ES2060100T3 - Microproteinas, procedimiento de preparacion, y aplicacion como medicamentos de estas proteinas. - Google Patents

Microproteinas, procedimiento de preparacion, y aplicacion como medicamentos de estas proteinas.

Info

Publication number
ES2060100T3
ES2060100T3 ES90401432T ES90401432T ES2060100T3 ES 2060100 T3 ES2060100 T3 ES 2060100T3 ES 90401432 T ES90401432 T ES 90401432T ES 90401432 T ES90401432 T ES 90401432T ES 2060100 T3 ES2060100 T3 ES 2060100T3
Authority
ES
Spain
Prior art keywords
microproteins
residue
proteins
preparation procedure
norleucine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90401432T
Other languages
English (en)
Inventor
Bertrand Castro
Anne Favel
Dung Le-Nguyen
Maria-Antonia Previero
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Application granted granted Critical
Publication of ES2060100T3 publication Critical patent/ES2060100T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

LA PETICION SE REFIERE A NUEVAS MICROPROTEINAS QUE CONTIENEN 28 AMINOACIDOS QUE RESPONDEN A LA FORMULA: (FIG. A), EN LA QUE X EN POSICION 4 REPRESENTA UN RESIDUO DE VALINA, LEUCINA, ISOLEUCINA, NORLEUCINA, ALANINA, CICLOHEXILALANINA, O-METILTEONINA, FENILGLICINA, ACIDO (ALFA)-AMINO BUTIRICO O ARGININA; Y EN POSICION 5 REPRESENTA UN RESIDUO DE ISOLEUCINA O DE SERINA; Z EN POSICION 7 REPRESENTA UN RESIDO DE METIONINA O DE NORLEUCINA, ENTENDIENDO QUE Z REPRESENTA UN RESIDUO DE NORLEUCINA CUANDO X REPRESENTA UN RESIDUO DE ARGININA, PROCEDIMIENTO PARA SU OBTENCION, APLICACION COMO MEDICAMENTOS DE ESTAS NUEVAS MICROPROTEINAS.
ES90401432T 1989-05-31 1990-05-30 Microproteinas, procedimiento de preparacion, y aplicacion como medicamentos de estas proteinas. Expired - Lifetime ES2060100T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8907155A FR2647677B1 (fr) 1989-05-31 1989-05-31 Nouvelles micro-proteines, procede de preparation et application a titre de medicaments de ces nouvelles micro-proteines

Publications (1)

Publication Number Publication Date
ES2060100T3 true ES2060100T3 (es) 1994-11-16

Family

ID=9382205

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90401432T Expired - Lifetime ES2060100T3 (es) 1989-05-31 1990-05-30 Microproteinas, procedimiento de preparacion, y aplicacion como medicamentos de estas proteinas.

Country Status (8)

Country Link
US (1) US5089474A (es)
EP (1) EP0401109B1 (es)
JP (1) JPH0368599A (es)
AT (1) ATE95195T1 (es)
CA (1) CA2017803A1 (es)
DE (1) DE69003595T2 (es)
ES (1) ES2060100T3 (es)
FR (1) FR2647677B1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5432155A (en) * 1993-06-29 1995-07-11 The Salk Institute For Biological Studies Conotoxins I
DE4342092B4 (de) * 1993-12-09 2007-01-11 Zentaris Gmbh Langwirkende Injektionssuspension und Verfahren zur Herstellung
RU2151611C1 (ru) * 1999-06-18 2000-06-27 Общество с ограниченной ответственностью НАУЧНО-ПРОИЗВОДСТВЕННОЕ ПРЕДПРИЯТИЕ "МЕДБИОФАРМ" Средство для регулирования йодного обмена или профилактики йоддефицитных состояний
US7282227B2 (en) * 2002-08-09 2007-10-16 Kentara Research Llc Method for treating hepatitis C with evaporate of Ecballium elaterium extract
US7297350B2 (en) * 2002-08-09 2007-11-20 Kentara Research Llc Evaporate of Ecbalium elaterium fruit extract for treating viral symptoms
AU2005287557B2 (en) * 2004-09-21 2011-10-13 Biontech Ag Use of microproteins as tryptase inhibitors
US20090099031A1 (en) * 2005-09-27 2009-04-16 Stemmer Willem P Genetic package and uses thereof
WO2007038619A2 (en) * 2005-09-27 2007-04-05 Amunix, Inc. Proteinaceous pharmaceuticals and uses thereof
US7855279B2 (en) * 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
US7846445B2 (en) 2005-09-27 2010-12-07 Amunix Operating, Inc. Methods for production of unstructured recombinant polymers and uses thereof
EP1996220B2 (en) * 2006-03-06 2023-08-16 Amunix Operating Inc. Unstructured recombinant polymers and uses thereof
US8933197B2 (en) * 2007-08-15 2015-01-13 Amunix Operating Inc. Compositions comprising modified biologically active polypeptides
BR122021021381B1 (pt) 2009-02-03 2023-05-16 Amunix Pharmaceuticals, Inc Método de aprimoramento de uma propriedade de uma proteína biologicamente ativa
JP2013502458A (ja) 2009-08-24 2013-01-24 アムニクス オペレーティング インコーポレイテッド 凝固第ｖｉｉ因子組成物ならびにそれを製造および使用する方法
JP6383666B2 (ja) 2012-02-15 2018-08-29 バイオベラティブ セラピューティクス インコーポレイテッド 組換え第ｖｉｉｉ因子タンパク質
BR112014020694A2 (pt) 2012-02-15 2018-05-08 Amunix Operating Inc. proteína de fusão do fator viii compreendendo polipeptídeo do fator viii fusionado a polipeptí-deo recombinante estendido (xten) e seu método de fabricação, ácido nucleico, vetores, célula hospedeira, bem como composição farmacêutica e seu uso no tratamento de coagulopatia, episódio de hemorragia e hemofilia a
WO2015023891A2 (en) 2013-08-14 2015-02-19 Biogen Idec Ma Inc. Factor viii-xten fusions and uses thereof
EA201890423A1 (ru) 2015-08-03 2018-07-31 Биовератив Терапьютикс Инк. Слитые белки фактора ix, способы их получения и применения
KR20260008164A (ko) 2016-12-02 2026-01-15 바이오버라티브 테라퓨틱스 인크. 키메라 응고 인자를 사용해 혈우병성 관절증을 치료하는 방법
MA52630B1 (fr) 2018-05-18 2025-07-31 Bioverativ Therapeutics Inc. Procédés de traitement de l'hémophilie a

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3230275A1 (de) * 1982-08-14 1984-02-16 Bayer Ag, 5090 Leverkusen Elastaseinhibitoren, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel
DE3587526T3 (de) * 1984-12-06 2002-08-08 Amgen Inc.(N.D.Ges D. Staates Delaware), Thousand Oaks Serinproteaseinhibitoren und isolierungsverfahren dazu.
US4829052A (en) * 1986-06-11 1989-05-09 Monsanto Company Serine protease inhibitors

Also Published As

Publication number Publication date
EP0401109A1 (fr) 1990-12-05
DE69003595T2 (de) 1994-02-17
JPH0368599A (ja) 1991-03-25
US5089474A (en) 1992-02-18
FR2647677A1 (fr) 1990-12-07
EP0401109B1 (fr) 1993-09-29
ATE95195T1 (de) 1993-10-15
CA2017803A1 (fr) 1990-11-30
FR2647677B1 (fr) 1991-09-27
DE69003595D1 (de) 1993-11-04

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