ATE90567T1 - Verfahren zur reinigung von vitamin-k-abhaengigen blutgerinnungsfaktoren. - Google Patents

Verfahren zur reinigung von vitamin-k-abhaengigen blutgerinnungsfaktoren.

Info

Publication number: ATE90567T1
Authority: AT; Austria
Prior art keywords: factors; vitamin; coagling; cleaning; procedure
Prior art date: 1987-12-22

Application number

AT89901619T

Other languages

English (en)

Inventor

Peter Anthony Feldman

Original Assignee

Central Blood Lab Authority

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-22

Filing date

1988-12-22

Publication date

1993-07-15

1988-12-22 Application filed by Central Blood Lab Authority filed Critical Central Blood Lab Authority

1993-07-15 Application granted granted Critical

1993-07-15 Publication of ATE90567T1 publication Critical patent/ATE90567T1/de

Links

230000001419 dependent effect Effects 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
239000008280 blood Substances 0.000 title 1
210000004369 blood Anatomy 0.000 title 1
238000004140 cleaning Methods 0.000 title 1
MBWXNTAXLNYFJB-NKFFZRIASA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-NKFFZRIASA-N 0.000 title 1
239000000203 mixture Substances 0.000 abstract 2
229920002684 Sepharose Polymers 0.000 abstract 1
229930003448 Vitamin K Natural products 0.000 abstract 1
239000003114 blood coagulation factor Substances 0.000 abstract 1
239000013522 chelant Substances 0.000 abstract 1
238000010828 elution Methods 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 abstract 1
229940024790 prothrombin complex concentrate Drugs 0.000 abstract 1
238000001179 sorption measurement Methods 0.000 abstract 1
235000019168 vitamin K Nutrition 0.000 abstract 1
239000011712 vitamin K Substances 0.000 abstract 1
150000003721 vitamin K derivatives Chemical class 0.000 abstract 1
229940046010 vitamin k Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Microbiology (AREA)
Peptides Or Proteins (AREA)
Compounds Of Unknown Constitution (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Physical Or Chemical Processes And Apparatus (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Cooling, Air Intake And Gas Exhaust, And Fuel Tank Arrangements In Propulsion Units (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
External Artificial Organs (AREA)

AT89901619T 1987-12-22 1988-12-22 Verfahren zur reinigung von vitamin-k-abhaengigen blutgerinnungsfaktoren. ATE90567T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB878729822A GB8729822D0 (en)	1987-12-22	1987-12-22	Chemical process
PCT/GB1988/001150 WO1989005650A2 (en)	1987-12-22	1988-12-22	Chemical process
EP89901619A EP0391974B1 (de)	1987-12-22	1988-12-22	Verfahren zur Reinigung von Vitamin-K-abhängigen Blutgerinnungsfaktoren

Publications (1)

Publication Number	Publication Date
ATE90567T1 true ATE90567T1 (de)	1993-07-15

Family

ID=10628844

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89901619T ATE90567T1 (de)	1987-12-22	1988-12-22	Verfahren zur reinigung von vitamin-k-abhaengigen blutgerinnungsfaktoren.

Country Status (9)

Country	Link
EP (1)	EP0391974B1 (de)
JP (1)	JPH0664B2 (de)
AT (1)	ATE90567T1 (de)
AU (1)	AU627446B2 (de)
DE (1)	DE3881895T2 (de)
DK (1)	DK175514B1 (de)
GB (1)	GB8729822D0 (de)
NO (1)	NO178882C (de)
WO (1)	WO1989005650A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT402262B (de) *	1991-06-20	1997-03-25	Immuno Ag	Arzneimittel enthaltend aktiviertes protein c
IT1262899B (it) *	1992-03-27	1996-07-22	Sclavo Spa	Processo per l'isolamento di fattore ix, fattore x e fattore ii altamente purificati dal complesso protrombinico o dal plasma umano
DE4430204A1 (de) *	1994-08-26	1996-02-29	Behringwerke Ag	Arzneimittel, welches als Gegenmittel für Blut-Antikoagulanzien geeignet ist und seine Verwendung
US5589571A (en) *	1994-10-28	1996-12-31	Cor Therapeutics, Inc.	Process for production of inhibited forms of activated blood factors
US5714583A (en) *	1995-06-07	1998-02-03	Genetics Institute, Inc.	Factor IX purification methods
AT409334B (de) *	1997-09-19	2002-07-25	Immuno Ag	Pharmazeutisches präparat enthaltend vitamin k-abhängige einzelfaktoren
SE0203551D0 (sv) *	2002-12-02	2002-12-02	Biovitrum Ab	Prothrombin purification
US20060068454A1 (en) *	2004-09-27	2006-03-30	Sysmex Corporation	Method of inactivating blood coagulation factor and blood coagulation factor-inactivated sample
GB0710321D0 (en)	2007-05-30	2007-07-11	Nhs Blood & Transplant	Method
US9956272B2 (en)	2007-05-30	2018-05-01	Bio Products Laboratory Limited	Methods for preparing factor X, activated factor X, inactivated factor X and inactivated factor Xa, and pharmaceutical compositions comprising same
US20140206844A1 (en)	2013-01-18	2014-07-24	Prothera Biologics	Methods for isolating blood products from an inter-alpha inhibitor protein-depleted blood product material
CN104328036B (zh) *	2014-10-28	2016-08-24	成都英德生物医药装备技术有限公司	一种人凝血酶原复合物吸附分离装置

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2303466C2 (de) *	1973-01-25	1975-03-20	Stanislaus Dipl.-Ing. 7340 Geislingen Malik	Verfahren zur Herstellung eines Wabenträgers
JPS5263835A (en) *	1975-11-21	1977-05-26	Hokusan Kk	Method of fabricating light shaped steel material
US4473553A (en) *	1983-12-02	1984-09-25	Miles Laboratories, Inc.	Process for producing a lipoprotein-poor concentrate of coagulation factors VII and VIIa
FR2632309B1 (fr) *	1988-06-07	1990-08-24	Lille Transfusion Sanguine	Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus
US4981952A (en) *	1988-10-04	1991-01-01	Eli Lilly And Company	Method for the purification of vitamin K-dependent proteins

1987
- 1987-12-22 GB GB878729822A patent/GB8729822D0/en active Pending
1988
- 1988-12-22 JP JP1501523A patent/JPH0664B2/ja not_active Expired - Lifetime
- 1988-12-22 DE DE89901619T patent/DE3881895T2/de not_active Expired - Fee Related
- 1988-12-22 AT AT89901619T patent/ATE90567T1/de not_active IP Right Cessation
- 1988-12-22 EP EP89901619A patent/EP0391974B1/de not_active Expired - Lifetime
- 1988-12-22 WO PCT/GB1988/001150 patent/WO1989005650A2/en not_active Ceased
- 1988-12-22 AU AU30329/89A patent/AU627446B2/en not_active Expired
1990
- 1990-06-21 NO NO902757A patent/NO178882C/no unknown
- 1990-06-22 DK DK199001534A patent/DK175514B1/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU627446B2 (en)	1992-08-27
NO178882B (no)	1996-03-18
NO902757L (no)	1990-06-21
DK153490A (da)	1990-06-22
WO1989005650A2 (en)	1989-06-29
JPH0664B2 (ja)	1994-01-05
NO178882C (no)	1996-06-26
DE3881895D1 (de)	1993-07-22
EP0391974A1 (de)	1990-10-17
EP0391974B1 (de)	1993-06-16
WO1989005650A3 (en)	1989-07-27
DK153490D0 (da)	1990-06-22
AU3032989A (en)	1989-07-19
DE3881895T2 (de)	1993-12-02
NO902757D0 (no)	1990-06-21
DK175514B1 (da)	2004-11-15
GB8729822D0 (en)	1988-02-03
JPH03501085A (ja)	1991-03-14

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Legal Events

Date	Code	Title	Description
1994-01-15	UEP	Publication of translation of european patent specification
2007-09-15	REN	Ceased due to non-payment of the annual fee