DK0424059T3 - Anvendelse af substituerede imidazoler - Google Patents

Anvendelse af substituerede imidazoler

Info

Publication number: DK0424059T3
Authority: DK; Denmark
Prior art keywords: imidazole; dimethylphenyl; ethyl; substituted imidazoles; compounds
Prior art date: 1989-10-17

Application number

DK90311245.6T

Other languages

Danish (da)

English (en)

Inventor

Risto Lammintausta

Eija Kalso

Original Assignee

Orion Yhtymae Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-17

Filing date

1990-10-15

Publication date

1993-04-05

1990-10-15 Application filed by Orion Yhtymae Oy filed Critical Orion Yhtymae Oy

1993-04-05 Application granted granted Critical

1993-04-05 Publication of DK0424059T3 publication Critical patent/DK0424059T3/da

Links

150000002460 imidazoles Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
RHDJRPPFURBGLQ-UHFFFAOYSA-N detomidine Chemical compound CC1=CC=CC(CC=2NC=NC=2)=C1C RHDJRPPFURBGLQ-UHFFFAOYSA-N 0.000 abstract 2
CUHVIMMYOGQXCV-UHFFFAOYSA-N medetomidine Chemical compound C=1C=CC(C)=C(C)C=1C(C)C1=CNC=N1 CUHVIMMYOGQXCV-UHFFFAOYSA-N 0.000 abstract 2
229960001894 detomidine Drugs 0.000 abstract 1
HRLIOXLXPOHXTA-NSHDSACASA-N dexmedetomidine Chemical compound C1([C@@H](C)C=2C(=C(C)C=CC=2)C)=CN=C[N]1 HRLIOXLXPOHXTA-NSHDSACASA-N 0.000 abstract 1
229960004253 dexmedetomidine Drugs 0.000 abstract 1
229960002140 medetomidine Drugs 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Neurology (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Golf Clubs (AREA)
Dental Preparations (AREA)
Stringed Musical Instruments (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Cephalosporin Compounds (AREA)

DK90311245.6T 1989-10-17 1990-10-15 Anvendelse af substituerede imidazoler DK0424059T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FI894911A FI894911A0 (fi)	1989-10-17	1989-10-17	En terapeutiskt vaerdefull foerening.

Publications (1)

Publication Number	Publication Date
DK0424059T3 true DK0424059T3 (da)	1993-04-05

Family

ID=8529172

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90311245.6T DK0424059T3 (da)	1989-10-17	1990-10-15	Anvendelse af substituerede imidazoler

Country Status (13)

Country	Link
US (1)	US5091402A (de)
EP (1)	EP0424059B1 (de)
JP (1)	JP2950597B2 (de)
AT (1)	ATE86109T1 (de)
AU (1)	AU624028B2 (de)
CA (1)	CA2027876C (de)
DE (1)	DE69001006T2 (de)
DK (1)	DK0424059T3 (de)
FI (1)	FI894911A0 (de)
HU (1)	HU207796B (de)
IE (1)	IE64062B1 (de)
NZ (2)	NZ245002A (de)
ZA (1)	ZA908301B (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2256135B (en) *	1991-05-31	1995-01-18	Orion Yhtymae Oy	Transdermal administration of 4-substituted imidazoles
US7091181B2 (en)	1994-12-12	2006-08-15	Omeros Corporation	Method of inhibition of pain and inflammation during surgery comprising administration of soluble TNF receptors
US5621113A (en) *	1996-03-28	1997-04-15	Ortho Pharmaceutical Corporation	4-[(thien-2-yl)methyl]-imidazole analgesics
US5750720A (en) *	1996-03-28	1998-05-12	Ortho Pharmaceutical Corporation	4- (thien-3-yl)methyl!-imidazole analgesics
AR015744A1 (es) *	1998-04-01	2001-05-16	Orion Corp	Uso de dexmedetomidina para sedacion en terapia intensiva
US6716867B1 (en)	1998-04-01	2004-04-06	Orion Corporation	Use of dexmedetomidine for ICU sedation
JP4647785B2 (ja) *	1998-09-28	2011-03-09	オリオンコーポレーション	脊椎内、髄腔内または硬膜外投与用医薬の製造における３−（１ｈ−イミダゾール−４−イルメチル）−インダン−５−オールの用途
US7973068B2 (en)	1998-10-20	2011-07-05	Omeros Corporation	Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
HK1048259B (en) *	1998-10-20	2005-06-03	Omeros Corporation	Irrigation solution and method for inhibition of pain and inflammation
US20030087962A1 (en)	1998-10-20	2003-05-08	Omeros Corporation	Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
EP1563838A3 (de) *	1998-10-20	2009-11-04	Omeros Corporation	Spülende Lösung und Methoden zur Hemmung von Schmerzen und Entzündungen
WO2001000192A2 (en) *	1999-06-25	2001-01-04	Orion Corporation	Method of administering an imidazole derivative to obtain analgesia
AU778522B2 (en)	1999-10-29	2004-12-09	Orion Corporation	Treatment or prevention of hypotension and shock
RU2008130448A (ru) *	2006-01-27	2010-03-10	Ф. Хоффманн-Ля Рош Аг (Ch)	Применение производных 4-имидазола для расстройств цнс
AU2007312390B2 (en)	2006-10-19	2013-03-28	F. Hoffmann-La Roche Ag	Aminomethyl-4-imidazoles
WO2008052907A1 (en)	2006-11-02	2008-05-08	F. Hoffmann-La Roche Ag	Substituted 2-imidazoles as modulators of the trace amine associated receptors
EP2084152A2 (de)	2006-11-16	2009-08-05	F. Hoffmann-Roche AG	Substituierte 4-imidazole
AU2007332641A1 (en)	2006-12-13	2008-06-19	F. Hoffmann-La Roche Ag	Novel 2 -imidazoles as ligands for trace amine associated receptors (TAAR)
US20080146523A1 (en)	2006-12-18	2008-06-19	Guido Galley	Imidazole derivatives
UA98951C2 (ru)	2007-02-02	2012-07-10	Ф. Хоффманн-Ля Рош Аг	2-аминооксазолины и лекарственное средство, которое их содержит
AU2008214774A1 (en)	2007-02-15	2008-08-21	F. Hoffmann-La Roche Ag	2-aminooxazolines as TAAR1 ligands
WO2009003868A2 (en)	2007-07-02	2009-01-08	F. Hoffmann-La Roche Ag	2 -imidazolines having a good affinity to the trace amine associated receptors (taars)
JP2010531836A (ja)	2007-07-03	2010-09-30	エフ．ホフマン−ラロシュアーゲー	４−イミダゾリン及びそれらの抗うつ剤としての使用
CA2694362A1 (en)	2007-07-27	2009-02-05	F. Hoffmann-La Roche Ag	2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as taar-ligands
WO2009019149A1 (en)	2007-08-03	2009-02-12	F. Hoffmann-La Roche Ag	Pyridinecarboxamide and benzamide derivatives as taar1 ligands
US8242153B2 (en)	2008-07-24	2012-08-14	Hoffmann-La Roche Inc.	4,5-dihydro-oxazol-2YL derivatives
WO2010093930A1 (en) *	2009-02-13	2010-08-19	Allergan, Inc.	Pharmaceutical compositions comprising (3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl)methanol
NZ596976A (en) *	2009-05-15	2014-05-30	Recro Pharma Inc	Sublingual dexmedetomidine compositions and methods of use thereof
US8354441B2 (en)	2009-11-11	2013-01-15	Hoffmann-La Roche Inc.	Oxazoline derivatives
US9452980B2 (en)	2009-12-22	2016-09-27	Hoffmann-La Roche Inc.	Substituted benzamides
MX2012007933A (es) *	2010-01-08	2012-08-15	Recro Pharma Inc	Composiciones de dexmedetomidina transdermicas topicas y metodos para su uso.
US20130096170A1 (en)	2011-10-14	2013-04-18	Hospira, Inc.	Methods of treating pediatric patients using dexmedetomidine
EP2782569A1 (de)	2011-11-21	2014-10-01	Allergan, Inc.	Pharmazeutische zusammensetzungen mit 4-[1-(2,3-dimethylphenyl-)ethyl-]3h-imidazolderivaten zur behandlung von netzhauterkrankungen
EP2787970B1 (de)	2011-12-11	2018-04-11	Recro Pharma, Inc.	Intranasale dexmedetomidinzusammensetzungen und verfahren zur verwendung davon
US8242158B1 (en)	2012-01-04	2012-08-14	Hospira, Inc.	Dexmedetomidine premix formulation
WO2015054061A1 (en)	2013-10-07	2015-04-16	Teikoku Pharma Usa, Inc.	Methods and compositions for transdermal delivery of a non-sedative amount of dexmedetomidine
US20150098997A1 (en)	2013-10-07	2015-04-09	Teikoku Pharma Usa, Inc.	Methods and Compositions for Treating Attention Deficit Hyperactivity Disorder, Anxiety and Insomnia Using Dexmedetomidine Transdermal Compositions
TWI704933B (zh)	2013-10-07	2020-09-21	美商帝國製藥美國股份有限公司	右美托咪啶經皮輸送裝置及使用其之方法
CN104814966B (zh) *	2015-04-20	2017-12-29	宋兴荣	一种椎管内麻醉剂及其制备方法和应用
EP3757102A1 (de)	2016-03-17	2020-12-30	F. Hoffmann-La Roche AG	5-ethyl-4-methyl-pyrazole-3-carboxamid-derivat mit wirkung als taar agonist
US9717796B1 (en)	2016-04-20	2017-08-01	Slypharma, Llc	Heat sterilizeable, premixed, ready to use dexmedetomidine solution packaged in a flexible plastic container
KR20250105683A (ko)	2016-10-31	2025-07-08	테이코쿠 팔마 유에스에이, 인코포레이티드	덱스메데토미딘 경피 전달 장치를 이용한 통증을 관리하는 방법
US11160791B2 (en)	2018-11-01	2021-11-02	Medefil, Inc.	Dexmedetomidine injection premix formulation in ready to use (RTU) bags

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2215206B (en) *	1988-02-29	1991-07-03	Farmos Oy	4-substituted imidazole derivatives useful in perioperative care

1989
- 1989-10-17 FI FI894911A patent/FI894911A0/fi not_active Application Discontinuation
1990
- 1990-10-11 JP JP2275142A patent/JP2950597B2/ja not_active Expired - Lifetime
- 1990-10-15 EP EP90311245A patent/EP0424059B1/de not_active Expired - Lifetime
- 1990-10-15 AU AU64642/90A patent/AU624028B2/en not_active Expired
- 1990-10-15 DK DK90311245.6T patent/DK0424059T3/da active
- 1990-10-15 DE DE9090311245T patent/DE69001006T2/de not_active Expired - Fee Related
- 1990-10-15 AT AT90311245T patent/ATE86109T1/de not_active IP Right Cessation
- 1990-10-16 HU HU906460A patent/HU207796B/hu unknown
- 1990-10-16 NZ NZ245002A patent/NZ245002A/en unknown
- 1990-10-16 NZ NZ235716A patent/NZ235716A/en unknown
- 1990-10-16 IE IE371090A patent/IE64062B1/en not_active IP Right Cessation
- 1990-10-17 US US07/599,189 patent/US5091402A/en not_active Expired - Lifetime
- 1990-10-17 ZA ZA908301A patent/ZA908301B/xx unknown
- 1990-10-17 CA CA002027876A patent/CA2027876C/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
FI894911A0 (fi)	1989-10-17
CA2027876A1 (en)	1991-04-18
ZA908301B (en)	1991-09-25
EP0424059A1 (de)	1991-04-24
CA2027876C (en)	2002-01-22
NZ235716A (en)	1997-04-24
AU624028B2 (en)	1992-05-28
EP0424059B1 (de)	1993-03-03
IE903710A1 (en)	1991-04-24
IE64062B1 (en)	1995-07-12
NZ245002A (en)	1997-07-27
HU906460D0 (en)	1991-04-29
JPH03133921A (ja)	1991-06-07
HU207796B (en)	1993-06-28
AU6464290A (en)	1991-04-26
ATE86109T1 (de)	1993-03-15
US5091402A (en)	1992-02-25
DE69001006D1 (de)	1993-04-08
HUT55228A (en)	1991-05-28
DE69001006T2 (de)	1993-07-08
JP2950597B2 (ja)	1999-09-20

Publication	Publication Date	Title
DK0424059T3 (da)	1993-04-05	Anvendelse af substituerede imidazoler
DE69007740D1 (de)	1994-05-05	Substituierte 5-[(Tetrazolyl)alkenyl]-Imidazole.
KR920701167A (ko)	1992-08-11	약제학적 활성 화합물
DE68907921D1 (de)	1993-09-09	Substituierte pyrrol-, pyrazol- und triazol-angiotensin ii-antagonisten.
AU554125B2 (en)	1986-08-07	4(aryl-alkyl)imidazole derivatives
GB2215206B (en)	1991-07-03	4-substituted imidazole derivatives useful in perioperative care
DE3684431D1 (de)	1992-04-23	Derivate des ((4-(4-(4-phenyl-1-piperazinyl)phenoxymethyl)-1,3-dioxolan-2yl)methyl)-1h-imidazol und 1h-1,2,4-triazol.
HK33189A (en)	1989-04-28	1,2,3,9-tetrahydro-3-(imidazol-1-ylmethyl)-4h-carbazol-4-one derivatives
ATE197951T1 (de)	2000-12-15	Neue imidazol derivate, ihre herstellung und therapeutische verwendung
ES537182A0 (es)	1985-12-16	Procedimiento de obtencion de compuestos de 1-aril-2-(3-(4-trifluormetilestiril)-1,2,4-triazol-1-il)-1-c 1,2,4,-triazol-1-il-metil) etanol de efecto antifugal.
BR9713542A (pt)	2000-01-25	Compostos de 2 - imidazolinilaminoindol úteis como agonistas do alfa - 2 - adrenoceptor
CA2371012A1 (en)	1993-01-07	4-(1h-pyrrol-1-yl) imidazoles
AU641952B2 (en)	1993-10-07	Substituted N-(imidazolyl)alkyl alanine derivatives
ES2127789T3 (es)	1999-05-01	Derivados de 1,2,4-triazol 4-sustituidos.
UA26893C2 (uk)	1999-12-29	Спосіб отримаhhя оhдасетроhу та його фармацевтичhо прийhятhих солей
ES2091489T3 (es)	1996-11-01	Derivados de imidazol y composiciones farmaceuticas que los contienen.
ATE179979T1 (de)	1999-05-15	Triazolopyrimidinderivate als angiotensin-ii rezeptor antagonisten
KR950704297A (ko)	1995-11-17	항헬리코박터 활성을 갖는 4-퀴놀리닐 유도체(4-quinolinyl derivatives with anti helicobacter activity)
DE60144246D1 (de)	2011-04-28	Imidazolderivate, verfahren zu deren herstellung und deren verwendung
EP1319658A4 (de)	2004-06-02	Imidazolderivate oder ihre salze
FI962322A0 (fi)	1996-06-03	(S,S,S)-N-(1-(2-karboksi-3-(N2-mesyylilysyyliamino)propyyli)1-syklopentyylikarbonyylityrosiinin kiteinen polymorfinen muoto
DE60209708D1 (de)	2006-05-04	Azol- oder triazol-derivate, verfahren zu deren herstellung und ihre verwendung als fungizide
LV11461A (lv)	1996-08-20	Dihloraizvietotie imidazola atvasinajumi ka pretsenisu lidzekli
KR840008801A (ko)	1984-12-19	아졸 유도체의 제조방법