AU2006279643B2 - Neurorestoration with R(+) pramipexole - Google Patents
Neurorestoration with R(+) pramipexole Download PDFInfo
- Publication number
- AU2006279643B2 AU2006279643B2 AU2006279643A AU2006279643A AU2006279643B2 AU 2006279643 B2 AU2006279643 B2 AU 2006279643B2 AU 2006279643 A AU2006279643 A AU 2006279643A AU 2006279643 A AU2006279643 A AU 2006279643A AU 2006279643 B2 AU2006279643 B2 AU 2006279643B2
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- Australia
- Prior art keywords
- daily
- formulation
- disease
- pramipexole
- tetrahydrobenzathiazole
- Prior art date
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- Ceased
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Medicinal Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US60/708,213 | 2005-08-15 | ||
| PCT/US2006/031831 WO2007022182A1 (en) | 2005-08-15 | 2006-08-15 | Neurorestoration with r(+) pramipexole |
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| AU2006279643B2 true AU2006279643B2 (en) | 2010-06-17 |
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| AU2006279643A Ceased AU2006279643B2 (en) | 2005-08-15 | 2006-08-15 | Neurorestoration with R(+) pramipexole |
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| US (3) | US20080234338A1 (2) |
| EP (1) | EP1917014B1 (2) |
| JP (2) | JP2009504748A (2) |
| AT (1) | ATE444750T1 (2) |
| AU (1) | AU2006279643B2 (2) |
| CA (1) | CA2619217A1 (2) |
| DE (1) | DE602006009670D1 (2) |
| ES (1) | ES2334061T3 (2) |
| IL (1) | IL189512A (2) |
| WO (1) | WO2007022182A1 (2) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US8017598B2 (en) | 2006-05-16 | 2011-09-13 | Knopp Neurosciences, Inc. | Compositions of R(+) and S(−) pramipexole and methods of using the same |
| US8518926B2 (en) | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
| US8524695B2 (en) | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
| US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
| US9512096B2 (en) | 2011-12-22 | 2016-12-06 | Knopp Biosciences, LLP | Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
| US9642840B2 (en) | 2013-08-13 | 2017-05-09 | Knopp Biosciences, Llc | Compositions and methods for treating plasma cell disorders and B-cell prolymphocytic disorders |
| US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
| US9763918B2 (en) | 2013-08-13 | 2017-09-19 | Knopp Biosciences Llc | Compositions and methods for treating chronic urticaria |
| US9849116B2 (en) | 2008-08-19 | 2017-12-26 | Knopp Biosciences Llc | Compositions and methods of using (R)-pramipexole |
| US10179774B2 (en) | 2007-03-14 | 2019-01-15 | Knopp Biosciences Llc | Synthesis of chirally purified substituted benzothiazole diamines |
| US10828284B2 (en) | 2013-07-12 | 2020-11-10 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to elevated levels of eosinophils and/or basophils |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2432527T3 (es) * | 2001-12-11 | 2013-12-04 | University Of Virginia Patent Foundation | Uso de pramipexol para tratar la esclerosis lateral amiotrófica |
| US20060281797A1 (en) * | 2001-12-11 | 2006-12-14 | University Of Virginia Patent Foundation | Neurorestoration with R(+) Pramipexole |
| US20050226926A1 (en) | 2002-07-25 | 2005-10-13 | Pfizer Inc | Sustained-release tablet composition of pramipexole |
| UA93608C2 (ru) | 2004-08-13 | 2011-02-25 | Берингер Ингельхайм Интернациональ Гмбх | композициЯ таблетки пролонгированного высвобождения, которая содержит прамипексол или его фармацевтически приемлемую соль, СПОСОБ EE ИЗГОТОВЛЕНИЯ И EE ПРИМЕНЕНИЕ |
| CN101022788B (zh) | 2004-08-13 | 2010-11-10 | 贝林格尔·英格海姆国际有限公司 | 包含普拉克索或其可药用盐的延长释放小球制剂、其制备方法及其用途 |
| ATE444750T1 (de) * | 2005-08-15 | 2009-10-15 | Univ Virginia | Neurorestauration mit r(+) pramipexol |
| WO2007090882A2 (en) * | 2006-02-10 | 2007-08-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical extended release compositions comprising pramipexole |
| EP2465500A1 (en) * | 2006-05-16 | 2012-06-20 | Knopp Neurosciences, Inc. | Therapeutically effective amounts of R(+) and S(-) pramipexole for use in the treatment of parkinson's disease |
| CN104107177A (zh) * | 2006-12-14 | 2014-10-22 | 诺普生物科学有限责任公司 | (r)-普拉克索的组合物以及使用该组合物的方法 |
| EP2136638A4 (en) * | 2007-03-14 | 2010-05-12 | Knopp Neurosciences Inc | MODIFIED RELEASE FORMULATIONS OF (6R) -4,5,6,7-TETRAHYDRO-N6-PROPYL-2,6-BENZOTHIAZOLE DIAMINE AND METHODS OF USE THEREOF |
| RU2470635C2 (ru) * | 2007-05-11 | 2012-12-27 | Сантен Фармасьютикал Ко., Лтд. | Профилактическое или терапевтическое средство, применяемое при заболеваниях заднего отдела глаза |
| GB0721333D0 (en) * | 2007-10-31 | 2007-12-12 | Motac Neuroscience Ltd | Medicaments |
| AU2010234244A1 (en) * | 2009-04-09 | 2011-10-13 | Purdue Pharma | Once-daily oral IR/CR pramipexole formulation |
| AU2010262970A1 (en) * | 2009-06-19 | 2012-01-12 | Knopp Neurosciences, Inc. | Compositions and methods for treating amyotrophic lateral sclerosis |
| KR101799429B1 (ko) | 2010-05-03 | 2017-11-21 | 에스케이바이오팜 주식회사 | 신경 세포 사멸 또는 신경 퇴화를 억제하기 위한 약학적 조성물 |
| WO2016194015A2 (en) * | 2015-06-04 | 2016-12-08 | Chiarugi Alberto | Use of r(+)-pramipexole (dexpramipexole) for the treatment of cerebral ischemia of the focal type |
| IL269550B2 (en) * | 2017-03-27 | 2025-01-01 | Chase Therapeutics Corp | Combining a 5HT3 antagonist and pramipexole for the treatment of synucleinopathies |
| IL312486B2 (en) | 2017-04-10 | 2025-05-01 | Chase Therapeutics Corp | NK1 antagonist combination and method for treating synucleinopathies |
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| WO2003049705A2 (en) * | 2001-12-11 | 2003-06-19 | University Of Virginia Patent Foundation | Use of pramipexole to treat amyotrophic lateral sclerosis |
| WO2005011687A1 (de) * | 2003-07-23 | 2005-02-10 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches system mit dem wirkstoff pramipexol |
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| US6156777A (en) * | 1994-12-15 | 2000-12-05 | Pharmacia & Upjohn Company | Use of pramipexole as a neuroprotective agent |
| ES2159362T3 (es) * | 1995-10-26 | 2001-10-01 | Sanofi Synthelabo | Utilizacion de la 1-(2-naft-2-iletil)-4-(3-trifluorometilfenil)-1,2,3,6-tetrahidropiridina para la preparacion de medicamentos destinados para el tratamiento de la esclerosis lateral amiotrofica. |
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-
2006
- 2006-08-15 AT AT06801521T patent/ATE444750T1/de not_active IP Right Cessation
- 2006-08-15 AU AU2006279643A patent/AU2006279643B2/en not_active Ceased
- 2006-08-15 DE DE602006009670T patent/DE602006009670D1/de active Active
- 2006-08-15 CA CA002619217A patent/CA2619217A1/en not_active Abandoned
- 2006-08-15 WO PCT/US2006/031831 patent/WO2007022182A1/en not_active Ceased
- 2006-08-15 ES ES06801521T patent/ES2334061T3/es active Active
- 2006-08-15 JP JP2008527061A patent/JP2009504748A/ja not_active Withdrawn
- 2006-08-15 EP EP06801521A patent/EP1917014B1/en not_active Not-in-force
- 2006-08-15 US US12/063,943 patent/US20080234338A1/en not_active Abandoned
-
2008
- 2008-02-13 IL IL189512A patent/IL189512A/en not_active IP Right Cessation
-
2011
- 2011-05-06 US US13/102,757 patent/US20110218222A1/en not_active Abandoned
-
2012
- 2012-10-23 JP JP2012233610A patent/JP2013014629A/ja active Pending
- 2012-12-27 US US13/728,504 patent/US20130116292A1/en not_active Abandoned
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| WO1996018395A1 (en) * | 1994-12-15 | 1996-06-20 | Pharmacia & Upjohn Company | Use of pramipexole as a neuroprotective agent |
| WO2003049705A2 (en) * | 2001-12-11 | 2003-06-19 | University Of Virginia Patent Foundation | Use of pramipexole to treat amyotrophic lateral sclerosis |
| WO2005011687A1 (de) * | 2003-07-23 | 2005-02-10 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches system mit dem wirkstoff pramipexol |
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Also Published As
| Publication number | Publication date |
|---|---|
| AU2006279643A1 (en) | 2007-02-22 |
| CA2619217A1 (en) | 2007-02-22 |
| ATE444750T1 (de) | 2009-10-15 |
| ES2334061T3 (es) | 2010-03-04 |
| EP1917014B1 (en) | 2009-10-07 |
| US20110218222A1 (en) | 2011-09-08 |
| IL189512A0 (en) | 2011-08-01 |
| IL189512A (en) | 2013-03-24 |
| WO2007022182A1 (en) | 2007-02-22 |
| JP2013014629A (ja) | 2013-01-24 |
| JP2009504748A (ja) | 2009-02-05 |
| DE602006009670D1 (de) | 2009-11-19 |
| EP1917014A1 (en) | 2008-05-07 |
| US20080234338A1 (en) | 2008-09-25 |
| US20130116292A1 (en) | 2013-05-09 |
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