ATE87623T1 - 6-epifumagillole, ihre herstellung und ihre verwendung. - Google Patents

6-epifumagillole, ihre herstellung und ihre verwendung.

Info

Publication number
ATE87623T1
ATE87623T1 AT90104177T AT90104177T ATE87623T1 AT E87623 T1 ATE87623 T1 AT E87623T1 AT 90104177 T AT90104177 T AT 90104177T AT 90104177 T AT90104177 T AT 90104177T AT E87623 T1 ATE87623 T1 AT E87623T1
Authority
AT
Austria
Prior art keywords
inhibiting activity
compound
optionally substituted
group
epifumagillols
Prior art date
Application number
AT90104177T
Other languages
English (en)
Inventor
Shoji Kishimoto
Takeshi Fujita
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ATE87623T1 publication Critical patent/ATE87623T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
AT90104177T 1989-03-06 1990-03-03 6-epifumagillole, ihre herstellung und ihre verwendung. ATE87623T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP5353689 1989-03-06
EP90104177A EP0387650B1 (de) 1989-03-06 1990-03-03 6-Epifumagillole, ihre Herstellung und ihre Verwendung

Publications (1)

Publication Number Publication Date
ATE87623T1 true ATE87623T1 (de) 1993-04-15

Family

ID=12945529

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90104177T ATE87623T1 (de) 1989-03-06 1990-03-03 6-epifumagillole, ihre herstellung und ihre verwendung.

Country Status (5)

Country Link
US (1) US5204345A (de)
EP (1) EP0387650B1 (de)
AT (1) ATE87623T1 (de)
CA (1) CA2011449C (de)
DE (1) DE69001187T2 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH26256A (en) * 1988-08-12 1992-04-01 Fujisawa Pharmaceutical Co Oxaspiro [2,5] octane derivative
EP1004318A3 (de) * 1991-06-21 2002-08-07 Takeda Chemical Industries, Ltd. Zyklodextrin-zusammensetzung
DE69311278T2 (de) * 1992-12-16 1997-10-30 Takeda Chemical Industries Ltd Stabile pharmazeutische Zubereitung mit Fumagillolderivaten
US5710148A (en) * 1995-03-06 1998-01-20 Senju Pharmaceuticals Co., Ltd. Corneal opacification inhibitory composition
FR2733498B1 (fr) * 1995-04-27 1997-05-30 Adir Nouveaux composes cyclohexaniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA2210600A1 (en) * 1996-07-17 1998-01-17 Takashi Houkan Inhibitor of tumor metastasis or recurrence
US6207704B1 (en) 1997-06-09 2001-03-27 Massachusetts Institute Of Technology Type 2 methionine aminopeptidase [MetAP2] inhibitors and uses thereof
WO1999061432A1 (en) * 1998-05-12 1999-12-02 Biochem Pharma Inc. Fumagillin analogs and their use as angiogenesis inhibitors
PL366216A1 (en) 2000-11-01 2005-01-24 Praecis Pharmaceuticals Inc. Therapeutic agents and methods of use thereof for the modulation of angiogenesis
US6548477B1 (en) 2000-11-01 2003-04-15 Praecis Pharmaceuticals Inc. Therapeutic agents and methods of use thereof for the modulation of angiogenesis
US20070161570A1 (en) * 2000-11-01 2007-07-12 Praecis Pharmaceuticals, Inc. Methionine aminopeptidase-2 inhibitors and methods of use thereof
US6919307B2 (en) 2000-11-01 2005-07-19 Praecis Pharmaceuticals, Inc. Therapeutic agents and methods of use thereof for the modulation of angiogenesis
US7105482B2 (en) 2000-11-01 2006-09-12 Praecis Pharmaceuticals, Inc. Methionine aminopeptidase-2 inhibitors and methods of use thereof
EP1436286B1 (de) * 2001-09-27 2009-08-19 Equispharm Co., Ltd. Fumagillolderivate und verfahren zu deren herstellung
KR100483836B1 (ko) * 2002-05-29 2005-04-20 주식회사 아이디알 푸마질롤 유도체 및 그의 제조방법
KR100455900B1 (ko) * 2001-09-27 2004-11-12 주식회사 아이디알 새로운 푸마질롤 유도체 및 그의 제조방법
US6803382B2 (en) 2001-11-09 2004-10-12 Galderma Research & Development, S.N.C. Angiogenesis inhibitors and pharmaceutical and cosmetic use thereof
FR2832149B1 (fr) * 2001-11-09 2006-01-06 Galderma Res & Dev Nouveaux inhibiteurs de l'angiogenese et leur utilisation pharmaceutique et cosmetique
US8865746B2 (en) * 2008-07-18 2014-10-21 Zafgen, Inc. Methods of treating an overweight or obese subject
WO2010065877A2 (en) 2008-12-04 2010-06-10 Zafgen Corporation Methods of treating an overweight or obese subject
WO2010065883A2 (en) 2008-12-04 2010-06-10 Zafgen Corporation Method of treating an overweight or obese subject
EP2486004B1 (de) 2009-10-09 2017-05-03 Zafgen, Inc. Sulfonverbindungen zur verwendung in der behandlung von adipositas
US8815309B2 (en) 2010-01-08 2014-08-26 Zafgen, Inc. Methods of treating a subject with benign prostate hyperplasia
AU2011204267B2 (en) 2010-01-08 2015-12-03 Zafgen Corporation Fumagillol type compounds and methods of making and using same
US20130023513A1 (en) 2010-01-12 2013-01-24 Hughes Thomas E Methods and Compositions for Treating Cardiovascular Disorders
WO2011127304A2 (en) 2010-04-07 2011-10-13 Zafgen Corporation Methods of treating an overweight subject
CN103249735B (zh) 2010-07-22 2016-04-06 扎夫根股份有限公司 三环化合物及其制备和使用方法
PH12013500934A1 (en) 2010-11-09 2022-10-24 Zafgen Inc Crystalline solids of a metap-2 inhibitor and methods of making and using same
US20140073691A1 (en) 2010-11-10 2014-03-13 Zafgen, Inc. Methods and composition for Treating Thyroid Hormone Related Disorders
US20130316994A1 (en) 2010-11-29 2013-11-28 Zafgen, Inc. Methods of Reducing Risk of Hepatobiliary Dysfunction During Rapid Weight Loss with METAP-2 Inhibitors
WO2012075020A1 (en) 2010-11-29 2012-06-07 Zafgen Corporation Treatment of obesity using non-daily administration of 6 - 0 - (4 - dimethylaminoethoxy) cinnamoyl fumagillol
US9189078B2 (en) 2010-12-20 2015-11-17 Apple Inc. Enhancing keycap legend visibility with optical components
KR20140006888A (ko) 2011-01-26 2014-01-16 자프겐 인크. 테트라졸화합물, 그리고, 이를 제조하는 방법 및 이를 이용하는 방법
CN103534244B (zh) 2011-03-08 2016-10-12 扎夫根股份有限公司 氧杂螺[2.5]辛烷衍生物及类似物
BR112013028666A2 (pt) 2011-05-06 2017-08-08 Zafgen Inc compostos de pirazolo sulfonamida tricícilos e métodos para fazer e usar o mesmo
CA2835261C (en) 2011-05-06 2019-06-04 Zafgen, Inc. Partially saturated tricyclic compounds and methods of making and using same
AU2012253759B2 (en) 2011-05-06 2016-01-21 Zafgen Inc. Tricyclic sulfonamide compounds and methods of making and using same
EP2763671A2 (de) 2011-10-03 2014-08-13 Zafgen, Inc. Verfahren zur behandlung von altersbedingten erkrankungen
JP2015509102A (ja) 2012-01-18 2015-03-26 ザフゲン，インコーポレイテッド 三環式スルホン化合物並びにその作製および使用方法
MX2014008706A (es) 2012-01-18 2015-03-05 Zafgen Inc Compuestos tricíclicos de sulfonamida y métodos para elaborarlos y usarlos.
US9260419B2 (en) 2012-05-07 2016-02-16 Zafgen, Inc. Polymorphic salt of a metap-2 inhibitor and methods of making and using same
AU2013259617A1 (en) 2012-05-08 2014-11-27 Zafgen, Inc. Treating hypothalamic obesity with MetAP2 inhibitors
MX356755B (es) 2012-05-09 2018-06-11 Zafgen Inc Compuestos de tipo fumagilol y metodos para su elaboración y uso.
JP2015536981A (ja) 2012-11-05 2015-12-24 ザフゲン，インコーポレイテッド 三環式化合物ならびにその製造および使用方法
NZ707773A (en) 2012-11-05 2019-05-31 Zafgen Inc Methods of treating liver diseases
BR112015010223A2 (pt) 2012-11-05 2017-07-11 Zafgen Inc compostos tricíclicos para o uso no tratamento e/ou controle de obesidade
CN105228610A (zh) 2013-03-14 2016-01-06 扎夫根股份有限公司 治疗肾疾病和其它病症的方法
AR105671A1 (es) 2015-08-11 2017-10-25 Zafgen Inc Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso
CN106432255A (zh) 2015-08-11 2017-02-22 扎夫根公司 烟曲霉素醇螺环化合物和制备和使用其的方法
US20250129033A1 (en) 2022-02-16 2025-04-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Metap2 inhibitors and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0629278B2 (ja) * 1985-06-26 1994-04-20 藤沢薬品工業株式会社 オキサスピロオクタン化合物
PH26256A (en) * 1988-08-12 1992-04-01 Fujisawa Pharmaceutical Co Oxaspiro [2,5] octane derivative

Also Published As

Publication number Publication date
US5204345A (en) 1993-04-20
EP0387650A1 (de) 1990-09-19
DE69001187T2 (de) 1993-07-08
EP0387650B1 (de) 1993-03-31
CA2011449A1 (en) 1990-09-06
CA2011449C (en) 2000-02-08
DE69001187D1 (de) 1993-05-06

Similar Documents

Publication Publication Date Title
DE69001187D1 (de) 6-epifumagillole, ihre herstellung und ihre verwendung.
PT88603A (pt) Immunomodulatory azapiranes
ATE124695T1 (de) Kondensierte heterocyclische verbindungen, ihre herstellung und verwendung.
DE69004598D1 (de) 6-Amino-6-desoxyfumagillole, ihre Herstellung und ihre Verwendung.
EP0288969A3 (en) Antiulcer composition
FI88795B (fi) Foerfarande foer framstaellning av tienyletylaminer
DK183789D0 (da) 2-alkyl-3-benzoylbenzofuraner og laegemidler indeholdende disse
ES8706610A1 (es) Proceso para preparar un derivado de aminoalcohol.
NO921837D0 (no) Asymmetrisk syntese av 3-substituerte furanosidforbindelser
PT84117A (en) Novel compounds
HU905000D0 (en) Process for producing compounds suitable for treatment of gastric ulcer
PT84367A (en) Process for the preparation of a fungicidal compound containing a naphthimidezolone
DK0455899T3 (da) Prostaglandin I-analog
TW265342B (de)
DE3778088D1 (de) Substituierte pyrimidochinoxaline.
RO92582B (ro) Procedeu pentru prepararea unor 5,6-dialcoxi-4-alchil-2 (1h)-chinazoline
GR3001003T3 (en) Novel pregnane derivatives, processes for their preparaton and pharmaceutical compositions containing same

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties