ATE92046T1 - 9-hydroxyamino-tetrahydroacridine, verfahren zu ihrer herstellung und ihre verwendung als medikamente. - Google Patents

9-hydroxyamino-tetrahydroacridine, verfahren zu ihrer herstellung und ihre verwendung als medikamente.

Info

Publication number: ATE92046T1
Authority: AT; Austria
Prior art keywords: loweralkyl; hydrogen; loweralkylcarbonyl; cycloalkyl; oxygen
Prior art date: 1987-04-20

Application number

AT88106108T

Other languages

English (en)

Inventor

Gregory Michael Shutske

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-04-20

Filing date

1988-04-16

Publication date

1993-08-15

1988-04-16 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1993-08-15 Application granted granted Critical

1993-08-15 Publication of ATE92046T1 publication Critical patent/ATE92046T1/de

Links

229940079593 drug Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
FEZWDCOULILNQI-UHFFFAOYSA-N n-(1,2,3,4-tetrahydroacridin-9-yl)hydroxylamine Chemical compound C1=CC=C2C(NO)=C(CCCC3)C3=NC2=C1 FEZWDCOULILNQI-UHFFFAOYSA-N 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
150000002431 hydrogen Chemical group 0.000 abstract 4
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
-1 loweralkyl Chemical group 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000002708 enhancing effect Effects 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
- C07D219/10—Nitrogen atoms attached in position 9
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)

AT88106108T 1987-04-20 1988-04-16 9-hydroxyamino-tetrahydroacridine, verfahren zu ihrer herstellung und ihre verwendung als medikamente. ATE92046T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3988387A	1987-04-20	1987-04-20
EP88106108A EP0288852B1 (de)	1987-04-20	1988-04-16	9-Hydroxyamino-tetrahydroacridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente

Publications (1)

Publication Number	Publication Date
ATE92046T1 true ATE92046T1 (de)	1993-08-15

Family

ID=21907847

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88106108T ATE92046T1 (de)	1987-04-20	1988-04-16	9-hydroxyamino-tetrahydroacridine, verfahren zu ihrer herstellung und ihre verwendung als medikamente.

Country Status (4)

Country	Link
EP (1)	EP0288852B1 (de)
AT (1)	ATE92046T1 (de)
DE (1)	DE3882573T2 (de)
ES (1)	ES2058167T3 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6075144A (en)	1987-04-20	2000-06-13	Hoechst Marion Roussel, Inc.	9-hydroxyamino tetrahydroacridine and related compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3318896A (en) *	1963-12-05	1967-05-09	Squibb & Sons Inc	Production of 12-substituted-6, 7, 8, 9, 10, 11-hexahydrocycloocta[b]quinolines
US4550113A (en) *	1982-08-19	1985-10-29	Nauchno-Issledovatelsky Institut Po Biologicheskikm Ispytaniyam Khimicheskikh Soedineny	9-Amino-2,3,5,6,7,8-hexahydro-1H-cyclopenta(b)quinoline monohydrate hydrochloride as stimulant of neuro-muscular transmission of smooth muscles
DE3582995D1 (de) *	1984-10-25	1991-07-04	Hoechst Roussel Pharma	9-amino-1,2,3,4-tetrahydroacridin-1-ol und verwandte verbindungen, verfahren zu ihrer herstellung und verwendung als arzneimittel.

1988
- 1988-04-16 DE DE88106108T patent/DE3882573T2/de not_active Expired - Fee Related
- 1988-04-16 EP EP88106108A patent/EP0288852B1/de not_active Expired - Lifetime
- 1988-04-16 AT AT88106108T patent/ATE92046T1/de not_active IP Right Cessation
- 1988-04-16 ES ES88106108T patent/ES2058167T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0288852A1 (de)	1988-11-02
EP0288852B1 (de)	1993-07-28
ES2058167T3 (es)	1994-11-01
DE3882573T2 (de)	1993-12-16
DE3882573D1 (de)	1993-09-02

Legal Events

Date	Code	Title	Description
1994-02-15	UEP	Publication of translation of european patent specification
2006-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE3772905D1 (de)	1991-10-17	Alpha-alkyl-4-amino-3-chinolin-methanole und 1-(4-aralkylamino-3-chinolyl)alkanone, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
ATE168689T1 (de)	1998-08-15	Substituierte (pyridinylamino)-benzisoxazole und -benzisothiazole, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ATE111899T1 (de)	1994-10-15	1,2,3,4-tetrahydro-1,9-acridindiamine, ein verfahren zu ihrer herstellung und ihre verwendung als medikamente.
DE3851643D1 (de)	1994-11-03	9-Amino-1,4-äthano-1,2,3,4-tetrahydroacridin und verwandte Verbindungen, Zwischenprodukte, ein Verfahren zur Herstellung davon und ihre Verwendung als Arzneimittel.
ATE92046T1 (de)	1993-08-15	9-hydroxyamino-tetrahydroacridine, verfahren zu ihrer herstellung und ihre verwendung als medikamente.
ATE123279T1 (de)	1995-06-15	Substituierte 9-amino-spiro(cycloalkyl(b>chinolin-2,1'cycloal ane>, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung als arzneimittel.
ATE104298T1 (de)	1994-04-15	Kondensierte heterocyclische derivate von 1,2,3,4-tetrahydroacridin, verfahren zu ihrer herstellung und ihre verwendung als medikament.
ATE122047T1 (de)	1995-05-15	4,5,5a,6-tetrahydro-3h-isoxyzolo(5,4,3- k1)acridinderivate, ein verfahren zu ihrer herstellung und ihre verwendung als medikamente.
AU590748B2 (en)	1989-11-16	Benzo(C)-1,5-naphthyridines, a process and intermediates for their preparation and their use as medicaments