ATE96663T1 - Antivirale pharmazeutische zusammensetzungen enthaltende hypericine oder pseudohypericine. - Google Patents

Antivirale pharmazeutische zusammensetzungen enthaltende hypericine oder pseudohypericine.

Info

Publication number: ATE96663T1
Authority: AT; Austria
Prior art keywords: pharmaceutical compositions; pseudohypericins; hypericins; compositions containing; hsv
Prior art date: 1986-08-08

Application number

AT87111467T

Other languages

English (en)

Inventor

David Lavie

Michel Revel

Dalia Rotman

Velde Vincent Vande

Original Assignee

Yeda Res & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-08-08

Filing date

1987-08-07

Publication date

1993-11-15

1987-08-07 Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev

1993-11-15 Application granted granted Critical

1993-11-15 Publication of ATE96663T1 publication Critical patent/ATE96663T1/de

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
230000000840 anti-viral effect Effects 0.000 title 1
YXBUQQDFTYOHQI-UHFFFAOYSA-N Pseudohypericin Chemical compound OC1=CC(O)=C2C(=O)C3=C(O)C=C(C)C4=C3C3=C2C1=C(C(O)=CC(O)=C1C2=O)C1=C3C1=C2C(O)=CC(CO)=C14 YXBUQQDFTYOHQI-UHFFFAOYSA-N 0.000 abstract 2
SSKVDVBQSWQEGJ-UHFFFAOYSA-N pseudohypericin Natural products C12=C(O)C=C(O)C(C(C=3C(O)=CC(O)=C4C=33)=O)=C2C3=C2C3=C4C(C)=CC(O)=C3C(=O)C3=C(O)C=C(O)C1=C32 SSKVDVBQSWQEGJ-UHFFFAOYSA-N 0.000 abstract 2
208000009889 Herpes Simplex Diseases 0.000 abstract 1
241000700588 Human alphaherpesvirus 1 Species 0.000 abstract 1
241000701074 Human alphaherpesvirus 2 Species 0.000 abstract 1
230000006819 RNA synthesis Effects 0.000 abstract 1
241000700605 Viruses Species 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
BTXNYTINYBABQR-UHFFFAOYSA-N hypericin Chemical compound C12=C(O)C=C(O)C(C(C=3C(O)=CC(C)=C4C=33)=O)=C2C3=C2C3=C4C(C)=CC(O)=C3C(=O)C3=C(O)C=C(O)C1=C32 BTXNYTINYBABQR-UHFFFAOYSA-N 0.000 abstract 1
229940005608 hypericin Drugs 0.000 abstract 1
PHOKTTKFQUYZPI-UHFFFAOYSA-N hypericin Natural products Cc1cc(O)c2c3C(=O)C(=Cc4c(O)c5c(O)cc(O)c6c7C(=O)C(=Cc8c(C)c1c2c(c78)c(c34)c56)O)O PHOKTTKFQUYZPI-UHFFFAOYSA-N 0.000 abstract 1
206010022000 influenza Diseases 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
230000002452 interceptive effect Effects 0.000 abstract 1
208000003265 stomatitis Diseases 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
208000024891 symptom Diseases 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
230000000699 topical effect Effects 0.000 abstract 1
208000005925 vesicular stomatitis Diseases 0.000 abstract 1
230000029812 viral genome replication Effects 0.000 abstract 1
230000003612 virological effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Plant Substances (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

AT87111467T 1986-08-08 1987-08-07 Antivirale pharmazeutische zusammensetzungen enthaltende hypericine oder pseudohypericine. ATE96663T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IL79661A IL79661A (en)	1986-08-08	1986-08-08	Antiviral composition containing hypericin or pseudohypericin
EP87111467A EP0256452B1 (de)	1986-08-08	1987-08-07	Antivirale pharmazeutische Zusammensetzungen enthaltende Hypericine oder Pseudohypericine

Publications (1)

Publication Number	Publication Date
ATE96663T1 true ATE96663T1 (de)	1993-11-15

Family

ID=11057015

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87111467T ATE96663T1 (de)	1986-08-08	1987-08-07	Antivirale pharmazeutische zusammensetzungen enthaltende hypericine oder pseudohypericine.

Country Status (6)

Country	Link
US (2)	US5047435A (de)
EP (1)	EP0256452B1 (de)
AT (1)	ATE96663T1 (de)
DE (1)	DE3788016T2 (de)
ES (1)	ES2061453T3 (de)
IL (1)	IL79661A (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9309574B1 (en)	1984-08-22	2016-04-12	The United States Of America As Represented By The Secretary, Department Of Health And Human Services	Molecular cloning of HIV-1 from immortalized cell lines
EP0332679B1 (de) *	1987-08-10	1993-06-16	New York University	Antivirale zusammensetzungen mit aromatischen polycyclischen dionen sowie methode zur behandlung retroviraler infektionen
WO1989009056A1 (en) *	1988-03-23	1989-10-05	New York University	Antiviral composition containing aromatic polycyclic diones and nucleoside analogs and method for treating retrovirus infections
WO1989009055A1 (en) *	1988-03-23	1989-10-05	New York University	Antiviral composition containing aromatic polycyclic diones and nucleoside analogs and method for treating retrovirus infections
IL93682A (en) *	1989-03-16	1996-06-18	Yeda Res & Dev	Polycyclic compounds with antigypical activity are used in the manufacture of medicines and pharmaceutical preparations containing them
US6187572B1 (en)	1990-04-16	2001-02-13	Baxter International Inc.	Method of inactivation of viral and bacterial blood contaminants
US5418130A (en) *	1990-04-16	1995-05-23	Cryopharm Corporation	Method of inactivation of viral and bacterial blood contaminants
US5316768A (en)	1990-12-28	1994-05-31	Murdock International Corporation	Pharmaceutical compositions having antiviral activity against human cytomegalovirus
WO1993014197A1 (en) *	1992-01-16	1993-07-22	New York University	Hypericin treatment of vaccine agents for improved immunogenicity
AU5959994A (en) *	1992-12-23	1994-07-19	Iowa State University Research Foundation Inc.	Molecular flashlight
DE9316320U1 (de) *	1993-10-20	1994-01-20	Beni Med Natuerliche Heilmitte	Kosmetische Zubereitung in Form von Lippenstiften mit antiviraler Wirkung
DE19547317A1 (de) *	1995-12-18	1998-12-24	Dreluso Pharm Dr Elten & Sohn	Antivirales Medikament
GR1002799B (el) *	1996-11-19	1997-11-04		Αντιικη δραση του φυτου hypericum perforatum l. κατα του ανθρωπινου κυτταρομεγαλοιου.
US6428819B1 (en)	1996-12-15	2002-08-06	David Lavie	Plant extracts for the preparation of pharmaceutical compositions for the treatment of hepatitis
IL119833A (en) *	1996-12-15	2001-01-11	Lavie David	Hypericum perforatum extracts for the preparation of pharmaceutical compositions for the treatment of hepatitis
DE19700788A1 (de) *	1997-01-11	1998-07-16	Michael O Ruepp	Johanniskraut-Trockenextrakte
IL121440A0 (en)	1997-07-31	1998-01-04	Yeda Res & Dev	The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in photodynamic therapy and certain such novel derivatives
WO1999036080A1 (en) *	1998-01-13	1999-07-22	Rexall Sundown, Inc.	St. john's wort and methyl donor composition and uses thereof
US6238671B1 (en)	1998-04-22	2001-05-29	Bionorica Arzneimittel Gmbh	Process for the gentle recovery of extract fractions from hypericum, pharmaceutical preparations containing the same and their use
US6159986A (en) *	1999-11-02	2000-12-12	Altman; David A.	Compounds and therapy for resisting memory loss in humans
DE10131641A1 (de)	2000-12-22	2002-06-27	Schwabe Willmar Gmbh & Co	Verbesserter und stabiler Extrakt aus Hypericum perforatum L., Verfahren zu seiner Herstellung und Verwendung als topisches Arzneimittel
US7037534B2 (en) *	2001-10-24	2006-05-02	Aphios Corporation	Inactivation of viral infections agents by chemiluminescence activated light-sensitive compounds
RU2220730C2 (ru) *	2002-03-13	2004-01-10	ЦНИИ Стоматологии	Способ лечения герпетического стоматита
EP1569630A4 (de) *	2002-11-25	2009-03-04	Univ New York	Verfahren zurverhinderung von phototoxischer schädigung während der photodynamischentherapie
CA2659800A1 (en) *	2006-08-03	2008-02-07	Hy Biopharma Inc.	Polycyclic dianthraquinones as inhibitors of inflammatory cytokines

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2707704A (en) *	1951-09-29	1955-05-03	Schenley Ind Inc	Process for the preparation of hypericin
US4209532A (en) *	1977-03-28	1980-06-24	Union Carbide Corporation	Biocidal 2-aryl-1,3-cyclohexane dione compounds and alkali metal and ammonium salts thereof
US4338122A (en) *	1979-09-26	1982-07-06	Union Carbide Corporation	Biocidal 2-aryl-1,3-cyclopentanedione compounds and alkali metal and ammonium salts thereof
CY1359A (en) *	1981-02-02	1987-08-07	Schering Corp	Aromatic heterocyclic esters of steroids, their preparation and pharmaceutical compositions containing them
US4540700A (en) *	1982-04-15	1985-09-10	Alcon Laboratories, Inc.	Treatment of diabetic complications with certain spiro-imidazolidine-diones
JPS59190921A (ja) *	1983-04-11	1984-10-29	Junko Nozaki	抗ウイルス活性物質

1986
- 1986-08-08 IL IL79661A patent/IL79661A/xx not_active IP Right Cessation
1987
- 1987-08-07 ES ES87111467T patent/ES2061453T3/es not_active Expired - Lifetime
- 1987-08-07 AT AT87111467T patent/ATE96663T1/de not_active IP Right Cessation
- 1987-08-07 DE DE87111467T patent/DE3788016T2/de not_active Expired - Fee Related
- 1987-08-07 EP EP87111467A patent/EP0256452B1/de not_active Expired - Lifetime
1989
- 1989-03-27 US US07/328,767 patent/US5047435A/en not_active Expired - Fee Related
- 1989-12-19 US US07/452,436 patent/US5049589A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0256452B1 (de)	1993-11-03
DE3788016D1 (de)	1993-12-09
ES2061453T3 (es)	1994-12-16
EP0256452A2 (de)	1988-02-24
IL79661A (en)	1991-01-31
EP0256452A3 (en)	1990-01-17
DE3788016T2 (de)	1994-03-03
IL79661A0 (en)	1987-08-31
US5047435A (en)	1991-09-10
US5049589A (en)	1991-09-17

Legal Events

Date	Code	Title	Description
1994-08-15	UEP	Publication of translation of european patent specification
2001-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE3788016D1 (de)	1993-12-09	Antivirale pharmazeutische Zusammensetzungen enthaltende Hypericine oder Pseudohypericine.
FI904445A0 (fi)	1990-09-10	Antivirala foereningar.
FI20001231A7 (fi)	2000-05-23	2-Deoksi-2,3-didehydro-N-asetyylineuramiinihapon johdannaisia ja niiden analogeja ja niiden käyttö antiviraalisina aineina
ES2133138T3 (es)	1999-09-01	Nucleosidos terapeuticos.
DK0911033T3 (da)	2004-03-29	Anvendelse af konsensusinterferon til reduktion af bivirkningerne af interferonbehandling i viral hepatitis
IL78553A (en)	1989-09-28	Therapeutic compositions of phosphonylmethoxyalkyl adenines
EP0270317A3 (de)	1990-01-17	Pharmaceutische Zuberatung zur Behandlung von Virus-Krankheiten
Zheng et al.	2001	Enhancement of the anti-herpetic effect of trichosanthin by acyclovir and interferon
ATE63747T1 (de)	1991-06-15	Antivirale verbindungen.
BR9811473A (pt)	2001-12-26	Infecção por rinovìrus inibida por óxido nìtrico
MX9203217A (es)	1992-07-01	Nucleosidos terapeuticos.
IT1181682B (it)	1987-09-30	Impiego di alcanoil l-carnitine per il trattamento terapeutico del parkinsonismo idiopatico o indotto
MX9301922A (es)	1993-10-01	Composiciones para el tratamiento de infeccion y enfermedad ocasionadas por el virus de hepatitis b (hbv).
ES2052922T3 (es)	1994-07-16	Nucleosidos terapeuticos.
PT81387B (pt)	1987-11-11	Processo para a preparacao de composicoes farmaceuticas contendo 1-beta-d-ribofuranosil-1,2,4-triazole-3-carboxamida, uteis no tratamento de doencas provocadas por virus em seres humanos
RU94016333A (ru)	1995-12-27	Лекарственное средство для лечения вирусных заболеваний
DE60011637D1 (de)	2004-07-22	Dioxolan nukleosidanalogen zur behandlung und vorbeugung von viralen infektionen
Carroll et al.	1978	Resistance of visna virus to interferon
DE69013134D1 (de)	1994-11-10	Extrakte von acanthospermum hispidum-pflanzen.
Prober	1987	Ribavirin: A new weapon against respiratory viruses?.
Iafrate et al.	1997	In vitro antiherpetic activity of brivudin: effect of variable exposure times and evaluation of drug interaction
Nikolaeva et al.	1976	Pathomorphological study of antiviral chemotherapeutic effectiveness of bonaphthon under experimental conditions
MY101495A (en)	1991-11-18	Treatment of diseases caused by viruses
Mihara et al.	1989	Treatment of Trigger Finger in Children
McGrath et al.	1990	Effects of GLQ 223 super (TM) on HIV replication in human monocyte/macrophages chronically infected in vitro with HIV.