ATE86256T1 - Thieno(triazolo)diazepinverbindungen, und medizinische verwendung derselben. - Google Patents

Thieno(triazolo)diazepinverbindungen, und medizinische verwendung derselben.

Info

Publication number: ATE86256T1
Authority: AT; Austria
Prior art keywords: thieno; triazolo; diazepin; compounds; same
Prior art date: 1987-05-28

Application number

AT88904639T

Other languages

English (en)

Inventor

Minoru Moriwaki

Masao Abe

Hiroshi Mikashima

Tetsuya Tahara

Original Assignee

Yoshitomi Pharmaceutical

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-05-28

Filing date

1988-05-25

Publication date

1993-03-15

1988-05-25 Application filed by Yoshitomi Pharmaceutical filed Critical Yoshitomi Pharmaceutical

1993-03-15 Application granted granted Critical

1993-03-15 Publication of ATE86256T1 publication Critical patent/ATE86256T1/de

Links

AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical class N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
POXWDTQUDZUOGP-UHFFFAOYSA-N 1h-1,4-diazepine Chemical compound N1C=CC=NC=C1 POXWDTQUDZUOGP-UHFFFAOYSA-N 0.000 abstract 1
IZRBVBIINCSSBW-UHFFFAOYSA-N 4-hexyl-9,13-dimethyl-7-(2-methylphenyl)-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaene Chemical compound S1C(CCCCCC)=CC2=C1N1C(C)=NN=C1C(C)N=C2C1=CC=CC=C1C IZRBVBIINCSSBW-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT88904639T 1987-05-28 1988-05-25 Thieno(triazolo)diazepinverbindungen, und medizinische verwendung derselben. ATE86256T1 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
JP13205887		1987-05-28
JP13719587		1987-05-29
JP14969887		1987-06-16
EP88904639A EP0315698B1 (de)	1987-05-28	1988-05-25	Thieno(triazolo)diazepinverbindungen, und medizinische verwendung derselben
PCT/JP1988/000506 WO1988009333A1 (fr)	1987-05-28	1988-05-25	Compose a base de thieno(triazolo)diazepine et applications medicales de ce compose

Publications (1)

Publication Number	Publication Date
ATE86256T1 true ATE86256T1 (de)	1993-03-15

Family

ID=27316424

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88904639T ATE86256T1 (de)	1987-05-28	1988-05-25	Thieno(triazolo)diazepinverbindungen, und medizinische verwendung derselben.

Country Status (6)

Country	Link
US (1)	US4960770A (de)
EP (1)	EP0315698B1 (de)
JP (1)	JP2531102B2 (de)
AT (1)	ATE86256T1 (de)
DE (1)	DE3878833T2 (de)
WO (1)	WO1988009333A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3502392A1 (de) *	1985-01-25	1986-07-31	Boehringer Ingelheim KG, 6507 Ingelheim	Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen
PH30676A (en) *	1986-07-22	1997-09-16	Boehringer Ingelhein Kg	Hetrazepine compounds which have useful pharmaceutical utility
US4959361A (en) *	1987-12-18	1990-09-25	Hoffmann-La Roche Inc.	Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists
MC1999A1 (fr) *	1987-12-18	1990-01-26	Hoffmann La Roche	Composes tricycliques
CA1324863C (en) *	1988-01-30	1993-11-30	Welfide Corporation	Thienotriazolodiazepine compounds and pharmaceutical uses thereof
US5382579A (en) *	1988-10-31	1995-01-17	Eisai Co., Ltd.	Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals
US5221671A (en) *	1988-10-31	1993-06-22	Eisai Co., Ltd.	Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals
US5468740A (en) *	1988-10-31	1995-11-21	Eisai Co., Ltd.	1,4-diazepine derivative and its pharmaceutical use
US5304553A (en) *	1988-10-31	1994-04-19	Eisai Co., Ltd.	1,4-diazepine derivative and its pharmaceutical use
EP0387613A1 (de) *	1989-03-03	1990-09-19	Boehringer Ingelheim Kg	Neue Thienodiazepine
JP2959598B2 (ja) *	1990-10-12	1999-10-06	吉富製薬株式会社	光学活性なチエノトリアゾロジアゼピン化合物
JPH10190985A (ja) *	1996-12-26	1998-07-21	Asahi Optical Co Ltd	カスケード走査光学系を備えた記録装置
WO2008067222A1 (en) *	2006-11-28	2008-06-05	Kalypsys, Inc.	Heterocyclic modulators of tgr5
CN102292341B (zh) *	2008-10-30	2014-09-10	环行医学有限责任公司	对apo a有活性的噻吩并三唑并二氮杂*衍生物
ES2606958T3 (es)	2010-05-14	2017-03-28	Dana-Farber Cancer Institute, Inc.	Compuestos de tienotriazolodiazepina para tratar una neoplasia
CN103154246B (zh)	2010-05-14	2015-11-25	达那-法伯癌症研究所	用于治疗白血病的组合物和方法
CN103180318B (zh)	2010-05-14	2017-05-10	达那-法伯癌症研究所	雄性避孕组合物以及使用方法
WO2012075456A1 (en)	2010-12-02	2012-06-07	Constellation Pharmaceuticals	Bromodomain inhibitors and uses thereof
AR084070A1 (es)	2010-12-02	2013-04-17	Constellation Pharmaceuticals Inc	Inhibidores del bromodominio y usos de los mismos
WO2012151512A2 (en)	2011-05-04	2012-11-08	Constellation Pharmaceuticals, Inc.	Bromodomain inhibitors and uses thereof
WO2012174487A2 (en)	2011-06-17	2012-12-20	Constellation Pharmaceuticals, Inc.	Bromodomain inhibitors and uses thereof
DE102011082013A1 (de) *	2011-09-01	2013-03-07	Bayer Pharma AG	6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
WO2013184878A1 (en)	2012-06-06	2013-12-12	Constellation Pharmaceuticals, Inc.	Benzo [b] isoxazoloazepine bromodomain inhibitors and uses thereof
TWI602820B (zh)	2012-06-06	2017-10-21	星宿藥物公司	溴域抑制劑及其用途
BR112016001457A2 (pt)	2013-07-25	2017-08-29	Dana Farber Cancer Inst Inc	Inibidores de fatores de transcrição e usos dos mesmos
US11446309B2 (en)	2013-11-08	2022-09-20	Dana-Farber Cancer Institute, Inc.	Combination therapy for cancer using bromodomain and extra-terminal (BET) protein inhibitors
MX2016009974A (es)	2014-01-31	2016-10-31	Dana Farber Cancer Inst Inc	Derivados de diaminopirimidina bencensulfona y sus usos.
EP3099693A4 (de)	2014-01-31	2017-08-16	Dana-Farber Cancer Institute, Inc.	Verwendungen von diazepinderivaten
WO2015131113A1 (en)	2014-02-28	2015-09-03	Tensha Therapeutics, Inc.	Treatment of conditions associated with hyperinsulinaemia
CN106687463B (zh)	2014-06-20	2019-04-09	星座制药公司	一种乙酰胺类化合物的晶型
WO2016022970A1 (en)	2014-08-08	2016-02-11	Dana-Farber Cancer Institute, Inc.	Dihydropteridinone derivatives and uses thereof
RU2017104897A (ru)	2014-08-08	2018-09-10	Дана-Фарбер Кэнсер Инститьют, Инк.	Производные диазепана и их применения
UA122130C2 (uk)	2014-10-27	2020-09-25	Тенша Терапеутікс, Інк.	Інгібітори бромодомену
CA2986441A1 (en)	2015-06-12	2016-12-15	Dana-Farber Cancer Institute, Inc.	Combination therapy of transcription inhibitors and kinase inhibitors
RU2018112953A (ru)	2015-09-11	2019-10-14	Дана-Фарбер Кэнсер Инститьют, Инк.	Ацетамидтиенотриазолодиазепины и пути их применения
US11306105B2 (en)	2015-09-11	2022-04-19	Dana-Farber Cancer Institute, Inc.	Cyano thienotriazolodiazepines and uses thereof
CR20180336A (es)	2015-11-25	2018-08-06	Dana Farber Cancer Inst Inc	Inhibidores de bromodominio bivalentes y usos de los mismos

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE51012T1 (de) *	1983-09-09	1990-03-15	Shell Int Research	Biopolymerzusammensetzungen und verfahren zur herstellung derselben.
DE3435973A1 (de) *	1984-10-01	1986-04-10	Boehringer Ingelheim KG, 6507 Ingelheim	Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung
ES2037013T3 (es) *	1986-01-21	1993-06-16	Boehringer Ingelheim Kg	Procedimiento para preparar tieno-1,4-diazepinas.
JPH06187623A (ja) *	1992-12-15	1994-07-08	Matsushita Electric Ind Co Ltd	磁気記録再生装置
JPH06222718A (ja) *	1993-01-27	1994-08-12	Sekisui Chem Co Ltd	装飾用粘着シートの貼り付け方法

1988
- 1988-05-25 DE DE8888904639T patent/DE3878833T2/de not_active Expired - Fee Related
- 1988-05-25 EP EP88904639A patent/EP0315698B1/de not_active Expired - Lifetime
- 1988-05-25 WO PCT/JP1988/000506 patent/WO1988009333A1/ja not_active Ceased
- 1988-05-25 US US07/304,989 patent/US4960770A/en not_active Expired - Fee Related
- 1988-05-25 AT AT88904639T patent/ATE86256T1/de not_active IP Right Cessation
1993
- 1993-06-28 JP JP5185489A patent/JP2531102B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0315698A4 (de)	1990-05-14
WO1988009333A1 (fr)	1988-12-01
EP0315698B1 (de)	1993-03-03
JPH06157316A (ja)	1994-06-03
DE3878833T2 (de)	1993-06-09
JP2531102B2 (ja)	1996-09-04
US4960770A (en)	1990-10-02
EP0315698A1 (de)	1989-05-17
DE3878833D1 (de)	1993-04-08

Legal Events

Date	Code	Title	Description
1993-08-15	UEP	Publication of translation of european patent specification
1995-02-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE3878833D1 (de)	1993-04-08	Thieno(triazolo)diazepinverbindungen, und medizinische verwendung derselben.
BG101289A (en)	1997-08-29	Pyrimido/5,4-d/pyrimidines, medicamentous forms containing them, their application and method for their preparation
NZ332645A (en)	2000-07-28	use of a bis-indolylmaleimide derivative for treating VEGF related diseases
DE69838172D1 (de)	2007-09-13	Oxindolylchinazolinderivate als angiogenesehemmer
DE68929372D1 (de)	2002-03-21	Thieno[3,2-f] (1,2,4- triazolo)[4,3-a] 1,4- diazepinderivate als PAF-Antagonisten
UA41290C2 (uk)	2001-09-17	Гетероариламіни, фармацевтична композиція, спосіб інгібування холінестерази у ссавців, спосіб покращення пам'яті
DE69722656D1 (de)	2003-07-10	Bicyclische arylcarboxamide und ihre therapeutische verwendung
ATE80394T1 (de)	1992-09-15	6,11-dihydro-11-(4-piperidyliden)-5hbenzo(5,6>cyclohepta(1,2-b>-pyrridine und zusammensetzungen sowie verfahren zur verwendung.
NO885549D0 (no)	1988-12-14	Fremgangsmaate for fremstilling av amid-derivater.
ATE233242T1 (de)	2003-03-15	Chinoline und chinazoline verbindungen und ihre therapeutische anwendung
PT87160A (pt)	1988-05-01	Verfahren zur herstellung von 3h-1,2,3-triazolo ]4,5-d" pyrimidinen
DE69502587D1 (de)	1998-06-25	2-heteroaryl-5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e] [1,4]diazepine und ihre verwendung zur vorbeugung und behandlung von hiv-infektion
DE69116788D1 (de)	1996-03-14	4-substituierte Dihydropyrido [4,3-d] pyrimidine als Analgetika und entzündungshemmende Mittel zur topischen Anwendung bei der Behandlung von Hauterkrankungen
DE3680845D1 (de)	1991-09-19	Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
ATE102626T1 (de)	1994-03-15	Heterocyclische verbindungen, ihre darstellung und verwendung.
ATE92318T1 (de)	1993-08-15	Isolierung von castanospermin und dessen verwendung als antidiabetisches heilmittel.
FI874413A0 (fi)	1987-10-07	Foerfarande foer framstaellning av aralkyl-4h-1,2,4-triazolderivat.
FR2448542A1 (fr)	1980-09-05	Derives de triazolapyrimidine utiles comme medicaments
DK177191D0 (da)	1991-10-23	Heterocyclic compounds and their preparation and use
CA1262904C (de)	1989-11-14
ATE131482T1 (de)	1995-12-15	Pyrido(2,3-b>(1,5>-benzoxazepin (und -thiazepin)- 5(6h)-one und -thione und ihre verwendung zur vorbeugung und behandlung von hiv-infektion
MX25922A (es)	1993-10-01	Pirido (3,4-b) pirrolo (1,2-e)(1,4,5)oxadiazepinasy compuestos analogos relacionados un procedimiento para su preparacion y su uso como medicamentos
JPS6479185A (en)	1989-03-24	Thieno(triazolo)diazepine compound
GB1234635A (de)	1971-06-09
ATE118777T1 (de)	1995-03-15	5-aryl-substituierte-2,3-dihydro-imidazo(1,2- a>furo(3,2-c>- oder thieno(2,3-c>pyridine.