AU2783492A - Phosphonopeptides with collagenase inhibiting activity - Google Patents

Phosphonopeptides with collagenase inhibiting activity

Info

Publication number
AU2783492A
AU2783492A AU27834/92A AU2783492A AU2783492A AU 2783492 A AU2783492 A AU 2783492A AU 27834/92 A AU27834/92 A AU 27834/92A AU 2783492 A AU2783492 A AU 2783492A AU 2783492 A AU2783492 A AU 2783492A
Authority
AU
Australia
Prior art keywords
leucyl
phosphono
propyl
methylamide
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU27834/92A
Other languages
English (en)
Inventor
David James Hunter
Roger Edward Markwell
Robert William Ward
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of AU2783492A publication Critical patent/AU2783492A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU27834/92A 1991-10-28 1992-10-16 Phosphonopeptides with collagenase inhibiting activity Abandoned AU2783492A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9122859 1991-10-28
GB919122859A GB9122859D0 (en) 1991-10-28 1991-10-28 Novel compounds

Publications (1)

Publication Number Publication Date
AU2783492A true AU2783492A (en) 1993-06-07

Family

ID=10703654

Family Applications (1)

Application Number Title Priority Date Filing Date
AU27834/92A Abandoned AU2783492A (en) 1991-10-28 1992-10-16 Phosphonopeptides with collagenase inhibiting activity

Country Status (10)

Country Link
EP (1) EP0612324A1 (fr)
JP (1) JPH07500600A (fr)
AU (1) AU2783492A (fr)
CA (1) CA2122147A1 (fr)
GB (1) GB9122859D0 (fr)
MX (1) MX9206191A (fr)
PT (1) PT101010A (fr)
TW (1) TW234127B (fr)
WO (1) WO1993009136A1 (fr)
ZA (1) ZA928258B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2132851C1 (ru) * 1993-08-05 1999-07-10 Синтекс (Ю.Эс.Эй) Инк. Производные амидов, являющиеся ингибиторами матричных металлопротеаз, фармацевтическая композиция
US5773428A (en) * 1993-08-05 1998-06-30 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors
US6013792A (en) * 1993-08-05 2000-01-11 Syntex (U.S.A.), Inc. Matrix metalloprotease inhibitors
US5840698A (en) * 1994-10-27 1998-11-24 Affymax Technologies N.V. Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5831004A (en) * 1994-10-27 1998-11-03 Affymax Technologies N.V. Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
JP2010520875A (ja) 2007-03-09 2010-06-17 レノビス， インコーポレイテッド Ｐ２ｘ７調節因子としてのビシクロヘテロアリール化合物およびその使用
EP2326619B1 (fr) 2008-08-01 2019-02-27 Bioxiness Pharmaceuticals, Inc. Analogues de methionine, et procedes d'utilisation de ceux-ci

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8726714D0 (en) * 1987-11-14 1987-12-16 Beecham Group Plc Compounds
EP0401963A1 (fr) * 1989-04-13 1990-12-12 Beecham Group p.l.c. Phosphonopeptides avec activité inhibitrice de collagénase
GB9008065D0 (en) * 1990-04-10 1990-06-06 Beecham Group Plc Novel compounds
GB9008078D0 (en) * 1990-04-10 1990-06-06 Beecham Group Plc Novel compounds

Also Published As

Publication number Publication date
MX9206191A (es) 1993-06-01
EP0612324A1 (fr) 1994-08-31
ZA928258B (en) 1994-04-26
WO1993009136A1 (fr) 1993-05-13
TW234127B (fr) 1994-11-11
JPH07500600A (ja) 1995-01-19
CA2122147A1 (fr) 1993-05-13
PT101010A (pt) 1994-01-31
GB9122859D0 (en) 1991-12-11

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