|
US836805A
(en)
|
1904-05-10 |
1906-11-27 |
Alva Battie Dozier |
Telephone or switchboard plug.
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US3992518A
(en)
|
1974-10-24 |
1976-11-16 |
G. D. Searle & Co. |
Method for making a microsealed delivery device
|
|
GB1478759A
(en)
|
1974-11-18 |
1977-07-06 |
Alza Corp |
Process for forming outlet passageways in pills using a laser
|
|
US4284444A
(en)
|
1977-08-01 |
1981-08-18 |
Herculite Protective Fabrics Corporation |
Activated polymer materials and process for making same
|
|
US4704362A
(en)
|
1977-11-08 |
1987-11-03 |
Genentech, Inc. |
Recombinant cloning vehicle microbial polypeptide expression
|
|
US4200098A
(en)
|
1978-10-23 |
1980-04-29 |
Alza Corporation |
Osmotic system with distribution zone for dispensing beneficial agent
|
|
US4235881A
(en)
|
1978-12-04 |
1980-11-25 |
Cort Joseph H |
Method for producing high potency factor VIII
|
|
US4200984A
(en)
|
1979-03-12 |
1980-05-06 |
Fink Ray D |
Detachable tool combining bracket and method
|
|
US4342832A
(en)
|
1979-07-05 |
1982-08-03 |
Genentech, Inc. |
Method of constructing a replicable cloning vehicle having quasi-synthetic genes
|
|
US4215051A
(en)
|
1979-08-29 |
1980-07-29 |
Standard Oil Company (Indiana) |
Formation, purification and recovery of phthalic anhydride
|
|
ZA811368B
(en)
|
1980-03-24 |
1982-04-28 |
Genentech Inc |
Bacterial polypedtide expression employing tryptophan promoter-operator
|
|
US4398908A
(en)
|
1980-11-28 |
1983-08-16 |
Siposs George G |
Insulin delivery system
|
|
US4456591A
(en)
|
1981-06-25 |
1984-06-26 |
Baxter Travenol Laboratories, Inc. |
Therapeutic method for activating factor VII
|
|
US4435173A
(en)
|
1982-03-05 |
1984-03-06 |
Delta Medical Industries |
Variable rate syringe pump for insulin delivery
|
|
US4542025A
(en)
|
1982-07-29 |
1985-09-17 |
The Stolle Research And Development Corporation |
Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
|
|
US4599311A
(en)
|
1982-08-13 |
1986-07-08 |
Kawasaki Glenn H |
Glycolytic promotersfor regulated protein expression: protease inhibitor
|
|
US4713339A
(en)
|
1983-01-19 |
1987-12-15 |
Genentech, Inc. |
Polycistronic expression vector construction
|
|
US4870008A
(en)
|
1983-08-12 |
1989-09-26 |
Chiron Corporation |
Secretory expression in eukaryotes
|
|
US4757006A
(en)
|
1983-10-28 |
1988-07-12 |
Genetics Institute, Inc. |
Human factor VIII:C gene and recombinant methods for production
|
|
US5004804A
(en)
|
1984-01-12 |
1991-04-02 |
Nordisk Gentofte |
Method and composition for preparation of factor VIIIC
|
|
US7138505B1
(en)
|
1984-01-12 |
2006-11-21 |
Novartis Vaccines And Diagnostics, Inc. |
Factor VIII:C nucleic acid molecules
|
|
EP0154316B1
(en)
|
1984-03-06 |
1989-09-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified lymphokine and production thereof
|
|
US5916588A
(en)
|
1984-04-12 |
1999-06-29 |
The Liposome Company, Inc. |
Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use
|
|
US5231112A
(en)
|
1984-04-12 |
1993-07-27 |
The Liposome Company, Inc. |
Compositions containing tris salt of cholesterol hemisuccinate and antifungal
|
|
US4965199A
(en)
|
1984-04-20 |
1990-10-23 |
Genentech, Inc. |
Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
|
|
US4931373A
(en)
|
1984-05-25 |
1990-06-05 |
Zymogenetics, Inc. |
Stable DNA constructs for expression of α-1 antitrypsin
|
|
JPS61502760A
(ja)
|
1984-07-24 |
1986-11-27 |
キイ・フア−マシユ−テイカルズ・インコ−ポレイテツド |
粘着性経皮投与層
|
|
US4766073A
(en)
|
1985-02-25 |
1988-08-23 |
Zymogenetics Inc. |
Expression of biologically active PDGF analogs in eucaryotic cells
|
|
US4885249A
(en)
|
1984-12-05 |
1989-12-05 |
Allelix, Inc. |
Aspergillus niger transformation system
|
|
US4970300A
(en)
|
1985-02-01 |
1990-11-13 |
New York University |
Modified factor VIII
|
|
US4965188A
(en)
|
1986-08-22 |
1990-10-23 |
Cetus Corporation |
Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
US5981216A
(en)
|
1985-04-01 |
1999-11-09 |
Alusuisse Holdings A.G. |
Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same
|
|
ATE72838T1
(de)
|
1985-04-12 |
1992-03-15 |
Genetics Inst |
Neue prokoagulierungsproteine.
|
|
GR860984B
(en)
|
1985-04-17 |
1986-08-18 |
Zymogenetics Inc |
Expression of factor vii and ix activities in mammalian cells
|
|
ATE74164T1
(de)
|
1985-04-22 |
1992-04-15 |
Genetics Inst |
Herstellung mit hoher leistung des aktivfaktors ix.
|
|
US4684479A
(en)
|
1985-08-14 |
1987-08-04 |
Arrigo Joseph S D |
Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures
|
|
KR910006424B1
(ko)
|
1985-08-21 |
1991-08-24 |
인코텍스 비.브이 |
편성브리프(brief) 제조방법
|
|
US4882279A
(en)
|
1985-10-25 |
1989-11-21 |
Phillips Petroleum Company |
Site selective genomic modification of yeast of the genus pichia
|
|
DE3785102T2
(de)
|
1986-01-03 |
1993-07-22 |
Genetics Inst |
Verfahren zur herstellung von faktor-viii:c-typ-proteinen.
|
|
US5198349A
(en)
|
1986-01-03 |
1993-03-30 |
Genetics Institute, Inc. |
Method for producing factor VIII:C and analogs
|
|
US5250421A
(en)
|
1986-01-03 |
1993-10-05 |
Genetics Institute, Inc. |
Method for producing factor VIII:C-type proteins
|
|
US4935349A
(en)
|
1986-01-17 |
1990-06-19 |
Zymogenetics, Inc. |
Expression of higher eucaryotic genes in aspergillus
|
|
US5595886A
(en)
|
1986-01-27 |
1997-01-21 |
Chiron Corporation |
Protein complexes having Factor VIII:C activity and production thereof
|
|
US4800159A
(en)
|
1986-02-07 |
1989-01-24 |
Cetus Corporation |
Process for amplifying, detecting, and/or cloning nucleic acid sequences
|
|
DK122686D0
(da)
|
1986-03-17 |
1986-03-17 |
Novo Industri As |
Fremstilling af proteiner
|
|
GB8610600D0
(en)
|
1986-04-30 |
1986-06-04 |
Novo Industri As |
Transformation of trichoderma
|
|
US5422260A
(en)
|
1986-05-29 |
1995-06-06 |
Genetics Institute, Inc. -Legal Affairs |
Human factor VIII:c muteins
|
|
US6759057B1
(en)
|
1986-06-12 |
2004-07-06 |
The Liposome Company, Inc. |
Methods and compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs
|
|
US5543502A
(en)
|
1986-06-24 |
1996-08-06 |
Novo Nordisk A/S |
Process for producing a coagulation active complex of factor VIII fragments
|
|
IE60901B1
(en)
|
1986-08-21 |
1994-08-24 |
Vestar Inc |
Improved treatment of systemic fungal infections with phospholipid particles encapsulating polyene antifungal antibiotics
|
|
US4933185A
(en)
|
1986-09-24 |
1990-06-12 |
Massachusetts Institute Of Technology |
System for controlled release of biologically active compounds
|
|
US5811128A
(en)
|
1986-10-24 |
1998-09-22 |
Southern Research Institute |
Method for oral or rectal delivery of microencapsulated vaccines and compositions therefor
|
|
US4912040A
(en)
|
1986-11-14 |
1990-03-27 |
Genetics Institute, Inc. |
Eucaryotic expression system
|
|
US6406713B1
(en)
|
1987-03-05 |
2002-06-18 |
The Liposome Company, Inc. |
Methods of preparing low-toxicity drug-lipid complexes
|
|
US4775207A
(en)
|
1987-03-17 |
1988-10-04 |
Bell Communications Research, Inc. |
Electro-optical switch
|
|
WO1988007089A1
(en)
|
1987-03-18 |
1988-09-22 |
Medical Research Council |
Altered antibodies
|
|
CA1331157C
(en)
|
1987-04-06 |
1994-08-02 |
Randal J. Kaufman |
Method for producing factor viii:c-type proteins
|
|
US6060447A
(en)
|
1987-05-19 |
2000-05-09 |
Chiron Corporation |
Protein complexes having Factor VIII:C activity and production thereof
|
|
IL86693A
(en)
|
1987-06-12 |
1994-06-24 |
Stichting Centraal Lab |
Proteins with factor VIII activity, process for their preparation using genetically engineered cells and pharmaceutical compositions containing them
|
|
US6346513B1
(en)
|
1987-06-12 |
2002-02-12 |
Baxter Trading Gmbh |
Proteins with factor VIII activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
|
|
DE3720246A1
(de)
|
1987-06-19 |
1988-12-29 |
Behringwerke Ag |
Faktor viii:c-aehnliches molekuel mit koagulationsaktivitaet
|
|
US4897268A
(en)
|
1987-08-03 |
1990-01-30 |
Southern Research Institute |
Drug delivery system and method of making the same
|
|
US4976696A
(en)
|
1987-08-10 |
1990-12-11 |
Becton, Dickinson And Company |
Syringe pump and the like for delivering medication
|
|
FR2619314B1
(fr)
|
1987-08-11 |
1990-06-15 |
Transgene Sa |
Analogue du facteur viii, procede de preparation et composition pharmaceutique le contenant
|
|
US4861800A
(en)
|
1987-08-18 |
1989-08-29 |
Buyske Donald A |
Method for administering the drug deprenyl so as to minimize the danger of side effects
|
|
US4994371A
(en)
|
1987-08-28 |
1991-02-19 |
Davie Earl W |
DNA preparation of Christmas factor and use of DNA sequences
|
|
AU598958B2
(en)
|
1987-11-12 |
1990-07-05 |
Vestar, Inc. |
Improved amphotericin b liposome preparation
|
|
US5270176A
(en)
|
1987-11-20 |
1993-12-14 |
Hoechst Aktiengesellschaft |
Method for the selective cleavage of fusion proteins with lysostaphin
|
|
GB8807504D0
(en)
|
1988-03-29 |
1988-05-05 |
Sandoz Ltd |
Improvements in/relating to organic compounds
|
|
US5037743A
(en)
|
1988-08-05 |
1991-08-06 |
Zymogenetics, Inc. |
BAR1 secretion signal
|
|
JP2717808B2
(ja)
|
1988-08-10 |
1998-02-25 |
テルモ株式会社 |
シリンジポンプ
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
US5534617A
(en)
|
1988-10-28 |
1996-07-09 |
Genentech, Inc. |
Human growth hormone variants having greater affinity for human growth hormone receptor at site 1
|
|
US6780613B1
(en)
|
1988-10-28 |
2004-08-24 |
Genentech, Inc. |
Growth hormone variants
|
|
US5004803A
(en)
|
1988-11-14 |
1991-04-02 |
Genetics Institute, Inc. |
Production of procoagulant proteins
|
|
EP0401384B1
(en)
|
1988-12-22 |
1996-03-13 |
Kirin-Amgen, Inc. |
Chemically modified granulocyte colony stimulating factor
|
|
ES2098261T3
(es)
|
1989-02-21 |
1997-05-01 |
Univ Washington |
Formas modificadas de hormonas reproductoras.
|
|
US5017378A
(en)
|
1989-05-01 |
1991-05-21 |
The University Of Virginia Alumni Patents Foundation |
Intraorgan injection of biologically active compounds contained in slow-release microcapsules or microspheres
|
|
WO1990013361A1
(en)
|
1989-05-04 |
1990-11-15 |
Southern Research Institute |
Improved encapsulation process and products therefrom
|
|
US5599907A
(en)
|
1989-05-10 |
1997-02-04 |
Somatogen, Inc. |
Production and use of multimeric hemoglobins
|
|
US5298022A
(en)
|
1989-05-29 |
1994-03-29 |
Amplifon Spa |
Wearable artificial pancreas
|
|
FR2647677B1
(fr)
|
1989-05-31 |
1991-09-27 |
Roussel Uclaf |
Nouvelles micro-proteines, procede de preparation et application a titre de medicaments de ces nouvelles micro-proteines
|
|
US7413537B2
(en)
|
1989-09-01 |
2008-08-19 |
Dyax Corp. |
Directed evolution of disulfide-bonded micro-proteins
|
|
SE465222C5
(sv)
|
1989-12-15 |
1998-02-10 |
Pharmacia & Upjohn Ab |
Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
|
|
US5318540A
(en)
|
1990-04-02 |
1994-06-07 |
Pharmetrix Corporation |
Controlled release infusion device
|
|
US5492534A
(en)
|
1990-04-02 |
1996-02-20 |
Pharmetrix Corporation |
Controlled release portable pump
|
|
US6552170B1
(en)
|
1990-04-06 |
2003-04-22 |
Amgen Inc. |
PEGylation reagents and compounds formed therewith
|
|
US5176502A
(en)
|
1990-04-25 |
1993-01-05 |
Becton, Dickinson And Company |
Syringe pump and the like for delivering medication
|
|
US6517859B1
(en)
|
1990-05-16 |
2003-02-11 |
Southern Research Institute |
Microcapsules for administration of neuroactive agents
|
|
US5215680A
(en)
|
1990-07-10 |
1993-06-01 |
Cavitation-Control Technology, Inc. |
Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles
|
|
US5583107A
(en)
|
1990-09-04 |
1996-12-10 |
Cor Therapeutics, Inc. |
Agents affecting thrombosis and hemostasis
|
|
FI932680L
(fi)
|
1990-12-13 |
1993-06-11 |
Upjohn Co |
Fusionspolypeptider
|
|
US5206161A
(en)
|
1991-02-01 |
1993-04-27 |
Genentech, Inc. |
Human plasma carboxypeptidase B
|
|
US20060122376A1
(en)
|
1991-02-07 |
2006-06-08 |
Chiron Corporation |
Protein complexes having factor VIII:C activity and production thereof
|
|
US5833982A
(en)
|
1991-02-28 |
1998-11-10 |
Zymogenetics, Inc. |
Modified factor VII
|
|
DK0575545T3
(da)
|
1991-03-15 |
2003-09-15 |
Amgen Inc |
Pegylering af polypeptider
|
|
US5846951A
(en)
|
1991-06-06 |
1998-12-08 |
The School Of Pharmacy, University Of London |
Pharmaceutical compositions
|
|
IE922437A1
(en)
|
1991-07-25 |
1993-01-27 |
Idec Pharma Corp |
Recombinant antibodies for human therapy
|
|
CA2078721A1
(en)
|
1991-09-24 |
1993-03-25 |
Hiroshi Yonemura |
Process for preparing human coagulation factor viii protein complex
|
|
FR2686899B1
(fr)
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
|
|
US5859204A
(en)
|
1992-04-07 |
1999-01-12 |
Emory University |
Modified factor VIII
|
|
US6376463B1
(en)
|
1992-04-07 |
2002-04-23 |
Emory University |
Modified factor VIII
|
|
US5364771A
(en)
|
1992-04-07 |
1994-11-15 |
Emory University |
Hybrid human/porcine factor VIII
|
|
US6037452A
(en)
|
1992-04-10 |
2000-03-14 |
Alpha Therapeutic Corporation |
Poly(alkylene oxide)-Factor VIII or Factor IX conjugate
|
|
DE69329795T2
(de)
|
1992-10-02 |
2001-07-05 |
Genetics Institute, Inc. |
Zusammensetzung, welche den koagulationsfaktor viii beinhaltet; verfahren zu deren herstellung und die benutzung eines oberflächenaktiven stoffes als stabilisator
|
|
US5563045A
(en)
|
1992-11-13 |
1996-10-08 |
Genetics Institute, Inc. |
Chimeric procoagulant proteins
|
|
DE669986T1
(de)
|
1992-11-13 |
1996-10-10 |
Idec Pharma Corp |
Völlig unfunktionelle konsensus-kozak-sequenzen zur säugetier-exprimierung.
|
|
US5573776A
(en)
|
1992-12-02 |
1996-11-12 |
Alza Corporation |
Oral osmotic device with hydrogel driving member
|
|
US6090925A
(en)
|
1993-03-09 |
2000-07-18 |
Epic Therapeutics, Inc. |
Macromolecular microparticles and methods of production and use
|
|
US5554730A
(en)
|
1993-03-09 |
1996-09-10 |
Middlesex Sciences, Inc. |
Method and kit for making a polysaccharide-protein conjugate
|
|
ATE163230T1
(de)
|
1993-03-09 |
1998-02-15 |
Epic Therapeutics Inc |
Makromolekulare mikropartikel und verfahren zu ihrer herstellung
|
|
US5981719A
(en)
|
1993-03-09 |
1999-11-09 |
Epic Therapeutics, Inc. |
Macromolecular microparticles and methods of production and use
|
|
SE504074C2
(sv)
|
1993-07-05 |
1996-11-04 |
Pharmacia Ab |
Proteinberedning för subkutan, intramuskulär eller intradermal administrering
|
|
US5576291A
(en)
|
1993-09-13 |
1996-11-19 |
Baxter International Inc. |
Activated factor VIII as a therapeutic agent and method of treating factor VIII deficiency
|
|
US5643575A
(en)
|
1993-10-27 |
1997-07-01 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US20020042079A1
(en)
|
1994-02-01 |
2002-04-11 |
Sanford M. Simon |
Methods and agents for measuring and controlling multidrug resistance
|
|
US5660848A
(en)
|
1994-11-02 |
1997-08-26 |
The Population Council, Center For Biomedical Research |
Subdermally implantable device
|
|
GB9422383D0
(en)
|
1994-11-05 |
1995-01-04 |
Wellcome Found |
Antibodies
|
|
SE503424C2
(sv)
|
1994-11-14 |
1996-06-10 |
Pharmacia Ab |
Process för rening av rekombinant koagulationsfaktor VIII
|
|
US6818439B1
(en)
|
1994-12-30 |
2004-11-16 |
Chiron Corporation |
Methods for administration of recombinant gene delivery vehicles for treatment of hemophilia and other disorders
|
|
US6030613A
(en)
|
1995-01-17 |
2000-02-29 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of therapeutics
|
|
US6086875A
(en)
|
1995-01-17 |
2000-07-11 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of immunogens
|
|
US6485726B1
(en)
|
1995-01-17 |
2002-11-26 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of therapeutics
|
|
US5739277A
(en)
|
1995-04-14 |
1998-04-14 |
Genentech Inc. |
Altered polypeptides with increased half-life
|
|
US6121022A
(en)
|
1995-04-14 |
2000-09-19 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US6096871A
(en)
|
1995-04-14 |
2000-08-01 |
Genentech, Inc. |
Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
|
|
US7846455B2
(en)
|
1996-07-15 |
2010-12-07 |
The United States Of America As Represented By The Department Of Health And Human Services |
Attenuated chimeric respiratory syncytial virus
|
|
SE9503380D0
(sv)
|
1995-09-29 |
1995-09-29 |
Pharmacia Ab |
Protein derivatives
|
|
GB9526733D0
(en)
|
1995-12-30 |
1996-02-28 |
Delta Biotechnology Ltd |
Fusion proteins
|
|
DE69735057T2
(de)
|
1996-03-12 |
2006-08-31 |
PG-TXL Co., L.P., Houston |
Wasserlösliche paclitaxel-prodrogen
|
|
US6441025B2
(en)
|
1996-03-12 |
2002-08-27 |
Pg-Txl Company, L.P. |
Water soluble paclitaxel derivatives
|
|
US8183344B2
(en)
|
1996-04-24 |
2012-05-22 |
University Of Michigan |
Inactivation resistant factor VIII
|
|
US7560107B2
(en)
|
1996-06-26 |
2009-07-14 |
Emory University |
Modified factor VIII
|
|
US6458563B1
(en)
|
1996-06-26 |
2002-10-01 |
Emory University |
Modified factor VIII
|
|
ATE386809T1
(de)
|
1996-08-02 |
2008-03-15 |
Bristol Myers Squibb Co |
Ein verfahren zur inhibierung immunglobulininduzierter toxizität aufgrund von der verwendung von immunoglobinen in therapie und in vivo diagnostik
|
|
CA2263455C
(en)
|
1996-08-23 |
2002-10-29 |
Sequus Pharmaceuticals, Inc. |
Liposomes containing a cisplatin compound
|
|
US6056973A
(en)
|
1996-10-11 |
2000-05-02 |
Sequus Pharmaceuticals, Inc. |
Therapeutic liposome composition and method of preparation
|
|
EP0932390A1
(en)
|
1996-10-11 |
1999-08-04 |
Sequus Pharmaceuticals, Inc. |
Therapeutic liposome composition and method
|
|
SK283760B6
(sk)
|
1996-10-15 |
2004-01-08 |
The Liposome Company, Inc. |
Farmaceutický prostriedok na dopravu bioaktívnych látok
|
|
US6361796B1
(en)
|
1996-10-25 |
2002-03-26 |
Shire Laboratories, Inc. |
Soluble form osmotic dose delivery system
|
|
ATE314054T1
(de)
|
1996-10-25 |
2006-01-15 |
Shire Lab Inc |
Osmotisches verabreichungssystem für lösliche dosen
|
|
WO1998022577A1
(en)
|
1996-11-15 |
1998-05-28 |
Maria Grazia Masucci |
Fusion proteins having increased half-lives
|
|
EP0842657A1
(en)
|
1996-11-19 |
1998-05-20 |
OctoPlus B.V. |
Microspheres for controlled release and processes to prepare these microspheres
|
|
US6395302B1
(en)
|
1996-11-19 |
2002-05-28 |
Octoplus B.V. |
Method for the preparation of microspheres which contain colloidal systems
|
|
WO1998023289A1
(en)
|
1996-11-27 |
1998-06-04 |
The General Hospital Corporation |
MODULATION OF IgG BINDING TO FcRn
|
|
US20020019036A1
(en)
|
1996-12-13 |
2002-02-14 |
Hans-Peter Schwarz |
Von willebrand factor derivatives and methods of isolating proteins that bind to von willebrand factor
|
|
US6294170B1
(en)
|
1997-08-08 |
2001-09-25 |
Amgen Inc. |
Composition and method for treating inflammatory diseases
|
|
AT405516B
(de)
|
1997-02-27 |
1999-09-27 |
Immuno Ag |
Faktor x-analoge mit modifizierter proteasespaltstelle
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
CA2225189C
(en)
|
1997-03-06 |
2010-05-25 |
Queen's University At Kingston |
Canine factor viii gene, protein and methods of use
|
|
ES2242997T3
(es)
|
1997-03-14 |
2005-11-16 |
Biogen Idec Inc. |
Metodo para integrar genes en sitios especificos en celulas de mamifero por medio de recombinacion homologa y vectores para realizar el mismo.
|
|
WO1998052976A1
(en)
|
1997-05-21 |
1998-11-26 |
Biovation Limited |
Method for the production of non-immunogenic proteins
|
|
US6310183B1
(en)
|
1997-09-10 |
2001-10-30 |
Novo Nordisk A/S |
Coagulation factor VIIa composition
|
|
US7786070B2
(en)
|
1997-09-10 |
2010-08-31 |
Novo Nordisk Healthcare A/G |
Subcutaneous administration of coagulation factor VII
|
|
DE19747261A1
(de)
|
1997-10-25 |
1999-04-29 |
Bayer Ag |
Osmotisches Arzneimittelfreisetzungssystem
|
|
GB9722131D0
(en)
|
1997-10-20 |
1997-12-17 |
Medical Res Council |
Method
|
|
DE69838526T2
(de)
|
1998-02-05 |
2008-07-03 |
Biosense Webster, Inc., Diamond Bar |
Gerät zum Freisetzen eines Medikaments im Herzen
|
|
CA2320958A1
(en)
|
1998-02-11 |
1999-08-19 |
Maxygen, Inc. |
Antigen library immunization
|
|
US20050260605A1
(en)
|
1998-02-11 |
2005-11-24 |
Maxygen, Inc. |
Targeting of genetic vaccine vectors
|
|
US6528624B1
(en)
|
1998-04-02 |
2003-03-04 |
Genentech, Inc. |
Polypeptide variants
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
US6242195B1
(en)
|
1998-04-02 |
2001-06-05 |
Genentech, Inc. |
Methods for determining binding of an analyte to a receptor
|
|
ES2292236T3
(es)
|
1998-04-02 |
2008-03-01 |
Genentech, Inc. |
Variantes de anticuerpos y sus fragmentos.
|
|
US6406632B1
(en)
|
1998-04-03 |
2002-06-18 |
Symyx Technologies, Inc. |
Rapid characterization of polymers
|
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
|
US7090976B2
(en)
|
1999-11-10 |
2006-08-15 |
Rigel Pharmaceuticals, Inc. |
Methods and compositions comprising Renilla GFP
|
|
GB9815157D0
(en)
|
1998-07-13 |
1998-09-09 |
Metron Designs Ltd |
High resolution pulse width setting from relatively low frequency clocks
|
|
EP1105427A2
(en)
|
1998-08-17 |
2001-06-13 |
Abgenix, Inc. |
Generation of modified molecules with increased serum half-lives
|
|
US6927044B2
(en)
|
1998-09-25 |
2005-08-09 |
Regeneron Pharmaceuticals, Inc. |
IL-1 receptor based cytokine traps
|
|
EP1129186B2
(de)
|
1998-11-10 |
2016-11-30 |
Stichting Sanquin Bloedvoorziening |
Ein faktor viii-polypeptid mit faktor viii:c-aktivität
|
|
EP1006183A1
(en)
|
1998-12-03 |
2000-06-07 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Recombinant soluble Fc receptors
|
|
US6329186B1
(en)
|
1998-12-07 |
2001-12-11 |
Novozymes A/S |
Glucoamylases with N-terminal extensions
|
|
US6358703B1
(en)
|
1998-12-10 |
2002-03-19 |
Bayer Corporation |
Expression system for factor VIII
|
|
US6713086B2
(en)
|
1998-12-18 |
2004-03-30 |
Abbott Laboratories |
Controlled release formulation of divalproex sodium
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
HU230769B1
(hu)
|
1999-01-15 |
2018-03-28 |
Genentech Inc. |
Módosított effektor-funkciójú polipeptid-változatok
|
|
NZ514442A
(en)
|
1999-03-03 |
2003-08-29 |
Optinose As |
Nasal delivery device
|
|
US6183770B1
(en)
|
1999-04-15 |
2001-02-06 |
Acutek International |
Carrier patch for the delivery of agents to the skin
|
|
US7666400B2
(en)
|
2005-04-06 |
2010-02-23 |
Ibc Pharmaceuticals, Inc. |
PEGylation by the dock and lock (DNL) technique
|
|
US6743211B1
(en)
|
1999-11-23 |
2004-06-01 |
Georgia Tech Research Corporation |
Devices and methods for enhanced microneedle penetration of biological barriers
|
|
US7829085B2
(en)
|
1999-07-14 |
2010-11-09 |
Life Sciences Research Partners Vzw |
Methods of treating hemostasis disorders using antibodies binding the C1 domain of factor VIII
|
|
CA2378473A1
(en)
|
1999-07-23 |
2001-02-01 |
The Regents Of The University Of California |
Modulation of platelet activation
|
|
CA2380633A1
(en)
|
1999-08-06 |
2001-02-15 |
Genentech, Inc. |
Peptide antagonists of factor viia
|
|
US6458387B1
(en)
|
1999-10-18 |
2002-10-01 |
Epic Therapeutics, Inc. |
Sustained release microspheres
|
|
US20030109428A1
(en)
|
1999-12-01 |
2003-06-12 |
John Bertin |
Novel molecules of the card-related protein family and uses thereof
|
|
US20050287153A1
(en)
|
2002-06-28 |
2005-12-29 |
Genentech, Inc. |
Serum albumin binding peptides for tumor targeting
|
|
US6352721B1
(en)
|
2000-01-14 |
2002-03-05 |
Osmotica Corp. |
Combined diffusion/osmotic pumping drug delivery system
|
|
HUP0204475A2
(en)
|
2000-02-11 |
2003-04-28 |
Merck Patent Gmbh |
Enhancing the circulating half-life of antibody-based fusion proteins
|
|
DE60138364D1
(de)
|
2000-02-11 |
2009-05-28 |
Bayer Healthcare Llc |
Gerinnungsfaktor vii oder viia konjugate
|
|
EP2206720A1
(en)
|
2000-04-12 |
2010-07-14 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
AU2001258536A1
(en)
|
2000-05-16 |
2001-11-26 |
Lipoxen Technologies Limited |
Derivatisation of proteins in aqueous solution
|
|
JP2001326635A
(ja)
|
2000-05-16 |
2001-11-22 |
Matsushita Electric Ind Co Ltd |
インターネットの課金システム
|
|
DE60140625D1
(de)
|
2000-08-15 |
2010-01-07 |
Univ Illinois |
Verfahren zur herstellung von mikropartikeln
|
|
MXPA03001984A
(es)
|
2000-09-13 |
2003-08-29 |
Novo Nordisk Healthcare Ag |
Variantes de factor vii de coagulacion humano.
|
|
KR100638184B1
(ko)
|
2000-09-19 |
2006-10-26 |
에모리 유니버시티 |
변형된 인자 ⅷ
|
|
DE10053224A1
(de)
|
2000-10-26 |
2002-05-08 |
Univ Goettingen Georg August |
Verfahren zur Exposition von Peptiden und Polypeptiden auf der Zelloberfläche von Bakterien
|
|
US20030228309A1
(en)
|
2000-11-08 |
2003-12-11 |
Theodora Salcedo |
Antibodies that immunospecifically bind to TRAIL receptors
|
|
AU2002226028A1
(en)
|
2000-11-14 |
2002-05-27 |
Board Of Regents, Unversity Of Texas Systems |
Mutant human factor ix with an increased resistance to inhibition by heparin
|
|
GB0029407D0
(en)
|
2000-12-01 |
2001-01-17 |
Affitech As |
Product
|
|
PT1355919E
(pt)
|
2000-12-12 |
2011-03-02 |
Medimmune Llc |
Moléculas com semivida longa, composições que as contêm e suas utilizações
|
|
US20030104591A1
(en)
|
2000-12-14 |
2003-06-05 |
Murray Christopher J. |
Methods and compositions for grafting functional loops into a protein
|
|
US20030049689A1
(en)
|
2000-12-14 |
2003-03-13 |
Cynthia Edwards |
Multifunctional polypeptides
|
|
US7276593B2
(en)
|
2000-12-29 |
2007-10-02 |
Curagen Corporation |
Proteins and nucleic acids encoding same
|
|
IN190699B
(pl)
|
2001-02-02 |
2003-08-16 |
Sun Pharmaceutical Ind Ltd |
|
|
EP1359936B1
(en)
|
2001-02-05 |
2008-02-20 |
Novo Nordisk Health Care AG |
Combined use of factor vii polypeptides and factor viii polypeptides
|
|
US6888319B2
(en)
|
2001-03-01 |
2005-05-03 |
Palomar Medical Technologies, Inc. |
Flashlamp drive circuit
|
|
US7211395B2
(en)
|
2001-03-09 |
2007-05-01 |
Dyax Corp. |
Serum albumin binding moieties
|
|
PE20020908A1
(es)
|
2001-03-21 |
2002-10-26 |
Cell Therapeutics Inc |
Produccion recombinante de polimeros polianionicos y uso de de los mismos
|
|
WO2002079415A2
(en)
|
2001-03-30 |
2002-10-10 |
Lexigen Pharmaceuticals Corp. |
Reducing the immunogenicity of fusion proteins
|
|
US20040106794A1
(en)
|
2001-04-16 |
2004-06-03 |
Schering Corporation |
3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
|
|
US20050048512A1
(en)
|
2001-04-26 |
2005-03-03 |
Avidia Research Institute |
Combinatorial libraries of monomer domains
|
|
US6890918B2
(en)
|
2001-04-30 |
2005-05-10 |
Shire Laboratories, Inc. |
Pharmaceutical compositions including ACE/NEP inhibitors and bioavailability enhancers
|
|
TW503179B
(en)
|
2001-05-07 |
2002-09-21 |
Benq Corp |
Ink jetting device having bubble valve and the method thereof
|
|
US6838093B2
(en)
|
2001-06-01 |
2005-01-04 |
Shire Laboratories, Inc. |
System for osmotic delivery of pharmaceutically active agents
|
|
CA2450125A1
(en)
|
2001-06-15 |
2002-12-27 |
Andre C. Schuh |
Gene therapy for hemophilia a
|
|
KR100407467B1
(ko)
|
2001-07-12 |
2003-11-28 |
최수봉 |
리모컨 방식의 인슐린 자동주사기
|
|
WO2003011213A2
(en)
|
2001-07-30 |
2003-02-13 |
Eli Lilly And Company |
Method for treating diabetes and obesity
|
|
KR20040039328A
(ko)
|
2001-09-04 |
2004-05-10 |
메르크 파텐트 게엠베하 |
변형된 펙터 ⅸ
|
|
JP2003110596A
(ja)
|
2001-09-28 |
2003-04-11 |
Hitachi Ltd |
データ通信サービス提供方法
|
|
EP2042196B1
(en)
|
2001-10-10 |
2016-07-13 |
ratiopharm GmbH |
Remodelling and glycoconjugation of Granulocyte Colony Stimulating Factor (G-CSF)
|
|
US7125843B2
(en)
|
2001-10-19 |
2006-10-24 |
Neose Technologies, Inc. |
Glycoconjugates including more than one peptide
|
|
US6960657B2
(en)
|
2001-11-02 |
2005-11-01 |
Novo Nordisk Healthcare A/G |
Human coagulation factor VII polypeptides
|
|
WO2003048345A1
(en)
|
2001-12-07 |
2003-06-12 |
Toolgen, Inc. |
Phenotypic screen of chimeric proteins
|
|
US20080167238A1
(en)
|
2001-12-21 |
2008-07-10 |
Human Genome Sciences, Inc. |
Albumin Fusion Proteins
|
|
EP2261250B1
(en)
|
2001-12-21 |
2015-07-01 |
Human Genome Sciences, Inc. |
GCSF-Albumin fusion proteins
|
|
US20080194481A1
(en)
|
2001-12-21 |
2008-08-14 |
Human Genome Sciences, Inc. |
Albumin Fusion Proteins
|
|
KR101271635B1
(ko)
|
2001-12-21 |
2013-06-12 |
휴먼 게놈 사이언시즈, 인코포레이티드 |
알부민 융합 단백질
|
|
US20040002587A1
(en)
|
2002-02-20 |
2004-01-01 |
Watkins Jeffry D. |
Fc region variants
|
|
CA2478011C
(en)
|
2002-03-01 |
2013-05-21 |
Immunomedics, Inc. |
Bispecific antibody point mutations for enhancing rate of clearance
|
|
US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
AU2002316574B2
(en)
|
2002-03-15 |
2008-05-01 |
Brandeis University |
Central airway administration for systemic delivery of therapeutics
|
|
SI1499719T1
(sl)
|
2002-04-30 |
2011-03-31 |
Bayer Healthcare Llc |
Polipeptidne variante faktorja VII ali VIIa
|
|
US6945952B2
(en)
|
2002-06-25 |
2005-09-20 |
Theraject, Inc. |
Solid solution perforator for drug delivery and other applications
|
|
US7294513B2
(en)
|
2002-07-24 |
2007-11-13 |
Wyatt Technology Corporation |
Method and apparatus for characterizing solutions of small particles
|
|
US7314709B2
(en)
|
2002-08-06 |
2008-01-01 |
Vanderbilt University |
Compositions and methods for detecting and quantifying COX-2 activity by lipoamino acid metabolism
|
|
EP1534335B9
(en)
|
2002-08-14 |
2016-01-13 |
Macrogenics, Inc. |
Fcgammariib-specific antibodies and methods of use thereof
|
|
AU2003275103A1
(en)
|
2002-09-17 |
2004-04-08 |
Diffusion Science, Inc. |
Electrochemical generation, storage and reaction of hydrogen and oxygen using gas permeable catalyst-coated hollow microspheres
|
|
US6911323B2
(en)
|
2002-09-25 |
2005-06-28 |
Novo Nordisk Healthcare A/G |
Human coagulation factor VII polypeptides
|
|
WO2004029207A2
(en)
|
2002-09-27 |
2004-04-08 |
Xencor Inc. |
Optimized fc variants and methods for their generation
|
|
DE60334141D1
(de)
|
2002-10-15 |
2010-10-21 |
Facet Biotech Corp |
VERÄNDERUNG VON FcRn-BINDUNGSAFFINITÄTEN ODER VON SERUMHALBWERTSZEITEN VON ANTIKÖRPERN MITTELS MUTAGENESE
|
|
GB2395337B
(en)
|
2002-11-14 |
2005-12-28 |
Gary Michael Wilson |
Warning Unit
|
|
JP2006524039A
(ja)
|
2003-01-09 |
2006-10-26 |
マクロジェニクス，インコーポレーテッド |
変異型Ｆｃ領域を含む抗体の同定および作製ならびにその利用法
|
|
US7041635B2
(en)
|
2003-01-28 |
2006-05-09 |
In2Gen Co., Ltd. |
Factor VIII polypeptide
|
|
EP1444986A1
(en)
|
2003-02-07 |
2004-08-11 |
Aventis Behring GmbH |
Pharmaceutical preparation for the improved treatment of blood-clotting disorders
|
|
WO2004075923A2
(en)
|
2003-02-26 |
2004-09-10 |
Nektar Therapeutics Al, Corporation |
Polymer-factor viii moiety conjugates
|
|
CA2515798A1
(en)
|
2003-02-27 |
2004-09-10 |
Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Research Council Of Canada |
Peptide inhibitors of thrombin as potent anticoagulants
|
|
CA2515989C
(en)
|
2003-02-28 |
2009-09-15 |
Kuraray Co., Ltd. |
Curable resin composition
|
|
US20090010920A1
(en)
|
2003-03-03 |
2009-01-08 |
Xencor, Inc. |
Fc Variants Having Decreased Affinity for FcyRIIb
|
|
US8388955B2
(en)
|
2003-03-03 |
2013-03-05 |
Xencor, Inc. |
Fc variants
|
|
US20050176108A1
(en)
|
2003-03-13 |
2005-08-11 |
Young-Min Kim |
Physiologically active polypeptide conjugate having prolonged in vivo half-life
|
|
US7132398B2
(en)
|
2003-05-06 |
2006-11-07 |
Dendreon Corporation |
Method of treatment of hemorrhagic disease using a factor VIIa/tissue factor inhibitor
|
|
TWI353991B
(en)
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
|
US7348004B2
(en)
|
2003-05-06 |
2008-03-25 |
Syntonix Pharmaceuticals, Inc. |
Immunoglobulin chimeric monomer-dimer hybrids
|
|
PT1624891E
(pt)
|
2003-05-06 |
2010-01-05 |
Syntonix Pharmaceuticals Inc |
Proteínas quiméricas de factor de coagulação-fc destinadas ao tratamento da hemofilia
|
|
US20070161087A1
(en)
|
2003-05-29 |
2007-07-12 |
Wolfgang Glaesner |
Glp-1 fusion proteins
|
|
WO2005017149A1
(en)
|
2003-06-03 |
2005-02-24 |
Cell Genesys, Inc. |
Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site
|
|
AU2004255553B2
(en)
|
2003-06-19 |
2009-08-20 |
Genentech, Inc. |
Compositions and methods for treating coagulation related disorders
|
|
WO2005016974A1
(en)
|
2003-08-12 |
2005-02-24 |
Lipoxen Technologies Limited |
Sialic acid derivatives for protein derivatisation and conjugation
|
|
CA2535489C
(en)
|
2003-08-14 |
2014-09-30 |
D. Collen Research Foundation Vzw |
Antibodies against factor viii with modified glycosylation in the variable region
|
|
US20050152979A1
(en)
|
2003-09-05 |
2005-07-14 |
Cell Therapeutics, Inc. |
Hydrophobic drug compositions containing reconstitution enhancer
|
|
CN1871252A
(zh)
|
2003-09-05 |
2006-11-29 |
Gtc生物治疗学公司 |
在转基因哺乳动物奶中生产融合蛋白的方法
|
|
ES2381110T3
(es)
|
2003-09-09 |
2012-05-23 |
Novo Nordisk Health Care Ag |
Polipéptidos de factor VII de coagulación
|
|
KR101241862B1
(ko)
|
2003-09-19 |
2013-03-13 |
노보 노르디스크 에이/에스 |
신규 ｇｌｐ-1 유도체
|
|
GB0324368D0
(en)
|
2003-10-17 |
2003-11-19 |
Univ Cambridge Tech |
Polypeptides including modified constant regions
|
|
US20050123997A1
(en)
|
2003-10-30 |
2005-06-09 |
Lollar John S. |
Modified fVIII having reduced immunogenicity through mutagenesis of A2 and C2 epitopes
|
|
US7211559B2
(en)
|
2003-10-31 |
2007-05-01 |
University Of Maryland, Baltimore |
Factor VIII compositions and methods
|
|
WO2005047327A2
(en)
|
2003-11-12 |
2005-05-26 |
Biogen Idec Ma Inc. |
NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO
|
|
EP1684790A4
(en)
|
2003-11-18 |
2008-04-30 |
Iconic Therapeutics Inc |
HOMOGENEOUS PREPARATIONS OF CHIMERIC PROTEINS
|
|
US20060040856A1
(en)
|
2003-12-03 |
2006-02-23 |
Neose Technologies, Inc. |
Glycopegylated factor IX
|
|
US20050249723A1
(en)
|
2003-12-22 |
2005-11-10 |
Xencor, Inc. |
Fc polypeptides with novel Fc ligand binding sites
|
|
CA2552788C
(en)
|
2004-01-12 |
2013-09-24 |
Applied Molecular Evolution, Inc. |
Fc region variants
|
|
EP1711533B1
(en)
|
2004-01-14 |
2013-12-11 |
Ohio University |
Methods of producing peptides/proteins in plants and peptides/proteins produced thereby
|
|
ES2567634T3
(es)
|
2004-02-09 |
2016-04-25 |
Human Genome Sciences, Inc. |
Proteínas de fusión de albúmina
|
|
US8076288B2
(en)
|
2004-02-11 |
2011-12-13 |
Amylin Pharmaceuticals, Inc. |
Hybrid polypeptides having glucose lowering activity
|
|
EP1737890A2
(en)
|
2004-03-24 |
2007-01-03 |
Xencor, Inc. |
Immunoglobulin variants outside the fc region
|
|
WO2005123780A2
(en)
|
2004-04-09 |
2005-12-29 |
Protein Design Labs, Inc. |
Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
KR100624013B1
(ko)
|
2004-06-25 |
2006-09-19 |
주식회사 녹십자홀딩스 |
동결건조된 알부민 비함유 재조합 사람 혈액응고 제 8인자 제제
|
|
US20080233100A1
(en)
|
2004-06-30 |
2008-09-25 |
Yiyou Chen |
Targeted enzymes
|
|
WO2006085967A2
(en)
|
2004-07-09 |
2006-08-17 |
Xencor, Inc. |
OPTIMIZED ANTI-CD20 MONOCONAL ANTIBODIES HAVING Fc VARIANTS
|
|
CN103172731A
(zh)
|
2004-07-15 |
2013-06-26 |
赞科股份有限公司 |
优化的Fc变体
|
|
CA2569707C
(en)
|
2004-08-13 |
2013-09-24 |
F. Hoffmann-La Roche Ag |
C-terminal modification of polypeptides
|
|
US7566701B2
(en)
|
2004-09-07 |
2009-07-28 |
Archemix Corp. |
Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
|
|
EA011879B1
(ru)
|
2004-09-24 |
2009-06-30 |
Эмджин Инк. |
МОЛЕКУЛЫ С МОДИФИЦИРОВАННЫМ Fc ФРАГМЕНТОМ
|
|
WO2006047350A2
(en)
|
2004-10-21 |
2006-05-04 |
Xencor, Inc. |
IgG IMMUNOGLOBULIN VARIANTS WITH OPTIMIZED EFFECTOR FUNCTION
|
|
US8367805B2
(en)
|
2004-11-12 |
2013-02-05 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
KR101468345B1
(ko)
|
2004-11-12 |
2014-12-03 |
바이엘 헬스케어 엘엘씨 |
Ｆｖｉｉｉ의 부위 지향 변형
|
|
CA2587463A1
(en)
|
2004-11-16 |
2006-11-30 |
Avidia Research Institute |
Protein scaffolds and uses therof
|
|
CA2591852A1
(en)
|
2004-12-27 |
2006-07-06 |
Baxter International Inc. |
Polymer-von willebrand factor-conjugates
|
|
WO2006081249A2
(en)
|
2005-01-25 |
2006-08-03 |
Cell Therapeutics, Inc. |
Conjugates of biologically active proteins having a modified in vivo half-life
|
|
US8263545B2
(en)
|
2005-02-11 |
2012-09-11 |
Amylin Pharmaceuticals, Inc. |
GIP analog and hybrid polypeptides with selectable properties
|
|
JP2008534559A
(ja)
|
2005-04-01 |
2008-08-28 |
ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト |
血液凝固ｆｖｉｉｉ類似体
|
|
GB0516091D0
(en)
|
2005-08-04 |
2005-09-14 |
Haemostatix Ltd |
Therapeutic agent
|
|
MX2008001865A
(es)
|
2005-08-12 |
2008-04-15 |
Human Genome Sciences Inc |
Proteinas de fusion de albumina.
|
|
EP1929005A1
(en)
|
2005-09-21 |
2008-06-11 |
Novo Nordisk Health Care AG |
Human coagulation factor vii polypeptides
|
|
US20090099031A1
(en)
|
2005-09-27 |
2009-04-16 |
Stemmer Willem P |
Genetic package and uses thereof
|
|
US7846445B2
(en)
|
2005-09-27 |
2010-12-07 |
Amunix Operating, Inc. |
Methods for production of unstructured recombinant polymers and uses thereof
|
|
EP1929073A4
(en)
|
2005-09-27 |
2010-03-10 |
Amunix Inc |
PROTEIN MEDICAMENT AND ITS USE
|
|
US7855279B2
(en)
|
2005-09-27 |
2010-12-21 |
Amunix Operating, Inc. |
Unstructured recombinant polymers and uses thereof
|
|
CN101384272B
(zh)
|
2005-12-20 |
2013-05-01 |
杜克大学 |
用于递送具有增强的药理性质的活性剂的方法和组合物
|
|
US20130172274A1
(en)
|
2005-12-20 |
2013-07-04 |
Duke University |
Methods and compositions for delivering active agents with enhanced pharmacological properties
|
|
US8048848B2
(en)
|
2006-02-03 |
2011-11-01 |
Prolor Biotech Ltd. |
Long-acting interferons and derivatives thereof and methods thereof
|
|
EP1816201A1
(en)
|
2006-02-06 |
2007-08-08 |
CSL Behring GmbH |
Modified coagulation factor VIIa with extended half-life
|
|
FR2897868B1
(fr)
|
2006-02-24 |
2012-08-31 |
Lab Francais Du Fractionnement |
Anticorps anti-idiotypiques neutralisant l'activite inhibitrice d'un anticorps inhibiteur dirige contre le domaine c1 du facteur viii.
|
|
EP1996937A4
(en)
|
2006-03-06 |
2009-04-08 |
Amunix Inc |
GENETIC PACKS AND USES THEREOF
|
|
WO2007104146A1
(en)
|
2006-03-13 |
2007-09-20 |
Tir Technology Lp |
Adaptive control apparatus and method for a solid-state lighting system
|
|
CA2647314A1
(en)
|
2006-03-31 |
2007-11-08 |
Baxter International Inc. |
Pegylated factor viii
|
|
US7645860B2
(en)
|
2006-03-31 |
2010-01-12 |
Baxter Healthcare S.A. |
Factor VIII polymer conjugates
|
|
US9283260B2
(en)
|
2006-04-21 |
2016-03-15 |
Amgen Inc. |
Lyophilized therapeutic peptibody formulations
|
|
WO2007130535A2
(en)
|
2006-05-04 |
2007-11-15 |
Molecular Innovations |
Novel protein fusion/tag technology
|
|
EP1867660A1
(en)
|
2006-06-14 |
2007-12-19 |
CSL Behring GmbH |
Proteolytically cleavable fusion protein comprising a blood coagulation factor
|
|
US7939632B2
(en)
|
2006-06-14 |
2011-05-10 |
Csl Behring Gmbh |
Proteolytically cleavable fusion proteins with high molar specific activity
|
|
AU2007260185B2
(en)
|
2006-06-14 |
2013-01-31 |
Csl Behring Gmbh |
Proteolytically cleavable fusion protein comprising a blood coagulation factor
|
|
EP2423305A1
(en)
|
2006-06-19 |
2012-02-29 |
Catalyst Biosciences, Inc. |
Modified coagulation factor IX polypeptides and use thereof for treatment
|
|
ES2516694T3
(es)
|
2006-07-21 |
2014-10-31 |
Ratiopharm Gmbh |
Glicosilación de péptidos a través de secuencias de glicosilación con unión en O
|
|
WO2008028117A2
(en)
|
2006-08-31 |
2008-03-06 |
Centocor, Inc. |
Glp-2 mimetibodies, polypeptides, compositions, methods and uses
|
|
JP2010503396A
(ja)
|
2006-09-14 |
2010-02-04 |
ヒューマン ジノーム サイエンシーズ， インコーポレイテッド |
アルブミン融合タンパク質
|
|
US8969532B2
(en)
|
2006-10-03 |
2015-03-03 |
Novo Nordisk A/S |
Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
|
|
US20100041872A1
(en)
|
2006-10-04 |
2010-02-18 |
Defrees Shawn |
Glycerol linked pegylated sugars and glycopeptides
|
|
WO2008049711A1
(en)
|
2006-10-27 |
2008-05-02 |
Novo Nordisk A/S |
Peptide extended insulins
|
|
CN101190945A
(zh)
|
2006-11-29 |
2008-06-04 |
中国人民解放军军事医学科学院放射与辐射医学研究所 |
特异性抗凝血物质的制备及其应用
|
|
EP1935430A1
(en)
|
2006-12-22 |
2008-06-25 |
CSL Behring GmbH |
Modified coagulation factors with prolonged in vivo half-life
|
|
AU2007338298B2
(en)
|
2006-12-22 |
2013-02-07 |
Csl Behring Gmbh |
Modified coagulation factors with prolonged in vivo half-life
|
|
MX2009007145A
(es)
|
2006-12-27 |
2009-08-27 |
Nektar Therapeutics Al Corp |
Conjugados de polimero con factor viii y factor de von willebrand que tienen una ligadura liberable.
|
|
EP2099475B1
(en)
|
2007-01-03 |
2016-08-24 |
Novo Nordisk Health Care AG |
Subcutaneous administration of coagulation factor viia-related polypeptides
|
|
US7700734B2
(en)
|
2007-01-09 |
2010-04-20 |
Shu-Wha Lin |
Recombinant human factor IX and use thereof
|
|
WO2008092643A2
(en)
|
2007-02-01 |
2008-08-07 |
Baxter International Inc. |
Improved fix-mutant proteins for hemophilia b treatment
|
|
BRPI0810172A2
(pt)
|
2007-04-13 |
2014-10-14 |
Catalyst Biosciences Inc |
Polipeptídeos de fator vii modificado e seus usos
|
|
AU2008245524A1
(en)
|
2007-04-26 |
2008-11-06 |
Cnj Holdings, Inc. |
Recombinant vitamin K dependent proteins with high sialic acid content and methods of preparing same
|
|
EP2162535A4
(en)
|
2007-06-04 |
2011-02-23 |
Novo Nordisk As |
O-linked glycosylation using N-acetylglucosamine transferases
|
|
ES2392569T3
(es)
|
2007-06-13 |
2012-12-11 |
Csl Behring Gmbh |
Uso de preparaciones FVIII estabilizadas VWF para administración extravascular en la terapia y el tratamiento profiláctico de trastornos de hemorragias
|
|
ATE502114T1
(de)
|
2007-06-21 |
2011-04-15 |
Univ Muenchen Tech |
Biologisch aktive proteine mit erhöhter in-vivo- und/oder in-vitro-stabilität
|
|
US8933197B2
(en)
|
2007-08-15 |
2015-01-13 |
Amunix Operating Inc. |
Compositions comprising modified biologically active polypeptides
|
|
AU2008311973B2
(en)
|
2007-10-15 |
2013-10-03 |
Cangene Corporation |
Human Factor IX variants with an extended half life
|
|
CN101965409A
(zh)
|
2007-11-01 |
2011-02-02 |
罗切斯特大学 |
具有增加的稳定性的重组因子viii
|
|
CA2704234A1
(en)
|
2007-11-09 |
2009-05-14 |
Baxter International Inc. |
Modified recombinant factor viii and von willebrand factor and methods of use
|
|
CN105816858B
(zh)
|
2007-12-28 |
2024-10-18 |
武田药品工业株式会社 |
重组vwf配方
|
|
KR100981092B1
(ko)
|
2008-02-29 |
2010-09-08 |
고려대학교 산학협력단 |
제8 혈액응고 인자와 폰 빌리 블란트 인자 변이체의 재조합발현 벡터 시스템
|
|
JP5444629B2
(ja)
|
2008-04-03 |
2014-03-19 |
富士通株式会社 |
照度センサ用光案内機構及び携帯電話機
|
|
JP2011517950A
(ja)
|
2008-04-16 |
2011-06-23 |
バイエル・ヘルスケア・エルエルシー |
第ｉｘ因子の部位特異的修飾
|
|
CA2721683A1
(en)
|
2008-04-16 |
2009-11-12 |
Bayer Healthcare Llc |
Modified factor ix polypeptides and uses thereof
|
|
TWI573806B
(zh)
|
2008-04-17 |
2017-03-11 |
巴克斯歐塔公司 |
生物活性胜肽
|
|
CN102105582A
(zh)
|
2008-04-21 |
2011-06-22 |
诺沃-诺迪斯克有限公司 |
高糖基化人凝血因子ix
|
|
EP2385844A2
(en)
|
2008-05-06 |
2011-11-16 |
Octapharma AG |
Complex comprising both heparin binding proteins and heparin-hydroxyalkyl starch conjugates
|
|
CA2726942A1
(en)
|
2008-06-04 |
2009-12-10 |
Bayer Healthcare Llc |
Fviii muteins for treatment of von willebrand disease
|
|
KR101648734B1
(ko)
|
2008-06-24 |
2016-08-18 |
체에스엘 베링 게엠베하 |
연장된 생체내 반감기를 갖는 인자 ｖｉｉｉ, 폰 빌레브란트 인자 또는 이들의 복합체
|
|
KR20110033242A
(ko)
|
2008-06-25 |
2011-03-30 |
바이엘 헬스케어 엘엘씨 |
면역원성이 감소된, 인자 ⅷ 뮤테인
|
|
DK2604693T3
(en)
|
2008-07-21 |
2016-05-30 |
Apogenix Gmbh |
Single-chain TNFSF molecules
|
|
CA2740793A1
(en)
|
2008-11-03 |
2010-06-03 |
Haiyan Jiang |
Method for the treatment of hemophilia
|
|
JP2012510060A
(ja)
|
2008-11-24 |
2012-04-26 |
バイエル・ヘルスケア・エルエルシー |
シリカをベースとする活性化部分トロンボプラスチン時間アッセイにおけるｐｅｇ化血液凝固因子の活性の測定方法
|
|
CL2011001856A1
(es)
|
2009-02-03 |
2012-03-09 |
Amunix Operating Inc |
Polipeptido recombinante extendido aislado (xten) que mejora las propiedades de una proteina biologicamente activa fusionada a el; proteina de fusion aislada que comprende xten ligado a una proteina biologicamente activa; composicion que comprende dicha proteina de fusion; y uso para preparar medicamentos para tratar enfermedades.
|
|
CA2748314C
(en)
|
2009-02-03 |
2018-10-02 |
Amunix Operating Inc. |
Extended recombinant polypeptides and compositions comprising same
|
|
US8680050B2
(en)
|
2009-02-03 |
2014-03-25 |
Amunix Operating Inc. |
Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same
|
|
US8703717B2
(en)
|
2009-02-03 |
2014-04-22 |
Amunix Operating Inc. |
Growth hormone polypeptides and methods of making and using same
|
|
WO2010111414A1
(en)
|
2009-03-24 |
2010-09-30 |
Bayer Healthcare Llc |
Factor viii variants and methods of use
|
|
EP3061460A1
(en)
|
2009-04-10 |
2016-08-31 |
Tufts Medical Center, Inc. |
Par-1 activation by metalloproteinase-1 (mmp-1)
|
|
GB0908515D0
(en)
|
2009-05-18 |
2009-06-24 |
Apitope Technology Bristol Ltd |
Peptide
|
|
JP5839597B2
(ja)
|
2009-06-08 |
2016-01-06 |
アムニクス オペレーティング インコーポレイテッド |
グルコース調節ポリペプチド並びにその作成及び使用方法
|
|
SI2440241T1
(sl)
|
2009-06-08 |
2017-11-30 |
Amunix Operating Inc. |
Polipeptidni rastni hormoni in postopki za njihovo izdelavo in uporabo
|
|
KR20120061898A
(ko)
|
2009-08-20 |
2012-06-13 |
체에스엘 베링 게엠베하 |
출혈성 장애의 치료요법 및 예방 치료에 있어서의 비정맥내 투여를 위한 알부민 융합 응고 인자
|
|
AU2010290131C1
(en)
|
2009-08-24 |
2015-12-03 |
Amunix Operating Inc. |
Coagulation factor VII compositions and methods of making and using same
|
|
WO2011028344A2
(en)
|
2009-08-25 |
2011-03-10 |
Amunix Operating Inc. |
Interleukin-1 receptor antagonist compositions and methods of making and using same
|
|
JP5544219B2
(ja)
|
2009-09-24 |
2014-07-09 |
富士フイルム株式会社 |
内視鏡システム
|
|
ES2717902T5
(es)
|
2009-10-02 |
2022-11-29 |
Childrens Hospital Philadelphia |
Composiciones y procedimientos para mejorar la función del factor VIII de coagulación
|
|
TWI423962B
(zh)
|
2009-10-07 |
2014-01-21 |
Lg Life Sciences Ltd |
有效作為黃嘌呤氧化酶抑制劑之新穎化合物、其製備方法及含該化合物之醫藥組成物
|
|
KR101808751B1
(ko)
|
2009-11-13 |
2017-12-13 |
그리폴스 테라퓨틱스 인코포레이티드 |
폰 빌레브란트 인자(ｖＷＦ)-함유 제제, 및 그와 관련된 방법, 키트 및 용도
|
|
HRP20171739T1
(hr)
|
2009-11-20 |
2018-03-09 |
Tonix Pharma Holdings Limited |
Postupci i kompozicije za liječenje simptoma povezanih s posttraumatskim stresnim poremećajem korištenjem ciklobenzaprina
|
|
PL3326643T3
(pl)
|
2009-12-06 |
2021-10-25 |
Bioverativ Therapeutics Inc. |
Chimeryczne i hybrydowe polipeptydy czynnika VIII-FC oraz sposoby ich zastosowania
|
|
US20110312881A1
(en)
|
2009-12-21 |
2011-12-22 |
Amunix, Inc. |
Bifunctional polypeptide compositions and methods for treatment of metabolic and cardiovascular diseases
|
|
US20130040888A1
(en)
|
2010-02-16 |
2013-02-14 |
Novo Nordisk A/S |
Factor VIII Molecules With Reduced VWF Binding
|
|
CN105153313A
(zh)
|
2010-02-16 |
2015-12-16 |
诺沃—诺迪斯克有限公司 |
因子viii融合蛋白
|
|
US8466059B2
(en)
|
2010-03-30 |
2013-06-18 |
Taiwan Semiconductor Manufacturing Company, Ltd. |
Multi-layer interconnect structure for stacked dies
|
|
EP2552967A4
(en)
|
2010-04-02 |
2014-10-08 |
Amunix Operating Inc |
BINDING FUSION PROTEINS, BINDING FUSION PROTEIN MEDICINAL CONJUGATES, XTEN MEDICAMENT CONJUGATES, AND METHOD FOR THEIR PREPARATION AND USE
|
|
WO2011123830A2
(en)
|
2010-04-02 |
2011-10-06 |
Amunix Operating Inc. |
Alpha 1-antitrypsin compositions and methods of making and using same
|
|
AU2011244228B2
(en)
|
2010-04-21 |
2015-07-30 |
Jan Astermark |
Genetic factors associated with inhibitor development in hemophilia A
|
|
TWI619713B
(zh)
|
2010-04-21 |
2018-04-01 |
普雷辛肯公司 |
用於激酶調節的化合物和方法及其適應症
|
|
RU2561465C2
(ru)
|
2010-05-20 |
2015-08-27 |
Аллерган, Инк. |
Разрушаемые клостридиальные токсины
|
|
SG10201505217WA
(en)
|
2010-07-09 |
2015-08-28 |
Biogen Hemophilia Inc |
Chimeric clotting factors
|
|
EP2591101B1
(en)
|
2010-07-09 |
2018-11-07 |
Bioverativ Therapeutics Inc. |
Systems for factor viii processing and methods thereof
|
|
UA126265C2
(uk)
|
2010-07-09 |
2022-09-14 |
Байовератів Терапьютікс Інк. |
Поліпептид фактора іх і спосіб його застосування
|
|
JP2013532176A
(ja)
|
2010-07-15 |
2013-08-15 |
ノヴォ ノルディスク アー／エス |
安定化させた第ｖｉｉｉ因子バリアント
|
|
US20130017997A1
(en)
|
2010-08-19 |
2013-01-17 |
Amunix Operating Inc. |
Factor VIII Compositions and Methods of Making and Using Same
|
|
CA2838833A1
(en)
|
2011-06-10 |
2012-12-13 |
Biogen Idec Ma Inc. |
Pro-coagulant compounds and methods of use thereof
|
|
CN103796670A
(zh)
*
|
2011-07-08 |
2014-05-14 |
比奥根艾迪克依蒙菲利亚公司 |
因子viii嵌合和杂合多肽及其使用方法
|
|
CN103917554B
(zh)
|
2011-10-18 |
2017-03-08 |
杰特有限公司 |
用于改善重构后纯化的因子viii的稳定性的方法
|
|
KR102018405B1
(ko)
|
2011-12-21 |
2019-09-04 |
어드밴스드 테크놀러지 머티리얼즈, 인코포레이티드 |
라이너에 기초한 운송 및 공급 시스템들
|
|
CN104160236A
(zh)
|
2012-01-11 |
2014-11-19 |
阿迪拉高尔夫公司 |
小直径十字弓弩箭
|
|
DK2804623T3
(da)
|
2012-01-12 |
2019-11-11 |
Bioverativ Therapeutics Inc |
Kimære faktor viii-polypeptider og anvendelser deraf
|
|
EP3970737A1
(en)
|
2012-01-12 |
2022-03-23 |
Bioverativ Therapeutics Inc. |
Reducing immunogenicity against factor viii in individuals undergoing factor viii therapy
|
|
WO2013120939A1
(en)
|
2012-02-15 |
2013-08-22 |
Csl Behring Gmbh |
Von willebrand factor variants having improved factor viii binding affinity
|
|
BR112014020694A2
(pt)
|
2012-02-15 |
2018-05-08 |
Amunix Operating Inc. |
proteína de fusão do fator viii compreendendo polipeptídeo do fator viii fusionado a polipeptí-deo recombinante estendido (xten) e seu método de fabricação, ácido nucleico, vetores, célula hospedeira, bem como composição farmacêutica e seu uso no tratamento de coagulopatia, episódio de hemorragia e hemofilia a
|
|
CA2864126A1
(en)
|
2012-02-15 |
2013-08-22 |
Biogen Idec Ma Inc. |
Recombinant factor viii proteins
|
|
EP2841091A1
(en)
|
2012-04-24 |
2015-03-04 |
Novo Nordisk A/S |
Pharmaceutical composition suitable for treatment of haemophilia
|
|
JP2015515482A
(ja)
|
2012-04-24 |
2015-05-28 |
ノヴォ ノルディスク アー／エス |
血友病の治療に適する化合物
|
|
NL2010965A
(en)
|
2012-06-22 |
2013-12-24 |
Asml Netherlands Bv |
Radiation source and lithographic apparatus.
|
|
HRP20200007T1
(hr)
|
2012-07-11 |
2020-03-20 |
Bioverativ Therapeutics Inc. |
Kompleks proteina faktora viii s xten i von willebrandovim faktorom, te njegova uporaba
|
|
EP2874981B1
(en)
|
2012-07-18 |
2017-06-14 |
Northwestern University |
Forming ethylene
|
|
EP3446700A1
(en)
|
2012-10-30 |
2019-02-27 |
Bioverativ Therapeutics Inc. |
Methods of using fviii polypeptide
|
|
WO2014100913A1
(en)
|
2012-12-24 |
2014-07-03 |
Beijing Anxinhuaide Biotech. Co., Ltd |
Improving the half life of a therapeutic polypeptide by fusing with a trimeric scaffold protein via a spacer
|
|
DK2968477T3
(da)
|
2013-03-15 |
2020-03-09 |
Bioverativ Therapeutics Inc |
Faktor viii-polypeptidformuleringer
|
|
AR095527A1
(es)
|
2013-03-15 |
2015-10-21 |
Biogen Idec Inc |
Formulaciones de polipéptido fc-factor ix
|
|
EP2796145B1
(en)
|
2013-04-22 |
2017-11-01 |
CSL Ltd. |
A covalent complex of von willebrand factor and faktor viii linked by a disulphide bridge
|
|
TW201536811A
(zh)
|
2013-05-31 |
2015-10-01 |
Biogen Idec Inc |
嵌合ｆｖｉｉ－ｘｔｅｎ分子及其用途
|
|
WO2014198699A2
(en)
|
2013-06-12 |
2014-12-18 |
Novo Nordisk A/S |
Compounds suitable for treatment of haemophilia
|
|
US10272137B2
(en)
|
2013-06-27 |
2019-04-30 |
The Board Of Regents Of The University Of Texas System |
Compositions and methods relating to myomaker-induced muscle cell fusion
|
|
SG10201710616XA
(en)
|
2013-06-28 |
2018-02-27 |
Biogen Ma Inc |
Thrombin cleavable linker with xten and its uses thereof
|
|
WO2014210547A1
(en)
|
2013-06-28 |
2014-12-31 |
Biogen Idec Ma Inc. |
Thrombin cleavable linker
|
|
WO2015021423A2
(en)
*
|
2013-08-08 |
2015-02-12 |
Biogen Idec Ma Inc. |
Purification of chimeric fviii molecules
|
|
US10548953B2
(en)
|
2013-08-14 |
2020-02-04 |
Bioverativ Therapeutics Inc. |
Factor VIII-XTEN fusions and uses thereof
|
|
US10325687B2
(en)
|
2013-12-06 |
2019-06-18 |
Bioverativ Therapeutics Inc. |
Population pharmacokinetics tools and uses thereof
|
|
AU2015204646B2
(en)
|
2014-01-10 |
2020-08-27 |
Bioverativ Therapeutics Inc. |
Factor VIII chimeric proteins and uses thereof
|
|
EP3152230B1
(en)
|
2014-06-06 |
2019-08-07 |
Octapharma AG |
Preparation comprising factor viii and von willebrand factor peptides
|
|
CA2953593C
(en)
|
2014-07-02 |
2023-09-26 |
Csl Limited |
Modified von willebrand factor
|
|
DK3193911T5
(da)
|
2014-07-25 |
2024-10-14 |
Csl Behring Gmbh |
Forbedrede faktor VII-præparater til brug ved behandling af hæmofili A
|
|
CA3237630A1
(en)
|
2014-08-13 |
2016-02-18 |
The Children's Hospital Of Philadelphia |
An improved expression cassette for packaging and expression of variant factor viii for the treatment of hemostasis disorders
|
|
ES2772933T3
(es)
|
2015-03-06 |
2020-07-08 |
CSL Behring Lengnau AG |
Factor de von Willebrand modificado que tiene una semivida mejorada
|
|
US9958572B2
(en)
|
2015-03-31 |
2018-05-01 |
Halliburton Energy Services, Inc. |
Synthetic test beds for fracturing optimization and methods of manufacture and use thereof
|
|
RU2017145014A
(ru)
|
2015-05-22 |
2019-06-24 |
Цсл Беринг Ленгнау Аг |
Усеченные полипептиды фактора фон виллебранда для лечения гемофилии
|
|
BR112018002150A2
(pt)
|
2015-08-03 |
2018-09-18 |
Bioverativ Therapeutics Inc |
proteínas de fusão do fator ix e métodos de fabricação e uso das mesmas
|
|
CN114686548A
(zh)
|
2015-10-14 |
2022-07-01 |
川斯勒佰尔公司 |
用于增强生产的rna相关酶的修饰
|
|
WO2017117630A1
(en)
|
2016-01-07 |
2017-07-13 |
Csl Limited |
Mutated von willebrand factor
|
|
JP6851381B6
(ja)
|
2016-01-07 |
2021-04-21 |
ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト |
変異切断型フォンウィルブランド因子
|
|
CN109790529A
(zh)
|
2016-06-24 |
2019-05-21 |
财团法人牧岩生命科学研究所 |
包含FVIII和vWF因子的嵌合蛋白及其用途
|
|
CA3043397A1
(en)
|
2016-11-11 |
2018-05-17 |
CSL Behring Lengnau AG |
Truncated von willebrand factor polypeptides for extravascular administration in the treatment or prophylaxis of a blood coagulation disorder
|
|
IL319473A
(en)
|
2016-12-02 |
2025-05-01 |
Bioverativ Therapeutics Inc |
Methods for treating hemophilic arthritis using chimeric blood clotting factors
|
|
CN110520149A
(zh)
|
2016-12-02 |
2019-11-29 |
比奥维拉迪维治疗股份有限公司 |
诱导对凝血因子的免疫耐受性的方法
|
|
BR112020022164A2
(pt)
|
2018-05-18 |
2021-02-02 |
Bioverativ Therapeutics Inc. |
métodos de tratamento de hemofilia a
|
|
JP7050015B2
(ja)
|
2019-01-17 |
2022-04-07 |
古河電池株式会社 |
鉛蓄電池
|
|
WO2021257899A1
(en)
|
2020-06-19 |
2021-12-23 |
Bioverativ Therapeutics Inc. |
Methods for treating hemophilia a and population pharmacokinetics tools for determining treatments and uses thereof
|
|
JP7777589B2
(ja)
|
2020-12-18 |
2025-11-28 |
ユーシービー バイオファルマ エスアールエル |
ジヒドロイソキノリニル誘導体
|