ATE95516T1 - Wasserloesliche salze der (+)2-(4-fluorphenyl)alpha-methyl-5-benzoxazolessigsaeure und deren herstellung. - Google Patents

Wasserloesliche salze der (+)2-(4-fluorphenyl)alpha-methyl-5-benzoxazolessigsaeure und deren herstellung.

Info

Publication number: ATE95516T1
Authority: AT; Austria
Prior art keywords: alpha; methyl; lysine; fluorphenyl; production
Prior art date: 1988-01-13

Application number

AT89100245T

Other languages

English (en)

Inventor

Diego Furlan

Original Assignee

Euroresearch Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-01-13

Filing date

1989-01-09

Publication date

1993-10-15

1989-01-09 Application filed by Euroresearch Srl filed Critical Euroresearch Srl

1993-10-15 Application granted granted Critical

1993-10-15 Publication of ATE95516T1 publication Critical patent/ATE95516T1/de

Links

ARPYQKTVRGFPIS-UHFFFAOYSA-N 2-[2-(4-fluorophenyl)-1,3-benzoxazol-5-yl]propanoic acid Chemical class N=1C2=CC(C(C(O)=O)C)=CC=C2OC=1C1=CC=C(F)C=C1 ARPYQKTVRGFPIS-UHFFFAOYSA-N 0.000 title abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract 2
KDXKERNSBIXSRK-UHFFFAOYSA-N lysine Chemical compound NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
238000002360 preparation method Methods 0.000 abstract 2
KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 abstract 1
239000004472 Lysine Substances 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
239000006071 cream Substances 0.000 abstract 1
235000018977 lysine Nutrition 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
WPLOVIFNBMNBPD-ATHMIXSHSA-N subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 abstract 1
239000000829 suppository Substances 0.000 abstract 1
239000006188 syrup Substances 0.000 abstract 1
235000020357 syrup Nutrition 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pain & Pain Management (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT89100245T 1988-01-13 1989-01-09 Wasserloesliche salze der (+)2-(4-fluorphenyl)alpha-methyl-5-benzoxazolessigsaeure und deren herstellung. ATE95516T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT8819057A IT1233836B (it)	1988-01-13	1988-01-13	Sali idrosolubili dell'acido (+)2-(4 fluorofenil)-alfa-metil-5 benzoxazolo acetato.
EP89100245A EP0324402B1 (de)	1988-01-13	1989-01-09	Wasserlösliche Salze der (+)2-(4-fluorphenyl)-alpha-methyl-5-benzoxazolessigsäure und deren Herstellung

Publications (1)

Publication Number	Publication Date
ATE95516T1 true ATE95516T1 (de)	1993-10-15

Family

ID=11154181

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89100245T ATE95516T1 (de)	1988-01-13	1989-01-09	Wasserloesliche salze der (+)2-(4-fluorphenyl)alpha-methyl-5-benzoxazolessigsaeure und deren herstellung.

Country Status (8)

Country	Link
US (2)	US4897408A (de)
EP (1)	EP0324402B1 (de)
JP (1)	JPH02783A (de)
KR (1)	KR890011866A (de)
AT (1)	ATE95516T1 (de)
DE (1)	DE68909619T2 (de)
ES (1)	ES2059569T3 (de)
IT (1)	IT1233836B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2687673B1 (fr) *	1992-01-13	1995-07-07	Jung Jean	Sels amines d'acides arylcarboxyliques, sterilisables, solubles dans l'eau, utilises en ophtalmologie et/ou dans la sphere otorhinolaryngologique.

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3598838A (en) *	1967-08-28	1971-08-10	Ajinomoto Kk	Method of purifying amino acids
FR2115060A1 (en) *	1970-11-26	1972-07-07	Metabio	Freeze-dried acetylsalicylates of lysine and arginine - easily prepd derivs of aspirin
GB1435721A (en) *	1972-05-18	1976-05-12	Lilly Industries Ltd	Benzoxazole derivatives
US3988466A (en) *	1973-06-01	1976-10-26	Kyowa Hakko Kogyo Co., Ltd.	Prevention of gastric lesions
GB1495488A (en) *	1976-06-23	1977-12-21	Ippco Int Pharma Patents Co Es	Optically active 2-(2-phenyl-5-benzoxazolyl)propionic acids
DE2945790C2 (de) *	1978-11-20	1987-03-12	Tanabe Seiyaku Co., Ltd., Osaka	Neutrales L-Ornithin-L-malat-dihydrat und neutrales L-Lysin-L-malat-monohydrat und Verfahren zu deren Herstellung
ES489664A1 (es) *	1979-03-20	1980-10-01	Lipha	Procedimiento de preparacion de la sal de lisina (+) del a- cido (+) amino-3-(pirrolil-1')-4 -metil-fenil-acetico
ES8101078A1 (es) *	1980-02-05	1980-12-16	Liofilizaciones Esterilizacion	Procedimiento para la obtencion de una sal soluble en agua de cefadroxilo
US4434163A (en) *	1981-06-01	1984-02-28	Pfizer Inc.	Water-soluble benzothiazine dioxide salts
IN160683B (de) *	1981-06-01	1987-07-25	Pfizer
LU83729A1 (fr) *	1981-11-04	1983-09-01	Galephar	Sels d'acide valproique,leur preparation et leur utilisation
US4749694A (en) *	1984-04-26	1988-06-07	Merck & Co., Inc.	Novel lysine esters used as absorption
IT1177017B (it) *	1984-10-22	1987-08-26	Ravizza Spa	Processo per la preparazione dell'acido 2(4-flurofenil)alfa-metil-5-benzox azoloacetico
IT1207994B (it) *	1986-01-03	1989-06-01	Therapicon Srl	Sali idrosulubili di composti adattivita' antiinfiammatoria ed analgesica, loro preparazione ed utilizzo in composizioni farmaceutiche.
IT1197289B (it) *	1986-09-26	1988-11-30	S I F I Societa Ind Farmaceuti	Sale di lisina dell'acido 4-bifenilacetico e sue composizioni oftalmiche

1988
- 1988-01-13 IT IT8819057A patent/IT1233836B/it active
1989
- 1989-01-05 US US07/293,668 patent/US4897408A/en not_active Expired - Fee Related
- 1989-01-09 AT AT89100245T patent/ATE95516T1/de not_active IP Right Cessation
- 1989-01-09 EP EP89100245A patent/EP0324402B1/de not_active Expired - Lifetime
- 1989-01-09 DE DE89100245T patent/DE68909619T2/de not_active Expired - Fee Related
- 1989-01-09 ES ES89100245T patent/ES2059569T3/es not_active Expired - Lifetime
- 1989-01-12 KR KR1019890000247A patent/KR890011866A/ko not_active Ceased
- 1989-01-13 JP JP1005056A patent/JPH02783A/ja active Pending
- 1989-11-17 US US07/437,664 patent/US5120851A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR890011866A (ko)	1989-08-23
IT8819057A0 (it)	1988-01-13
IT1233836B (it)	1992-04-21
ES2059569T3 (es)	1994-11-16
DE68909619D1 (de)	1993-11-11
US4897408A (en)	1990-01-30
EP0324402A1 (de)	1989-07-19
JPH02783A (ja)	1990-01-05
DE68909619T2 (de)	1994-05-11
EP0324402B1 (de)	1993-10-06
US5120851A (en)	1992-06-09

Legal Events

Date	Code	Title	Description
1994-06-15	UEP	Publication of translation of european patent specification
1995-10-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69411625D1 (de)	1998-08-20	Benzofuranyl- und Thiophenylalkancarbonsäurederivate
IT1284046B1 (it)	1998-05-08	Processo per la preparazione di tetraazamacrocicli
KR850700216A (ko)	1985-12-26	활성성분을 용해시키기 위한 방법 및 이로부터 얻어진 제약 조성물
AU4540789A (en)	1990-03-08	Imide derivatives, and their production and use
KR860003249A (ko)	1986-05-21	피록시캄 1수화물의 제조 방법
DK472387D0 (da)	1987-09-10	Naphthalin- og indanderivater samt laegemidler med indhold af saadanne forbindelser
PT86314A (de)	1988-01-01	Zytostatisch wirksame anthracyclinderivate
DE3676335D1 (de)	1991-02-07	Auf mercaptoethansulfonsaeuren basierende pharmazeutische zusammensetzungen, organische abkoemmlinge von mercaptoethansulfonsaeuren sowie verfahren zu deren herstellung.
ATE95516T1 (de)	1993-10-15	Wasserloesliche salze der (+)2-(4-fluorphenyl)alpha-methyl-5-benzoxazolessigsaeure und deren herstellung.
DE69316382D1 (de)	1998-02-19	Herstellung von derivaten von n-acetyl neuraminicsäure
ES2144995T3 (es)	2000-07-01	Preparacion de derivados de indol.
FI99013B (fi)	1997-06-13	Analogiamenetelmä terapeuttisesti käyttökelpoisten bentsimidatsolijohdannaisten valmistamiseksi
ATE14121T1 (de)	1985-07-15	Verfahren zur herstellung von 1h-indazol-3-ylessigs\|ure-derivaten.
KR900016226A (ko)	1990-11-13	세포디짐 나트륨의 제조방법
EP0056867A3 (de)	1982-08-25	Verfahren zur Herstellung von 4,4',7,7'-Tetrachlorthioindigo
SU1541218A1 (ru)	1996-05-20	Способ получения производных декстрана
JPS55135597A (en)	1980-10-22	Preparation of amoxicillin
TH34889A (th)	1999-09-14	การเตรียม 2-(10, 11-ไดไฮโดร-10-ออกโซไดเบนโซ [b,f] ไธเอพิน-2-อิล) กรดโพรพิโอนิค
ES2007387A6 (es)	1989-06-16	Procedimiento para la obtencion de un derivado del acido cromoglicico
NO892692D0 (no)	1989-06-28	Fremgangsmaate for fremstilling av 5-fluornikotinsyre-derivater og salter derav eller 2-(5-fluornikotinoyl) - eddiksyrederivater.
KR890009405A (ko)	1989-08-01	비경구용 세파만돌나페이트 제제의 제조방법