ATE94560T1 - L-prolin-derivate, deren herstellung und deren biologische anwendungen. - Google Patents

L-prolin-derivate, deren herstellung und deren biologische anwendungen.

Info

Publication number
ATE94560T1
ATE94560T1 AT88402761T AT88402761T ATE94560T1 AT E94560 T1 ATE94560 T1 AT E94560T1 AT 88402761 T AT88402761 T AT 88402761T AT 88402761 T AT88402761 T AT 88402761T AT E94560 T1 ATE94560 T1 AT E94560T1
Authority
AT
Austria
Prior art keywords
derivatives
group
production
alkyl
formula
Prior art date
Application number
AT88402761T
Other languages
English (en)
Inventor
Pierre-Yves Fiez-Vandal
Original Assignee
Inorgan Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inorgan Sa filed Critical Inorgan Sa
Application granted granted Critical
Publication of ATE94560T1 publication Critical patent/ATE94560T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Protection Of Transformers (AREA)
  • Measurement Of Force In General (AREA)
AT88402761T 1987-11-03 1988-11-03 L-prolin-derivate, deren herstellung und deren biologische anwendungen. ATE94560T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8715228A FR2622581B1 (fr) 1987-11-03 1987-11-03 Nouveaux derives de l-proline, leur preparation et leurs applications biologiques
EP88402761A EP0316218B1 (de) 1987-11-03 1988-11-03 L-Prolin-Derivate, deren Herstellung und deren biologische Anwendungen

Publications (1)

Publication Number Publication Date
ATE94560T1 true ATE94560T1 (de) 1993-10-15

Family

ID=9356437

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88402761T ATE94560T1 (de) 1987-11-03 1988-11-03 L-prolin-derivate, deren herstellung und deren biologische anwendungen.

Country Status (12)

Country Link
US (1) US5212158A (de)
EP (1) EP0316218B1 (de)
JP (1) JP2694191B2 (de)
KR (1) KR0121793B1 (de)
AT (1) ATE94560T1 (de)
CA (1) CA1340227C (de)
DE (1) DE3884139T2 (de)
ES (1) ES2061710T3 (de)
FI (1) FI885083A7 (de)
FR (1) FR2622581B1 (de)
IE (1) IE64509B1 (de)
IL (1) IL88275A0 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0445606B1 (de) * 1990-02-27 1997-01-22 The Agency of Industrial Science and Technology Oligopeptide, sie enthaltende pharmazeutische und Futterzusammensetzung und Benützung von Oligopeptiden
JP3343181B2 (ja) * 1995-09-20 2002-11-11 生化学工業株式会社 桂皮酸誘導体
US7671029B2 (en) 1999-08-06 2010-03-02 Immupharma Sa Compositions and methods for enhanced pharmacological activity of compositions comprising peptide drug substances
US6908900B2 (en) * 2001-01-17 2005-06-21 Zimmer & Associates Ag Compositions and methods for enhanced pharmacological activity through oral and parenteral administration of compositions comprising polypeptide drug substances and other poorly absorbed active ingredients
US20030060413A1 (en) * 2001-09-06 2003-03-27 Zimmer Robert H. Derivatives of pseudo-peptides, their preparation and their biological uses
US20050192228A1 (en) * 2001-02-05 2005-09-01 Jean Rapin Tripeptide derivatives for the treatment of neurodegenerative diseases
DE10105039A1 (de) * 2001-02-05 2002-08-08 Tell Pharm Ag Hergiswil Tripeptid-Derivate für die Behandlung neurodegenerativer Krankheiten
DE10105041A1 (de) * 2001-02-05 2002-08-14 Tell Pharm Ag Hergiswil Tripeptide und Tripeptid-Derivate für die Behandlung neurodegenerativer Krankheiten
DE10105040A1 (de) * 2001-02-05 2002-08-14 Tell Pharm Ag Hergiswil Tripeptid-Derivate für die Behandlung von postläsionalen Krankheiten des Nervensystems
DE10105038B4 (de) * 2001-02-05 2005-07-07 Neurotell Ag Tripeptid-Derivate für die Behandlung von postläsionalen Krankheiten des Nervensystems
US7252446B2 (en) * 2004-03-31 2007-08-07 Brother Kogoy Kabushiki Kaisha Image forming apparatus
FR2932179B1 (fr) 2008-06-09 2012-12-07 I R D Procede microbiologique de synthese de derives cinnamoyl amides d'acides amines
UY32827A (es) * 2009-08-12 2011-02-28 Glaxo Group Ltd Inhibidores de catepsina c
US8841463B2 (en) 2011-02-11 2014-09-23 Glaxosmithkline Intellectual Property Development Limited Cathepsin C inhibitors
US20150038547A1 (en) * 2013-07-31 2015-02-05 Rory Powell Blake Biological Basis of Adult Wellness
US20160045473A1 (en) * 2012-08-01 2016-02-18 Rory Powell Blake Biological Basis Of Adult Wellness

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523598A (en) * 1975-03-08 1978-09-06 Reckitt & Colmann Prod Ltd Tripeptides
US4260682A (en) * 1979-04-04 1981-04-07 Ryan James W High sensitivity assays for angiotensin converting enzyme
DE3164437D1 (en) * 1980-08-25 1984-08-02 Kabivitrum Ab Peptide substrates for determination of protease activity
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
EP0124317B1 (de) * 1983-04-27 1990-04-11 Ici Americas Inc. Prolin-Derivate
JPS63112597A (ja) * 1986-10-29 1988-05-17 Tokuyama Soda Co Ltd アミノ酸誘導体
US4804743A (en) * 1987-01-29 1989-02-14 Warner-Lambert Copmany Proline-containing renin inhibitors

Also Published As

Publication number Publication date
FI885083A7 (fi) 1989-05-04
KR0121793B1 (ko) 1997-11-27
DE3884139D1 (de) 1993-10-21
FR2622581B1 (fr) 1990-02-16
US5212158A (en) 1993-05-18
IL88275A0 (en) 1989-06-30
DE3884139T2 (de) 1994-05-05
EP0316218A1 (de) 1989-05-17
FR2622581A1 (fr) 1989-05-05
JPH01157998A (ja) 1989-06-21
IE883321L (en) 1989-05-03
IE64509B1 (en) 1995-08-09
ES2061710T3 (es) 1994-12-16
FI885083A0 (fi) 1988-11-03
JP2694191B2 (ja) 1997-12-24
EP0316218B1 (de) 1993-09-15
KR890008091A (ko) 1989-07-08
CA1340227C (fr) 1998-12-15

Similar Documents

Publication Publication Date Title
ATE94560T1 (de) L-prolin-derivate, deren herstellung und deren biologische anwendungen.
ATE33838T1 (de) Thiazolidinderivate, ihre herstellung und diese enthaltende zusammensetzungen.
MX9200344A (es) Derivados de benzamida, proceso para su preparacion y composicion farmaceutica que los contiene.
ATE102193T1 (de) Thiazolidinedionederivate.
HUP0002122A2 (hu) Ciklusos tio-szubsztituált acilaminosav-amid származékok
ES2055791T3 (es) Compuestos heterociclicos.
ES488788A0 (es) Procedimiento de preparacion de una composicion farmaceuticaen particular psicotropa.
EA200100533A1 (ru) Производные эритромицина, способ их получения и их применение в качестве лекарственных средств
EA200000826A1 (ru) Галоидированные производные амидиноаминокислот, применимые в качестве ингибиторов no-синтазы
DE3777852D1 (de) Dekahydrochinolinderivate, verfahren zu ihrer herstellung, zwischenprodukte zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende zubereitungen.
DK1022276T3 (da) Epoxysuccinamidderivater
ES2014482B3 (es) Nuevas 2-tiazolil imidazo/1,2-a/pirimidinas y sus sales, su procedimiento de preparacion, su aplicacion a titulo de medicamentos y las composiciones que las encierran.
DE3561819D1 (en) Derivatives of methylenediphosphonic acid, process for their preparation and antirheumatic pharmaceutical compositions containing them
NO177995C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 1,3-dioksanderivater
ES2057415T3 (es) Derivados biciclicos.
DE69600329D1 (de) Benzothiazol-Derivate
MA21752A1 (fr) Procede de preparation de nouveaux derives de la i - arylsulfonyl 2 - piperidinone .
DE68918832D1 (de) Benzoxazepinderivate.
IT1241988B (it) 2- amminotetraline-6, 7-sostituite attive come immunomodulanti e composizioni farmaceutiche che le contengono
HUP9801117A2 (hu) Eljárás optikailag aktív aminszármazékok előállítására
ES2045514T3 (es) Utilizacion de derivados del cromano para el tratamiento de los estados depresivos.
DE3871383D1 (de) 4-amino-1-trifluoromethyl-tetralin-derivate, deren herstellung und deren therapeutische verwendung.
PT92175A (pt) Processo para a preparacao de 3-amino-sidnoniminas substituidas e de produtos intermediarios farmacologicamente activos
ATE116287T1 (de) N-oxyimidsäurederivate.
ATE53839T1 (de) 2,3-dihydro-3-phenyl-benzofuran-2-onacetamidderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
EEIH Change in the person of patent owner
EEFA Change of the company name
EELA Cancelled due to lapse of time