AU2003254343A1 - Benzothiophene urea, benzofurane urea, and indole urea, and use of the same as alpha-7 achr agonists - Google Patents

Benzothiophene urea, benzofurane urea, and indole urea, and use of the same as alpha-7 achr agonists

Info

Publication number
AU2003254343A1
AU2003254343A1 AU2003254343A AU2003254343A AU2003254343A1 AU 2003254343 A1 AU2003254343 A1 AU 2003254343A1 AU 2003254343 A AU2003254343 A AU 2003254343A AU 2003254343 A AU2003254343 A AU 2003254343A AU 2003254343 A1 AU2003254343 A1 AU 2003254343A1
Authority
AU
Australia
Prior art keywords
urea
benzofurane
benzothiophene
alpha
indole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003254343A
Other languages
English (en)
Inventor
Frank-Gerhard Boss
Christina Erb
Timo Flessner
Frank-Thorsten Hafner
Dieter Lang
Joachim Luithle
Katrin Schnizler
Franz-Josef Van Der Staay
Marja Van Kampen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer Healthcare AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare AG filed Critical Bayer Healthcare AG
Publication of AU2003254343A1 publication Critical patent/AU2003254343A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2003254343A 2002-07-29 2003-07-14 Benzothiophene urea, benzofurane urea, and indole urea, and use of the same as alpha-7 achr agonists Abandoned AU2003254343A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10234424A DE10234424A1 (de) 2002-07-29 2002-07-29 Benzothiophen-, Benzofuran- und Indolharnstoffe
DE10234424.8 2002-07-29
PCT/EP2003/007588 WO2004013136A1 (de) 2002-07-29 2003-07-14 Benzothiophen-, benzofuran- und indolharnstoffe und deren verwendung als alpha7-achr agonisten

Publications (1)

Publication Number Publication Date
AU2003254343A1 true AU2003254343A1 (en) 2004-02-23

Family

ID=30128473

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003254343A Abandoned AU2003254343A1 (en) 2002-07-29 2003-07-14 Benzothiophene urea, benzofurane urea, and indole urea, and use of the same as alpha-7 achr agonists

Country Status (8)

Country Link
US (6) US7795453B2 (2)
EP (1) EP1527073B1 (2)
JP (1) JP4601424B2 (2)
AU (1) AU2003254343A1 (2)
CA (1) CA2494352C (2)
DE (2) DE10234424A1 (2)
ES (1) ES2291694T3 (2)
WO (1) WO2004013136A1 (2)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
MXPA04012439A (es) 2002-06-10 2005-04-19 Bayer Healthcare Ag Amidas de acidos 2-heteroarilcarboxilicos.
DE10234424A1 (de) * 2002-07-29 2004-02-12 Bayer Ag Benzothiophen-, Benzofuran- und Indolharnstoffe
GB0220581D0 (en) 2002-09-04 2002-10-09 Novartis Ag Organic Compound
AR049401A1 (es) 2004-06-18 2006-07-26 Novartis Ag Aza-biciclononanos
GB0415746D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
GB0521508D0 (en) * 2005-10-21 2005-11-30 Novartis Ag Organic compounds
GB0525672D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525673D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
LT2889033T (lt) 2008-11-19 2018-07-10 Forum Pharmaceuticals Inc. Šizofrenijos negatyvių simptomų gydymas (r)-7-chlor-n-(chinuklidin-3-il)benzo[b]tiofen-2-karboksamidu ir jo farmaciniu požiūriu priimtinomis druskomis
JP5808319B2 (ja) * 2009-05-11 2015-11-10 フォルム ファーマシューティカルズ、インコーポレイテッド アセチルコリンエステラーゼ阻害剤と組み合わせた特定のα７ニコチン酸受容体を用いた認知障害の治療
JO3250B1 (ar) 2009-09-22 2018-09-16 Novartis Ag إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
PE20170923A1 (es) 2010-05-17 2017-07-12 Forum Pharmaceuticals Inc Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida monohidratado
WO2012101060A1 (en) 2011-01-27 2012-08-02 Novartis Ag Use of nicotinic acetylcholine receptor alpha 7 activators
AU2012232711B2 (en) 2011-03-18 2016-04-28 Novartis Ag Combinations of alpha 7 nicotinic acetylcholine receptor activators and mGluR5 antagonists for use in dopamine induced dyskinesia in Parkinson's Disease
ES2776996T3 (es) 2011-10-20 2020-08-03 Novartis Ag Biomarcadores predictivos de la sensibilidad al tratamiento por el activador del receptor de la acetilcolina nicotínico alfa 7
EP3461481A1 (en) 2012-05-08 2019-04-03 Forum Pharmaceuticals Inc. Methods of maintaining, treating or improving cognitive function
CN104837499B (zh) 2012-12-11 2018-02-23 诺华有限公司 预测对α7烟碱型乙酰胆碱受体激活剂治疗响应性的生物标志物
EP3623371A1 (en) 2014-12-16 2020-03-18 Axovant Sciences GmbH Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors
CN107847494A (zh) 2015-06-10 2018-03-27 阿考温特科学股份有限公司 作为α7‑烟碱乙酰胆碱受体激动剂的氨基苯并异噁唑化合物
JP2018523707A (ja) 2015-08-12 2018-08-23 アクソバント サイエンシズ ゲーエムベーハー α７−ニコチン性アセチルコリン受容体のアゴニストとしてのジェミナル置換アミノベンゾイソオキサゾール化合物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4605652A (en) 1985-02-04 1986-08-12 A. H. Robins Company, Inc. Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes
HU895334D0 (en) 1986-07-30 1990-01-28 Sandoz Ag Process for the preparation of nasal pharmaceutical compositions
DE3841313A1 (de) 1988-12-08 1990-06-13 Bayer Ag Schwarzes pigment, verfahren zu seiner herstellung sowie dessen verwendung
US5189041A (en) 1990-11-16 1993-02-23 Syntex (U.S.A.) Inc. Tricyclic 5-ht3 receptor antagonists
GB9201749D0 (en) 1992-01-28 1992-03-11 Smithkline Beecham Plc Medicaments
US6169759B1 (en) 1999-03-22 2001-01-02 Golden Bridge Technology Common packet channel
SE9903997D0 (sv) * 1999-11-03 1999-11-03 Astra Ab New compounds
GB0010955D0 (en) 2000-05-05 2000-06-28 Novartis Ag Organic compounds
JP4616971B2 (ja) * 2000-07-18 2011-01-19 田辺三菱製薬株式会社 １−アザビシクロアルカン化合物およびその医薬用途
US6492385B2 (en) 2000-08-18 2002-12-10 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
WO2002016355A2 (en) * 2000-08-21 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic) acetylcholine receptor ligands
US6599916B2 (en) 2000-08-21 2003-07-29 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
DE10164139A1 (de) * 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
DE10234424A1 (de) * 2002-07-29 2004-02-12 Bayer Ag Benzothiophen-, Benzofuran- und Indolharnstoffe
PE20170923A1 (es) * 2010-05-17 2017-07-12 Forum Pharmaceuticals Inc Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida monohidratado

Also Published As

Publication number Publication date
EP1527073A1 (de) 2005-05-04
US8153799B2 (en) 2012-04-10
US20060106096A1 (en) 2006-05-18
DE50308015D1 (de) 2007-10-04
JP2005538111A (ja) 2005-12-15
US9714242B2 (en) 2017-07-25
EP1527073B1 (de) 2007-08-22
US20130060039A1 (en) 2013-03-07
US7795453B2 (en) 2010-09-14
CA2494352C (en) 2011-11-08
CA2494352A1 (en) 2004-02-12
US20150065537A1 (en) 2015-03-05
DE10234424A1 (de) 2004-02-12
US20190367504A1 (en) 2019-12-05
WO2004013136A1 (de) 2004-02-12
ES2291694T3 (es) 2008-03-01
US8772511B2 (en) 2014-07-08
US10196388B2 (en) 2019-02-05
JP4601424B2 (ja) 2010-12-22
US20180127409A1 (en) 2018-05-10
US20100324085A1 (en) 2010-12-23

Similar Documents

Publication Publication Date Title
AU2003254343A1 (en) Benzothiophene urea, benzofurane urea, and indole urea, and use of the same as alpha-7 achr agonists
AU2003215172A1 (en) Message accessing
AU2003262747A1 (en) Compounds, compositions, and methods
AU2003236527A1 (en) Compounds, compositions, and methods
AU2003270015A1 (en) Compounds, compositions, and methods
EP1503993A4 (en) COMPOUNDS, METHODS AND COMPOSITIONS
EP1513820A4 (en) COMPOUNDS, COMPOSITIONS AND METHODS
AU2003287160A1 (en) Substituted indoles and their use as hcv inhibitors
AU2003265681A1 (en) Indoles having anti-diabetic activity
DK1467629T3 (da) Granulater, der indeholder forderenzymer
AU2003299612A8 (en) Compounds, compositions and methods
PL373577A1 (en) Compounds, compositions, and methods
AU2003253910A1 (en) Methods for the regeneration and transformation of cotton
AU2003277079A1 (en) Compounds, compositions, and methods
AU2003286474A8 (en) Compositions, solutions, and methods used for transplantation
ZA200501175B (en) 2,4-substituted indoles and their use as 5-HT6 modulators
AU2003223443A1 (en) Secure animal carrier
PL376020A1 (en) 2,7-substituted indoles and their use as 5-ht6 modulators
AU2003290507A1 (en) Compounds, compositions and methods
IL167936A0 (en) Compounds, compositions,and methods
AU2003235649A1 (en) Shared resource domains
AU2003290722A1 (en) Methods and compositions for detecting telomerase activity
AU2003241394A1 (en) Cooperation of concurrent, distributed networks of resources
AU2003300031A1 (en) Compounds, compositions, and methods
AU2003267169A1 (en) Compounds, compositions and methods

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase