ATE87621T1 - Antikrebs-chinazolinon-derivate. - Google Patents

Antikrebs-chinazolinon-derivate.

Info

Publication number: ATE87621T1
Authority: AT; Austria
Prior art keywords: group; heteroatom; cancer; quinazolinone derivatives; halogeno
Prior art date: 1985-05-31

Application number

AT86304148T

Other languages

English (en)

Inventor

Terence Richard Jones

Ann Lesley Jackman

David Richard Newell

Original Assignee

British Tech Group

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-05-31

Filing date

1986-05-30

Publication date

1993-04-15

1986-05-30 Application filed by British Tech Group filed Critical British Tech Group

1993-04-15 Application granted granted Critical

1993-04-15 Publication of ATE87621T1 publication Critical patent/ATE87621T1/de

Links

AVRPFRMDMNDIDH-UHFFFAOYSA-N 1h-quinazolin-2-one Chemical class C1=CC=CC2=NC(O)=NC=C21 AVRPFRMDMNDIDH-UHFFFAOYSA-N 0.000 title 1
230000001093 anti-cancer Effects 0.000 title 1
125000005842 heteroatom Chemical group 0.000 abstract 5
125000001183 hydrocarbyl group Chemical group 0.000 abstract 3
125000005843 halogen group Chemical group 0.000 abstract 2
229920006395 saturated elastomer Polymers 0.000 abstract 2
229930195734 saturated hydrocarbon Natural products 0.000 abstract 2
229930195735 unsaturated hydrocarbon Natural products 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000002837 carbocyclic group Chemical group 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT86304148T 1985-05-31 1986-05-30 Antikrebs-chinazolinon-derivate. ATE87621T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB858513754A GB8513754D0 (en)	1985-05-31	1985-05-31	Anti-cancer quinazoline derivatives
EP86304148A EP0204529B1 (de)	1985-05-31	1986-05-30	Antikrebs-Chinazolinon-Derivate

Publications (1)

Publication Number	Publication Date
ATE87621T1 true ATE87621T1 (de)	1993-04-15

Family

ID=10579966

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86304148T ATE87621T1 (de)	1985-05-31	1986-05-30	Antikrebs-chinazolinon-derivate.

Country Status (17)

Country	Link
US (1)	US5236927A (de)
EP (1)	EP0204529B1 (de)
JP (1)	JPS61282368A (de)
AT (1)	ATE87621T1 (de)
AU (1)	AU592271B2 (de)
DE (1)	DE3688150T2 (de)
DK (1)	DK255786A (de)
ES (1)	ES8800911A1 (de)
FI (1)	FI862303A7 (de)
GB (2)	GB8513754D0 (de)
GR (1)	GR861418B (de)
HU (1)	HUT45512A (de)
IL (1)	IL78910A0 (de)
NO (1)	NO862170L (de)
NZ (1)	NZ216363A (de)
PT (1)	PT82682B (de)
ZA (1)	ZA864051B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8607683D0 (en) *	1986-03-27	1986-04-30	Ici Plc	Anti-tumor agents
GB8707053D0 (en) *	1987-03-25	1987-04-29	Ici Plc	Anti-tumour agents
US4857530A (en) *	1987-11-03	1989-08-15	Warner-Lambert Company	Substituted quinazolinones as anticancer agents
GB8809978D0 (en) *	1988-04-27	1988-06-02	Ici Plc	Anti-tumour agents
EP0365763A1 (de) *	1988-09-30	1990-05-02	Agouron Pharmaceuticals, Inc.	Zyklische Verbindungen als Antiproleferahne
US5286726A (en) *	1990-04-12	1994-02-15	The Regents Of The University Of Michigan	Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
GB9013615D0 (en) *	1990-06-19	1990-08-08	Wellcome Found	Pharmaceutical compounds
US6762188B1 (en)	1990-06-19	2004-07-13	Smithkline Beecham Corporation	Pharmaceutically active benzoquinazoline compounds
GB9105771D0 (en) *	1991-03-19	1991-05-01	Cancer Res Inst Royal	Anti-cancer compounds
GB9205320D0 (en) *	1992-03-11	1992-04-22	Ici Plc	Anti-tumour compounds
GB9205907D0 (en) *	1992-03-18	1992-04-29	Cancer Res Inst Royal	Anti-cancer compounds
US5430148A (en) *	1992-03-31	1995-07-04	Agouron Pharmaceuticals, Inc.	Antiproliferative quinazolines
GB9223352D0 (en) *	1992-11-06	1992-12-23	Ici Plc	Tricyclic compounds
US7262058B2 (en) *	2001-03-09	2007-08-28	Nonda Katopodis	Method for determining lipid associated sialoprotein in body fluids
US20060047952A1 (en) *	2002-10-18	2006-03-02	Koninklijke Philips Electronics, N.V.	Method, system, device , signal and computer program product for metadata protection in tv-anytime
WO2004041755A2 (en) *	2002-11-04	2004-05-21	Nps Pharmaceuticals, Inc.	Quinazolinone compounds as calcilytics
WO2007011618A1 (en) *	2005-07-15	2007-01-25	Schering Corporation	Quinazoline derivatives useful in cancer treatment
CN101263125A (zh) *	2005-07-15	2008-09-10	先灵公司	用于癌症治疗的喹唑啉衍生物
CA2663436A1 (en)	2006-10-04	2008-04-10	Pfizer Products Inc.	Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists
TWI469971B (zh)	2007-10-26	2015-01-21	Univ California	二芳基乙內醯脲類化合物
PT2445502T (pt)	2009-06-25	2017-09-22	Alkermes Pharma Ireland Ltd	Compostos heterocíclicos para o tratamento de distúrbios neurológicos e psicológicos
EP2521711B1 (de) *	2010-01-07	2017-08-16	Alkermes Pharma Ireland Limited	Quartäre ammoniumsalz-prodrugs
NZ604423A (en)	2010-06-24	2015-01-30	Alkermes Pharma Ireland Ltd	Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives
ES2972387T3 (es)	2011-03-18	2024-06-12	Alkermes Pharma Ireland Ltd	Composiciones farmacéuticas que comprenden ésteres de sorbitán
CA2867121C (en)	2012-03-19	2021-05-25	Alkermes Pharma Ireland Limited	Pharmaceutical compositions comprising fatty acid esters
WO2013142202A1 (en)	2012-03-19	2013-09-26	Alkermes Pharma Ireland Limited	Pharmaceutical compositions comprising glycerol esters
US9999670B2 (en)	2012-03-19	2018-06-19	Alkermes Pharma Ireland Limited	Pharmaceutical compositions comprising benzyl alcohol
JP6654042B2 (ja)	2012-09-19	2020-02-26	アルカームスファーマアイルランドリミテッド	貯蔵安定性が改善された医薬組成物
AU2015231278B2 (en)	2014-03-20	2020-01-23	Alkermes Pharma Ireland Limited	Aripiprazole formulations having increased injection speeds
AU2019230014B2 (en)	2018-03-05	2024-11-28	Alkermes Pharma Ireland Limited	Aripiprazole dosing strategy
WO2024028999A1 (ja) *	2022-08-03	2024-02-08	Ils株式会社	Ｎ－［４－メチルアミノベンゾイル］－ｌ－グルタミン酸ジエチルエステルの製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1021196A (en) *	1964-02-20	1966-03-02	Parke Davis & Co	Novel amino acids and means for producing the same
US3471498A (en) *	1967-08-11	1969-10-07	Parke Davis & Co	Certain n-p-((2,4-diamino-6-quinazolinyl)-methyl)benzoylamino acids
EP0031237B1 (de) *	1979-12-19	1984-10-17	National Research Development Corporation	Chinazolinderivate, Verfahren zu ihrer Herstellung, sie enthaltende Zusammensetzungen und ihre Verwendung als Anti-Krebs-Mittel
GB8607683D0 (en) *	1986-03-27	1986-04-30	Ici Plc	Anti-tumor agents

1985
- 1985-05-31 GB GB858513754A patent/GB8513754D0/en active Pending
1986
- 1986-05-26 IL IL78910A patent/IL78910A0/xx unknown
- 1986-05-30 AT AT86304148T patent/ATE87621T1/de not_active IP Right Cessation
- 1986-05-30 ES ES555548A patent/ES8800911A1/es not_active Expired
- 1986-05-30 AU AU58220/86A patent/AU592271B2/en not_active Ceased
- 1986-05-30 NZ NZ216363A patent/NZ216363A/xx unknown
- 1986-05-30 EP EP86304148A patent/EP0204529B1/de not_active Expired - Lifetime
- 1986-05-30 JP JP61125587A patent/JPS61282368A/ja active Pending
- 1986-05-30 HU HU862288A patent/HUT45512A/hu unknown
- 1986-05-30 GB GB08613184A patent/GB2175903B/en not_active Expired
- 1986-05-30 FI FI862303A patent/FI862303A7/fi not_active Application Discontinuation
- 1986-05-30 NO NO862170A patent/NO862170L/no unknown
- 1986-05-30 PT PT82682A patent/PT82682B/pt not_active IP Right Cessation
- 1986-05-30 GR GR861418A patent/GR861418B/el unknown
- 1986-05-30 ZA ZA864051A patent/ZA864051B/xx unknown
- 1986-05-30 DE DE8686304148T patent/DE3688150T2/de not_active Expired - Fee Related
- 1986-05-30 DK DK255786A patent/DK255786A/da not_active Application Discontinuation
1990
- 1990-12-12 US US07/625,695 patent/US5236927A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
GB8513754D0 (en)	1985-07-03
GB8613184D0 (en)	1986-07-02
ES555548A0 (es)	1987-12-01
NO862170L (no)	1986-12-01
US5236927A (en)	1993-08-17
DE3688150D1 (de)	1993-05-06
DE3688150T2 (de)	1993-07-29
AU5822086A (en)	1986-12-04
HUT45512A (en)	1988-07-28
EP0204529B1 (de)	1993-03-31
NZ216363A (en)	1989-07-27
AU592271B2 (en)	1990-01-04
FI862303A0 (fi)	1986-05-30
PT82682B (pt)	1988-03-03
IL78910A0 (en)	1986-09-30
DK255786D0 (da)	1986-05-30
ZA864051B (en)	1987-01-28
ES8800911A1 (es)	1987-12-01
FI862303A7 (fi)	1986-12-01
DK255786A (da)	1986-12-01
GB2175903A (en)	1986-12-10
JPS61282368A (ja)	1986-12-12
PT82682A (en)	1986-06-01
GR861418B (en)	1986-09-26
EP0204529A3 (en)	1987-11-19
GB2175903B (en)	1988-10-12
EP0204529A2 (de)	1986-12-10

Legal Events

Date	Code	Title	Description
1993-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE3688150D1 (de)	1993-05-06	Antikrebs-chinazolinon-derivate.
MX166257B (es)	1992-12-24	Composicion de revestimiento que contiene grupos de carbamato de hidroxialquilo
ES2066991T3 (es)	1995-03-16	Agentes hipoglucemiantes de oxazolidinadiona.
ES2036551T3 (es)	1996-07-16	Compuestos heterociclicos.
DK345989A (da)	1990-01-13	Quinolinderivater
AR247744A1 (es)	1995-03-31	Compuestos organosilano y catalizadores que contienen dichos compuestos
ES2055384T3 (es)	1994-08-16	Compuestos dioxafosforinanos y composiciones poliolefinicas estabilizadas con ellos.
ATE69050T1 (de)	1991-11-15	Organische verbindungen und ihre pharmazeutische verwendung.
ATE50773T1 (de)	1990-03-15	Alkylresorcinolphosphite.
MX170732B (es)	1993-09-10	Composicion de derivados de succinimida y su uso
ATE38675T1 (de)	1988-12-15	Phosphatesterderivate und ihre verwendung als anti-krebsmittel.
KR850002979A (ko)	1985-05-28	1,2,3-트리티안화합물의 신규 제조방법
DE3688128D1 (de)	1993-04-29	Isoindolinderivate und verfahren zu ihrer herstellung.
ATE65986T1 (de)	1991-08-15	Propanolabkoemmlinge.
ES2019633B3 (es)	1991-07-01	Compuestos de azaantraceno.
SU1241688A1 (ru)	1999-05-27	C,n-фосфорилированные имидаты, обладающие противочумной активностью