ATE86662T1 - Verfahren und nukleinsaeure zur herstellung von lecithin: cholestrinacyltransferase. - Google Patents

Verfahren und nukleinsaeure zur herstellung von lecithin: cholestrinacyltransferase.

Info

Publication number: ATE86662T1
Authority: AT; Austria
Prior art keywords: lecithin; acyltransferase; nucleic acid; cholesterol; cholestrinacyltransferase
Prior art date: 1985-11-08

Application number

AT86308624T

Other languages

English (en)

Inventor

Bradford Walter Baer

Dennis Theodore Drayna

Richard Mark Lawn

John William Mclean

Original Assignee

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-11-08

Filing date

1986-11-05

Publication date

1993-03-15

1986-11-05 Application filed by Genentech Inc filed Critical Genentech Inc

1993-03-15 Application granted granted Critical

1993-03-15 Publication of ATE86662T1 publication Critical patent/ATE86662T1/de

Links

IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 title abstract 4
229940067606 lecithin Drugs 0.000 title abstract 4
235000010445 lecithin Nutrition 0.000 title abstract 4
239000000787 lecithin Substances 0.000 title abstract 4
150000007523 nucleic acids Chemical class 0.000 title abstract 2
102000039446 nucleic acids Human genes 0.000 title abstract 2
108020004707 nucleic acids Proteins 0.000 title abstract 2
102000001494 Sterol O-Acyltransferase Human genes 0.000 abstract 3
108010054082 Sterol O-acyltransferase Proteins 0.000 abstract 3
102000057234 Acyl transferases Human genes 0.000 abstract 2
108700016155 Acyl transferases Proteins 0.000 abstract 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000004113 cell culture Methods 0.000 abstract 1
235000012000 cholesterol Nutrition 0.000 abstract 1
230000002708 enhancing effect Effects 0.000 abstract 1
239000013604 expression vector Substances 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/803—Physical recovery methods, e.g. chromatography, grinding

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

AT86308624T 1985-11-08 1986-11-05 Verfahren und nukleinsaeure zur herstellung von lecithin: cholestrinacyltransferase. ATE86662T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/796,473 US5049488A (en)	1985-11-08	1985-11-08	Method and nucleic acid for the preparation of lecithin:cholesterol acyltransferase
EP86308624A EP0222591B1 (de)	1985-11-08	1986-11-05	Verfahren und Nukleinsäure zur Herstellung von Lecithin: Cholestrinacyltransferase

Publications (1)

Publication Number	Publication Date
ATE86662T1 true ATE86662T1 (de)	1993-03-15

Family

ID=25168273

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86308624T ATE86662T1 (de)	1985-11-08	1986-11-05	Verfahren und nukleinsaeure zur herstellung von lecithin: cholestrinacyltransferase.

Country Status (5)

Country	Link
US (1)	US5049488A (de)
EP (1)	EP0222591B1 (de)
JP (1)	JPS62111682A (de)
AT (1)	ATE86662T1 (de)
DE (1)	DE3687948T2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2083152T3 (es) *	1990-11-30	1996-04-01	Monoclonetics Int	Metodos para el diagnostico de dolores cronicos lumbares y cervicales.
US5844097A (en) *	1990-11-30	1998-12-01	Monoclonetics International, Inc.	Methods for the diagnosis of peripheral nerve damage
WO1993000443A1 (en) *	1991-06-26	1993-01-07	Bio-Technology General Corp.	Purification of recombinant apolipoprotein e from bacteria
FR2731710B1 (fr) *	1995-03-14	1997-04-30	Rhone Poulenc Rorer Sa	Virus recombinants exprimant la lecithine cholesterol acyltransferase et utilisations en therapie genique
CA2236982C (en) *	1995-11-09	2010-07-27	The Government Of The United States Of America Represented By The Secretary Of The Department Of Health And Human Services	The use of lecithin-cholesterol acyltransferase (lcat) in the treatment of atherosclerosis
EP0973914B1 (de)	1997-04-11	2006-12-13	Takeda Pharmaceutical Company Limited	Proteine mit lecithin-cholesterin acetyltransferase-ähnlicher aktivität, deren herstellung und verwendung
CA2294793A1 (fr)	1997-06-30	1999-01-14	Rhone-Poulenc Rorer S.A.	Amelioration du transfert d'acide nucleique dans le muscle strie et combinaison permettant la mise en oeuvre du procede
KR20010020570A (ko)	1997-06-30	2001-03-15	자끄 사비나	다세포 진핵 생물 세포중으로 개선된 핵산 전달방법 및이를 위한 콤비네이션
WO2001005943A2 (en) *	1999-07-14	2001-01-25	Betagene, Inc.	Lcat recombinant cell line compositions and methods
WO2002053575A1 (en) *	2001-01-03	2002-07-11	Genaissance Pharmaceutuicals, Inc.	Drug target isogenes: polymorphisms in the lecithin-cholesterol acyltransferase gene
AU2002243902A1 (en) *	2001-02-08	2002-08-19	Millennium Pharmaceuticals, Inc.	60491, a novel human acyltransferase family member and uses thereof
US20140171365A1 (en) *	2011-03-25	2014-06-19	The Trustees Of Columbia University In The City Of New York	Pegylated human hdl particle and process for production thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4358535A (en) *	1980-12-08	1982-11-09	Board Of Regents Of The University Of Washington	Specific DNA probes in diagnostic microbiology
CA1215903A (en) *	1981-06-25	1986-12-30	Hideo Misaki	Assay method for component relating to lipids, composition for assay and process for production of enzyme used therefor
US4499184A (en) *	1982-06-01	1985-02-12	Eastman Kodak Company	Analysis for total cholesterol using lecithin:cholesterol acyl transferase (LCAT)

1985
- 1985-11-08 US US06/796,473 patent/US5049488A/en not_active Expired - Lifetime
1986
- 1986-11-05 DE DE8686308624T patent/DE3687948T2/de not_active Expired - Lifetime
- 1986-11-05 EP EP86308624A patent/EP0222591B1/de not_active Expired - Lifetime
- 1986-11-05 AT AT86308624T patent/ATE86662T1/de not_active IP Right Cessation
- 1986-11-07 JP JP61266493A patent/JPS62111682A/ja active Pending

Also Published As

Publication number	Publication date
DE3687948D1 (de)	1993-04-15
EP0222591A3 (en)	1988-09-21
JPS62111682A (ja)	1987-05-22
EP0222591B1 (de)	1993-03-10
US5049488A (en)	1991-09-17
EP0222591A2 (de)	1987-05-20
DE3687948T2 (de)	1993-06-17

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Legal Events

Date	Code	Title	Description
1993-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties