ATE123279T1 - Substituierte 9-amino-spiro(cycloalkyl(b>chinolin-2,1'cycloal ane>, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung als arzneimittel. - Google Patents
Substituierte 9-amino-spiro(cycloalkyl(b>chinolin-2,1'cycloal ane>, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung als arzneimittel.Info
- Publication number
- ATE123279T1 ATE123279T1 AT88104815T AT88104815T ATE123279T1 AT E123279 T1 ATE123279 T1 AT E123279T1 AT 88104815 T AT88104815 T AT 88104815T AT 88104815 T AT88104815 T AT 88104815T AT E123279 T1 ATE123279 T1 AT E123279T1
- Authority
- AT
- Austria
- Prior art keywords
- cycloalkyl
- loweralkyl
- hydrogen
- products
- cycloal
- Prior art date
Links
- 239000013067 intermediate product Substances 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 150000002431 hydrogen Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- -1 loweralkyl Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/031,825 US4762841A (en) | 1987-03-30 | 1987-03-30 | Substituted 9-amino-spiro(cycloalkyl(b)quinoline-2,1'cycloalkanes) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE123279T1 true ATE123279T1 (de) | 1995-06-15 |
Family
ID=21861615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88104815T ATE123279T1 (de) | 1987-03-30 | 1988-03-25 | Substituierte 9-amino-spiro(cycloalkyl(b>chinolin-2,1'cycloal ane>, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung als arzneimittel. |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4762841A (de) |
| EP (1) | EP0285018B1 (de) |
| AT (1) | ATE123279T1 (de) |
| DE (1) | DE3853895T2 (de) |
| ES (1) | ES2074424T3 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL85741A (en) * | 1987-03-17 | 1996-05-14 | Hoechst Roussel Pharma | Substituted tetrahydroacridines a process for their preparation and pharmaceutical compositions containing substituted alpha-amino-tetrahydroacridines |
| US5037833A (en) * | 1988-07-25 | 1991-08-06 | Hoechst-Roussel Pharmaceuticals Inc. | N-[substituted alkylidene]fused-bicycloalkylidene quinolinamines useful for enhancing the cholinergic function in a mammal |
| US5013741A (en) * | 1987-09-08 | 1991-05-07 | Hoechst-Roussel Pharmaceuticals Incorporated | N-[substituted alkylidene]-1,2,3,4-tetrahydro-9-acridinamines useful for enhancing the cholinergic function in a mammal |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3232945A (en) * | 1962-08-13 | 1966-02-01 | S E Massengill Company | 7,8,9,10-tetrahalo-6h-cyclohepta-(b)-quinolines |
| US3580915A (en) * | 1968-09-16 | 1971-05-25 | American Home Prod | 1,2,3,4-tetrahydrobenzol(b)(1,6)naphthyridine derivatives |
| US3541066A (en) * | 1968-09-16 | 1970-11-17 | American Home Prod | 2,3-dihydro-1,4-ethanobenzo(b)(1,5)naphthyridine derivatives |
| US3657233A (en) * | 1970-04-30 | 1972-04-18 | American Home Prod | 10-morpholino-1 2 3 4-tetrahydrobenzo(b)(1 6)naphthyridine derivatives |
| US3637706A (en) * | 1970-04-30 | 1972-01-25 | American Home Prod | 10-(4 - (lower)alkylpiperazino) - 1 2 3 4-tetrahydrobenzo(b)(1 6) naphthyridine derivatives useful as cns depressants |
| US3647800A (en) * | 1970-04-30 | 1972-03-07 | American Home Prod | 10-substituted - 1 2 3 4 - tetrahydrobenzo(b)(1 6)naphthyridines useful as cns depressants |
| US3674290A (en) * | 1970-05-04 | 1972-07-04 | Maremont Corp | Coupling |
| ES431307A1 (es) * | 1973-11-16 | 1976-09-01 | Thomae Gmbh Dr K | Procedimiento para la preparacion de nuevos derivados de quinoleina. |
| US4108998A (en) * | 1976-11-08 | 1978-08-22 | American Home Products Corp. | Furo[3,4-b]quinoline derivatives and pharmaceutical compositions and methods employing them |
| EP0179383B1 (de) * | 1984-10-25 | 1991-05-29 | Hoechst-Roussel Pharmaceuticals Incorporated | 9-Amino-1,2,3,4-tetrahydroacridin-1-ol und verwandte Verbindungen, Verfahren zu ihrer Herstellung und Verwendung als Arzneimittel |
| US4695573A (en) * | 1984-10-25 | 1987-09-22 | Hoechst-Roussel Pharmaceuticals Inc. | 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds |
| US4631286A (en) * | 1984-10-25 | 1986-12-23 | Hoechst-Roussel Pharmaceuticals Inc. | 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds |
-
1987
- 1987-03-30 US US07/031,825 patent/US4762841A/en not_active Expired - Lifetime
-
1988
- 1988-03-25 EP EP88104815A patent/EP0285018B1/de not_active Expired - Lifetime
- 1988-03-25 ES ES88104815T patent/ES2074424T3/es not_active Expired - Lifetime
- 1988-03-25 AT AT88104815T patent/ATE123279T1/de not_active IP Right Cessation
- 1988-03-25 DE DE3853895T patent/DE3853895T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0285018A3 (en) | 1989-06-14 |
| EP0285018A2 (de) | 1988-10-05 |
| ES2074424T3 (es) | 1995-09-16 |
| EP0285018B1 (de) | 1995-05-31 |
| US4762841A (en) | 1988-08-09 |
| DE3853895T2 (de) | 1995-12-14 |
| DE3853895D1 (de) | 1995-07-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |