ATE86104T1 - Mehrstufen-einkapselungs/ladeverfahren zur herstellung von lipophile heilmittel enthaltenden liposomen. - Google Patents

Mehrstufen-einkapselungs/ladeverfahren zur herstellung von lipophile heilmittel enthaltenden liposomen.

Info

Publication number: ATE86104T1
Authority: AT; Austria
Prior art keywords: acid; drug; lipophilic drug; cationic; aqueous phase
Prior art date: 1987-11-18

Application number

AT89900483T

Other languages

English (en)

Inventor

Eric Anton Forssen

Original Assignee

Vestar Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-11-18

Filing date

1988-11-18

Publication date

1993-03-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22402210&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE86104(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1988-11-18 Application filed by Vestar Inc filed Critical Vestar Inc

1993-03-15 Application granted granted Critical

1993-03-15 Publication of ATE86104T1 publication Critical patent/ATE86104T1/de

Links

238000000034 method Methods 0.000 title abstract 3
239000002502 liposome Substances 0.000 title abstract 2
238000005538 encapsulation Methods 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
229940079593 drug Drugs 0.000 abstract 4
239000003814 drug Substances 0.000 abstract 4
239000002253 acid Substances 0.000 abstract 3
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract 2
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 abstract 2
239000008346 aqueous phase Substances 0.000 abstract 2
125000002091 cationic group Chemical group 0.000 abstract 2
-1 long chain fatty acid diester phospholipid Chemical class 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 abstract 1
UOQHWNPVNXSDDO-UHFFFAOYSA-N 3-bromoimidazo[1,2-a]pyridine-6-carbonitrile Chemical compound C1=CC(C#N)=CN2C(Br)=CN=C21 UOQHWNPVNXSDDO-UHFFFAOYSA-N 0.000 abstract 1
STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 abstract 1
150000001450 anions Chemical class 0.000 abstract 1
229940045799 anthracyclines and related substance Drugs 0.000 abstract 1
229940034982 antineoplastic agent Drugs 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
239000012736 aqueous medium Substances 0.000 abstract 1
229910000019 calcium carbonate Inorganic materials 0.000 abstract 1
150000001768 cations Chemical class 0.000 abstract 1
229960000975 daunorubicin Drugs 0.000 abstract 1
STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 abstract 1
229960004679 doxorubicin Drugs 0.000 abstract 1
229940099563 lactobionic acid Drugs 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
150000003904 phospholipids Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- A61K9/1278—Post-loading, e.g. by ion or pH gradient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Dispersion Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT89900483T 1987-11-18 1988-11-18 Mehrstufen-einkapselungs/ladeverfahren zur herstellung von lipophile heilmittel enthaltenden liposomen. ATE86104T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US12235487A	1987-11-18	1987-11-18
PCT/US1988/003995 WO1989004656A1 (en)	1987-11-18	1988-11-18	Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
EP89900483A EP0394314B2 (de)	1987-11-18	1988-11-18	Mehrstufen-einkapselungs/ladeverfahren zur herstellung von lipophile heilmittel enthaltenden liposomen

Publications (1)

Publication Number	Publication Date
ATE86104T1 true ATE86104T1 (de)	1993-03-15

Family

ID=22402210

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89900483T ATE86104T1 (de)	1987-11-18	1988-11-18	Mehrstufen-einkapselungs/ladeverfahren zur herstellung von lipophile heilmittel enthaltenden liposomen.

Country Status (12)

Country	Link
EP (1)	EP0394314B2 (de)
JP (1)	JP2870657B2 (de)
KR (1)	KR960013282B1 (de)
AT (1)	ATE86104T1 (de)
AU (1)	AU609926B2 (de)
CA (1)	CA1331860C (de)
DE (1)	DE3878922T2 (de)
DK (1)	DK175736B1 (de)
HK (1)	HK120093A (de)
IE (1)	IE63518B1 (de)
NO (1)	NO300954B1 (de)
WO (1)	WO1989004656A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5227170A (en) *	1989-06-22	1993-07-13	Vestar, Inc.	Encapsulation process
IS1685B (is) *	1990-12-11	1998-02-24	Bracco International B.V.	Aðferð við að búa til fitukúlur (liposomes) sem eru gæddar auknum hæfileika til að draga í sig og halda í sér aðskotaefnum
WO1993015720A1 (en) *	1992-02-11	1993-08-19	Vestar, Inc.	Inhibition of aggregation of drug containing particles
DE19639811A1 (de) *	1996-09-27	1998-04-02	Artur Herzog Dr Mesmer	Verwendung einer Liposomenlösung zur Verstärkung der Wirksamkeit und/oder Verminderung der Toxizität von Arzneimitteln
EP2198854B1 (de)	1997-09-18	2011-11-30	Pacira Pharmaceuticals, Inc.	Retardierte Freisetzung Liposomaler Anesthetischer Zusammensetzungen
ATE554748T1 (de)	1997-11-14	2012-05-15	Pacira Pharmaceuticals Inc	Herstellung von multivesikulären liposomen
US12151024B2 (en)	2021-01-22	2024-11-26	Pacira Pharmaceuticals, Inc.	Manufacturing of bupivacaine multivesicular liposomes
US11357727B1 (en)	2021-01-22	2022-06-14	Pacira Pharmaceuticals, Inc.	Manufacturing of bupivacaine multivesicular liposomes
US11033495B1 (en)	2021-01-22	2021-06-15	Pacira Pharmaceuticals, Inc.	Manufacturing of bupivacaine multivesicular liposomes
US11278494B1 (en)	2021-01-22	2022-03-22	Pacira Pharmaceuticals, Inc.	Manufacturing of bupivacaine multivesicular liposomes
EP4415713A4 (de)	2021-10-14	2025-08-06	Pacira Pharmaceuticals Inc	Bupivacain-multivesikuläre liposomformulierungen und verwendungen davon
US12251468B1 (en)	2024-05-20	2025-03-18	Pacira Pharmaceuticals, Inc.	Manufacturing of bupivacaine multivesicular liposomes
US12156940B1 (en)	2024-05-20	2024-12-03	Pacira Pharmaceuticals, Inc.	Manufacturing of bupivacaine multivesicular liposomes
US12251472B1 (en)	2024-05-20	2025-03-18	Pacira Pharmaceuticals, Inc.	Manufacturing of bupivacaine multivesicular liposomes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4505830A (en) *	1981-09-21	1985-03-19	The Lubrizol Corporation	Metal working using lubricants containing basic alkali metal salts
CA1270198A (en) *	1984-08-08	1990-06-12	Marcel B. Bally	Encapsulation of antineoplastic agents in liposomes
IE58981B1 (en) *	1985-10-15	1993-12-15	Vestar Inc	Anthracycline antineoplastic agents encapsulated in phospholipid micellular particles
CA1338702C (en) *	1987-03-05	1996-11-12	Lawrence D. Mayer	High drug:lipid formulations of liposomal- antineoplastic agents

1988
- 1988-11-17 IE IE344188A patent/IE63518B1/en not_active IP Right Cessation
- 1988-11-18 JP JP1500971A patent/JP2870657B2/ja not_active Expired - Lifetime
- 1988-11-18 WO PCT/US1988/003995 patent/WO1989004656A1/en not_active Ceased
- 1988-11-18 KR KR1019890701340A patent/KR960013282B1/ko not_active Expired - Lifetime
- 1988-11-18 AT AT89900483T patent/ATE86104T1/de not_active IP Right Cessation
- 1988-11-18 CA CA000583476A patent/CA1331860C/en not_active Expired - Lifetime
- 1988-11-18 EP EP89900483A patent/EP0394314B2/de not_active Expired - Lifetime
- 1988-11-18 AU AU28162/89A patent/AU609926B2/en not_active Expired
- 1988-11-18 DE DE3878922T patent/DE3878922T2/de not_active Expired - Lifetime
1990
- 1990-05-16 NO NO902184A patent/NO300954B1/no unknown
- 1990-05-17 DK DK199001221A patent/DK175736B1/da not_active IP Right Cessation
1993
- 1993-11-04 HK HK1200/93A patent/HK120093A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
JPH03501019A (ja)	1991-03-07
JP2870657B2 (ja)	1999-03-17
NO300954B1 (no)	1997-08-25
DE3878922T2 (de)	1996-04-11
AU2816289A (en)	1989-06-14
EP0394314B1 (de)	1993-03-03
CA1331860C (en)	1994-09-06
EP0394314B2 (de)	1995-12-06
NO902184D0 (no)	1990-05-16
EP0394314A1 (de)	1990-10-31
DE3878922D1 (de)	1993-04-08
KR960013282B1 (ko)	1996-10-02
AU609926B2 (en)	1991-05-09
IE883441L (en)	1989-05-18
IE63518B1 (en)	1995-05-03
HK120093A (en)	1993-11-12
NO902184L (no)	1990-07-13
EP0394314A4 (en)	1991-01-09
KR890701092A (ko)	1989-12-19
DK122190D0 (da)	1990-05-17
DK175736B1 (da)	2005-02-07
DK122190A (da)	1990-07-17
WO1989004656A1 (en)	1989-06-01

Legal Events

Date	Code	Title
1993-08-15	UEP	Publication of translation of european patent specification
1996-06-15	UEP	Publication of translation of european patent specification
1996-08-15	EEIH	Change in the person of patent owner
2009-02-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE86104T1 (de)	1993-03-15	Mehrstufen-einkapselungs/ladeverfahren zur herstellung von lipophile heilmittel enthaltenden liposomen.
AU587232B2 (en)	1989-08-10	Anthracycline antineoplastic agents encapsulated in phospholipid micellular particles and methods for using same for tumor therapy
AU606880B2 (en)	1991-02-21	Improved treatment of systematic fungal infections with phospholipid particles encapsulating polyene antifungal antibiotics
IL91343A0 (en)	1990-03-19	Anti-neoplastic combination preparations
SE8201351L (sv)	1982-03-04	Sett att framstella liposomberedningar
ES2147744T3 (es)	2000-10-01	Sistema de administracion cosmetico para acido salicilico y proceso para su preparacion.
ATE71834T1 (de)	1992-02-15	Liposomzubereitung und ihre herstellung.
ES2006457A4 (es)	1989-05-01	Un procedimiento para la preparacion de una formulacion farmaceutica.
IT1203515B (it)	1989-02-15	Complessi di saponine con fosfolipidi e composizioni farmaceutiche e cosmetiche che li contengono
ES2186792T3 (es)	2003-05-16	Metodos de fabricar liposomas que contienen fotosensibilizantes hidro-monobenzoporfirinicos.
SE8504945L (sv)	1986-04-23	Farmaceutiska kompositioner innehallande antracyklinglykosider
ATE59757T1 (de)	1991-01-15	Phospholipidhaltige produkte, deren herstellung und verwendung.
KR880008802A (ko)	1988-09-13	수불용성 유효 성분의 인지질 전달 매체
ATE112679T1 (de)	1994-10-15	Wässrige bereitung von liposomenzusammensetzungen.
ES2137966T3 (es)	2000-01-01	Vehiculos para administracion oral de substancias farmaceuticamente activas inestables frente a los acidos.
GT197642325A (es)	1978-01-17	Peptidos.