UA UA93002686A patent/UA37179C2/uk unknown
1994
- 1994-06-22 US US08/264,104 patent/US5468758A/en not_active Expired - Lifetime
1995
- 1995-06-30 HU HU95P/P00677P patent/HU211131A9/hu unknown
1997
- 1997-05-13 BR BR1100564-5A patent/BR1100564A/pt active IP Right Grant
2000
- 2000-01-17 UY UY25939A patent/UY25939A1/es not_active Application Discontinuation
- 2000-01-17 UY UY25938A patent/UY25938A1/es unknown

Also Published As

Publication number	Publication date
DE69319955D1 (de)	1998-09-03
EP0567767A1 (de)	1993-11-03
NO931112D0 (no)	1993-03-25
SK22693A3 (en)	1993-11-10
FI931329A0 (fi)	1993-03-25
BR1100564A (pt)	2000-06-27
US5468758A (en)	1995-11-21
JP3279707B2 (ja)	2002-04-30
SI9300150B (sl)	1998-06-30
HRP930479A2 (en)	1995-02-28
HK1010719A1 (en)	1999-06-25
HRP930479B1 (en)	1999-10-31
PL298263A1 (en)	1994-01-10
NO931112L (no)	1993-09-27
FI931329L (fi)	1993-09-27
SK280555B6 (sk)	2000-03-13
CA2092510A1 (en)	1993-09-27
CZ286590B6 (cs)	2000-05-17
PH30413A (en)	1997-05-09
NO300975B1 (no)	1997-08-25
UY25939A1 (es)	2001-08-27
HU211075B (en)	1995-10-30
PL172890B1 (pl)	1997-12-31
NZ247234A (en)	1995-12-21
DK0567767T3 (da)	1999-02-01
AU3541393A (en)	1993-09-30
DE69319955T2 (de)	1999-04-15
CA2092510C (en)	2004-02-03
EP0567767B1 (de)	1998-07-29
IL105143A (en)	1996-10-16
CZ44393A3 (en)	1994-01-19
MX9301668A (es)	1993-09-01
SG43225A1 (en)	1997-10-17
AU654082B2 (en)	1994-10-20
UY25938A1 (es)	2000-09-29
TW385310B (en)	2000-03-21
HU9300868D0 (en)	1993-06-28
UA37179C2 (uk)	2001-05-15
JPH0673053A (ja)	1994-03-15
HU211131A9 (en)	1995-10-30
FI113472B (fi)	2004-04-30
RU2125054C1 (ru)	1999-01-20
ES2118846T3 (es)	1998-10-01
HUT63846A (en)	1993-10-28
SI9300150A (en)	1993-09-30

Legal Events

Date	Code	Title	Description
1999-01-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
AU663200B2 (en)	1995-09-28	New 3-(hydroxybenzylidenyl)-indolin-2-ones, processes for their preparation and pharmaceutical compositions containing them
NO942953D0 (no)	1994-08-09	11-benzaldoksimestradienderivater, fremgangsmåte for deres fremstilling smat legemddel inneholdende slike
HUT56370A (en)	1991-08-28	Process for producing tricyclic carbapenem derivatives and pharmaceutical compositions comprising such compounds as active ingredient
ZA932168B (en)	1993-11-08	Naphthylalkylamines, process for preparing them and pharmaceutical compositions containing them
ZA896067B (en)	1990-06-27	Chemical compounds
PL309874A1 (en)	1996-02-05	Novel derivatives of pyrrolocarbasol, method of obtaining them and pharmaceutical composition containing such derivatives
DK0430201T3 (de)	1997-06-16
NZ222185A (en)	1990-07-26	N-substituted methanesulphonamide derivatives, and anticancer compositions containing such
PT91203A (pt)	1990-02-08	Processo para a preparacao de novos derivados de antibioticos bu-3608 e de composicoes farmaceuticas que os contem
AU4912893A (en)	1994-05-05	Pyrazolo(4,3-c)pyridines, a process for their preparation and their use as serotonin reuptake inhibitors
DE69319955D1 (de)	1998-09-03	Kristalline Formen von Endo-2,3-Dihydro-N-(8-Methyl-8-Azabicyclo(3.2.1)Oct-3-yl)-2-Oxo-1H-Benzimidazol-1-Carboxamid Hydrochlorid Monohydrat und von Endo-3-Ethyl-2,3-Dihydro-N-(8-Methyl-8-Azabicyclo(3.2.1)Oct-3-yl)-2-Oxo-1H-Benzimidazol-1-Carboxamid Hydrochlorid Monohydrat als 5-HT Antagonisten
IL108085A0 (en)	1994-04-12	Serotoninergic ergoline derivatives their preparation and pharmacutical compositions containing them
IL95619A0 (en)	1991-06-30	N-azabicyclo(3.3.0)octane amides of aromatic acids and pharmaceutical compositions containing them
AU657423B2 (en)	1995-03-09	Novel piperidine derivatives and process for preparation thereof
PL286188A1 (en)	1991-04-22	Method of obtaining renine retarding aminooligohydroxy derivatives
ZA83773B (en)	1984-10-31	Substituted dibenzodiazepinones,processes for their preparation,and pharmaceutical compositions containing these compounds
DE68913099D1 (de)	1994-03-24	Amino-substituierte verbrückte azabicyclische Chinoloncarbonsäure und Ester.
IT1254562B (it)	1995-09-25	Forma cristallina dell'endo-3-etil-2,3-diidro-n-(8-metil-8-azabiciclo (3.2.1) ott-3-il)- 2-oxo-1h-benzimidazolo-1-carbossamide cloridrato
IT1254565B (it)	1995-09-25	Forma cristallina dell'endo-2,3-diidro-n-(8 metil-8-azabiciclo-(3.2.1) ott-3-il)-2-oxo-1h-benzimidazolo-1-carbossamide cloridrato
MY103509A (en)	1993-06-30	Indole derivatives.