ATE117723T1 - Saurer fibroblast-wachstumsfaktor-mutant. - Google Patents

Saurer fibroblast-wachstumsfaktor-mutant.

Info

Publication number: ATE117723T1
Authority: AT; Austria
Prior art keywords: bovine; mutant; afgf; human; growth factor
Prior art date: 1987-10-22

Application number

AT88202306T

Other languages

English (en)

Inventor

Jnr Kenneth A Thomas

David L Linemeyer

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-22

Filing date

1988-10-14

Publication date

1995-02-15

1988-10-14 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1995-02-15 Application granted granted Critical

1995-02-15 Publication of ATE117723T1 publication Critical patent/ATE117723T1/de

Links

108090000386 Fibroblast Growth Factor 1 Proteins 0.000 title abstract 2
102000003971 Fibroblast Growth Factor 1 Human genes 0.000 title 1
108090000623 proteins and genes Proteins 0.000 abstract 4
241000283690 Bos taurus Species 0.000 abstract 3
101000846416 Homo sapiens Fibroblast growth factor 1 Proteins 0.000 abstract 2
101000846393 Bos taurus Fibroblast growth factor 1 Proteins 0.000 abstract 1
102100031706 Fibroblast growth factor 1 Human genes 0.000 abstract 1
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
230000004071 biological effect Effects 0.000 abstract 1
239000013604 expression vector Substances 0.000 abstract 1
229960002897 heparin Drugs 0.000 abstract 1
229920000669 heparin Polymers 0.000 abstract 1
230000035772 mutation Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Medicinal Chemistry (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Biochemistry (AREA)
Plant Pathology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Physics & Mathematics (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
Hematology (AREA)
Toxicology (AREA)
Diabetes (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT88202306T 1987-10-22 1988-10-14 Saurer fibroblast-wachstumsfaktor-mutant. ATE117723T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US11260087A	1987-10-22	1987-10-22
US24443188A	1988-09-16	1988-09-16

Publications (1)

Publication Number	Publication Date
ATE117723T1 true ATE117723T1 (de)	1995-02-15

Family

ID=26810140

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88202306T ATE117723T1 (de)	1987-10-22	1988-10-14	Saurer fibroblast-wachstumsfaktor-mutant.

Country Status (13)

Country	Link
EP (1)	EP0319052B1 (de)
JP (1)	JPH082309B2 (de)
KR (1)	KR970009340B1 (de)
AT (1)	ATE117723T1 (de)
AU (1)	AU623351B2 (de)
CA (1)	CA1340363C (de)
DE (1)	DE3852870T2 (de)
DK (1)	DK174961B1 (de)
ES (1)	ES2070125T3 (de)
IE (1)	IE65360B1 (de)
IL (1)	IL88034A (de)
NZ (1)	NZ226543A (de)
PT (1)	PT88824B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0392605A1 (de) *	1989-04-13	1990-10-17	Merck & Co. Inc.	Methode zur Steigerung der Expression des sauren Fibroblast-Wachstumsfaktors
EP0406738A3 (en) *	1989-07-03	1991-08-14	Takeda Chemical Industries, Ltd.	Production of acidic fgf protein
CA2020720A1 (en) *	1989-07-13	1991-01-14	Shigeko Yamazaki	Method for the purification of therapeutically active recombinant acidic fibroblast growth factor
US5126323A (en) *	1989-11-16	1992-06-30	Genetics Institute, Inc.	Homogeneous purified k-fgf and compositions containing the same
JPH06503962A (ja) *	1990-12-18	1994-05-12	アムジエン・インコーポレーテツド	増強された安定性及び生物学的活性を有する酸性線維芽細胞成長因子の類似体
US5348941A (en) *	1992-04-01	1994-09-20	Merck & Co., Inc.	Stabilizers for fibroblast growth factors
US6743422B1 (en)	1996-10-15	2004-06-01	Amgen, Inc.	Keratinocyte growth factor-2 products
JP4088111B2 (ja) *	2002-06-28	2008-05-21	日立電線株式会社	多孔質基板とその製造方法、ＧａＮ系半導体積層基板とその製造方法
JP5401312B2 (ja) *	2007-06-29	2014-01-29	第一三共株式会社	組換えＣ−末端α−アミド化酵素誘導体
PL221356B1 (pl) *	2012-04-21	2016-03-31	Wrocławskie Ct Badań Eit & Spółka Z Ograniczoną Odpowiedzialności	Zmodyfikowany genetycznie, rekombinowany czynnik wzrostu fibroblastów (FGF1) skoniugowany z nanocząsteczkami metalu lub tlenku metalu, jego sekwencja DNA i aminokwasowa oraz zastosowanie
CH717226B1 (it) *	2020-07-14	2021-09-30	Contrad Swiss Sa	Idrogel per applicazione topica efficace nel limitare la degenerazione di tendini e muscoli.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL90047A (en) *	1982-10-19	1992-12-01	Cetus Oncology Corp	Cysteine-depleted biologically active muteins other than interferon - '
US4711848A (en) *	1984-03-14	1987-12-08	Zymogenetics, Inc.	Site specific mutagenesis in alpha-1-antitrypsin
EP0248819B2 (de) *	1985-09-12	2000-08-30	Scios Inc.	Rekombinanter fibroblast-wachstumsfaktor
US4868113A (en) *	1986-03-03	1989-09-19	Rorer Biotechnology, Inc.	Recombinant DNA vector encoding human endothelial cell growth factor

1988
- 1988-10-12 NZ NZ226543A patent/NZ226543A/en unknown
- 1988-10-13 IL IL8803488A patent/IL88034A/en active Protection Beyond IP Right Term
- 1988-10-14 ES ES88202306T patent/ES2070125T3/es not_active Expired - Lifetime
- 1988-10-14 DE DE3852870T patent/DE3852870T2/de not_active Expired - Lifetime
- 1988-10-14 AT AT88202306T patent/ATE117723T1/de not_active IP Right Cessation
- 1988-10-14 EP EP88202306A patent/EP0319052B1/de not_active Expired - Lifetime
- 1988-10-21 IE IE318888A patent/IE65360B1/en not_active IP Right Cessation
- 1988-10-21 DK DK198805874A patent/DK174961B1/da not_active IP Right Cessation
- 1988-10-21 AU AU24305/88A patent/AU623351B2/en not_active Expired
- 1988-10-21 CA CA000580927A patent/CA1340363C/en not_active Expired - Fee Related
- 1988-10-21 KR KR88013730A patent/KR970009340B1/ko not_active Expired - Lifetime
- 1988-10-21 JP JP63264261A patent/JPH082309B2/ja not_active Expired - Lifetime
- 1988-10-21 PT PT88824A patent/PT88824B/pt not_active IP Right Cessation

Also Published As

Publication number	Publication date
JPH082309B2 (ja)	1996-01-17
KR890006815A (ko)	1989-06-16
EP0319052B1 (de)	1995-01-25
IE883188L (en)	1989-04-22
AU2430588A (en)	1989-04-27
EP0319052A2 (de)	1989-06-07
DK174961B1 (da)	2004-03-29
DK587488D0 (da)	1988-10-21
IL88034A0 (en)	1989-06-30
PT88824B (pt)	1993-04-30
AU623351B2 (en)	1992-05-14
KR970009340B1 (en)	1997-06-10
DE3852870D1 (de)	1995-03-09
DE3852870T2 (de)	1995-08-17
DK587488A (da)	1989-06-06
CA1340363C (en)	1999-02-02
ES2070125T3 (es)	1995-06-01
EP0319052A3 (en)	1990-04-25
NZ226543A (en)	1992-02-25
JPH02484A (ja)	1990-01-05
IE65360B1 (en)	1995-10-18
IL88034A (en)	1994-06-24

Legal Events

Date	Code	Title	Description
1995-06-15	UEP	Publication of translation of european patent specification
2009-01-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE284954T1 (de)	2005-01-15	Hyaluronan synthase gen und seine verwendung
ES8306324A1 (es)	1983-06-01	"proceso para la produccion microbiana de interferon fibroblasto humano".
ATE105869T1 (de)	1994-06-15	Formen des koloniestimulierungsfaktors 1.
DZ467A1 (fr)	2004-09-13	Interferon immunitaire urbain.
DE3750056D1 (de)	1994-07-21	Polypeptid-Mutanten des menschlichen TNF und für diese Mutanten codierende DNS.
SE9102079L (sv)	1991-07-03	Renad ciliaer neurotropisk faktor
NO981044D0 (no)	1998-03-10	Sirkulært DNA-molekyl med kondisjonell replikasjonsopprinnelse, dets fremstilling og anvendelse derav i genterapi
DK129385D0 (da)	1985-03-22	Peptider og fremstilling deraf
ATE69466T1 (de)	1991-11-15	Superoxyddismutase.
DE3852870D1 (de)	1995-03-09	Saurer Fibroblast-Wachstumsfaktor-Mutant.
ATE391175T1 (de)	2008-04-15	Multidrug resistenz gen
ATE79403T1 (de)	1992-08-15	Herstellung von thrombin-inhibitoren.
DE3688900D1 (de)	1993-09-23	Expression von protein c.
NL300046I1 (nl)	2001-09-03	Eiwit met uraat oxidase activiteit, recombinant gen dat hiervoor codeert, expressievector, micro-organismen en getransformeerde cellen.
DK619086D0 (da)	1986-12-19	Gm-csf-protein, derivater deraf, samt fremstilling og anvendelse af saadanne proteiner
IE871871L (en)	1988-01-11	Cloning and expression of acidic fibroblast growth factor
ES2076152T3 (es)	1995-11-01	Definicion y estructura de genes para proteasa a y proteasa b procedente de streptomices griseus.
DE3850774D1 (de)	1994-08-25	Rinder-interleukin-1-alpha.
NO177570B (no)	1995-07-03	Fremgangsmåte ved fremstilling av peptider med fibronektinbindende egenskaper, mikroorganisme og DNA-sekvens som koder for peptider med fibronektinbindende egenskaper
ATE194624T1 (de)	2000-07-15	Mutanten von menschlichem antithrombin iii
EP0302838A3 (en)	1989-11-08	Cloning of the gene coding the isoamylase enzyme and its use in the production of said enzyme
ATE91717T1 (de)	1993-08-15	Verfahren zur herstellung von proteinen in loeslicher form.
EP0422217A4 (en)	1992-08-19	Human recombinant placental ribonuclease inhibitor and method of production
DE3586580D1 (de)	1992-10-08	Zur wirksamen gen-expression faehiger vektor und verwendung desselben.
MY103637A (en)	1993-08-28	Neutrophil-activating factor