ATE95195T1 - Mikroproteine, verfahren zur herstellung derselben und anwendung dieser mikroproteine als arzneimittel. - Google Patents

Mikroproteine, verfahren zur herstellung derselben und anwendung dieser mikroproteine als arzneimittel.

Info

Publication number: ATE95195T1
Authority: AT; Austria
Prior art keywords: microproteins; residue; norleucine; pharmaceuticals; manufacture
Prior art date: 1989-05-31

Application number

AT90401432T

Other languages

English (en)

Inventor

Bertrand Castro

Anne Favel

Dung Le-Nguyen

Maria-Antonia Previero

Original Assignee

Roussel Uclaf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-31

Filing date

1990-05-30

Publication date

1993-10-15

1990-05-30 Application filed by Roussel Uclaf filed Critical Roussel Uclaf

1993-10-15 Application granted granted Critical

1993-10-15 Publication of ATE95195T1 publication Critical patent/ATE95195T1/de

Links

239000003814 drug Substances 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 abstract 3
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 2
125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 abstract 2
229960000310 isoleucine Drugs 0.000 abstract 2
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 abstract 2
BVAUMRCGVHUWOZ-ZETCQYMHSA-N (2s)-2-(cyclohexylazaniumyl)propanoate Chemical compound OC(=O)[C@H](C)NC1CCCCC1 BVAUMRCGVHUWOZ-ZETCQYMHSA-N 0.000 abstract 1
QWCKQJZIFLGMSD-UHFFFAOYSA-N 2-Aminobutanoic acid Natural products CCC(N)C(O)=O QWCKQJZIFLGMSD-UHFFFAOYSA-N 0.000 abstract 1
QWCKQJZIFLGMSD-GSVOUGTGSA-N D-alpha-aminobutyric acid Chemical compound CC[C@@H](N)C(O)=O QWCKQJZIFLGMSD-GSVOUGTGSA-N 0.000 abstract 1
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
ZGUNAGUHMKGQNY-ZETCQYMHSA-N L-alpha-phenylglycine zwitterion Chemical compound OC(=O)[C@@H](N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-ZETCQYMHSA-N 0.000 abstract 1
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 1
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
FYCWLJLGIAUCCL-DMTCNVIQSA-N O-methyl-L-threonine Chemical compound CO[C@H](C)[C@H](N)C(O)=O FYCWLJLGIAUCCL-DMTCNVIQSA-N 0.000 abstract 1
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 1
235000004279 alanine Nutrition 0.000 abstract 1
229940024606 amino acid Drugs 0.000 abstract 1
235000001014 amino acid Nutrition 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
229930182817 methionine Natural products 0.000 abstract 1
125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 abstract 1
239000004474 valine Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Steroid Compounds (AREA)

AT90401432T 1989-05-31 1990-05-30 Mikroproteine, verfahren zur herstellung derselben und anwendung dieser mikroproteine als arzneimittel. ATE95195T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8907155A FR2647677B1 (fr)	1989-05-31	1989-05-31	Nouvelles micro-proteines, procede de preparation et application a titre de medicaments de ces nouvelles micro-proteines
EP90401432A EP0401109B1 (de)	1989-05-31	1990-05-30	Mikroproteine, Verfahren zur Herstellung derselben und Anwendung dieser Mikroproteine als Arzneimittel

Publications (1)

Publication Number	Publication Date
ATE95195T1 true ATE95195T1 (de)	1993-10-15

Family

ID=9382205

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90401432T ATE95195T1 (de)	1989-05-31	1990-05-30	Mikroproteine, verfahren zur herstellung derselben und anwendung dieser mikroproteine als arzneimittel.

Country Status (8)

Country	Link
US (1)	US5089474A (de)
EP (1)	EP0401109B1 (de)
JP (1)	JPH0368599A (de)
AT (1)	ATE95195T1 (de)
CA (1)	CA2017803A1 (de)
DE (1)	DE69003595T2 (de)
ES (1)	ES2060100T3 (de)
FR (1)	FR2647677B1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5432155A (en) *	1993-06-29	1995-07-11	The Salk Institute For Biological Studies	Conotoxins I
DE4342092B4 (de) *	1993-12-09	2007-01-11	Zentaris Gmbh	Langwirkende Injektionssuspension und Verfahren zur Herstellung
RU2151611C1 (ru) *	1999-06-18	2000-06-27	Общество с ограниченной ответственностью НАУЧНО-ПРОИЗВОДСТВЕННОЕ ПРЕДПРИЯТИЕ "МЕДБИОФАРМ"	Средство для регулирования йодного обмена или профилактики йоддефицитных состояний
US7297350B2 (en) *	2002-08-09	2007-11-20	Kentara Research Llc	Evaporate of Ecbalium elaterium fruit extract for treating viral symptoms
US7282227B2 (en) *	2002-08-09	2007-10-16	Kentara Research Llc	Method for treating hepatitis C with evaporate of Ecballium elaterium extract
AU2005287557B2 (en) *	2004-09-21	2011-10-13	Biontech Ag	Use of microproteins as tryptase inhibitors
JP2009509535A (ja) *	2005-09-27	2009-03-12	アムニクス，インコーポレイテッド	タンパク様薬剤およびその使用
US7855279B2 (en)	2005-09-27	2010-12-21	Amunix Operating, Inc.	Unstructured recombinant polymers and uses thereof
US20090099031A1 (en) *	2005-09-27	2009-04-16	Stemmer Willem P	Genetic package and uses thereof
US7846445B2 (en)	2005-09-27	2010-12-07	Amunix Operating, Inc.	Methods for production of unstructured recombinant polymers and uses thereof
AU2007223855B2 (en) *	2006-03-06	2013-05-16	Amunix Operating Inc.	Unstructured recombinant polymers and uses thereof
JP2010536341A (ja) *	2007-08-15	2010-12-02	アムニクス，インコーポレイテッド	生物学的に活性なポリペプチドの特性を改変するための組成物および方法
ES2610356T3 (es)	2009-02-03	2017-04-27	Amunix Operating Inc.	Polipéptidos recombinantes extendidos y composiciones que comprenden los mismos
CA2771999A1 (en)	2009-08-24	2011-03-10	Amunix Operating Inc.	Coagulation factor vii compositions and methods of making and using same
JP6256882B2 (ja)	2012-02-15	2018-01-10	アムニクスオペレーティングインコーポレイテッド	第ｖｉｉｉ因子組成物、ならびに組成物の作製方法および用途
EP2822577B1 (de)	2012-02-15	2019-02-06	Bioverativ Therapeutics Inc.	Rekombinante faktor-viii-proteine
TW202003554A (zh)	2013-08-14	2020-01-16	美商百歐維拉提夫治療公司	因子ｖｉｉｉ－ｘｔｅｎ融合物及其用途
EA201890423A1 (ru)	2015-08-03	2018-07-31	Биовератив Терапьютикс Инк.	Слитые белки фактора ix, способы их получения и применения
MX2019006444A (es)	2016-12-02	2019-10-30	Bioverativ Therapeutics Inc	Métodos de tratamiento de artropatía hemofílica utilizando factores de coagulación quiméricos.
PL3793588T3 (pl)	2018-05-18	2025-09-01	Bioverativ Therapeutics Inc.	Sposoby leczenia hemofilii a

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3230275A1 (de) *	1982-08-14	1984-02-16	Bayer Ag, 5090 Leverkusen	Elastaseinhibitoren, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel
AU591474B2 (en) *	1984-12-06	1989-12-07	Amgen, Inc.	Serine protease inhibitors and methods for isolation of same
US4829052A (en) *	1986-06-11	1989-05-09	Monsanto Company	Serine protease inhibitors

1989
- 1989-05-31 FR FR8907155A patent/FR2647677B1/fr not_active Expired - Fee Related
1990
- 1990-05-24 US US07/528,834 patent/US5089474A/en not_active Expired - Fee Related
- 1990-05-30 EP EP90401432A patent/EP0401109B1/de not_active Expired - Lifetime
- 1990-05-30 AT AT90401432T patent/ATE95195T1/de not_active IP Right Cessation
- 1990-05-30 ES ES90401432T patent/ES2060100T3/es not_active Expired - Lifetime
- 1990-05-30 DE DE90401432T patent/DE69003595T2/de not_active Expired - Fee Related
- 1990-05-30 CA CA002017803A patent/CA2017803A1/fr not_active Abandoned
- 1990-05-31 JP JP2140143A patent/JPH0368599A/ja active Pending

Also Published As

Publication number	Publication date
CA2017803A1 (fr)	1990-11-30
DE69003595D1 (de)	1993-11-04
EP0401109B1 (de)	1993-09-29
FR2647677B1 (fr)	1991-09-27
ES2060100T3 (es)	1994-11-16
JPH0368599A (ja)	1991-03-25
FR2647677A1 (fr)	1990-12-07
EP0401109A1 (de)	1990-12-05
DE69003595T2 (de)	1994-02-17
US5089474A (en)	1992-02-18

Legal Events

Date	Code	Title	Description
1994-06-15	UEP	Publication of translation of european patent specification
1995-08-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE95195T1 (de)	1993-10-15	Mikroproteine, verfahren zur herstellung derselben und anwendung dieser mikroproteine als arzneimittel.
ATE363535T1 (de)	2007-06-15	Stabile bakterizide proteine, welche die permeabilität erhöhen und pharmazeutische zusammensetzungen, diese enthaltend
HU906177D0 (en)	1991-08-28	Process for the production of peptide derivatives and medical and diagnostical preparations containing such derivatives
FI910286A0 (fi)	1991-01-18	Analoger av humant insulin och preparat innehaollande dessa.
HUP0001293A1 (hu)	2000-08-28	Heterociklusos vegyületek és ezeket tartalmazó gyógyászati készítmények béta-amiloid-peptidek gátlására
CA2117466A1 (fr)	1993-09-16	Application de l'amino-2 trifluoromethoxy-6 benzothiazole pour obtenir un medicament destine au traitement des maladies du motoneurone
FR2695317B1 (fr)	1995-03-10	Composition apte à stimuler la sécrétion d'insuline destinée au traitement du diabète non insulino-dépendant.
ATE121755T1 (de)	1995-05-15	Deletionsanaloga von magaininpeptiden.
AU1094892A (en)	1992-08-27	Improved activation of recombinant proteins
ATE10626T1 (de)	1984-12-15	N-substituierte omega-(2-oxo-imidazolin-1-yl)alkans[uren, deren salze und ester, verfahren zu deren herstellung und diese aktiven substanzen enthaltende pharmazeutische zubereitungen.
AU5372590A (en)	1990-11-01	New carboxamide group-containing (meth)acrylic acid esters, adhesive components, containing these compounds, for the treatment of collagen-containing materials and preparation and use of these adhesive components
WO2002048180A3 (de)	2003-01-30	Peptide und/oder proteine sowie verwendung desselben zur herstellung eines therapeutischen und/oder präventiven arzneimittels
KR910002899A (ko)	1991-02-26	혈조절 펩타이드
EP0329008A3 (de)	1991-08-28	Cephalosporinderivative und Verfahren zu ihrer Herstellung
CA2096532A1 (en)	1992-05-20	New human recombinant gamma-interferon
ATE138936T1 (de)	1996-06-15	Neue peptidderivate, verfahren zu deren herstellung und deren anwendung als heilmittel
ATE25708T1 (de)	1987-03-15	Biologisch aktive konjugate, ihre herstellung und ihre anwendung.
IL86638A0 (en)	1988-11-30	(2-cyano-2-oximinoacetyl)-amino acid derivatives,their preparation and their use as pesticides
ATE141615T1 (de)	1996-09-15	Neue peptid-derivate mit bradikyninantagonischer wirkung, verfahren zur deren herstellung und pharmazeutische zubereitungen die sie enthalten
DE69315730D1 (de)	1998-01-29	Verfahren zur Herstellung von Peptiden und neue Zwischenverbindungen dazu
EP0351676A3 (de)	1990-06-27	Benzothiazolone
ATE102025T1 (de)	1994-03-15	Nichtfestes augenarzneimittel und verfahren zur herstellung dieses arzneimittels.
EP0373461A3 (de)	1990-10-10	Benzazole
ES2135389T3 (es)	1999-11-01	Antagonistas de endotelina.
IL86637A0 (en)	1988-11-30	(2-cyano-2-oximinoacetyl)-amino acid derivatives,their preparation and their use as pesticides