AU2654399A - Cyclic amine modulators of chemokine receptor activity - Google Patents
Cyclic amine modulators of chemokine receptor activity Download PDFInfo
- Publication number
- AU2654399A AU2654399A AU26543/99A AU2654399A AU2654399A AU 2654399 A AU2654399 A AU 2654399A AU 26543/99 A AU26543/99 A AU 26543/99A AU 2654399 A AU2654399 A AU 2654399A AU 2654399 A AU2654399 A AU 2654399A
- Authority
- AU
- Australia
- Prior art keywords
- alkyl
- pct
- substituted
- phenyl
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 0 CC(CCN(CC1)CCC1N(CC=C)C(OCc1ccccc1)=*)(CN(C)*)c1c[s]cc1 Chemical compound CC(CCN(CC1)CCC1N(CC=C)C(OCc1ccccc1)=*)(CN(C)*)c1c[s]cc1 0.000 description 2
- DUAJOWDGYKHLJR-UHFFFAOYSA-N CCN(C1CCN(CCC(CN(C)S(c2ccccc2)(=O)=O)c2ccc[s]2)CC1)C(OCc1ccccc1)=O Chemical compound CCN(C1CCN(CCC(CN(C)S(c2ccccc2)(=O)=O)c2ccc[s]2)CC1)C(OCc1ccccc1)=O DUAJOWDGYKHLJR-UHFFFAOYSA-N 0.000 description 1
- WHPXWVYSBHIUMT-UHFFFAOYSA-N CCN(C1CCN(CCC(CN(C)S(c2ccccc2)(O)=O)c2c[s]cc2)CC1)C(OCc1ccccc1)=O Chemical compound CCN(C1CCN(CCC(CN(C)S(c2ccccc2)(O)=O)c2c[s]cc2)CC1)C(OCc1ccccc1)=O WHPXWVYSBHIUMT-UHFFFAOYSA-N 0.000 description 1
- LYUSSTYBMZVVAG-MUUNZHRXSA-N CN(C[C@@H](CCN(CC1)CCC1N(CC#C)C(OCc(cc1)ccc1[N+]([O-])=O)=O)c1cc(Cl)ccc1)S(c1ccccc1)(O)=O Chemical compound CN(C[C@@H](CCN(CC1)CCC1N(CC#C)C(OCc(cc1)ccc1[N+]([O-])=O)=O)c1cc(Cl)ccc1)S(c1ccccc1)(O)=O LYUSSTYBMZVVAG-MUUNZHRXSA-N 0.000 description 1
- UECQRASLNMADGA-GDLZYMKVSA-N CN(C[C@@H](CCN(CC1)CCC1N(CC#C)C(OCc(cc1)ccc1[N+]([O-])=O)=O)c1ccccc1)S(c1ccccc1)(O)=O Chemical compound CN(C[C@@H](CCN(CC1)CCC1N(CC#C)C(OCc(cc1)ccc1[N+]([O-])=O)=O)c1ccccc1)S(c1ccccc1)(O)=O UECQRASLNMADGA-GDLZYMKVSA-N 0.000 description 1
- RLMBKQNRPRZEFL-GDLZYMKVSA-N CN(C[C@@H](CCN(CC1)CCC1N(CC#C)C(OCc1ccccc1)=O)c1cc(Cl)ccc1)S(c1ccccc1)(=O)=O Chemical compound CN(C[C@@H](CCN(CC1)CCC1N(CC#C)C(OCc1ccccc1)=O)c1cc(Cl)ccc1)S(c1ccccc1)(=O)=O RLMBKQNRPRZEFL-GDLZYMKVSA-N 0.000 description 1
- UNXXYTGACLKVSG-WJOKGBTCSA-N CN(C[C@@H](CCN(CC1)CCC1N(CC1CC1)C(OCc1ccccc1)=O)c1ccccc1)S(c1ccccc1)(=O)=O Chemical compound CN(C[C@@H](CCN(CC1)CCC1N(CC1CC1)C(OCc1ccccc1)=O)c1ccccc1)S(c1ccccc1)(=O)=O UNXXYTGACLKVSG-WJOKGBTCSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7344698P | 1998-02-02 | 1998-02-02 | |
| US60073446 | 1998-02-02 | ||
| GB9810890 | 1998-05-20 | ||
| GBGB9810890.5A GB9810890D0 (en) | 1998-05-20 | 1998-05-20 | Cyclic amine modulators of chemokine receptor activity |
| PCT/US1999/002165 WO1999038514A1 (fr) | 1998-02-02 | 1999-02-01 | Amines cycliques utilisees en tant que modulateurs de l'activite du recepteur de chemokine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2654399A true AU2654399A (en) | 1999-08-16 |
Family
ID=26313719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU26543/99A Abandoned AU2654399A (en) | 1998-02-02 | 1999-02-01 | Cyclic amine modulators of chemokine receptor activity |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1052992A1 (fr) |
| JP (1) | JP2002501898A (fr) |
| AU (1) | AU2654399A (fr) |
| CA (1) | CA2319781A1 (fr) |
| WO (1) | WO1999038514A1 (fr) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6025154A (en) | 1995-06-06 | 2000-02-15 | Human Genome Sciences, Inc. | Polynucleotides encoding human G-protein chemokine receptor HDGNR10 |
| US6743594B1 (en) | 1995-06-06 | 2004-06-01 | Human Genome Sciences, Inc. | Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5) |
| CZ20012502A3 (cs) * | 1999-01-13 | 2002-03-13 | Millennium Pharmaceuticals, Inc. | Funkcionalizované heterocykly jako modulátory chemokinových receptorů |
| SE9902987D0 (sv) | 1999-08-24 | 1999-08-24 | Astra Pharma Prod | Novel compounds |
| AR025884A1 (es) | 1999-10-01 | 2002-12-18 | Takeda Pharmaceutical | Compuestos de amina ciclica, su produccion y su uso |
| FR2802206B1 (fr) | 1999-12-14 | 2005-04-22 | Sod Conseils Rech Applic | Derives de 4-aminopiperidine et leur utilisation en tant que medicament |
| GB0004152D0 (en) | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel compounds |
| GB0004153D0 (en) | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel use |
| GB0004151D0 (en) | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel use |
| GB0013060D0 (en) | 2000-05-31 | 2000-07-19 | Astrazeneca Ab | Chemical compounds |
| GB0021670D0 (en) | 2000-09-04 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
| DE60137435D1 (de) | 2000-09-15 | 2009-03-05 | Anormed Inc | Chemokin rezeptor bindenden heterozyklische verbindungen |
| US6734191B2 (en) * | 2000-09-15 | 2004-05-11 | Anormed, Inc. | Chemokine receptor binding heterocyclic compounds |
| RU2297413C2 (ru) * | 2000-09-15 | 2007-04-20 | Анормед, Инк. | Гетероциклические соединения, моделирующие активность хемокинового рецептора, их применение и содержащая их фармацевтическая композиция |
| HK1052011A1 (zh) * | 2000-09-15 | 2003-08-29 | Anormed Inc. | 趋化因子受体结合杂环化合物 |
| RU2277092C2 (ru) * | 2000-09-15 | 2006-05-27 | Анормед, Инк. | Гетероциклические соединения, их применение и фармацевтическая композиция для лечения состояний, опосредованных схсr4 и ccr5 |
| AU2002213467A8 (en) | 2000-10-11 | 2009-07-30 | Chemocentryx Inc | Modulation of ccr4 function |
| US7175988B2 (en) | 2001-02-09 | 2007-02-13 | Human Genome Sciences, Inc. | Human G-protein Chemokine Receptor (CCR5) HDGNR10 |
| GB0104050D0 (en) | 2001-02-19 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
| GB0107228D0 (en) | 2001-03-22 | 2001-05-16 | Astrazeneca Ab | Chemical compounds |
| GB0108099D0 (en) * | 2001-03-30 | 2001-05-23 | Hoffmann La Roche | Aminopiperidine derivatives |
| US7144903B2 (en) | 2001-05-23 | 2006-12-05 | Amgen Inc. | CCR4 antagonists |
| ATE319703T1 (de) | 2001-07-02 | 2006-03-15 | Piperidinverbindungen, die sich als modulatoren der chemokinrezeptoraktivität eignen | |
| GB0117899D0 (en) * | 2001-07-23 | 2001-09-12 | Astrazeneca Ab | Chemical compounds |
| SE0102640D0 (sv) | 2001-07-31 | 2001-07-31 | Astrazeneca Ab | Novel compounds |
| GB0120461D0 (en) | 2001-08-22 | 2001-10-17 | Astrazeneca Ab | Novel compounds |
| GB0122503D0 (en) | 2001-09-18 | 2001-11-07 | Astrazeneca Ab | Chemical compounds |
| SE0103818D0 (sv) | 2001-11-15 | 2001-11-15 | Astrazeneca Ab | Chemical compounds |
| US7393934B2 (en) | 2001-12-21 | 2008-07-01 | Human Genome Sciences, Inc. | Human G-protein chemokine receptor (CCR5) HDGNR10 |
| SE0200843D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
| SE0200844D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
| RU2366655C2 (ru) | 2003-03-14 | 2009-09-10 | Оно Фармасьютикал Ко., Лтд. | Азотсодержащие гетероциклические производные и лекарственные средства, содержащие их в качестве активного ингредиента |
| SE0300957D0 (sv) | 2003-04-01 | 2003-04-01 | Astrazeneca Ab | Chemical compounds |
| WO2004092169A1 (fr) | 2003-04-18 | 2004-10-28 | Ono Pharmaceutical Co., Ltd. | Compose de spiropiperidine et son utilisation medicinale |
| SE0301369D0 (sv) | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | Chemical compounds |
| EP1723178A4 (fr) | 2004-03-12 | 2007-12-12 | Human Genome Sciences Inc | Recepteur humain (ccr5) hdgnr10 de chimiokine de la proteine g |
| TW200538098A (en) * | 2004-03-22 | 2005-12-01 | Astrazeneca Ab | Therapeutic agents |
| SE0400925D0 (sv) * | 2004-04-06 | 2004-04-06 | Astrazeneca Ab | Chemical compounds |
| TW200610761A (en) | 2004-04-23 | 2006-04-01 | Astrazeneca Ab | Chemical compounds |
| US8143404B2 (en) | 2004-09-13 | 2012-03-27 | Ono Pharmaceutical Co., Ltd | Nitrogenous heterocylic derivative and medicine containing the same as an active ingredient |
| EP1889622A4 (fr) | 2005-05-31 | 2009-12-23 | Ono Pharmaceutical Co | Compose de spiropiperidine et son utilisation medicinale |
| WO2006138350A2 (fr) * | 2005-06-15 | 2006-12-28 | Anormed Inc. | Composes de liaison au recepteur de la chimiokine |
| JP2009501793A (ja) | 2005-07-21 | 2009-01-22 | アストラゼネカ・アクチエボラーグ | 新規ピペリジン誘導体 |
| EP2657235A1 (fr) | 2005-10-28 | 2013-10-30 | Ono Pharmaceutical Co., Ltd. | Composé contenant un groupe basique et son utilisation |
| WO2007058322A1 (fr) | 2005-11-18 | 2007-05-24 | Ono Pharmaceutical Co., Ltd. | Composé contenant un groupe basique et son utilisation |
| CA2644368A1 (fr) | 2006-03-10 | 2007-09-20 | Ono Pharmaceutical Co., Ltd. | Derive heterocyclique azote et agent pharmaceutique comprenant le derive en tant que principe actif |
| JP5245827B2 (ja) | 2006-07-31 | 2013-07-24 | 小野薬品工業株式会社 | スピロ結合した環状基を含有する化合物およびその用途 |
| US8278302B2 (en) | 2009-04-08 | 2012-10-02 | Boehringer Ingelheim International Gmbh | Substituted piperidines as CCR3 antagonists |
| WO2010129351A1 (fr) | 2009-04-28 | 2010-11-11 | Schepens Eye Research Institute | Procédé pour identifier et pour traiter une dégénérescence maculaire liée à l'âge |
| UA109290C2 (uk) | 2010-10-07 | 2015-08-10 | Спільні кристали і солі інгібіторів ccr3 | |
| WO2013024022A1 (fr) | 2011-08-12 | 2013-02-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes et compositions pharmaceutiques pour traiter l'hypertension pulmonaire |
| US8680280B2 (en) | 2012-04-02 | 2014-03-25 | Boehringer Ingelheim International Gmbh | Process for the manufacturing of CRR inhibitors |
| US10213421B2 (en) | 2012-04-04 | 2019-02-26 | Alkahest, Inc. | Pharmaceutical formulations comprising CCR3 antagonists |
| DK3209655T3 (da) | 2014-10-24 | 2020-09-28 | Landos Biopharma Inc | Lanthioninsyntease C-lignende 2-baserede Therapeutica |
| KR20230026522A (ko) | 2019-12-20 | 2023-02-24 | 란도스 바이오파마, 인크. | 란티오닌 c-유사 단백질 2 리간드, 이로 제조된 세포, 및 이를 사용하는 치료법 |
| US11629196B2 (en) | 2020-04-27 | 2023-04-18 | Incelldx, Inc. | Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2719311B1 (fr) * | 1994-03-18 | 1998-06-26 | Sanofi Sa | Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic. |
| FR2738819B1 (fr) * | 1995-09-14 | 1997-12-05 | Sanofi Sa | Nouveaux composes antagonistes selectifs du recepteur nk3 humain, procede pour leur obtention et compositions pharmaceutiques les contenant |
| JPH09249566A (ja) * | 1996-03-19 | 1997-09-22 | Takeda Chem Ind Ltd | ピペリジン化合物含有ケモカイン受容体拮抗剤 |
-
1999
- 1999-02-01 JP JP2000529247A patent/JP2002501898A/ja not_active Withdrawn
- 1999-02-01 EP EP99906697A patent/EP1052992A1/fr not_active Withdrawn
- 1999-02-01 AU AU26543/99A patent/AU2654399A/en not_active Abandoned
- 1999-02-01 WO PCT/US1999/002165 patent/WO1999038514A1/fr not_active Ceased
- 1999-02-01 CA CA002319781A patent/CA2319781A1/fr not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002501898A (ja) | 2002-01-22 |
| WO1999038514A1 (fr) | 1999-08-05 |
| CA2319781A1 (fr) | 1999-08-05 |
| EP1052992A1 (fr) | 2000-11-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |