ES2061710T3 - Nuevos derivados de l-prolina, su preparacion y sus aplicaciones biologicas. - Google Patents

Nuevos derivados de l-prolina, su preparacion y sus aplicaciones biologicas.

Info

Publication number
ES2061710T3
ES2061710T3 ES88402761T ES88402761T ES2061710T3 ES 2061710 T3 ES2061710 T3 ES 2061710T3 ES 88402761 T ES88402761 T ES 88402761T ES 88402761 T ES88402761 T ES 88402761T ES 2061710 T3 ES2061710 T3 ES 2061710T3
Authority
ES
Spain
Prior art keywords
derivatives
proline
preparation
biological applications
new derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88402761T
Other languages
English (en)
Inventor
Pierre-Yves Fiez-Vandal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ekita Investments NV
Original Assignee
Ekita Investments NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ekita Investments NV filed Critical Ekita Investments NV
Application granted granted Critical
Publication of ES2061710T3 publication Critical patent/ES2061710T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Psychiatry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Protection Of Transformers (AREA)
  • Measurement Of Force In General (AREA)

Abstract

LOS DERIVADOS DE L - PROLINA DE LA INVENCION RESPONDEN A LA FORMULA(I) EN LA QUE R1 RESPONDE A LA FORMULA(II), EN LA QUE R ES UN CARBONILO, UN ACILO - Y - CO - O UN OXI - ACILO - O - Y - CO Y ES UN ALCOILO O UN ALQUENILO, Z ES UNO O VARIOS ATOMOS DE H, O UNO O VARIOS SUSTITUYENTES ELEGIDOS DE ENTRE HALOGENO, CF3, ALCOILO, ALCOXI, Y PARA DOS SUSTITUYENTE VECINOS, ALCOYLENODIOXI; R2 ES - NH2, - OH, O UN DERIVADO DE ESTOS GRUPOS; A1 Y A2 SON RESIDUOS DE ACIDOS AMINADOS; Y B1 Y B2 REPRESENTAN UN H O UN METILO, Y LAS SALES FARMACOLOGICAMENTE ACEPTABLES DE ESTOS DERIVADOS. ESTOS DERIVADOS SON UTILES PARTICULARMENTE COMO PRINCIPIOS ACTIVOS DE MEDICAMENTOS CON UNA ACCION NOOTROPA EN PARTICULAR.
ES88402761T 1987-11-03 1988-11-03 Nuevos derivados de l-prolina, su preparacion y sus aplicaciones biologicas. Expired - Lifetime ES2061710T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8715228A FR2622581B1 (fr) 1987-11-03 1987-11-03 Nouveaux derives de l-proline, leur preparation et leurs applications biologiques

Publications (1)

Publication Number Publication Date
ES2061710T3 true ES2061710T3 (es) 1994-12-16

Family

ID=9356437

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88402761T Expired - Lifetime ES2061710T3 (es) 1987-11-03 1988-11-03 Nuevos derivados de l-prolina, su preparacion y sus aplicaciones biologicas.

Country Status (12)

Country Link
US (1) US5212158A (es)
EP (1) EP0316218B1 (es)
JP (1) JP2694191B2 (es)
KR (1) KR0121793B1 (es)
AT (1) ATE94560T1 (es)
CA (1) CA1340227C (es)
DE (1) DE3884139T2 (es)
ES (1) ES2061710T3 (es)
FI (1) FI885083A7 (es)
FR (1) FR2622581B1 (es)
IE (1) IE64509B1 (es)
IL (1) IL88275A0 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69124274T2 (de) * 1990-02-27 1997-08-14 Agency Ind Science Techn Oligopeptide, sie enthaltende pharmazeutische und Futterzusammensetzung und Benützung von Oligopeptiden
JP3343181B2 (ja) * 1995-09-20 2002-11-11 生化学工業株式会社 桂皮酸誘導体
US6908900B2 (en) * 2001-01-17 2005-06-21 Zimmer & Associates Ag Compositions and methods for enhanced pharmacological activity through oral and parenteral administration of compositions comprising polypeptide drug substances and other poorly absorbed active ingredients
US7671029B2 (en) 1999-08-06 2010-03-02 Immupharma Sa Compositions and methods for enhanced pharmacological activity of compositions comprising peptide drug substances
US20030060413A1 (en) * 2001-09-06 2003-03-27 Zimmer Robert H. Derivatives of pseudo-peptides, their preparation and their biological uses
US20050192228A1 (en) * 2001-02-05 2005-09-01 Jean Rapin Tripeptide derivatives for the treatment of neurodegenerative diseases
DE10105040A1 (de) * 2001-02-05 2002-08-14 Tell Pharm Ag Hergiswil Tripeptid-Derivate für die Behandlung von postläsionalen Krankheiten des Nervensystems
DE10105039A1 (de) * 2001-02-05 2002-08-08 Tell Pharm Ag Hergiswil Tripeptid-Derivate für die Behandlung neurodegenerativer Krankheiten
DE10105041A1 (de) * 2001-02-05 2002-08-14 Tell Pharm Ag Hergiswil Tripeptide und Tripeptid-Derivate für die Behandlung neurodegenerativer Krankheiten
DE10105038B4 (de) * 2001-02-05 2005-07-07 Neurotell Ag Tripeptid-Derivate für die Behandlung von postläsionalen Krankheiten des Nervensystems
US7252446B2 (en) * 2004-03-31 2007-08-07 Brother Kogoy Kabushiki Kaisha Image forming apparatus
FR2932179B1 (fr) 2008-06-09 2012-12-07 I R D Procede microbiologique de synthese de derives cinnamoyl amides d'acides amines
UY32827A (es) * 2009-08-12 2011-02-28 Glaxo Group Ltd Inhibidores de catepsina c
US8841463B2 (en) 2011-02-11 2014-09-23 Glaxosmithkline Intellectual Property Development Limited Cathepsin C inhibitors
US20160045473A1 (en) * 2012-08-01 2016-02-18 Rory Powell Blake Biological Basis Of Adult Wellness
US20150038547A1 (en) * 2013-07-31 2015-02-05 Rory Powell Blake Biological Basis of Adult Wellness

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523598A (en) * 1975-03-08 1978-09-06 Reckitt & Colmann Prod Ltd Tripeptides
US4260682A (en) * 1979-04-04 1981-04-07 Ryan James W High sensitivity assays for angiotensin converting enzyme
DE3164437D1 (en) * 1980-08-25 1984-08-02 Kabivitrum Ab Peptide substrates for determination of protease activity
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
EP0124317B1 (en) * 1983-04-27 1990-04-11 Ici Americas Inc. Proline derivatives
JPS63112597A (ja) * 1986-10-29 1988-05-17 Tokuyama Soda Co Ltd アミノ酸誘導体
US4804743A (en) * 1987-01-29 1989-02-14 Warner-Lambert Copmany Proline-containing renin inhibitors

Also Published As

Publication number Publication date
IE64509B1 (en) 1995-08-09
IL88275A0 (en) 1989-06-30
EP0316218B1 (fr) 1993-09-15
JPH01157998A (ja) 1989-06-21
JP2694191B2 (ja) 1997-12-24
ATE94560T1 (de) 1993-10-15
FR2622581A1 (fr) 1989-05-05
CA1340227C (fr) 1998-12-15
FR2622581B1 (fr) 1990-02-16
EP0316218A1 (fr) 1989-05-17
FI885083A0 (fi) 1988-11-03
IE883321L (en) 1989-05-03
DE3884139T2 (de) 1994-05-05
KR0121793B1 (ko) 1997-11-27
FI885083A7 (fi) 1989-05-04
US5212158A (en) 1993-05-18
DE3884139D1 (de) 1993-10-21
KR890008091A (ko) 1989-07-08

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