ATE86109T1 - Verwendung von substituierten imidazolen zur herstellung eines analgetikums. - Google Patents

Verwendung von substituierten imidazolen zur herstellung eines analgetikums.

Info

Publication number: ATE86109T1
Authority: AT; Austria
Prior art keywords: imidazole; analgesic; manufacture; substituted imidazole; dimethylphenyl
Prior art date: 1989-10-17

Application number

AT90311245T

Other languages

English (en)

Inventor

Eija Kalso

Risto Lammintausta

Original Assignee

Orion Yhtymae Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-17

Filing date

1990-10-15

Publication date

1993-03-15

1990-10-15 Application filed by Orion Yhtymae Oy filed Critical Orion Yhtymae Oy

1993-03-15 Application granted granted Critical

1993-03-15 Publication of ATE86109T1 publication Critical patent/ATE86109T1/de

Links

RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 2
RAXXELZNTBOGNW-UHFFFAOYSA-O Imidazolium Chemical class C1=C[NH+]=CN1 RAXXELZNTBOGNW-UHFFFAOYSA-O 0.000 title 1
230000000202 analgesic effect Effects 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
RHDJRPPFURBGLQ-UHFFFAOYSA-N detomidine Chemical compound CC1=CC=CC(CC=2NC=NC=2)=C1C RHDJRPPFURBGLQ-UHFFFAOYSA-N 0.000 abstract 2
CUHVIMMYOGQXCV-UHFFFAOYSA-N medetomidine Chemical compound C=1C=CC(C)=C(C)C=1C(C)C1=CNC=N1 CUHVIMMYOGQXCV-UHFFFAOYSA-N 0.000 abstract 2
229960001894 detomidine Drugs 0.000 abstract 1
HRLIOXLXPOHXTA-NSHDSACASA-N dexmedetomidine Chemical compound C1([C@@H](C)C=2C(=C(C)C=CC=2)C)=CN=C[N]1 HRLIOXLXPOHXTA-NSHDSACASA-N 0.000 abstract 1
229960004253 dexmedetomidine Drugs 0.000 abstract 1
229960002140 medetomidine Drugs 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Golf Clubs (AREA)
Stringed Musical Instruments (AREA)
Dental Preparations (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Cephalosporin Compounds (AREA)

AT90311245T 1989-10-17 1990-10-15 Verwendung von substituierten imidazolen zur herstellung eines analgetikums. ATE86109T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FI894911A FI894911A0 (fi)	1989-10-17	1989-10-17	En terapeutiskt vaerdefull foerening.
EP90311245A EP0424059B1 (de)	1989-10-17	1990-10-15	Verwendung von substituierten Imidazolen zur Herstellung eines Analgetikums

Publications (1)

Publication Number	Publication Date
ATE86109T1 true ATE86109T1 (de)	1993-03-15

Family

ID=8529172

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90311245T ATE86109T1 (de)	1989-10-17	1990-10-15	Verwendung von substituierten imidazolen zur herstellung eines analgetikums.

Country Status (13)

Country	Link
US (1)	US5091402A (de)
EP (1)	EP0424059B1 (de)
JP (1)	JP2950597B2 (de)
AT (1)	ATE86109T1 (de)
AU (1)	AU624028B2 (de)
CA (1)	CA2027876C (de)
DE (1)	DE69001006T2 (de)
DK (1)	DK0424059T3 (de)
FI (1)	FI894911A0 (de)
HU (1)	HU207796B (de)
IE (1)	IE64062B1 (de)
NZ (2)	NZ235716A (de)
ZA (1)	ZA908301B (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2256135B (en) *	1991-05-31	1995-01-18	Orion Yhtymae Oy	Transdermal administration of 4-substituted imidazoles
US7091181B2 (en)	1994-12-12	2006-08-15	Omeros Corporation	Method of inhibition of pain and inflammation during surgery comprising administration of soluble TNF receptors
US5621113A (en) *	1996-03-28	1997-04-15	Ortho Pharmaceutical Corporation	4-[(thien-2-yl)methyl]-imidazole analgesics
US5750720A (en) *	1996-03-28	1998-05-12	Ortho Pharmaceutical Corporation	4- (thien-3-yl)methyl!-imidazole analgesics
US6716867B1 (en)	1998-04-01	2004-04-06	Orion Corporation	Use of dexmedetomidine for ICU sedation
AR015744A1 (es) *	1998-04-01	2001-05-16	Orion Corp	Uso de dexmedetomidina para sedacion en terapia intensiva
DK1117399T3 (da)	1998-09-28	2005-03-29	Orion Corp	Anvendelse af 3-(1H-imidazol-4-ylmethyl)indan-5-ol til fremstilling af et lægemiddel til intraspinal, intrathekal eller epidural indgivelse
EP1563838A3 (de) *	1998-10-20	2009-11-04	Omeros Corporation	Spülende Lösung und Methoden zur Hemmung von Schmerzen und Entzündungen
AU1319200A (en) *	1998-10-20	2000-05-08	Omeros Medical Systems, Inc.	Irrigation solution and method for inhibition of pain and inflammation
US20030087962A1 (en)	1998-10-20	2003-05-08	Omeros Corporation	Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
US7973068B2 (en)	1998-10-20	2011-07-05	Omeros Corporation	Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
WO2001000192A2 (en) *	1999-06-25	2001-01-04	Orion Corporation	Method of administering an imidazole derivative to obtain analgesia
ATE312606T1 (de)	1999-10-29	2005-12-15	Orion Corp	Verwendung eines imidazolderivats zur behandlung oder verhütung von hypotension und schock
JP2009524616A (ja) *	2006-01-27	2009-07-02	エフ．ホフマン−ラロシュアーゲー	Ｃｎｓ疾患のための４−イミダゾール誘導体の使用
MX2009003801A (es)	2006-10-19	2009-04-22	Hoffmann La Roche	Aminometil-4-imidazoles.
BRPI0718054A2 (pt)	2006-11-02	2013-11-05	Hoffmann La Roche	2-imidazóis substituídos como moduladores de receptores associados à traços de aminas
AU2007321376A1 (en)	2006-11-16	2008-05-22	F. Hoffmann-La Roche Ag	Substituted 4-imidazoles
WO2008071574A1 (en)	2006-12-13	2008-06-19	F. Hoffmann-La Roche Ag	Novel 2 -imidazoles as ligands for trace amine associated receptors (taar)
US20080146523A1 (en)	2006-12-18	2008-06-19	Guido Galley	Imidazole derivatives
CA2675221C (en)	2007-02-02	2016-02-23	F. Hoffmann-La Roche Ag	Novel 2-aminooxazolines as taar1 ligands
MX2009008465A (es)	2007-02-15	2009-08-20	Hoffmann La Roche	Nuevas 2-aminooxazolinas como ligandos de taar1.
CA2691082A1 (en)	2007-07-02	2009-01-08	F. Hoffmann-La Roche Ag	2 -imidazolines having a good affinity to the trace amine associated receptors (taars)
BRPI0812833A2 (pt)	2007-07-03	2014-12-09	Hoffmann La Roche	4-imidazolinas e seu uso como antidepressivos
KR101133862B1 (ko)	2007-07-27	2012-04-06	에프. 호프만-라 로슈 아게	Ｔａａｒ 리간드로서의 2-아제티딘메테인아민 및 2-피롤리딘메테인아민
CA2695331A1 (en)	2007-08-03	2009-02-12	F. Hoffmann-La Roche Ag	Pyridinecarboxamide and benzamide derivatives as taar1 ligands
US8242153B2 (en)	2008-07-24	2012-08-14	Hoffmann-La Roche Inc.	4,5-dihydro-oxazol-2YL derivatives
CA2752148A1 (en)	2009-02-13	2010-08-19	Daniel W. Gil	Pharmaceutical compositions comprising (3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl)methanol
RU2572692C2 (ru) *	2009-05-15	2016-01-20	Рекро Фарма, Инк.	Сублингвальные композиции дексмедетомидина и способы их применения
US8354441B2 (en)	2009-11-11	2013-01-15	Hoffmann-La Roche Inc.	Oxazoline derivatives
US9452980B2 (en)	2009-12-22	2016-09-27	Hoffmann-La Roche Inc.	Substituted benzamides
US20130072532A1 (en) *	2010-01-08	2013-03-21	Recro Pharma, Inc.	Topical transdermal dexmedetomidine compositions and methods of use thereof
US20130096170A1 (en)	2011-10-14	2013-04-18	Hospira, Inc.	Methods of treating pediatric patients using dexmedetomidine
CA2856507C (en)	2011-11-21	2017-03-21	Allergan, Inc.	Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases
EP2787970B1 (de)	2011-12-11	2018-04-11	Recro Pharma, Inc.	Intranasale dexmedetomidinzusammensetzungen und verfahren zur verwendung davon
US8242158B1 (en)	2012-01-04	2012-08-14	Hospira, Inc.	Dexmedetomidine premix formulation
TWI709417B (zh)	2013-10-07	2020-11-11	美商帝國製藥美國股份有限公司	使用右美托咪啶經皮組成物用於治療注意力不足過動症、焦慮及失眠的方法及組成物
RU2646512C2 (ru)	2013-10-07	2018-03-05	ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК.	Устройства для трансдермальной доставки дексмедетомидина и способы их применения
KR101891185B1 (ko)	2013-10-07	2018-08-24	테이코쿠 팔마 유에스에이, 인코포레이티드	비진정량의 덱스메데토미딘의 경피 전달을 위한 방법 및 조성물
CN104814966B (zh) *	2015-04-20	2017-12-29	宋兴荣	一种椎管内麻醉剂及其制备方法和应用
RS60825B1 (sr)	2016-03-17	2020-10-30	Hoffmann La Roche	Aktivnost derivata 5-etiol-4-metil-pirazol-3-karboksamida kao agonista taar-a
US9717796B1 (en)	2016-04-20	2017-08-01	Slypharma, Llc	Heat sterilizeable, premixed, ready to use dexmedetomidine solution packaged in a flexible plastic container
KR20190060007A (ko)	2016-10-31	2019-05-31	테이코쿠 팔마 유에스에이, 인코포레이티드	덱스메데토미딘 경피 전달 장치를 이용한 통증을 관리하는 방법
US11160791B2 (en)	2018-11-01	2021-11-02	Medefil, Inc.	Dexmedetomidine injection premix formulation in ready to use (RTU) bags

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2215206B (en) *	1988-02-29	1991-07-03	Farmos Oy	4-substituted imidazole derivatives useful in perioperative care

1989
- 1989-10-17 FI FI894911A patent/FI894911A0/fi not_active Application Discontinuation
1990
- 1990-10-11 JP JP2275142A patent/JP2950597B2/ja not_active Expired - Lifetime
- 1990-10-15 DK DK90311245.6T patent/DK0424059T3/da active
- 1990-10-15 AT AT90311245T patent/ATE86109T1/de not_active IP Right Cessation
- 1990-10-15 EP EP90311245A patent/EP0424059B1/de not_active Expired - Lifetime
- 1990-10-15 AU AU64642/90A patent/AU624028B2/en not_active Expired
- 1990-10-15 DE DE9090311245T patent/DE69001006T2/de not_active Expired - Fee Related
- 1990-10-16 NZ NZ235716A patent/NZ235716A/en unknown
- 1990-10-16 NZ NZ245002A patent/NZ245002A/en unknown
- 1990-10-16 IE IE371090A patent/IE64062B1/en not_active IP Right Cessation
- 1990-10-16 HU HU906460A patent/HU207796B/hu unknown
- 1990-10-17 ZA ZA908301A patent/ZA908301B/xx unknown
- 1990-10-17 US US07/599,189 patent/US5091402A/en not_active Expired - Lifetime
- 1990-10-17 CA CA002027876A patent/CA2027876C/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP2950597B2 (ja)	1999-09-20
DE69001006T2 (de)	1993-07-08
HUT55228A (en)	1991-05-28
FI894911A0 (fi)	1989-10-17
ZA908301B (en)	1991-09-25
IE64062B1 (en)	1995-07-12
DE69001006D1 (de)	1993-04-08
HU207796B (en)	1993-06-28
US5091402A (en)	1992-02-25
AU624028B2 (en)	1992-05-28
NZ235716A (en)	1997-04-24
IE903710A1 (en)	1991-04-24
CA2027876C (en)	2002-01-22
EP0424059A1 (de)	1991-04-24
HU906460D0 (en)	1991-04-29
AU6464290A (en)	1991-04-26
CA2027876A1 (en)	1991-04-18
DK0424059T3 (da)	1993-04-05
EP0424059B1 (de)	1993-03-03
NZ245002A (en)	1997-07-27
JPH03133921A (ja)	1991-06-07

Legal Events

Date	Code	Title	Description
1993-08-15	UEP	Publication of translation of european patent specification
2006-07-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69001006D1 (de)	1993-04-08	Verwendung von substituierten imidazolen zur herstellung eines analgetikums.
SU1621803A3 (ru)	1991-01-15	Способ борьбы с грибками
GB2215206B (en)	1991-07-03	4-substituted imidazole derivatives useful in perioperative care
DE69329727D1 (de)	2001-01-11	Neue imidazol derivate, ihre herstellung und therapeutische verwendung
DE68907921D1 (de)	1993-09-09	Substituierte pyrrol-, pyrazol- und triazol-angiotensin ii-antagonisten.
ES537182A0 (es)	1985-12-16	Procedimiento de obtencion de compuestos de 1-aril-2-(3-(4-trifluormetilestiril)-1,2,4-triazol-1-il)-1-c 1,2,4,-triazol-1-il-metil) etanol de efecto antifugal.
DK0403159T3 (da)	2000-08-14	Imidazolylalkensyrer
EA200100554A1 (ru)	2001-12-24	Замещенные пиразолы как ингибиторы p38 киназы
KR890006593A (ko)	1989-06-14	아르마타제 억제4(5)- 이미다졸
ATE229334T1 (de)	2002-12-15	Verwendung von crf-antagonisten
DE69816284D1 (de)	2003-08-14	Azol-verbindungen, ihre herstellung und ihre verwendung
ATE154937T1 (de)	1997-07-15	Steroide zur behandlung von prostatisch- hypertrophe, ihre herstellung und verwendung
CA2371012A1 (en)	1993-01-07	4-(1h-pyrrol-1-yl) imidazoles
KR920019781A (ko)	1992-11-20	벤즈이미다졸류로부터 유도된 항진정 항히스타민제
BR9713542A (pt)	2000-01-25	Compostos de 2 - imidazolinilaminoindol úteis como agonistas do alfa - 2 - adrenoceptor
ATE119524T1 (de)	1995-03-15	Substituierte n-(imidazolyl)alkyl-alanin- derivate.
DE69225240D1 (de)	1998-05-28	Substituierte imidazol derivate und deren herstellung und verwendung
FI973283A0 (fi)	1997-08-08	5-(4-substituoitu piperidinyyli-1)-3-aryyli-valeriaanahappojohdannaisia takykiniinireseptoriantagonisteina
ATE66476T1 (de)	1991-09-15	Thianaphthen-derivate, ihre herstellung und verwendung.
KR950704297A (ko)	1995-11-17	항헬리코박터 활성을 갖는 4-퀴놀리닐 유도체(4-quinolinyl derivatives with anti helicobacter activity)
YU101291A (sh)	1993-11-16	Postupak za dobijanje triazolil-izopropanola
PL322969A1 (en)	1998-03-02	Substituted phenylamidines, pharmaceutic compositions containing theses compounds and method of obtaining them
ATE30718T1 (de)	1987-11-15	Herstellung von 1-benzyl azetidin-3-ol und von dem entsprechenden halid acid.
DE3575920D1 (de)	1990-03-15	Gegen mikroben wirkende n-(1-(alkyl oder arylmethyl)-4(1h)-pyridinyliden)-alkanamine, ihre saeureadditionssalze und verfahren zur herstellung, verfahren zur verwendung und zusammensetzungen daraus.
PE87998A1 (es)	1998-12-30	DERIVADOS DE BENZO [g] QUINOLINA