ATE87209T1 - Verwendung von adenosin-derivaten als antidementia-mittel. - Google Patents

Verwendung von adenosin-derivaten als antidementia-mittel.

Info

Publication number: ATE87209T1
Authority: AT; Austria
Prior art keywords: antidementia agent; agent; dementia; adenosin; derivatives
Prior art date: 1986-04-25

Application number

AT87105843T

Other languages

English (en)

Inventor

Masayoshi Goto

Nobutaka Demura

Tsutomu Osaki

Original Assignee

Hoechst Japan

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-04-25

Filing date

1987-04-21

Publication date

1993-04-15

1987-04-21 Application filed by Hoechst Japan filed Critical Hoechst Japan

1993-04-15 Application granted granted Critical

1993-04-15 Publication of ATE87209T1 publication Critical patent/ATE87209T1/de

Links

229940125682 antidementia agent Drugs 0.000 title abstract 3
239000002664 nootropic agent Substances 0.000 title abstract 3
OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical class C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title 1
150000003835 adenosine derivatives Chemical class 0.000 abstract 2
BIXYYZIIJIXVFW-UUOKFMHZSA-N (2R,3R,4S,5R)-2-(6-amino-2-chloro-9-purinyl)-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O BIXYYZIIJIXVFW-UUOKFMHZSA-N 0.000 abstract 1
208000024827 Alzheimer disease Diseases 0.000 abstract 1
206010012289 Dementia Diseases 0.000 abstract 1
206010039966 Senile dementia Diseases 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
125000003917 carbamoyl group Chemical class [H]N([H])C(*)=O 0.000 abstract 1
MWEQTWJABOLLOS-UHFFFAOYSA-L disodium;[[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-oxidophosphoryl] hydrogen phosphate;trihydrate Chemical compound O.O.O.[Na+].[Na+].C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)C(O)C1O MWEQTWJABOLLOS-UHFFFAOYSA-L 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT87105843T 1986-04-25 1987-04-21 Verwendung von adenosin-derivaten als antidementia-mittel. ATE87209T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP61094738A JPH0696534B2 (ja)	1986-04-25	1986-04-25	抗痴呆剤
EP87105843A EP0253962B1 (de)	1986-04-25	1987-04-21	Verwendung von Adenosin-Derivaten als Anti-Dementia-Mittel

Publications (1)

Publication Number	Publication Date
ATE87209T1 true ATE87209T1 (de)	1993-04-15

Family

ID=14118453

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87105843T ATE87209T1 (de)	1986-04-25	1987-04-21	Verwendung von adenosin-derivaten als antidementia-mittel.

Country Status (12)

Country	Link
US (1)	US5023244A (de)
EP (1)	EP0253962B1 (de)
JP (1)	JPH0696534B2 (de)
AT (1)	ATE87209T1 (de)
AU (1)	AU610822B2 (de)
CA (1)	CA1287298C (de)
DE (1)	DE3784977T2 (de)
DK (1)	DK169656B1 (de)
IE (1)	IE60886B1 (de)
IL (1)	IL82298A0 (de)
PT (1)	PT84765B (de)
ZA (1)	ZA872879B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4843066A (en) *	1986-11-27	1989-06-27	Nippon Zoki Pharmaceutical Co., Ltd.	Novel adenosine derivatives and pharmaceutical composition containing them as an active ingredient
CA2049977A1 (en) *	1989-03-24	1990-09-25	Hirofumi Kitaoka	Nootropic agent
US5206222A (en) *	1991-05-22	1993-04-27	Vanderbilt University	Methods for the reduction of myocardial reperfusion injury
US5432164A (en) *	1991-10-24	1995-07-11	Novo Nordisk A/S	C2,N6 -disubstituted adenosine derivatives
FR2685918B1 (fr) *	1992-01-08	1995-06-23	Union Pharma Scient Appl	Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant.
FR2687678B1 (fr) *	1992-01-31	1995-03-31	Union Pharma Scient Appl	Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant.
DK62692D0 (de) *	1992-05-14	1992-05-14	Novo Nordisk As
DK62592D0 (de) *	1992-05-14	1992-05-14	Novo Nordisk As
US5589467A (en) *	1993-09-17	1996-12-31	Novo Nordisk A/S	2,5',N6-trisubstituted adenosine derivatives
YU44900A (sh)	1998-01-31	2003-01-31	Glaxo Group Limited	Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola
JP3933870B2 (ja)	1998-06-23	2007-06-20	グラクソグループリミテッド	２−（プリン−９−イル）−テトラヒドロフラン−３，４−ジオール誘導体
ES2385931T3 (es)	2000-07-07	2012-08-03	Spectrum Pharmaceuticals, Inc.	MÉTODOS PARA EL TRATAMIENTO DE NEUROPATíA PERIFÉRICA INDUCIDA POR UNA ENFERMEDAD Y AFECCIONES RELACIONADAS.
US6759427B2 (en) *	2001-04-20	2004-07-06	Spectrum Pharmaceuticals, Inc.	Synthesis and methods of use of tetrahydroindolone analogues and derivatives
US20030069203A1 (en) *	2001-06-04	2003-04-10	Lee Steve S.	Method for increasing human performance by reducing muscle fatigue and recovery time through oral administration of adenosine triphosphate
US7629329B2 (en) *	2001-06-04	2009-12-08	Tsi Health Sciences, Inc.	Method for increasing muscle mass and strength through administration of adenosine triphosphate
US20030055249A1 (en) *	2001-07-17	2003-03-20	Fick David B.	Synthesis and methods of use of pyrimidine analogues and derivatives
PE20060272A1 (es)	2004-05-24	2006-05-22	Glaxo Group Ltd	(2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a
GB0514809D0 (en)	2005-07-19	2005-08-24	Glaxo Group Ltd	Compounds
IT202300022302A1 (it) *	2023-10-24	2025-04-24	Univ Degli Studi Di Roma “La Sapienza”	Trattamento di malattie degenerative neuromuscolari

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4224438A (en) *	1970-07-14	1980-09-23	Boehringer Mannheim Gmbh	Adenosine-5'-carboxylic acid amides
US4029884A (en) *	1971-03-18	1977-06-14	Abbott Laboratories	Adenosine-5'-carboxylic acid amides
US3864483A (en) *	1972-03-22	1975-02-04	Abbott Lab	Adenosine-5{40 -carboxylic acid amides
US3992531A (en) *	1973-12-26	1976-11-16	Abbott Laboratories	2-Substituted adenosine-5'-carboxylates in the treatment of anginal pain
LU73052A1 (de) *	1975-07-24	1977-03-24
DE2610985A1 (de) *	1976-03-16	1977-09-29	Byk Gulden Lomberg Chem Fab	Arzneimittel enthaltend beta-d-1 (6-amino-9h-purin-9-yl)-1-deoxyribofuranuronsaeurederivate
LU75374A1 (de) *	1976-07-13	1978-02-08
US4167565A (en) *	1976-11-08	1979-09-11	Abbott Laboratories	Adenosine-5'-carboxamides and method of use

1986
- 1986-04-25 JP JP61094738A patent/JPH0696534B2/ja not_active Expired - Lifetime
1987
- 1987-04-21 DE DE8787105843T patent/DE3784977T2/de not_active Expired - Lifetime
- 1987-04-21 AT AT87105843T patent/ATE87209T1/de not_active IP Right Cessation
- 1987-04-21 EP EP87105843A patent/EP0253962B1/de not_active Expired - Lifetime
- 1987-04-22 IL IL82298A patent/IL82298A0/xx not_active IP Right Cessation
- 1987-04-23 ZA ZA872879A patent/ZA872879B/xx unknown
- 1987-04-24 AU AU71946/87A patent/AU610822B2/en not_active Expired
- 1987-04-24 PT PT84765A patent/PT84765B/pt unknown
- 1987-04-24 IE IE106987A patent/IE60886B1/en not_active IP Right Cessation
- 1987-04-24 DK DK209187A patent/DK169656B1/da not_active IP Right Cessation
- 1987-04-24 CA CA000535565A patent/CA1287298C/en not_active Expired - Lifetime
1989
- 1989-09-15 US US07/407,696 patent/US5023244A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
PT84765A (en)	1987-05-01
US5023244A (en)	1991-06-11
CA1287298C (en)	1991-08-06
PT84765B (pt)	1989-12-29
DK209187D0 (da)	1987-04-24
IE871069L (en)	1987-10-25
ZA872879B (en)	1987-11-25
DK169656B1 (da)	1995-01-09
EP0253962A2 (de)	1988-01-27
IL82298A0 (en)	1987-10-30
EP0253962A3 (en)	1988-11-30
DE3784977D1 (de)	1993-04-29
IE60886B1 (en)	1994-08-24
AU7194687A (en)	1987-10-29
EP0253962B1 (de)	1993-03-24
JPH0696534B2 (ja)	1994-11-30
JPS62252726A (ja)	1987-11-04
DK209187A (da)	1987-10-26
AU610822B2 (en)	1991-05-30
DE3784977T2 (de)	1993-08-05

Legal Events

Date	Code	Title	Description
1993-10-15	UEP	Publication of translation of european patent specification
2007-07-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE87209T1 (de)	1993-04-15	Verwendung von adenosin-derivaten als antidementia-mittel.
DK172089D0 (da)	1989-04-10	1,3-dioxolanderivater samt fremgangsmaade til fremstilling deraf
FI882369A7 (fi)	1988-05-19	Menetelmä lääkeaineena käyttökelpoisten piperidiinijohdannaisten valmistamiseksi
DK11992D0 (da)	1992-01-31	Epipodophyllotoxinglycosid-4'-phosphatderivater, deres fremstilling og anvendelse
DE68901043D1 (de)	1992-04-30	Waessriges pharmazeutisches praeparat.
IT8720059A0 (it)	1987-04-10	Process per la preparazione di (2,2)-paraciclofano e suoi derivati.
IT8620938A0 (it)	1986-06-27	Processo per la preparazione di (2,2)-paraciclofano e suoi derivati,
ATE109783T1 (de)	1994-08-15	23-oxo(keto) und 23-imino-derivate von ll-f28249- verbindungen.
DE3889302D1 (de)	1994-06-01	9-(Acylamino)tetrahydroacridinderivate und wahrnehmungssteigernde Mittel davon als aktiver Wirkstoff.
FI895447A7 (fi)	1989-11-15	Substituoidut terapeuttisina aineina käytettävät adeniinijohdannaiset
NO912545L (no)	1991-12-30	Nye 3,3'-ditiobis(propionsyrer) og estere derav samt fremgangsmaate for deres fremstilling
IL84894A0 (en)	1988-06-30	Resolution of 1,4-dihydropyridine derivatives and optically active derivative salts of such derivatives
FI886057L (fi)	1989-07-01	Menetelmä farmaseuttisten piperidiinijohdannaisten valmistamiseksi
DK191988D0 (da)	1988-04-08	Pyrrolidin-2-(1,3-dicarbonyl)-derivater, deres fresmtilling og anvendelse
DE68927651D1 (de)	1997-02-27	Derivate von Fluorphosphonat-Nukleotiden
PT87550A (pt)	1989-05-31	Process for the preparation of pyrimidine derivatives and of pharmaceutical compositions containing the same
ATE111104T1 (de)	1994-09-15	Nukleosid-derivate.
PT87705A (pt)	1988-07-01	Process for the preparation of 6-deoxy guanine derivative
DK587689A (da)	1990-05-24	2-azabicyclo(2,2,1)hept-5-en-2-eddikesyre og derivater deraf, deres fremstilling og anvendelse
NO903338L (no)	1991-01-29	Fremgangsmaate for mikrobiologisk fremstilling av l-carnitin.
FI884461A7 (fi)	1989-04-30	Menetelmä trans-1,1,2-trifenyylibut-1-eenijohdannaisten valmistamiseksi
FI890864A0 (fi)	1989-02-23	Anvaendning av 1,4-dihydropyridinderivat.
IT8722407A0 (it)	1987-10-23	Derivati dell'efedrina esterificata aventi attivita' antiulcera prolungata nel tempo.
MX15990A (es)	1993-09-01	Derivados de acido 3-pirrolidiniltio-1- azabiciclo(3.2.0)hept-2-eno-2-carboxilico, su obtencion y usos.
DK37787A (da)	1987-07-25	2,3-dioxabicyclooe3,3,0aaoctan-derivater og deres anvendelse som laegemidler