ATE87632T1 - Reinigung von faktor viii:c durch phospholipidaffinit|t. - Google Patents

Reinigung von faktor viii:c durch phospholipidaffinit|t.

Info

Publication number: ATE87632T1
Authority: AT; Austria
Prior art keywords: factor viii; purification; phospholipidaffinite; factor; phosphatidylserine
Prior art date: 1987-07-16

Application number

AT88111301T

Other languages

English (en)

Inventor

James E Brown

Cynthia A Cowgill

Original Assignee

Miles Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-07-16

Filing date

1988-07-14

Publication date

1993-04-15

1988-07-14 Application filed by Miles Inc filed Critical Miles Inc

1993-04-15 Application granted granted Critical

1993-04-15 Publication of ATE87632T1 publication Critical patent/ATE87632T1/de

Links

229960000301 factor viii Drugs 0.000 title abstract 4
238000000746 purification Methods 0.000 title 1
TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 abstract 3
108010054218 Factor VIII Proteins 0.000 abstract 3
102000001690 Factor VIII Human genes 0.000 abstract 3
ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 abstract 3
150000003904 phospholipids Chemical class 0.000 abstract 3
JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 abstract 2
WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 abstract 2
150000008104 phosphatidylethanolamines Chemical class 0.000 abstract 2
238000001261 affinity purification Methods 0.000 abstract 1
230000004927 fusion Effects 0.000 abstract 1
108010047303 von Willebrand Factor Proteins 0.000 abstract 1
102100036537 von Willebrand factor Human genes 0.000 abstract 1
229960001134 von willebrand factor Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Toxicology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Hematology (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT88111301T 1987-07-16 1988-07-14 Reinigung von faktor viii:c durch phospholipidaffinit|t. ATE87632T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/074,123 US4795806A (en)	1987-07-16	1987-07-16	Phospholipid affinity purification of Factor VIII:C
EP88111301A EP0303064B1 (de)	1987-07-16	1988-07-14	Reinigung von Faktor VIII:C durch Phospholipid-Affinität

Publications (1)

Publication Number	Publication Date
ATE87632T1 true ATE87632T1 (de)	1993-04-15

Family

ID=22117866

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88111301T ATE87632T1 (de)	1987-07-16	1988-07-14	Reinigung von faktor viii:c durch phospholipidaffinit\|t.

Country Status (6)

Country	Link
US (1)	US4795806A (de)
EP (1)	EP0303064B1 (de)
AT (1)	ATE87632T1 (de)
DE (1)	DE3879803T2 (de)
ES (1)	ES2053631T3 (de)
GR (1)	GR3007541T3 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU5930890A (en) *	1989-06-20	1991-01-08	Scripps Clinic And Research Foundation	The phospholipid binding domain of factor viii
US5110907A (en) *	1989-08-01	1992-05-05	Alpha Therapeutic Corporation	Factor viii complex purification using heparin affinity chromatography
AU7254894A (en) *	1993-07-23	1995-02-20	Baxter International Inc.	Activated human factor viii and method of preparation
US5576291A (en) *	1993-09-13	1996-11-19	Baxter International Inc.	Activated factor VIII as a therapeutic agent and method of treating factor VIII deficiency
DE4337573C1 (de) *	1993-11-04	1995-05-18	Octapharma Ag	Verfahren zur Herstellung einer virusinaktivierten Faktor VIII enthaltenden Fraktion mittels chromatographischer Methoden
EP0965597A4 (de) *	1996-12-27	2003-01-08	Mochida Pharm Co Ltd	Zellmembran-wirksame medikamente
CA2634663C (en)	1999-02-22	2009-08-25	University Of Connecticut	Novel albumin-free factor viii formulations
US8110218B2 (en) *	2000-11-30	2012-02-07	The Research Foundation Of State University Of New York	Compositions and methods for less immunogenic protein-lipid complexes
US7351688B2 (en) *	2003-02-05	2008-04-01	The Research Foundation Of State University Of New York	Compositions and methods for less immunogenic protein formulations
WO2005017526A1 (en) *	2003-08-05	2005-02-24	The Research Foundation Of State University Of New York	Reconstitution medium for protein and peptide formulations
WO2007002886A2 (en) *	2005-06-29	2007-01-04	The Research Foundation Of State University Of New York	Compositions and methods for less immunogenic pr0tein-lip1d complexes
EP1915176A4 (de) *	2005-07-15	2008-12-03	Univ Vermont	Hochsensitive immunassays und antikörper zum nachweis von blutfaktor viii
WO2007021822A2 (en) *	2005-08-09	2007-02-22	The Research Foundation Of State Of University Of New York At Buffalo	Compositions and methods of preparation of liposomal microparticulate il-12
US7875288B2 (en) *	2006-03-30	2011-01-25	The Research Foundation Of State University Of New York	Method for treating blood coagulation disorders
JP5160534B2 (ja) *	2006-03-30	2013-03-13	ザリサーチファウンデイションオブステイトユニバーシティーオブニューヨーク	低免疫原性および長時間循環性タンパク質−脂質複合体の組成物
WO2008102469A1 (ja) *	2007-02-23	2008-08-28	Kwansei Gakuin Educational Foundation	蛋白質結晶化剤および蛋白質結晶化剤を用いた蛋白質結晶化方法
EP2385825B1 (de)	2008-11-07	2018-10-10	University of Connecticut	Faktor-viii-formulierungen
EP2651433A1 (de) *	2010-12-16	2013-10-23	Novo Nordisk A/S	Wässrige faktor-viii-lösung

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4022758A (en) *	1973-06-19	1977-05-10	Ab Kabi	Isolation of coagulation factors I and VIII from biological material
DE3101752A1 (de) *	1981-01-21	1982-08-26	Behringwerke Ag, 3550 Marburg	"verfahren zur reinigung der blutgerinnungsfaktoren ii, vii, ix und/oder x und danach hergestellte praeparationen"
US4461833A (en) *	1982-06-23	1984-07-24	University Patents, Inc.	Chromatographically purifying proteolytic procoagulant enzyme from animal tissue extract
US4397841A (en) *	1982-06-28	1983-08-09	Monsanto Company	Production of blood coagulation factor VIII:C
US4508709A (en) *	1983-12-05	1985-04-02	Armour Pharmaceutical Company	Process for purifying factor VIII:C
GB8403473D0 (en) *	1984-02-09	1984-03-14	Special Trustees For St Thomas	Purification of factor viii
US4675385A (en) *	1985-03-27	1987-06-23	Alpha Therapeutic Corporation	Isolation of human plasma procoagulant protein factor VIII from biological factors

1987
- 1987-07-16 US US07/074,123 patent/US4795806A/en not_active Expired - Lifetime
1988
- 1988-07-14 AT AT88111301T patent/ATE87632T1/de not_active IP Right Cessation
- 1988-07-14 EP EP88111301A patent/EP0303064B1/de not_active Expired - Lifetime
- 1988-07-14 DE DE8888111301T patent/DE3879803T2/de not_active Expired - Fee Related
- 1988-07-14 ES ES88111301T patent/ES2053631T3/es not_active Expired - Lifetime
1993
- 1993-04-01 GR GR930400557T patent/GR3007541T3/el unknown

Also Published As

Publication number	Publication date
EP0303064A3 (en)	1990-05-16
EP0303064A2 (de)	1989-02-15
US4795806A (en)	1989-01-03
EP0303064B1 (de)	1993-03-31
DE3879803D1 (de)	1993-05-06
GR3007541T3 (de)	1993-08-31
ES2053631T3 (es)	1994-08-01
DE3879803T2 (de)	1993-07-08

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Legal Events

Date	Code	Title	Description
1993-09-15	UEP	Publication of translation of european patent specification
2001-04-15	REN	Ceased due to non-payment of the annual fee