ATE85975T1 - Phenolische thioaether, deren herstellung und verwendung. - Google Patents
Phenolische thioaether, deren herstellung und verwendung.Info
- Publication number
- ATE85975T1 ATE85975T1 AT89306331T AT89306331T ATE85975T1 AT E85975 T1 ATE85975 T1 AT E85975T1 AT 89306331 T AT89306331 T AT 89306331T AT 89306331 T AT89306331 T AT 89306331T AT E85975 T1 ATE85975 T1 AT E85975T1
- Authority
- AT
- Austria
- Prior art keywords
- branched
- straight
- group
- phenolic
- thioaethers
- Prior art date
Links
- 102000007330 LDL Lipoproteins Human genes 0.000 abstract 3
- 108010007622 LDL Lipoproteins Proteins 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- -1 Phenolic thioethers Chemical class 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000036425 denaturation Effects 0.000 abstract 1
- 238000004925 denaturation Methods 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000010348 incorporation Methods 0.000 abstract 1
- 210000002540 macrophage Anatomy 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15784988 | 1988-06-24 | ||
| EP89306331A EP0348203B1 (de) | 1988-06-24 | 1989-06-23 | Phenolische Thioäther, deren Herstellung und Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE85975T1 true ATE85975T1 (de) | 1993-03-15 |
Family
ID=15658708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89306331T ATE85975T1 (de) | 1988-06-24 | 1989-06-23 | Phenolische thioaether, deren herstellung und verwendung. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5084214A (de) |
| EP (1) | EP0348203B1 (de) |
| JP (1) | JP2754039B2 (de) |
| KR (1) | KR900000337A (de) |
| AT (1) | ATE85975T1 (de) |
| DE (1) | DE68904995T2 (de) |
| ES (1) | ES2053996T3 (de) |
| GR (1) | GR3007139T3 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU203869B (en) * | 1989-07-14 | 1991-10-28 | Richter Gedeon Vegyeszet | Process for producing salts ofnew acrylic acid derivatives and pharmaceutical compositions containing them |
| ZA911101B (en) * | 1990-02-14 | 1991-11-27 | Chugai Pharmaceutical Co Ltd | Inhibition of modified ldl products |
| JPH0629236B2 (ja) * | 1990-05-02 | 1994-04-20 | ナショナル サイエンス カウンシル | 2,6―ジメトキシヒドロキノン―3―メルカプトプロピオン酸および2,6―ジメトキシヒドロキノン―3―メルカプト酢酸およびその抗癌用途 |
| US5674900A (en) * | 1995-06-06 | 1997-10-07 | Shaman Pharmaceuticals, Inc. | Terpenoid-type quinones for treatment of diabetes |
| AU2006202461B2 (en) * | 1997-05-14 | 2009-12-03 | Atherogenics, Inc. | Compositions and methods for the inhibition of the expression of VCAM-1 |
| CN1275596C (zh) * | 1997-05-14 | 2006-09-20 | 阿特罗吉尼克斯公司 | 普罗布考单酯在制备用于治疗心血管疾病和炎性疾病的药物中的应用 |
| US6670398B2 (en) * | 1997-05-14 | 2003-12-30 | Atherogenics, Inc. | Compounds and methods for treating transplant rejection |
| EP1695959A1 (de) * | 1997-05-14 | 2006-08-30 | Atherogenics, Inc. | Verbindungen und Methoden zur Hemmung der VCAM-1 Expression |
| US6852878B2 (en) | 1998-05-14 | 2005-02-08 | Atherogenics, Inc. | Thioketals and thioethers for inhibiting the expression of VCAM-1 |
| WO1999001118A2 (en) | 1997-07-01 | 1999-01-14 | Atherogenics, Inc. | Antioxidant enhancement of therapy for hyperproliferative conditions |
| US6881860B2 (en) | 2000-04-11 | 2005-04-19 | Atherogenics, Inc. | Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality |
| US8026280B2 (en) | 2001-03-27 | 2011-09-27 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
| US7312247B2 (en) | 2001-03-27 | 2007-12-25 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
| US7842727B2 (en) * | 2001-03-27 | 2010-11-30 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
| US7314953B2 (en) * | 2001-03-27 | 2008-01-01 | Errant Gene Therapeutics, Llc | Treatment of lung cells with histone deacetylase inhibitors |
| US6495719B2 (en) | 2001-03-27 | 2002-12-17 | Circagen Pharmaceutical | Histone deacetylase inhibitors |
| US20030064967A1 (en) * | 2001-04-11 | 2003-04-03 | Jayraz Luchoomun | Methods to increase plasma HDL cholesterol levels and improve HDL functionality with probucol monoesters |
| EP1511477A4 (de) * | 2002-05-22 | 2008-04-09 | Errant Gene Therapeutics Llc | Histondeacetylase-hemmer auf basis von alpha-ketoepoxid-verbindungen |
| US6960683B2 (en) | 2002-07-12 | 2005-11-01 | Atherogenics, Inc. | Salt forms of poorly soluble probucol esters and ethers |
| WO2005112914A2 (en) | 2004-04-20 | 2005-12-01 | Atherogenics, Inc. | Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease |
| US20070260087A1 (en) | 2004-04-20 | 2007-11-08 | Atherogenics, Inc. | Process of Preparing Esters and Ethers of Probucol and Derivatives Thereof |
| US20060160902A1 (en) * | 2004-11-08 | 2006-07-20 | Wiech Norbert L | Histone deacetylase inhibitors |
| ES2745411T3 (es) * | 2006-07-27 | 2020-03-02 | Wang Nai Fang | Compuestos y composiciones de arilsulfanilo para administración de agentes activos |
| EP2139320A4 (de) * | 2007-03-26 | 2010-09-08 | Salutria Pharmaceuticals Llc | Verfahren und zusammensetzungen von probucol-derivaten für die behandlung von diabetes |
| WO2008118946A1 (en) * | 2007-03-27 | 2008-10-02 | Atherogenics, Inc. | Methods and compositions using certain phenolic derivatives for the treatment of diabetes |
| US7897776B2 (en) | 2007-04-23 | 2011-03-01 | Salutria Pharmaceuticals Llc | Sulfonamide containing compounds for treatment of inflammatory disorders |
| CA3145096A1 (en) | 2018-06-27 | 2020-01-02 | Cornell University | Substituted alkylphenols as hcn1 antagonists |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1936463A1 (de) * | 1969-07-17 | 1971-02-04 | Boehringer Sohn Ingelheim | Substituierte Phenole |
| CA1037964A (en) * | 1973-02-14 | 1978-09-05 | Eugene R. Wagner | 2-((3,5-di-tert-buryl-4-hydroxyphenyl)thio)alkanoic acids and derivatives and esters |
| US4012523A (en) * | 1974-01-24 | 1977-03-15 | The Dow Chemical Company | Hypolipidemic 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-(thio or sulfonyl) alkanoic acids and derivatives |
| US4029812A (en) * | 1976-02-18 | 1977-06-14 | The Dow Chemical Company | Novel hypolipidemic 2-(3,5-di-tert-butyl-4-hydroxyphenyl)thio carboxamides |
| EP0079855A1 (de) * | 1981-11-12 | 1983-05-25 | Ciba-Geigy Ag | Alkylierte Hydroxyphenylthioalkansäureester |
| AU584669B2 (en) * | 1985-02-04 | 1989-06-01 | G.D. Searle & Co. | Novel disubstituted 4-hydroxyphenylthio anilides |
| US4663333A (en) * | 1985-02-04 | 1987-05-05 | G. D. Searle & Co. | Acylaminoalkylpyridines ad use in treatment of inflammation and allergy reactions |
| US4847305A (en) * | 1987-06-05 | 1989-07-11 | G. D. Searle & Co. | Phenolic thioethers as inhibitors of 5-lipoxygenase |
| JPS63310821A (ja) * | 1987-06-05 | 1988-12-19 | ジー.ディー.サール アンド カンパニー | 5−リポキシゲナーゼの阻害剤としてのフエノール性チオエーテル、スルホキサイドおよびジスルフアイド |
-
1989
- 1989-05-26 JP JP1133900A patent/JP2754039B2/ja not_active Expired - Fee Related
- 1989-05-31 US US07/359,718 patent/US5084214A/en not_active Expired - Fee Related
- 1989-06-23 DE DE8989306331T patent/DE68904995T2/de not_active Expired - Fee Related
- 1989-06-23 EP EP89306331A patent/EP0348203B1/de not_active Expired - Lifetime
- 1989-06-23 ES ES89306331T patent/ES2053996T3/es not_active Expired - Lifetime
- 1989-06-23 AT AT89306331T patent/ATE85975T1/de active
- 1989-06-24 KR KR1019890008778A patent/KR900000337A/ko not_active Ceased
-
1993
- 1993-02-25 GR GR920403170T patent/GR3007139T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0348203B1 (de) | 1993-02-24 |
| GR3007139T3 (de) | 1993-07-30 |
| DE68904995D1 (de) | 1993-04-01 |
| JP2754039B2 (ja) | 1998-05-20 |
| KR900000337A (ko) | 1990-01-30 |
| DE68904995T2 (de) | 1993-08-19 |
| JPH0285246A (ja) | 1990-03-26 |
| US5084214A (en) | 1992-01-28 |
| ES2053996T3 (es) | 1994-08-01 |
| EP0348203A1 (de) | 1989-12-27 |
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