ATE88091T1 - 2-alkoxy-n-(1-azabicyclo(2.2.2)-oct-3-yl) benzamide und thiobenzamide mit antischizophrener wirkung. - Google Patents

2-alkoxy-n-(1-azabicyclo(2.2.2)-oct-3-yl) benzamide und thiobenzamide mit antischizophrener wirkung.

Info

Publication number: ATE88091T1
Authority: AT; Austria
Prior art keywords: alkoxy; thiobenzamides; benzamides; azabicyclo; oct
Prior art date: 1987-09-04

Application number

AT88308182T

Other languages

English (en)

Inventor

Robert John Naylord

Brenda Naylor

Original Assignee

Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-04

Filing date

1988-09-05

Publication date

1993-04-15

1988-09-05 Application filed by Synthelabo filed Critical Synthelabo

1993-04-15 Application granted granted Critical

1993-04-15 Publication of ATE88091T1 publication Critical patent/ATE88091T1/de

Links

229940054066 benzamide antipsychotics Drugs 0.000 title abstract 2
150000003936 benzamides Chemical class 0.000 title abstract 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Chemical group 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
-1 amino, methylamino Chemical group 0.000 abstract 1
230000002932 anti-schizophrenic effect Effects 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Psychiatry (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT88308182T 1987-09-04 1988-09-05 2-alkoxy-n-(1-azabicyclo(2.2.2)-oct-3-yl) benzamide und thiobenzamide mit antischizophrener wirkung. ATE88091T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB878720805A GB8720805D0 (en)	1987-09-04	1987-09-04	2-alkoxy-n-(1-azabicyclo(2 2 2)oct-3-yl)benzamides & thiobenzamides
EP88308182A EP0306345B1 (de)	1987-09-04	1988-09-05	2-Alkoxy-n-(1-azabicyclo(2.2.2)-oct-3-yl) benzamide und Thiobenzamide mit antischizophrener Wirkung

Publications (1)

Publication Number	Publication Date
ATE88091T1 true ATE88091T1 (de)	1993-04-15

Family

ID=10623261

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88308182T ATE88091T1 (de)	1987-09-04	1988-09-05	2-alkoxy-n-(1-azabicyclo(2.2.2)-oct-3-yl) benzamide und thiobenzamide mit antischizophrener wirkung.

Country Status (12)

Country	Link
US (1)	US4877794A (de)
EP (1)	EP0306345B1 (de)
JP (1)	JPH0269417A (de)
AT (1)	ATE88091T1 (de)
AU (1)	AU614768B2 (de)
CA (1)	CA1318595C (de)
DE (1)	DE3880240T2 (de)
DK (1)	DK492688A (de)
GB (1)	GB8720805D0 (de)
IL (1)	IL87662A0 (de)
PH (1)	PH25429A (de)
ZA (1)	ZA886586B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE85217T1 (de) *	1988-08-04	1993-02-15	Synthelabo	Antischizophren-wirksame s-n-(1-azabicyclo (2.2.2.>oct-3-yl)benzamide und thiobenzamide.
JPH0669963B2 (ja) *	1989-04-21	1994-09-07	サンド・アクチエンゲゼルシャフト	５ｈｔ▲下３▼受容体拮抗薬の治療的用途
US5236931A (en) *	1992-03-26	1993-08-17	A. H. Robins Company, Incorporated	2-substituted benzamide and benzoate derivatives of 3-aminoquinuclidine and 3-quinuclidinol
US6486172B2 (en)	2000-08-18	2002-11-26	Pharmacia & Upjohn Company	Quinuclidine-substituted aryl compounds for treatment of disease
AU2001282874A1 (en)	2000-08-18	2002-03-04	Pharmacia And Upjohn Company	Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands)
MXPA04000779A (es) *	2001-08-24	2004-04-20	Pharmacia & Up John Company	7-aza[2.2.1]bicicloheptanos sustituidos con arilo para el tratamiento de enfermedades.
US6852716B2 (en)	2002-02-15	2005-02-08	Pfizer Inc	Substituted-aryl compounds for treatment of disease
MXPA04007083A (es) *	2002-02-20	2004-10-29	Upjohn Co	Compuestos azabiciclicos para el tratamiento de enfermedades.
FR2861076B1 (fr) *	2003-10-17	2006-01-06	Sanofi Synthelabo	Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique
WO2010042799A2 (en)	2008-10-09	2010-04-15	Howard Hughes Medical Institute	Novel chimeric ligand-gated ion channels and methods of use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL7611713A (nl) *	1975-11-03	1977-05-05	Thomae Gmbh Dr K	Werkwijze voor de bereiding van verbindingen en preparaten met waardevolle farmacologische eigen- schappen.
FR2531083B1 (fr) *	1982-06-29	1986-11-28	Sandoz Sa	Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
FR2529548A1 (fr) *	1982-07-02	1984-01-06	Delalande Sa	Nouveaux derives de l'amino-3 quinuclidine, leur procede et leur application en therapeutique
US4593034A (en) *	1984-04-06	1986-06-03	A. H. Robins Company, Inc.	2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamides and thiobenzamides
US4605652A (en) *	1985-02-04	1986-08-12	A. H. Robins Company, Inc.	Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes
EP0385517B1 (de) *	1985-03-14	1993-04-14	BEECHAM GROUP plc	Arzneimittel zur Behandlung von Erbrechen
GB8511988D0 (en) *	1985-05-11	1985-06-19	Beecham Group Plc	Compounds
ES2051753T3 (es) *	1986-12-16	1994-07-01	Robins Co Inc A H	N-(1-azabiciclo(2.2.2)octo-3-il) benzamidas y tiobenzamidas ansioliticas.

1987
- 1987-09-04 GB GB878720805A patent/GB8720805D0/en active Pending
1988
- 1988-09-02 IL IL87662A patent/IL87662A0/xx unknown
- 1988-09-05 PH PH37505A patent/PH25429A/en unknown
- 1988-09-05 ZA ZA886586A patent/ZA886586B/xx unknown
- 1988-09-05 DE DE88308182T patent/DE3880240T2/de not_active Expired - Fee Related
- 1988-09-05 EP EP88308182A patent/EP0306345B1/de not_active Expired - Lifetime
- 1988-09-05 DK DK492688A patent/DK492688A/da not_active Application Discontinuation
- 1988-09-05 AU AU21834/88A patent/AU614768B2/en not_active Ceased
- 1988-09-05 JP JP63220559A patent/JPH0269417A/ja active Pending
- 1988-09-05 AT AT88308182T patent/ATE88091T1/de not_active IP Right Cessation
- 1988-09-06 US US07/240,868 patent/US4877794A/en not_active Expired - Fee Related
- 1988-09-06 CA CA000576593A patent/CA1318595C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU2183488A (en)	1989-03-09
GB8720805D0 (en)	1987-10-14
US4877794A (en)	1989-10-31
CA1318595C (en)	1993-06-01
EP0306345A3 (en)	1989-06-14
DK492688A (da)	1989-03-05
IL87662A0 (en)	1989-02-28
DK492688D0 (da)	1988-09-05
DE3880240D1 (de)	1993-05-19
JPH0269417A (ja)	1990-03-08
ZA886586B (en)	1990-05-30
EP0306345B1 (de)	1993-04-14
DE3880240T2 (de)	1993-10-28
AU614768B2 (en)	1991-09-12
EP0306345A2 (de)	1989-03-08
PH25429A (en)	1991-07-01

Legal Events

Date	Code	Title	Description
1993-12-15	UEP	Publication of translation of european patent specification
1994-12-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
AU575929B2 (en)	1988-08-11	N-(3-quinuclidinyl) benzamides and thiobenzamides
OA09334A (fr)	1992-09-15	"Dérivés d'acides aminés".
ATE85217T1 (de)	1993-02-15	Antischizophren-wirksame s-n-(1-azabicyclo (2.2.2.>oct-3-yl)benzamide und thiobenzamide.
DE3880240D1 (de)	1993-05-19	2-alkoxy-n-(1-azabicyclo(2.2.2)-oct-3-yl) benzamide und thiobenzamide mit antischizophrener wirkung.
DE3876712D1 (de)	1993-01-28	Antianaerobe naphthyridinverbindungen.
GB8823605D0 (en)	1988-11-16	Therapeutic agents
AU634584B2 (en)	1993-02-25	Aroyl-ureas
NZ235130A (en)	1993-05-26	Cephalosporin derivatives; oxygen and carbon analogues thereof; pharmaceutical compositions; methods of preparation and treatment
FI852990L (fi)	1986-02-04	Saosom antiarytmiska aemnen anvaendbara 2,5-pyrrolidindionderivat.
GR3005011T3 (de)	1993-05-24